{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:54:19Z","timestamp":1782298459085,"version":"3.54.5"},"reference-count":134,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seminarsinnephrology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.semnephrol.2019.06.008","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T18:06:39Z","timestamp":1568052399000},"page":"484-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hemolysis and Kidney Injury in Cardiac Surgery: The Protective Role of Nitric Oxide Therapy"],"prefix":"10.1016","volume":"39","author":[{"given":"Stefano","family":"Spina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Pinciroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Berra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2019.06.008_bib0001","first-page":"1","article-title":"ESC\/EACTS guidelines on myocardial revascularization","volume":"2018","author":"Neumann","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0002","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/ejcts\/ezt119","article-title":"Evaluation of cardiac surgery mortality rates: 30-day mortality or longer follow-up?","volume":"44","author":"Siregar","year":"2013","journal-title":"Eur J Cardiothoracic Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0003","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.athoracsur.2013.10.040","article-title":"In-hospital mortality after cardiac surgery: patient characteristics, timing, and association with postoperative length of intensive care unit and hospital stay","volume":"97","author":"Mazzeffi","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0004","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1200388","article-title":"Off-pump or on-pump coronary-artery bypass grafting at 30 days","volume":"366","author":"Lamy","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCULATIONAHA.108.786913","article-title":"Acute kidney injury after cardiac surgery. Focus on modifiable risk factors","volume":"119","author":"Karkouti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0006","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.2016.0548","article-title":"High-dose perioperative atorvastatin and acute kidney injury following cardiac surgery: a randomized clinical trial","volume":"315","author":"Billings","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0007","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/ALN.0000000000000959","article-title":"Platelet counts, acute kidney injury, and mortality after coronary artery bypass grafting surgery","volume":"124","author":"Kertai","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0008","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00134-016-4670-3","article-title":"Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial","volume":"43","author":"Meersch","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0009","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008834","article-title":"Cardiac and vascular surgery\u2013associated acute kidney injury: the 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group","volume":"7","author":"Nadim","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0010","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1001\/jama.2015.4189","article-title":"Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial","volume":"313","author":"Zarbock","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0011","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1001\/jama.2014.13573","article-title":"Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial","volume":"312","author":"Bove","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0012","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1161\/CIRCULATIONAHA.106.635573","article-title":"Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery","volume":"114","author":"Mehta","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0013","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1161\/CIRCULATIONAHA.108.800011","article-title":"Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery","volume":"119","author":"Hobson","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0014","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4103\/0971-9784.191578","article-title":"Cardiac surgery-associated acute kidney injury","volume":"19","author":"Ortega-Loubon","year":"2016","journal-title":"Ann Card Anaesth"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/SHK.0b013e3181e76274","article-title":"The association between the transfusion of older blood and outcomes after trauma","volume":"35","author":"Hassan","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0016","first-page":"1","article-title":"Acute kidney injury following cardiac surgery: current understanding and future directions","volume":"20","author":"O'Neal","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0017","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0003-4975(02)04559-9","article-title":"Is kidney function altered by the duration of cardiopulmonary bypass?","volume":"75","author":"Boldt","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0018","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.athoracsur.2011.09.010","article-title":"Predicting acute kidney injury after cardiac surgery: a systematic review","volume":"93","author":"Huen","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0019","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1681\/ASN.2011090940","article-title":"Obesity and oxidative stress predict AKI after cardiac surgery","volume":"23","author":"Billings","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0020","first-page":"1","article-title":"Prevention of cardiac surgery-associated acute kidney injury","volume":"31","author":"Meersch","year":"2016","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0021","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/ndt\/gfr275","article-title":"Effect of mean arterial pressure, haemoglobin and blood transfusion during cardiopulmonary bypass on post-operative acute kidney injury","volume":"27","author":"Haase","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0022","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1681\/ASN.2014080764","article-title":"Plasma IL-6 and IL-10 concentrations predict AKI and long-term mortality in adults after cardiac surgery","volume":"26","author":"Zhang","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0023","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000357871","article-title":"Heme oxygenase-1 and acute kidney injury following cardiac surgery","volume":"4","author":"Billings","year":"2014","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0024","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1051\/ject\/200840257","article-title":"Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: a review in search of a treatment algorithm","volume":"40","author":"Vercaemst","year":"2008","journal-title":"J Extra Corpor Technol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0025","series-title":"Heart-lung bypass: principles and techniques of extracorporeal circulation","author":"Galletti","year":"1962"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2014.00340","article-title":"Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage","volume":"5","author":"Vermeulen Windsant","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0027","first-page":"9265","article-title":"EDRF produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Med Sci"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0028","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1096\/fasebj.3.9.2545495","article-title":"Endothelium-derived relaxing and contracting factors","volume":"3","author":"Furchgott","year":"1989","journal-title":"FASEB J"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0029","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0030","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: From marvel to menace","volume":"113","author":"F\u00f6rstermann","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0031","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1006\/bbrc.1993.1543","article-title":"Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules","volume":"192","author":"Ziche","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0032","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/emboj\/17.11.3045","article-title":"Defective smooth muscle regulation in cGMP kinase I-deficient mice","volume":"17","author":"Pfeifer","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0033","doi-asserted-by":"crossref","unstructured":"Rasmussen H, Kelley G, Douglas JS. Interactions between Ca2+ and cAMP messenger system in regulation of airway smooth muscle contraction. Am J Physiol. 1990;258:L279-88.","DOI":"10.1152\/ajplung.1990.258.6.L279"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0034","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI89741","article-title":"Intravascular hemolysis and the pathophysiology of sickle cell disease","volume":"127","author":"Kato","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0035","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"Reiter","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0036","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"Rother","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0037","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0162-0134(00)80291-3","article-title":"Oxidation of nitrogen oxides by bound dioxygen in hemoproteins","volume":"14","author":"Doyle","year":"1981","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0038","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the haemoglobin scavenger receptor","volume":"409","author":"Kristiansen M","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0039","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0020-711X(88)90093-6","article-title":"The physiological significance of heme oxygenase","volume":"20","author":"Abraham","year":"1988","journal-title":"Int J Biochem"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0040","article-title":"Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs","volume":"119","author":"Boretti","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0041","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1182\/blood-2003-08-2760","article-title":"Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease","volume":"104","author":"Jison","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0042","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/BF03401897","article-title":"Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)","volume":"1","author":"Prestera","year":"1995","journal-title":"Mol Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0043","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.294.1.81","article-title":"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease","volume":"294","author":"Morris","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0044","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s000180050352","article-title":"Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization","volume":"55","author":"Boucher","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bcmd.2010.02.005","article-title":"Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype","volume":"44","author":"Landburg","year":"2010","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0046","first-page":"236","article-title":"Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability","volume":"109","author":"Hsu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0047","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.molmed.2016.01.004","article-title":"Heme: modulator of plasma systems in hemolytic diseases","volume":"22","author":"Roumenina","year":"2016","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0048","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.coi.2015.11.006","article-title":"Red alert: labile heme is an alarmin","volume":"38","author":"Soares","year":"2016","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0049","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2013-04-495887","article-title":"Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease","volume":"123","author":"Belcher","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0050","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0051","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2013-09-529420","article-title":"Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation","volume":"123","author":"Cardenes","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0052","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/ALN.0b013e31825575e6","article-title":"Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers","volume":"117","author":"Berra","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0053","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0054","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","article-title":"Endothelial dysfunction","volume":"23","author":"Bonetti","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0055","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/HYPERTENSIONAHA.110.160812","article-title":"Relation of brachial and digital measures of vascular function in the community: the Framingham Heart Study","volume":"57","author":"Hamburg","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0056","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/PCC.0000000000000047","article-title":"Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children","volume":"15","author":"Mamikonian","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0057","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.jvca.2016.06.009","article-title":"Pulmonary and systemic vascular resistances after cardiopulmonary bypass: role of hemolysis","volume":"31","author":"Rezoagli","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0058","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1161\/01.CIR.88.5.2128","article-title":"Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass","volume":"88","author":"Wessel","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0059","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1161\/01.CIR.0000134595.80170.62","article-title":"Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential","volume":"109","author":"Ichinose","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0060","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/00000542-199112000-00011","article-title":"Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep","volume":"75","author":"Fratacci","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0061","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction","volume":"83","author":"Frostell","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0062","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(92)92686-A","article-title":"Inhaled nitric oxide in persistent pulmonary hypertension of the newborn","volume":"340","author":"Roberts","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0063","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cardiores.2007.04.014","article-title":"Inhaled NO as a therapeutic agent","volume":"75","author":"Bloch","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0064","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1126\/science.276.5321.2034","article-title":"Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient","volume":"276","author":"Stamler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcm.2012.08.011","article-title":"Improving outcomes after cardiac arrest using NO inhalation","volume":"23","author":"Ichinose","year":"2013","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0066","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI200112761","article-title":"Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery","volume":"108","author":"Cannon","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0067","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1164\/rccm.201405-0850OC","article-title":"Autologous transfusion of stored red blood cells increases pulmonary artery pressure","volume":"190","author":"Berra","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0068","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1172\/JCI116364","article-title":"NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties","volume":"91","author":"Keaney","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0069","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/380221a0","article-title":"S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control","volume":"380","author":"Jia","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0070","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01.hdx.0000098613.53486.08","article-title":"Evidence for the extrapulmonary localization of inhaled nitric oxide","volume":"5","author":"Lecour","year":"2003","journal-title":"Heart Dis"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0071","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.niox.2018.08.006","article-title":"Pharmacological preconditioning with inhaled nitric oxide (NO): organ-specific differences in the lifetime of blood and tissue NO metabolites","volume":"80","author":"Nagasaka","year":"2018","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0072","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/bja\/79.5.631","article-title":"Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine","volume":"79","author":"Troncy","year":"1997","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0073","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1748-1716.2008.01908.x","article-title":"Prolonged exposure to inhaled nitric oxide transiently modifies tubular function in healthy piglets and promotes tubular apoptosis","volume":"195","author":"Go\u017adzik","year":"2009","journal-title":"Acta Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0074","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/niox.2001.0386","article-title":"Systemic biochemical effects of inhaled NO in rats: increased expressions of NOS III, nitrotyrosine-, and phosphotyrosine-immunoreactive proteins in liver and kidney tissues","volume":"5","author":"Kielbasa","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.CCM.0000250319.91575.BB","article-title":"Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis","volume":"35","author":"Da","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0076","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0096594","article-title":"Organ dysfunction among piglets treated with inhaled nitric oxide and intravenous hydrocortisone during prolonged endotoxin infusion","volume":"9","author":"G\u00f6ranson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0077","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179475","article-title":"Inhaled nitric oxide prevents NSAID-induced renal impairment in pseudo-normovolaemic piglets","volume":"12","author":"Junot","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0078","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1172\/JCI25040","article-title":"Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin","volume":"115","author":"Minneci","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0079","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1164\/rccm.201501-0145OC","article-title":"Effects of aged stored autologous red blood cells on human endothelial function","volume":"192","author":"Risbano","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0080","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1056\/NEJMoa1707572","article-title":"Age of red cells for transfusion and outcomes in critically ill adults","volume":"377","author":"Cooper","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0081","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa1609014","article-title":"Effect of short-term vs. long-term blood storage on mortality after transfusion","volume":"375","author":"Heddle","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0082","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1056\/NEJMoa1500704","article-title":"Age of transfused blood in critically ill adults","volume":"372","author":"Lacroix","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0083","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/ALN.0b013e3182746ba4","article-title":"Erythrocyte storage duration is not associated with increased mortality in noncardiac surgical patients: a retrospective analysis of 6,994 patients","volume":"118","author":"Saager","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0084","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/2012.jama.11953","article-title":"Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial","volume":"308","author":"Fergusson","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0085","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/lt.23379","article-title":"Duration of red blood cell storage and outcomes following orthotopic liver transplantation","volume":"18","author":"Dunn","year":"2012","journal-title":"Liver Transplant"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0086","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1097\/CCM.0b013e31828cf456","article-title":"Adverse effects of hemorrhagic shock resuscitation with stored blood are ameliorated by inhaled nitric oxide in lambs","volume":"41","author":"Baron","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0087","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/ALN.0b013e318272d866","article-title":"Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock","volume":"117","author":"Lei","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0088","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1537-2995.2011.03473.x","article-title":"Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice","volume":"52","author":"Yu","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0089","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/ALN.0b013e318246ef77","article-title":"Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide","volume":"116","author":"Baron","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0090","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1001\/jama.297.20.2232","article-title":"Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children","volume":"297","author":"Idro","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0091","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1212\/WNL.0b013e31826aacd4","article-title":"Neurologic outcomes in retinopathy-negative cerebral malaria survivors","volume":"79","author":"Postels","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0092","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/nm1499","article-title":"Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria","volume":"12","author":"Gramaglia","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0093","article-title":"Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria","volume":"6:e27714.","author":"Serghides","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0094","doi-asserted-by":"crossref","first-page":"ofv111","DOI":"10.1093\/ofid\/ofv111","article-title":"Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial","volume":"2","author":"Mwanga-Amumpaire","year":"2015","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCRESAHA.111.253419","article-title":"Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles","volume":"110","author":"Terpolilli","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0096","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/jcbfm.2012.176","article-title":"Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice","volume":"33","author":"Terpolilli","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0097","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12975-012-0217-2","article-title":"Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury","volume":"4","author":"Zhu","year":"2013","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0098","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1177\/0271678X15605848","article-title":"Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms","volume":"36","author":"Terpolilli","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0099","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/neu.2018.5824","article-title":"Inhaled nitric oxide protects cerebral autoregulation and reduces hippocampal neuronal cell necrosis after traumatic brain injury in newborn and juvenile pigs","volume":"36","author":"Hekierski","year":"2019","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0100","first-page":"1","article-title":"Inhaled nitric oxide protects cerebral autoregulation and reduces hippocampal necrosis after traumatic brain injury through inhibition of ET-1, ERK MAPK and IL-6 upregulation in pigs","volume":"9","author":"Curvello","year":"2018","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0101","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13054-015-1050-2","article-title":"Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study","volume":"19","author":"Derwall","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0102","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cardiores.2003.09.019","article-title":"Nitric oxide in myocardial ischemia\/reperfusion injury","volume":"61","author":"Schulz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0103","doi-asserted-by":"crossref","first-page":"H379","DOI":"10.1152\/ajpheart.01172.2005","article-title":"Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury","volume":"291","author":"Hataishi","year":"2006","journal-title":"Am J Physiol Circ Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0104","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jacc.2007.04.069","article-title":"Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion","volume":"50","author":"Liu","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1590\/s0102-865020180070000003","article-title":"The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism","volume":"33","author":"Zhang","year":"2018","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0106","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/ALN.0000000000000149","article-title":"Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice","volume":"120","author":"Kida","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0107","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/ALN.0b013e318186316e","article-title":"Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury","volume":"109","author":"Nagasaka","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0108","doi-asserted-by":"crossref","first-page":"H1477","DOI":"10.1152\/ajpheart.00948.2010","article-title":"Soluble guanylate cyclase-alpha1 is required for the cardioprotective effects of inhaled nitric oxide","volume":"300","author":"Nagasaka","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0109","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2003.11.011","article-title":"Circulating no pool: assessment of nitrite and nitroso species in blood and tissues","volume":"36","author":"Rassaf","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0110","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1164\/rccm.201710-2150OC","article-title":"Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery","volume":"198","author":"Lei","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0111","first-page":"A11400","article-title":"Abstract 11400: nitric oxide exerts organoprotective effects in cardiac surgery","volume":"138","author":"Kamenshchikov","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0112","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa1413579","article-title":"A multicenter trial of remote ischemic preconditioning for heart surgery","volume":"373","author":"Meybohm","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0113","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/jama.2012.14144","article-title":"Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial","volume":"308","author":"Dieleman","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0114","doi-asserted-by":"crossref","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","article-title":"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning","volume":"285","author":"Zhao","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jtcvs.2002.08.001","article-title":"Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation","volume":"127","author":"Gianetti","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0116","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jtcvs.2012.09.100","article-title":"Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children - a randomized trial","volume":"146","author":"Checchia","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0117","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1007\/s00134-016-4420-6","article-title":"Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial","volume":"42","author":"James","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0118","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.jtcvs.2018.08.117","article-title":"Nitric oxide provides myocardial protection when added to the cardiopulmonary bypass circuit during cardiac surgery: randomized trial","volume":"157","author":"Kamenshchikov","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0119","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.jvca.2013.02.005","article-title":"Methemoglobinemia: a review and recommendations for management","volume":"28","author":"Cortazzo","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/MAT.0000000000000425","article-title":"The pathophysiology of nitrogen dioxide during inhaled nitric oxide therapy","volume":"63","author":"Petit","year":"2017","journal-title":"ASAIO J"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0121","doi-asserted-by":"crossref","first-page":"H777","DOI":"10.1152\/ajpheart.2001.280.2.H777","article-title":"Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1","volume":"280","author":"McMullan","year":"2001","journal-title":"Am J Physiol Circ Physiol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0122","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/1874303X01306010036","article-title":"Methemoglobinemia-induced acute kidney injury","volume":"6","author":"Nayer","year":"2013","journal-title":"Open Urol Nephrol J"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0123","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.86.4.339","article-title":"The pathogenesis of the renal injury produced in the dog by hemoglobin or methemoglobin","volume":"86","author":"Harrison","year":"1947","journal-title":"J Exp Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0124","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-4804(66)80031-8","article-title":"Experimental studies of acute renal failure. 3. Histopathology of the renal lesion produced by methemoglobin","volume":"6","author":"Schaefer","year":"1966","journal-title":"J Surg Res"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2215\/CJN.01970211","article-title":"AKI associated with macroscopic glomerular hematuria: clinical and pathophysiologic consequences","volume":"7","author":"Moreno","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0126","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s001340050982","article-title":"Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide","volume":"25","author":"Lundin","year":"1999","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0127","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.39139.716794.55","article-title":"Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis","volume":"334","author":"Adhikari","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0128","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13054-015-0880-2","article-title":"Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials","volume":"19","author":"Ruan","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0129","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/CIRCULATIONAHA.115.019955","article-title":"Haptoglobin or hemopexin therapy prevents acute adverse effects of resuscitation after prolonged storage of red cells","volume":"134","author":"Graw","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0130","unstructured":"Tanaka K, Kanamori Y, Sato T, et al. Administration of haptoglobin during cardiopulmonary bypass surgery. ASAIO Trans. 1991;37:M482-3."},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0131","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF01744743","article-title":"Pharmacological intervention for renal protection during cardiopulmonary bypass","volume":"8","author":"Hashimoto","year":"1993","journal-title":"Heart Vessels"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0132","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4326\/jjcvs.22.404","article-title":"Hemolytic renal damage during cardiopulmonary bypass and the preventive effect of haptoglobin","volume":"22","author":"Nomura","year":"1993","journal-title":"Jpn J Cardiovasc Surg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0133","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1213\/ANE.0000000000002093","article-title":"Haptoglobin administration in cardiovascular surgery patients: its association with the risk of postoperative acute kidney injury","volume":"124","author":"Kubota","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1016\/j.semnephrol.2019.06.008_bib0134","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/bph.14512","article-title":"Inhaled nitric oxide","volume":"176","author":"Yu","year":"2019","journal-title":"Br J Pharmacol"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929519300610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929519300610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:34:58Z","timestamp":1759448098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929519300610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":134,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0270929519300610"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2019.06.008","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemolysis and Kidney Injury in Cardiac Surgery: The Protective Role of Nitric Oxide Therapy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2019.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}