{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:43Z","timestamp":1790662183045,"version":"4.1.0"},"reference-count":148,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008786","name":"Keck School of Medicine of USC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seminarsinnephrology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.semnephrol.2019.04.005","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T22:01:18Z","timestamp":1562709678000},"page":"353-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology"],"prefix":"10.1016","volume":"39","author":[{"given":"Renee","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria M.","family":"Pastor-Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2019.04.005_bib0001","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s004670050653","article-title":"Collecting duct morphogenesis","volume":"13","author":"Davies","year":"1999","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0002","first-page":"F1","article-title":"Structural-functional relationship along the distal nephron","volume":"250","author":"Madsen","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0003","series-title":"The kidney: structure and function in health and disease","author":"Smith","year":"1951"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0004","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1172\/JCI71944","article-title":"Opening lines of communication in the distal nephron","volume":"123","author":"Kleyman","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1681\/ASN.2012121183","article-title":"Salt and pepper distribution of cell types in the collecting duct","volume":"24","author":"Sampogna","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0006","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-physiol-012110-142253","article-title":"Terminal differentiation in epithelia: the role of integrins in hensin polymerization","volume":"73","author":"Al-Awqati","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0007","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1172\/JCI63492","article-title":"Renal beta-intercalated cells maintain body fluid and electrolyte balance","volume":"123","author":"Gueutin","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0008","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM198710223171702","article-title":"\u201cSalt-sensitive\u201d essential hypertension in men. Is the sodium ion alone important?","volume":"317","author":"Kurtz","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0009","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2215\/CJN.07400715","article-title":"Acid-base homeostasis","volume":"10","author":"Hamm","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0010","first-page":"F680","article-title":"Control of bicarbonate transport in collecting tubules from normal and remnant kidneys","volume":"256","author":"Hamm","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0011","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.2215\/CJN.10311013","article-title":"Urea and ammonia metabolism and the control of renal nitrogen excretion","volume":"10","author":"Weiner","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0012","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/j.2040-4603.2014.tb00593.x","article-title":"Molecular mechanisms and regulation of urinary acidification","volume":"4","author":"Kurtz","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0013","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000479968","article-title":"Acid-base and electrolyte disorders in patients with and without chronic kidney disease: an update","volume":"3","author":"Dhondup","year":"2017","journal-title":"Kidney Dis (Basel)"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0014","doi-asserted-by":"crossref","first-page":"F1162","DOI":"10.1152\/ajprenal.00645.2009","article-title":"Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase","volume":"298","author":"Gong","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0015","doi-asserted-by":"crossref","first-page":"F130","DOI":"10.1152\/ajprenal.00406.2007","article-title":"Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells","volume":"294","author":"Paunescu","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0016","doi-asserted-by":"crossref","first-page":"F120","DOI":"10.1152\/ajprenal.00507.2014","article-title":"Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4","volume":"309","author":"Sun","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0017","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI40145","article-title":"The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice","volume":"120","author":"Leviel","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0018","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1073\/pnas.1221496110","article-title":"Renal intercalated cells are rather energized by a proton than a sodium pump","volume":"110","author":"Chambrey","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0019","first-page":"197","article-title":"Architecture and cell structures in the distal nephron of the rat kidney","volume":"17","author":"Crayen","year":"1978","journal-title":"Cytobiologie"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0020","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-physiol-020911-153225","article-title":"A new look at electrolyte transport in the distal tubule","volume":"74","author":"Eladari","year":"2012","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0021","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1073\/pnas.86.14.5429","article-title":"Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase","volume":"86","author":"Alper","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0022","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.ASN.0000088027.54400.C6","article-title":"Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury","volume":"14","author":"Mishra","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0023","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ki.2011.109","article-title":"Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract","volume":"80","author":"Spencer","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0024","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrneph.2015.105","article-title":"Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis","volume":"11","author":"Becknell","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121419","article-title":"Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor","volume":"10","author":"Azroyan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0026","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20101411","article-title":"Regulation of pendrin by pH: dependence on glycosylation","volume":"434","author":"Azroyan","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0027","first-page":"1","article-title":"Structural analysis of the rabbit kidney","volume":"56","author":"Kaissling","year":"1979","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0028","doi-asserted-by":"crossref","first-page":"F998","DOI":"10.1152\/ajprenal.00067.2003","article-title":"Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct","volume":"285","author":"Liu","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0029","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jemt.1060090206","article-title":"Relationship between structure and function in distal tubule and collecting duct","volume":"9","author":"Madsen","year":"1988","journal-title":"J Electron Microsc Tech"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0030","series-title":"Seldin and Giebisch's the kidney: physiology and pathophysiology","first-page":"595","article-title":"Structural organization of the mammalian kidney","author":"Kriz","year":"2013"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0031","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/ki.1987.111","article-title":"Intercalated cells of the rat inner medullary collecting duct","volume":"31","author":"Clapp","year":"1987","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0032","doi-asserted-by":"crossref","first-page":"e55286","DOI":"10.1371\/journal.pone.0055286","article-title":"Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone","volume":"8","author":"Mohebbi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0033","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/331622a0","article-title":"An H+-ATPase in opposite plasma membrane domains in kidney epithelial cell subpopulations","volume":"331","author":"Brown","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0034","doi-asserted-by":"crossref","first-page":"F427","DOI":"10.1152\/ajprenal.00022.2013","article-title":"Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation","volume":"305","author":"Wall","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1011","article-title":"Intercalated cell subtypes in connecting tubule and cortical collecting duct of rat and mouse","volume":"10","author":"Kim","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 5","key":"10.1016\/j.semnephrol.2019.04.005_bib0036","first-page":"S61","article-title":"Physiology and molecular biology of renal carbonic anhydrase","volume":"15","author":"Schwartz","year":"2002","journal-title":"J Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0037","doi-asserted-by":"crossref","first-page":"C521","DOI":"10.1152\/ajpcell.1992.263.2.C521","article-title":"Conditional immortalization of bicarbonate-secreting intercalated cells from rabbit","volume":"263","author":"Edwards","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0038","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00374853","article-title":"Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties","volume":"428","author":"Gekle","year":"1994","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0039","doi-asserted-by":"crossref","first-page":"C558","DOI":"10.1152\/ajpcell.1997.273.2.C558","article-title":"Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cells","volume":"273","author":"Guntupalli","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0040","doi-asserted-by":"crossref","first-page":"C1571","DOI":"10.1152\/ajpcell.1996.270.6.C1571","article-title":"Plasticity in epithelial polarity of renal intercalated cells: targeting of the H(+)-ATPase and band 3","volume":"270","author":"Al-Awqati","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0041","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(94)90382-4","article-title":"An induced extracellular matrix protein reverses the polarity of band 3 in intercalated epithelial cells","volume":"76","author":"van Adelsberg","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0042","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/sj.ki.5002500","article-title":"Role of SNAREs and H+-ATPase in the targeting of proton pump-coated vesicles to collecting duct cell apical membrane","volume":"72","author":"Schwartz","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0043","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1681\/ASN.2009050477","article-title":"Deletion of the pH sensor GPR4 decreases renal acid excretion","volume":"21","author":"Sun","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0044","doi-asserted-by":"crossref","first-page":"e9989","DOI":"10.1073\/pnas.1710964114","article-title":"Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq","volume":"114","author":"Chen","year":"2017","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1172\/JCI115268","article-title":"Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat","volume":"88","author":"Bastani","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0046","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1152\/ajprenal.00584.2009","article-title":"Cyclic AMP stimulates apical V-ATPase accumulation, microvillar elongation and proton extrusion in kidney collecting duct A-intercalated cells","volume":"298","author":"Paunescu","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0047","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1083\/jcb.11.1.248","article-title":"Cilia in different segments of the rat nephron","volume":"11","author":"Latta","year":"1961","journal-title":"J Biophys Biochem Cytol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0048","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1681\/ASN.2009080817","article-title":"Intercalated cell BK-alpha\/beta4 channels modulate sodium and potassium handling during potassium adaptation","volume":"21","author":"Holtzclaw","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0049","doi-asserted-by":"crossref","first-page":"F621","DOI":"10.1152\/ajprenal.00412.2007","article-title":"Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms","volume":"294","author":"Lynch","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0050","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1083\/jcb.105.4.1637","article-title":"Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase","volume":"105","author":"Brown","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0051","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ar.1092180303","article-title":"Nonclathrin-coated vesicles are involved in endocytosis in kidney collecting duct intercalated cells","volume":"218","author":"Brown","year":"1987","journal-title":"Anat Rec"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0052","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.273.18.10939","article-title":"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules","volume":"273","author":"Ludwig","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0053","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MNH.0b013e32833ce65f","article-title":"The renal H,K-ATPases","volume":"19","author":"Greenlee","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0054","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1097\/01.ASN.0000135060.83250.07","article-title":"Differential regulation of basolateral Cl-\/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct","volume":"15","author":"Barone","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0055","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1681\/ASN.2005111174","article-title":"Chloride\/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion","volume":"17","author":"Xu","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0056","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.00057.2005","article-title":"Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct","volume":"289","author":"Najjar","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0057","doi-asserted-by":"crossref","first-page":"F629","DOI":"10.1152\/ajprenal.00191.2003","article-title":"Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects","volume":"285","author":"Woda","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0058","first-page":"F143","article-title":"Low-conductance K channels in apical membrane of rat cortical collecting tubule","volume":"256","author":"Frindt","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0059","doi-asserted-by":"crossref","first-page":"F966","DOI":"10.1152\/ajprenal.00191.2006","article-title":"High-conductance K channels in intercalated cells of the rat distal nephron","volume":"292","author":"Palmer","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0060","doi-asserted-by":"crossref","first-page":"F780","DOI":"10.1152\/ajprenal.00002.2008","article-title":"Effect of aldosterone on BK channel expression in mammalian cortical collecting duct","volume":"295","author":"Estilo","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0061","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmet.2013.10.005","article-title":"Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia","volume":"18","author":"Shibata","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0062","doi-asserted-by":"crossref","first-page":"F410","DOI":"10.1152\/ajprenal.00518.2010","article-title":"WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism","volume":"301","author":"Zhuang","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0063","doi-asserted-by":"crossref","first-page":"C846","DOI":"10.1152\/ajpcell.00133.2013","article-title":"Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase","volume":"305","author":"Wang","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0064","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.071516798","article-title":"Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion","volume":"98","author":"Royaux","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0065","doi-asserted-by":"crossref","first-page":"9727","DOI":"10.1073\/pnas.96.17.9727","article-title":"Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear","volume":"96","author":"Everett","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0066","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endo.141.2.7303","article-title":"Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells","volume":"141","author":"Royaux","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0067","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ng1297-411","article-title":"Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)","volume":"17","author":"Everett","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0068","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/7783","article-title":"The Pendred syndrome gene encodes a chloride-iodide transport protein","volume":"21","author":"Scott","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0069","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0140-6736(58)90866-3","article-title":"Association of congenital deafness with goitre; the nature of the thyroid defect","volume":"1","author":"Morgans","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0070","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0140-6736(01)74403-0","article-title":"Deaf-mutism and goitre","volume":"148","author":"Pendred","year":"1896","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0071","doi-asserted-by":"crossref","first-page":"F1262","DOI":"10.1152\/ajprenal.00206.2005","article-title":"Intercalated cell H+\/OH- transporter expression is reduced in Slc26a4 null mice","volume":"289","author":"Kim","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0072","doi-asserted-by":"crossref","first-page":"F833","DOI":"10.1152\/ajprenal.00474.2005","article-title":"Dietary Cl(-) restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells","volume":"291","author":"Verlander","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0073","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/01.HYP.0000145863.96091.89","article-title":"NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation","volume":"44","author":"Wall","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0074","doi-asserted-by":"crossref","first-page":"C641","DOI":"10.1152\/ajpcell.1995.269.3.C641","article-title":"Cloning of a bovine renal epithelial Na+ channel subunit","volume":"269","author":"Fuller","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0075","first-page":"F291","article-title":"Microelectrode assessment of chloride-conductive properties of cortical collecting duct","volume":"247","author":"Sansom","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0076","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1681\/ASN.2007030277","article-title":"Angiotensin II activates H+-ATPase in type A intercalated cells","volume":"19","author":"Pech","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0077","doi-asserted-by":"crossref","first-page":"C1658","DOI":"10.1152\/ajpcell.00419.2008","article-title":"Pendrin in the mouse kidney is primarily regulated by Cl- excretion but also by systemic metabolic acidosis","volume":"295","author":"Hafner","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0078","doi-asserted-by":"crossref","first-page":"F1314","DOI":"10.1152\/ajprenal.00155.2007","article-title":"Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice","volume":"293","author":"Kim","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0079","doi-asserted-by":"crossref","first-page":"F1314","DOI":"10.1152\/ajprenal.00114.2011","article-title":"Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin","volume":"301","author":"Verlander","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0080","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1681\/ASN.2009121257","article-title":"Pendrin modulates ENaC function by changing luminal HCO3","volume":"21","author":"Pech","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0081","doi-asserted-by":"crossref","first-page":"F229","DOI":"10.1152\/ajprenal.00147.2002","article-title":"Localization of pendrin in mouse kidney","volume":"284","author":"Wall","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0082","doi-asserted-by":"crossref","first-page":"F744","DOI":"10.1152\/ajprenal.00037.2002","article-title":"Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney","volume":"283","author":"Kim","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0083","doi-asserted-by":"crossref","first-page":"C207","DOI":"10.1152\/ajpcell.2000.278.1.C207","article-title":"Human pendrin expressed in Xenopus laevis oocytes mediates chloride\/formate exchange","volume":"278","author":"Scott","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0084","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1159\/000335114","article-title":"Impact of bicarbonate, ammonium chloride, and acetazolamide on hepatic and renal SLC26A4 expression","volume":"28","author":"Alesutan","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0085","doi-asserted-by":"crossref","first-page":"F1069","DOI":"10.1152\/ajprenal.90581.2008","article-title":"Role of pendrin in iodide balance: going with the flow","volume":"297","author":"Kim","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0086","doi-asserted-by":"crossref","first-page":"C1206","DOI":"10.1152\/ajpcell.00512.2001","article-title":"AE4 is a DIDS-sensitive Cl(-)\/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct","volume":"283","author":"Ko","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0087","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ki.2010.195","article-title":"Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct","volume":"78","author":"Purkerson","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0088","doi-asserted-by":"crossref","first-page":"21872","DOI":"10.1073\/pnas.1010364107","article-title":"Deletion of hensin\/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis","volume":"107","author":"Gao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0089","first-page":"3290","article-title":"Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice","volume":"119","author":"Jeong","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0090","first-page":"318","article-title":"Regulation of luminal acidification by the V-ATPase","volume":"28","author":"Breton","year":"2013","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0091","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0092","doi-asserted-by":"crossref","first-page":"e4471","DOI":"10.1371\/journal.pone.0004471","article-title":"The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis","volume":"4","author":"Vidarsson","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0093","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1172\/JCI20665","article-title":"Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1","volume":"113","author":"Blomqvist","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0094","doi-asserted-by":"crossref","first-page":"e91042","DOI":"10.1172\/jci.insight.91042","article-title":"Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus","volume":"2","author":"Poulsen","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0095","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2012-1044","article-title":"Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment","volume":"34","author":"Moeller","year":"2013","journal-title":"Endocr Rev"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0096","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/01.ASN.0000050413.43662.55","article-title":"RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron","volume":"14","author":"Quentin","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0097","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/31.4.6827083","article-title":"Lectin binding sites in kidney. A comparative study of 14 animal species","volume":"31","author":"Holthofer","year":"1983","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0098","doi-asserted-by":"crossref","first-page":"F1306","DOI":"10.1152\/ajprenal.00668.2014","article-title":"Harvest and primary culture of the murine aldosterone-sensitive distal nephron","volume":"308","author":"Labarca","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0099","first-page":"F257","article-title":"Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct","volume":"269","author":"Sakairi","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0100","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.RES.0000251306.40546.08","article-title":"Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion","volume":"99","author":"Jia","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0101","doi-asserted-by":"crossref","first-page":"36599","DOI":"10.1074\/jbc.M807129200","article-title":"Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone","volume":"283","author":"Pochynyuk","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0102","doi-asserted-by":"crossref","first-page":"F501","DOI":"10.1152\/ajprenal.00147.2001","article-title":"ATP masks stretch activation of epithelial sodium channels in A6 distal nephron cells","volume":"282","author":"Ma","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0103","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1074\/jbc.M110.176552","article-title":"Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30","volume":"286","author":"Mironova","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0104","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11906-015-0538-0","article-title":"Relative roles of principal and intercalated cells in the regulation of sodium balance and blood pressure","volume":"17","author":"Chambrey","year":"2015","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0105","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1096\/fj.07-8807com","article-title":"Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption","volume":"21","author":"Rieg","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0106","doi-asserted-by":"crossref","first-page":"F943","DOI":"10.1152\/ajprenal.00303.2013","article-title":"AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney","volume":"305","author":"Alzamora","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0107","doi-asserted-by":"crossref","first-page":"24676","DOI":"10.1074\/jbc.M110.106278","article-title":"PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells","volume":"285","author":"Alzamora","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0108","doi-asserted-by":"crossref","first-page":"F981","DOI":"10.1152\/ajprenal.00362.2013","article-title":"Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase","volume":"306","author":"Al-bataineh","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0109","doi-asserted-by":"crossref","first-page":"C672","DOI":"10.1152\/ajpcell.00004.2009","article-title":"AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells","volume":"296","author":"Hallows","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0110","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nchembio.1589","article-title":"Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase","volume":"10","author":"Gidon","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0111","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1152\/ajprenal.00584.2009","article-title":"cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells","volume":"298","author":"Paunescu","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0112","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/ki.2011.196","article-title":"Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney","volume":"80","author":"Xu","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0113","doi-asserted-by":"crossref","first-page":"F1353","DOI":"10.1152\/ajprenal.00008.2012","article-title":"Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1\/2 signaling pathway","volume":"303","author":"Fisher","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0114","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1074\/jbc.M112.441782","article-title":"Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct","volume":"288","author":"Bourgeois","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0115","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/MNH.0b013e32833bfa4e","article-title":"Molecular physiology of the Rh ammonia transport proteins","volume":"19","author":"Weiner","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0116","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00424-003-1142-8","article-title":"Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters","volume":"447","author":"Nakhoul","year":"2004","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0117","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10157-014-1063-1","article-title":"pH-sensitive expression of calcium-sensing receptor (CaSR) in type-B intercalated cells of the cortical collecting ducts (CCD) in mouse kidney","volume":"19","author":"Yasuoka","year":"2015","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0118","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00424-017-2084-x","article-title":"Dietary K(+) and Cl(-) independently regulate basolateral conductance in principal and intercalated cells of the collecting duct","volume":"470","author":"Tomilin","year":"2018","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0119","doi-asserted-by":"crossref","first-page":"F1463","DOI":"10.1152\/ajprenal.00077.2015","article-title":"Effect of dietary protein restriction on renal ammonia metabolism","volume":"308","author":"Lee","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00424-017-2049-0","article-title":"Acute regulated expression of pendrin in human urinary exosomes","volume":"470","author":"Pathare","year":"2018","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0121","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.kint.2017.10.018","article-title":"Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid\/alkali loading and the defects in distal renal tubular acidosis","volume":"93","author":"Pathare","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124902","article-title":"Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance","volume":"10","author":"Jensen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0123","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1182\/blood-2002-09-2824","article-title":"A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane","volume":"101","author":"Bruce","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0124","doi-asserted-by":"crossref","first-page":"25526","DOI":"10.1074\/jbc.M302816200","article-title":"Rh-RhAG\/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation","volume":"278","author":"Nicolas","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0125","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1074\/jbc.M114.610048","article-title":"Evidence of a structural and functional ammonium transporter RhBG.anion exchanger 1.ankyrin-G complex in kidney epithelial cells","volume":"290","author":"Genetet","year":"2015","journal-title":"J Biol Chem."},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0126","series-title":"The kidney: physiology and pathophysiology","first-page":"1441","article-title":"Control of Na+ transport by aldosterone","author":"Verrey","year":"2000"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0127","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000087575","article-title":"Renal handling of NH3\/NH4+: recent concepts","volume":"101","author":"Karim","year":"2005","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0128","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ki.1980.195","article-title":"Effect of mineralocorticoid replacement therapy on renal acid-base homeostasis in adrenalectomized patients","volume":"18","author":"Sebastian","year":"1980","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0129","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1097\/HJH.0b013e3282f05bae","article-title":"Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor","volume":"25","author":"Batenburg","year":"2007","journal-title":"J Hypertens"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0130","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/ndt\/gfl846","article-title":"Prorenin and the (pro)renin receptor\u2013an update","volume":"22","author":"Jan Danser","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0131","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI0214276","article-title":"Pivotal role of the renin\/prorenin receptor in angiotensin II production and cellular responses to renin","volume":"109","author":"Nguyen","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0132","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/HYPERTENSIONAHA.108.127258","article-title":"Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma","volume":"53","author":"Cousin","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0133","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/hr.2010.284","article-title":"The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space","volume":"34","author":"Yoshikawa","year":"2011","journal-title":"Hypertens Res"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0134","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jash.2008.11.003","article-title":"Collecting duct renin: a major player in angiotensin II-dependent hypertension","volume":"3","author":"Prieto-Carrasquero","year":"2009","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0135","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1161\/01.HYP.34.6.1265","article-title":"Elements of a paracrine tubular renin-angiotensin system along the entire nephron","volume":"34","author":"Rohrwasser","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0136","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/HYPERTENSIONAHA.109.128645","article-title":"The (pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney","volume":"54","author":"Advani","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0137","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147831","article-title":"Colocalization of the (pro)renin receptor\/Atp6ap2 with H+-ATPases in mouse kidney but prorenin does not acutely regulate intercalated cell H+-ATPase activity","volume":"11","author":"Daryadel","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0138","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/ndt\/14.8.1904","article-title":"Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy","volume":"14","author":"Deinum","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0139","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1517\/13543784.15.10.1137","article-title":"Prorenin receptor blockers: effects on cardiovascular complications of diabetes and hypertension","volume":"15","author":"Ichihara","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0140","first-page":"306","article-title":"Renin, prorenin and the kidney: a new chapter in an old saga","volume":"22","author":"Ichihara","year":"2009","journal-title":"J Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0141","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.ki.5001627","article-title":"Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats","volume":"70","author":"Kaneshiro","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0142","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1681\/ASN.2017030243","article-title":"Aldosterone is essential for angiotensin II-induced upregulation of pendrin","volume":"29","author":"Hirohama","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0143","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/HYPERTENSIONAHA.116.08519","article-title":"Hypokalemia and Pendrin induction by aldosterone","volume":"69","author":"Xu","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0144","doi-asserted-by":"crossref","first-page":"F1473","DOI":"10.1152\/ajprenal.00437.2010","article-title":"In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule","volume":"299","author":"Ackermann","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0145","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1681\/ASN.V981347","article-title":"11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules","volume":"9","author":"Bostanjoglo","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0146","first-page":"E454","article-title":"Adrenocortical hormone secretory response to chronic NH4Cl-induced metabolic acidosis","volume":"252","author":"Schambelan","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0147","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00424-009-0657-z","article-title":"Regulated acid-base transport in the collecting duct","volume":"458","author":"Wagner","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.semnephrol.2019.04.005_bib0148","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/MNH.0b013e3282f29086","article-title":"The interaction of pendrin and the epithelial sodium channel in blood pressure regulation","volume":"17","author":"Wall","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929519300385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929519300385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:32:54Z","timestamp":1759447974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929519300385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":148,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0270929519300385"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2019.04.005","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2019.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}