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Mechanisms of toxicity. In: Klaassen CD, ed. Cassarett and Doull's toxicology: the basic science of poisons. 9th ed. New York, NY: McGraw-Hill Education; 2019:65-125."},{"key":"10.1016\/j.semnephrol.2018.12.010_bib0106","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0090-9556(25)06742-X","article-title":"Species similarities and differences in pharmacokinetics","volume":"23","author":"Lin","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.semnephrol.2018.12.010_bib0107","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.1073\/pnas.0506483102","article-title":"A human transporter protein that mediates the final excretion step for toxic organic cations","volume":"102","author":"Otsuka","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2018.12.010_bib0108","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1681\/ASN.2006030205","article-title":"Identification and functional characterization of a new human kidney-specific H+\/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2","volume":"17","author":"Masuda","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2018.12.010_bib0109","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1124\/jpet.105.094052","article-title":"Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? 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