{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:49:55Z","timestamp":1770742195534,"version":"3.49.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seminarsinnephrology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.semnephrol.2022.01.007","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T06:23:35Z","timestamp":1653287015000},"page":"2-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel Biomarkers in Kidney Transplantation"],"prefix":"10.1016","volume":"42","author":[{"given":"Karim M.","family":"Yatim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil R.","family":"Azzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.semnephrol.2022.01.007_bib0001","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/ajt.16502","article-title":"OPTN\/SRTR 2019 annual data report: kidney","volume":"21","author":"Hart","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0002","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2215\/CJN.08570814","article-title":"Immunosuppressive Medications","volume":"11","author":"Wiseman","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0003","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-6143.2004.00332.x","article-title":"Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era","volume":"4","author":"Meier-Kriesche","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ndt\/gfq730","article-title":"Kidney allograft survival: the long and short of it","volume":"26","author":"Lodhi","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0005","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1093\/ndt\/gfp428","article-title":"Creatinine as the gold standard for kidney injury biomarker studies?","volume":"24","author":"Waikar","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0006","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1097\/TP.0000000000001321","article-title":"Establishing biomarkers in transplant medicine","volume":"100","author":"Anglicheau","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0007","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1681\/ASN.2016080858","article-title":"Moving biomarkers toward clinical implementation in kidney transplantation","volume":"28","author":"Menon","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0008","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/TP.0000000000001664","article-title":"Transplantomics","volume":"101","author":"Sirota","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0009","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/TP.0b013e3182105fb8","article-title":"Transplantomics and biomarkers in organ transplantation: a report from the first international conference","volume":"91","author":"Sarwal","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.trre.2016.05.002","article-title":"Computational immuno-biology for organ transplantation and regenerative medicine","volume":"30","author":"V\u00e1squez-Montoya","year":"2016","journal-title":"Transplant Rev"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0011","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/jcm9020572","article-title":"Application of artificial intelligence techniques to predict survival in kidney transplantation: a review","volume":"9","author":"D\u00edez-Sanmart\u00edn","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmedinf.2019.103957","article-title":"Machine learning in predicting graft failure following kidney transplantation: a systematic review of published predictive models","volume":"130","author":"Senanayake","year":"2019","journal-title":"Int J Med Inform"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0013","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1681\/ASN.2017010004","article-title":"Precision transplant medicine: biomarkers to the rescue","volume":"29","author":"Naesens","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0014","unstructured":"BEST (Biomarkers, EndpointS,and other Tools) resource. 2016. Accessed June 5, 2021. www.ncbi.nlm.nih.gov\/books\/NBK326791"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0015","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCULATIONAHA.105.594929","article-title":"Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models","volume":"115","author":"Zou","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0016","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0017","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fpubh.2017.00307","article-title":"Sensitivity, specificity, and predictive values: foundations, pliabilities, and pitfalls in research and practice","volume":"5","author":"Trevethan","year":"2017","journal-title":"Front Public Health"},{"issue":"4","key":"10.1016\/j.semnephrol.2022.01.007_bib0018","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1681\/ASN.2020060850","article-title":"Discovery and validation of a urinary exosome mRNA signature for the diagnosis of human kidney transplant rejection","volume":"32","author":"Fekih","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0019","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/ajt.12079","article-title":"Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies","volume":"13","author":"Reeve","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0020","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1681\/ASN.2013111149","article-title":"Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection","volume":"25","author":"Loupy","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0021","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1172\/JCI41789","article-title":"A molecular classifier for predicting future graft loss in late kidney transplant biopsies","volume":"120","author":"Einecke","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001759","article-title":"The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study","volume":"11","author":"Roedder","year":"2014","journal-title":"PLoS Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0023","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa035588","article-title":"Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling","volume":"349","author":"Sarwal","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0024","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1681\/ASN.2018111098","article-title":"A peripheral blood gene expression signature to diagnose subclinical acute rejection","volume":"30","author":"Zhang","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0025","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/MNH.0000000000000361","article-title":"A critical review of biomarkers in kidney transplantation","volume":"26","author":"Safa","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0026","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jclinepi.2011.09.002","article-title":"Tradeoffs between accuracy measures for electronic health care data algorithms","volume":"65","author":"Chubak","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0027","doi-asserted-by":"crossref","first-page":"230","DOI":"10.5500\/wjt.v10.i9.230","article-title":"Role of novel biomarkers in kidney transplantation","volume":"10","author":"Swanson","year":"2020","journal-title":"World J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0028","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1056\/NEJM196904032801401","article-title":"Significance of the positive crossmatch test in kidney transplantation","volume":"280","author":"Patel","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0029","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1111\/j.1600-6143.2012.04253.x","article-title":"A peripheral blood diagnostic test for acute rejection in renal transplantation","volume":"12","author":"Li","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/TP.0b013e318295ee5a","article-title":"A rapid noninvasive assay for the detection of renal transplant injury","volume":"96","author":"Sigdel","year":"2013","journal-title":"Transplant J"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0031","doi-asserted-by":"crossref","first-page":"eaba2501","DOI":"10.1126\/scitranslmed.aba2501","article-title":"A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection","volume":"12","author":"Yang","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0032","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1681\/ASN.2016091034","article-title":"Cell-free DNA and active rejection in kidney allografts","volume":"28","author":"Bloom","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0033","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(16)30826-1","article-title":"Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study","volume":"388","author":"O\u2019Connell","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0034","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1373\/clinchem.2009.129072","article-title":"Cell-free DNA as a noninvasive acute rejection marker in renal transplantation","volume":"55","author":"Moreira","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/gm253","article-title":"Biomarkers in solid organ transplantation: establishing personalized transplantation medicine","volume":"3","author":"Roedder","year":"2011","journal-title":"Genome Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0036","unstructured":"FDA. Discussion paper on laboratory developed tests (LDTs). 2017. Accessed June 5, 2021. https:\/\/www.fda.gov\/media\/102367\/download"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0037","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/469156a","article-title":"Bring on the biomarkers","volume":"469","author":"Poste","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0038","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1681\/ASN.V12122807","article-title":"Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch","volume":"12","author":"Karpinski","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0039","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMoa067160","article-title":"Antibodies against MICA antigens and kidney-transplant rejection","volume":"357","author":"Zou","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0040","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1097\/01.tp.0000542869.07515.27","article-title":"Antibody-mediated rejection with and without HLA donor-specific antibodies in kidney-transplantation","volume":"102","author":"Crespo","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0041","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1600-6143.2006.01711.x","article-title":"Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study","volume":"7","author":"Mao","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0042","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1432-2277.2005.00085.x","article-title":"Prevalence and significance of anti-HLA and donor-specific antibodies long-term after renal transplantation","volume":"18","author":"Cardarelli","year":"2005","journal-title":"Transplant Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0043","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1111\/j.1600-6143.2005.01016.x","article-title":"Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure","volume":"5","author":"Mizutani","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0044","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/j.ackd.2016.08.004","article-title":"Donor-specific antibody monitoring: where is the beef?","volume":"23","author":"Ma","year":"2016","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0045","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.4049\/jimmunol.163.4.2267","article-title":"Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes","volume":"163","author":"Heeger","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0046","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1600-6143.2003.00132.x","article-title":"Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients","volume":"3","author":"Hricik","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0047","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1111\/j.1600-6143.2005.00958.x","article-title":"Pre-transplant IFN-\u03b3 ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients","volume":"5","author":"Augustine","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0048","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1016\/j.transproceed.2007.06.080","article-title":"Pretransplant donor-specific interferon-\u03b3 ELISPOT assay predicts acute rejection episodes in renal transplant recipients","volume":"39","author":"Kim","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0049","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.kint.2016.12.024","article-title":"Posttransplant peripheral blood donor\u2013specific interferon-\u03b3 enzyme-linked immune spot assay differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients","volume":"92","author":"Crespo","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0050","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1111\/ajt.13401","article-title":"Interferon gamma ELISPOT testing as a risk-stratifying biomarker for kidney transplant injury: results from the CTOT-01 multicenter study","volume":"15","author":"Hricik","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0051","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/TP.0000000000002026","article-title":"Analysis of biomarkers within the initial 2 years posttransplant and 5-year kidney transplant outcomes","volume":"102","author":"Faddoul","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0052","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imr.12926","article-title":"Innate and adaptive \u03b3\u03b4 T cells: How, when, and why","volume":"298","author":"Papadopoulou","year":"2020","journal-title":"Immunol Rev"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0053","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12882-019-1541-5","article-title":"Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study","volume":"20","author":"Aschauer","year":"2019","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0054","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12882-016-0395-3","article-title":"Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection","volume":"17","author":"Alachkar","year":"2016","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0055","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1002\/eji.201040301","article-title":"Analysis of the peripheral T-cell repertoire in kidney transplant patients","volume":"40","author":"Miqueu","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0056","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010760","article-title":"Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients","volume":"7","author":"Morris","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0057","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1111\/ajt.12431","article-title":"TCR repertoire analysis by next generation sequencing allows complex differential diagnosis of T cell\u2013related pathology","volume":"13","author":"Dziubianau","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0058","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1038\/s41467-019-09930-3","article-title":"Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing","volume":"10","author":"Pineda","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0059","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/CDLI.7.2.307-311.2000","article-title":"Measurement of T-lymphocyte responses in whole-blood cultures using newly synthesized DNA and ATP","volume":"7","author":"Sottong","year":"2000","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0060","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.tp.0000234837.02126.70","article-title":"Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay","volume":"82","author":"Kowalski","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0061","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2215\/CJN.04210510","article-title":"Single time point immune function assay (ImmuKnowTM) testing does not aid in the prediction of future opportunistic infections or acute rejection","volume":"6","author":"Huskey","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0062","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1309\/23YGPB1E758ECCFP","article-title":"Measurements of global cell-mediated immunity in renal transplant recipients with BK virus reactivation","volume":"129","author":"Batal","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0063","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.humimm.2009.07.027","article-title":"Significance of immune cell function monitoring in renal transplantation after thymoglobulin induction therapy","volume":"70","author":"Serban","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0064","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1111\/ajt.12503","article-title":"Trends in immune cell function assay and donor-specific HLA antibodies in kidney transplantation: a 3-year prospective study","volume":"13","author":"Libri","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0065","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5114\/ceji.2014.42132","article-title":"Serial ImmuKnow assay in stable kidney transplant recipients","volume":"39","author":"Moon","year":"2014","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0066","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.transproceed.2014.09.109","article-title":"Performance of the ImmuKnow assay in differentiating infection and acute rejection after kidney transplantation: a meta-analysis","volume":"46","author":"Wang","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0067","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1097\/TP.0000000000000650","article-title":"Immunosuppression modifications based on an immune response assay","volume":"99","author":"Ravaioli","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0136","first-page":"241","article-title":"Les acides nucl\u00e9iques du plasma sanguin chez l\u2019homme","volume":"142","author":"Mandel","year":"1948","journal-title":"C R Seances Soc Biol Fil"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0069","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/ajt.15192","article-title":"Repeat kidney transplant recipients with active rejection have elevated donor-derived cell-free DNA","volume":"19","author":"Mehta","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0070","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1093\/clinchem\/45.10.1741","article-title":"Presence of donor- and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism","volume":"45","author":"Zhang","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0071","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208207","article-title":"Plasma donor-derived cell-free DNA kinetics after kidney transplantation using a single tube multiplex PCR assay","volume":"13","author":"Gielis","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0068","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/TP.0000000000002482","article-title":"Donor-specific cell-free DNA as a biomarker in solid organ transplantation. a systematic review","volume":"103","author":"Knight","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0072","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1111\/ajt.13387","article-title":"Cell-free DNA: an upcoming biomarker in transplantation","volume":"15","author":"Gielis","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0073","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s40425-019-0653-6","article-title":"Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment","volume":"7","author":"Hurkmans","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0074","doi-asserted-by":"crossref","first-page":"e568","DOI":"10.1097\/TXD.0000000000001019","article-title":"Donor-derived cell-free DNA in infections in kidney transplant recipients: case series","volume":"6","author":"Goussous","year":"2020","journal-title":"Transplant Direct"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0075","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.transproceed.2015.08.035","article-title":"Donor-derived cell-free DNA is a novel universal biomarker for allograft rejection in solid organ transplantation","volume":"47","author":"Beck","year":"2015","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0076","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/ajt.15289","article-title":"Early clinical experience using donor-derived cell-free DNA to detect rejection in kidney transplant recipients","volume":"19","author":"Huang","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0077","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/ajt.15822","article-title":"High levels of dd-cfDNA identify patients with TCMR 1A and borderline allograft rejection at elevated risk of graft injury","volume":"20","author":"Stites","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0078","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/jcm10020193","article-title":"Donor-derived cell-free DNA in kidney transplantation as a potential rejection biomarker: a systematic literature review","volume":"10","author":"Martuszewski","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0079","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fmed.2018.00358","article-title":"Non-invasive biomarkers of acute rejection in kidney transplantation: novel targets and strategies","volume":"5","author":"Eikmans","year":"2019","journal-title":"Front Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0080","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/ajt.15142","article-title":"Diagnostic application of kidney allograft-derived absolute cell-free DNA levels during transplant dysfunction","volume":"19","author":"Whitlam","year":"2019","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.semnephrol.2022.01.007_bib0081","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1097\/TP.0000000000002665","article-title":"Analytical validation of a single-nucleotide polymorphism-based donor-derived cell-free DNA assay for detecting rejection in kidney transplant patients","volume":"103","author":"Altu","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0082","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/jcm8010019","article-title":"Optimizing detection of kidney transplant injury by assessment of donor-derived cell-free DNA via massively multiplex PCR","volume":"8","author":"Sigdel","year":"2018","journal-title":"J Clin Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0083","first-page":"1116","article-title":"Donor-derived cell free DNA: is it all the same?","volume":"360","author":"Melancon","year":"2020","journal-title":"Kidney"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0084","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1097\/TP.0000000000001287","article-title":"Molecular and functional noninvasive immune monitoring in the ESCAPE study for prediction of subclinical renal allograft rejection","volume":"101","author":"Crespo","year":"2017","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.semnephrol.2022.01.007_bib0085","article-title":"Interim Results of the kSORT in the SAILOR Randomized Multicenter Trial [abstract]. https:\/\/atcmeetingabstracts.com\/abstract\/interim-results-of-the-ksort-in-the-sailor-randomized-multicenter-trial\/. Accessed February 6, 2022","volume":"17","author":"Lindner","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0086","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/ajt.16179","article-title":"Diagnostic performance of kSORT, a blood-based mRNA assay for noninvasive detection of rejection after kidney transplantation: a retrospective multicenter cohort study","volume":"21","author":"Loon","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0087","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.transproceed.2019.01.054","article-title":"Application of TruGraf v1: a novel molecular biomarker for managing kidney transplant recipients with stable renal function","volume":"51","author":"Marsh","year":"2019","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0088","doi-asserted-by":"crossref","first-page":"e14145","DOI":"10.1111\/ctr.14145","article-title":"Avoiding surveillance biopsy: use of a noninvasive biomarker assay in a real-life scenario","volume":"35","author":"Ang","year":"2021","journal-title":"Clin Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0089","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/eurheartj\/ehv682","article-title":"Clinical usefulness of gene-expression profile to rule out acute rejection after heart transplantation: CARGO II","volume":"37","author":"Crespo-Leiro","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0090","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1056\/NEJMoa0912965","article-title":"Gene-expression profiling for rejection surveillance after cardiac transplantation","volume":"362","author":"Pham","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0091","doi-asserted-by":"crossref","first-page":"l4923","DOI":"10.1136\/bmj.l4923","article-title":"Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study","volume":"366","author":"Loupy","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0092","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/mps3040068","article-title":"KidneyCare guided immuno-optimization in renal allografts: the KIRA protocol","volume":"3","author":"Gray","year":"2020","journal-title":"Methods Protoc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0093","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/01.TP.0000082542.99416.11","article-title":"Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates","volume":"76","author":"Furness","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0094","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/01.tp.0000282870.71282.ed","article-title":"To biopsy or not to biopsy? Should we screen the histology of stable renal grafts?","volume":"84","author":"Thaunat","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0095","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/j.1600-6143.2005.00988.x","article-title":"Safety and adequacy of renal transplant protocol biopsies","volume":"5","author":"Schwarz","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0096","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/tri.12660","article-title":"Nature, timing, and severity of complications from ultrasound-guided percutaneous renal transplant biopsy","volume":"29","author":"Redfield","year":"2016","journal-title":"Transplant Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0097","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/ndt\/gfr473","article-title":"Identification of lesions indicating rejection in kidney transplant biopsies: tubulitis is severely under-detected by conventional microscopy","volume":"27","author":"Elshafie","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0098","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1046\/j.1523-1755.2001.00030.x","article-title":"Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project. International variation in the interpretation of renal transplant biopsies: report of the CERTPAP Project","volume":"60","author":"Furness","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0099","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1111\/j.1600-6143.2005.00974.x","article-title":"Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection","volume":"5","author":"Einecke","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0100","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/j.1600-6143.2004.00526.x","article-title":"Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes","volume":"4","author":"Flechner","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0101","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/00007890-200109150-00034","article-title":"Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology","volume":"72","author":"Akalin","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0102","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1600-6143.2011.03964.x","article-title":"Intragraft gene expression in positive crossmatch kidney allografts: ongoing inflammation mediates chronic antibody-mediated injury","volume":"12","author":"Dean","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0103","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/ajt.12150","article-title":"Molecular diagnosis of antibody-mediated rejection in human kidney transplants","volume":"13","author":"Sellar\u00e9s","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0104","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ki.2013.300","article-title":"Antibody-mediated rejection, T cell\u2013mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies","volume":"85","author":"Halloran","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0105","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1111\/ajt.14329","article-title":"Real time central assessment of kidney transplant indication biopsies by microarrays: the INTERCOMEX study","volume":"17","author":"Halloran","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0106","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1681\/ASN.2014111064","article-title":"Reassessing the significance of intimal arteritis in kidney transplant biopsy specimens","volume":"26","author":"Salazar","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0107","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.614343","article-title":"Use of the tissue common rejection module score in kidney transplant as an objective measure of allograft inflammation","volume":"11","author":"Zarinsefat","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0108","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.semnephrol.2007.03.004","article-title":"Chronic allograft nephropathy","volume":"27","author":"Vadivel","year":"2007","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0109","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJM200103293441301","article-title":"Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and Granzyme B in urine","volume":"344","author":"Li","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1215555","article-title":"Urinary-cell mRNA profile and acute cellular rejection in kidney allografts","volume":"369","author":"Suthanthiran","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0111","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1681\/ASN.2008040406","article-title":"Large-scale proteomics and phosphoproteomics of urinary exosomes","volume":"20","author":"Gonzales","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0112","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fphys.2012.00228","article-title":"Role of exosomes\/microvesicles in the nervous system and use in emerging therapies","volume":"3","author":"Lai","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0113","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1016\/j.transproceed.2013.08.079","article-title":"Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation","volume":"45","author":"Alvarez","year":"2013","journal-title":"Transplant Proc"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204204","article-title":"Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: a cross-sectional study","volume":"13","author":"Lim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fmed.2014.00057","article-title":"Perturbations in the urinary exosome in transplant rejection","volume":"1","author":"Sigdel","year":"2015","journal-title":"Front Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0116","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1021\/acsnano.7b05083","article-title":"Integrated kidney exosome analysis for the detection of kidney transplant rejection","volume":"11","author":"Park","year":"2017","journal-title":"Acs Nano"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0117","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1600-6143.2010.03032.x","article-title":"MicroRNAs as immune regulators: implications for transplantation","volume":"10","author":"Harris","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0118","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2215\/CJN.08020718","article-title":"MicroRNAs in AKI and kidney transplantation","volume":"14","author":"Ledeganck","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0119","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trim.2016.09.001","article-title":"Free microRNA levels in plasma distinguish T-cell mediated rejection from stable graft function after kidney transplantation","volume":"39","author":"Matz","year":"2016","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0120","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0121","doi-asserted-by":"crossref","first-page":"e60702","DOI":"10.1371\/journal.pone.0060702","article-title":"Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection","volume":"8","author":"Danger","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0122","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1073\/pnas.0813121106","article-title":"MicroRNA expression profiles predictive of human renal allograft status","volume":"106","author":"Anglicheau","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0123","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1111\/j.1600-6143.2011.03666.x","article-title":"MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF\/TA","volume":"11","author":"Scian","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0124","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1111\/j.1600-6143.2011.03679.x","article-title":"Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients","volume":"11","author":"Lorenzen","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trim.2015.05.002","article-title":"Differential expression of microRNAs in renal transplant patients with acute T-cell mediated rejection","volume":"33","author":"Soltaninejad","year":"2015","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0126","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/TP.0b013e3182751efd","article-title":"MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis","volume":"94","author":"Ben-Dov","year":"2012","journal-title":"Transplant J"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0127","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/01.TP.0000441322.95539.b3","article-title":"Acute pyelonephritis in renal allografts\u2013a new role for MicroRNAs?","volume":"97","author":"Oghumu","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0128","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/ajt.12426","article-title":"Multicenter validation of urinary CXCL9 as a risk-stratifying biomarker for kidney transplant injury","volume":"13","author":"Hricik","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0129","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/j.1600-6143.2011.03680.x","article-title":"Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection","volume":"11","author":"Jackson","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0130","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/TP.0b013e31826784ad","article-title":"Pretransplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation","volume":"94","author":"Chen","year":"2012","journal-title":"Transplant J"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0131","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.kint.2015.12.049","article-title":"Mining the human urine proteome for monitoring renal transplant injury","volume":"89","author":"Sigdel","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0132","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.ASN.0000101031.52826.BE","article-title":"Proteomic-based detection of urine proteins associated with acute renal allograft rejection","volume":"15","author":"Schaub","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0133","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1797.2005.00387.x","article-title":"Prospects for urinary proteomics: exosomes as a source of urinary biomarkers","volume":"10","author":"Hoorn","year":"2005","journal-title":"Nephrology"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0134","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.3390\/jcm9082325","article-title":"Clinical and analytical validation of a novel urine-based test for the detection of allograft rejection in renal transplant patients","volume":"9","author":"Nolan","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.semnephrol.2022.01.007_bib0135","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1681\/ASN.2015010107","article-title":"Urine metabolite profiles predictive of human kidney allograft status","volume":"27","author":"Suhre","year":"2016","journal-title":"J Am Soc Nephrol"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929522000079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929522000079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:38:54Z","timestamp":1759448334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929522000079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0270929522000079"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2022.01.007","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Biomarkers in Kidney Transplantation","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2022.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}