{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:14:30Z","timestamp":1792620870571,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1800820N"],"award-info":[{"award-number":["1800820N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["3M190551"],"award-info":[{"award-number":["3M190551"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/21\/103"],"award-info":[{"award-number":["C14\/21\/103"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seminarsinnephrology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nephrology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.semnephrol.2023.151481","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T03:50:30Z","timestamp":1704945030000},"page":"151481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regional Citrate Anticoagulation: A Tale of More Than Two Stories"],"prefix":"10.1016","volume":"43","author":[{"given":"Thomas","family":"Demuynck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Grooteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Ter Wee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cozzolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Meijers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0001","first-page":"130","article-title":"Untersuchungen ueber die Faserstoffgerinnung. Nova Acta Regiae Societatis scientiarum","volume":"10","author":"Hammarsten","year":"1875","journal-title":"Uppsala Series III"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0002","first-page":"739","article-title":"Nouvelle th\u00e9orie chimique de la coagulation du sang Archives de Physiologie Normale et Pathologique","author":"Arthus MP","year":"1890","journal-title":"Archives de Physiologie Normale et Pathologique, 5th series Paris"},{"issue":"6","key":"10.1016\/j.semnephrol.2023.151481_bib0003","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/tme.12074","article-title":"Blood transfusion; additional historical aspects. Part 2. The introduction of chemical anticoagulants; trials of \u201cphosphate of soda.\u201d","volume":"23","author":"Boulton","year":"2013","journal-title":"Transfus Med"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0004","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2141.2000.01827.x","article-title":"The introduction of citrate as an anticoagulant for transfusion and of glucose as a red cell preservative","volume":"108","author":"Mollison","year":"2000","journal-title":"Br J Haematol"},{"issue":"7-8","key":"10.1016\/j.semnephrol.2023.151481_bib0005","first-page":"155","article-title":"[The artificial kidney and the experiences gained with it in the clinic]","volume":"90","author":"Kolff","year":"1946","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"12","key":"10.1016\/j.semnephrol.2023.151481_bib0006","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1681\/ASN.V8121959","article-title":"The artificial kidney: A dialyser with a great area. 1944","volume":"8","author":"Kolff","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0007","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00000441-196107000-00005","article-title":"Regional anticoagulation during hemodialysis using citrate","volume":"242","author":"Morita","year":"1961","journal-title":"Am J Med Sci"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0008","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1056\/NEJM198302033080506","article-title":"Regional citrate anticoagulation for hemodialysis in the patient at high risk for bleeding","volume":"308","author":"Pinnick","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151476","article-title":"How to ensure patency of the extracorporeal circuit in hemodialysis: global perspectives","author":"Santos AV","year":"2023","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151478","article-title":"Bleeding risk in hemodialysis Patients","author":"van Eck van der Sluijs","year":"2023","journal-title":"Semin Nephrol"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0011","article-title":"Plasma citrate homeostasis: How it is regulated; and its physiological and clinical implications. An important, but neglected, relationship in medicine","volume":"1","author":"Costello","year":"2016","journal-title":"HSOA J Hum Endocrinol"},{"issue":"6 Pt 2","key":"10.1016\/j.semnephrol.2023.151481_bib0012","first-page":"F796","article-title":"Role of citrate excretion in acid\u2013base balance in diuretic-induced alkalosis in the rat","volume":"248","author":"Kaufman","year":"1985","journal-title":"Am J Physiol"},{"issue":"1 Pt 2","key":"10.1016\/j.semnephrol.2023.151481_bib0013","first-page":"F182","article-title":"Complementary role of citrate and bicarbonate excretion in acid\u2013base balance in the rat","volume":"255","author":"Kaufman","year":"1988","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.semnephrol.2023.151481_bib0014","first-page":"439","article-title":"Citrate anticoagulation for continuous renal replacement therapy (CRRT) in patients with acute kidney injury admitted to the intensive care unit","volume":"2","author":"Davenport","year":"2009","journal-title":"NDT Plus"},{"issue":"7","key":"10.1016\/j.semnephrol.2023.151481_bib0015","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/ndt\/gfp017","article-title":"Citrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation","volume":"24","author":"Kozik-Jaromin","year":"2009","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0016","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0750-7658(88)80009-1","article-title":"[Regional anticoagulation with citrate in hemodialysis in patients with a high risk for hemorrhage]","volume":"7","author":"Perdrix","year":"1988","journal-title":"Ann Fr Anesth Reanim"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0017","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/08860228509104839","article-title":"Regional sodium citrate anticoagulation in patients with active bleeding undergoing hemodialysis","volume":"9","author":"Ashouri","year":"1985","journal-title":"Uremia Invest"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000184287","article-title":"Citrate regional anticoagulation in haemodialysis","volume":"46","author":"Hocken","year":"1987","journal-title":"Nephron"},{"issue":"3","key":"10.1016\/j.semnephrol.2023.151481_bib0019","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0272-6386(87)80061-6","article-title":"Severe metabolic alkalosis complicating regional citrate hemodialysis","volume":"9","author":"Kelleher","year":"1987","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0020","first-page":"22","article-title":"Metabolic alkalosis induced by regional citrate hemodialysis","volume":"35","author":"Silverstein","year":"1989","journal-title":"ASAIO Trans"},{"issue":"2","key":"10.1016\/j.semnephrol.2023.151481_bib0021","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1053\/ajkd.2002.30551","article-title":"Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate","volume":"39","author":"Evenepoel","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0022","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s13054-015-1027-1","article-title":"Discrepant post filter ionized calcium concentrations by common blood gas analyzers in CRRT using regional citrate anticoagulation","volume":"19","author":"Schwarzer","year":"2015","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.semnephrol.2023.151481_bib0023","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000089652","article-title":"Regional citrate anticoagulation during hemodialysis: A simplified procedure using Duocart biofiltration","volume":"23","author":"Ridel","year":"2005","journal-title":"Blood Purif"},{"issue":"3","key":"10.1016\/j.semnephrol.2023.151481_bib0024","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0272-6386(86)80025-7","article-title":"Regional anticoagulation: Hemodialysis with hypertonic trisodium citrate","volume":"8","author":"von Brecht","year":"1986","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.semnephrol.2023.151481_bib0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0272-6386(00)70203-4","article-title":"Dialysate made from dry chemicals using citric acid increases dialysis dose","volume":"35","author":"Ahmad","year":"2000","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0026","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1046\/j.1523-1755.1999.00444.x","article-title":"Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding","volume":"55","author":"Palsson","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0027","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2369-10-7","article-title":"Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: Consequences on haemodynamics, coagulation, acid\u2013base status, and electrolytes","volume":"10","author":"Gabutti","year":"2009","journal-title":"BMC Nephrol"},{"issue":"1-3","key":"10.1016\/j.semnephrol.2023.151481_bib0028","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000334157","article-title":"Effects of citrate acid concentrate (citrasate\u00ae) on heparin N requirements and hemodialysis adequacy: A multicenter, prospective noninferiority trial","volume":"33","author":"Sands","year":"2012","journal-title":"Blood Purif"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5301\/ijao.5000172","article-title":"A significant proportion of patients treated with citrate containing dialysate need additional anticoagulation","volume":"36","author":"Stegmayr","year":"2013","journal-title":"Int J Artif Organs"},{"issue":"2","key":"10.1016\/j.semnephrol.2023.151481_bib0030","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ndt\/gfq396","article-title":"Anticoagulation during haemodialysis using a citrate-enriched dialysate: A feasibility study","volume":"26","author":"Cheng","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0031","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5301\/ijao.5000098","article-title":"In vitro investigations of citrate clearance with different dialysis filters","volume":"35","author":"Hartmann","year":"2012","journal-title":"Int J Artif Organs"},{"issue":"10","key":"10.1016\/j.semnephrol.2023.151481_bib0032","first-page":"2025","article-title":"Critical deviations of ionized calcium measurements when using blood gas analyzers to monitor citrate dialysis","volume":"62","author":"Feldkamp","year":"2016","journal-title":"Clin Lab"},{"issue":"8","key":"10.1016\/j.semnephrol.2023.151481_bib0033","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/ndt\/gfv347","article-title":"Effects of citrate dialysate in chronic dialysis: A multicentre randomized crossover study","volume":"31","author":"Schmitz","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"1-3","key":"10.1016\/j.semnephrol.2023.151481_bib0034","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000371569","article-title":"Citrate versus acetate-based dialysate in on-line haemodiafiltration. A prospective cross-over study","volume":"39","author":"Molina Nu\u00f1ez","year":"2015","journal-title":"Blood Purif"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/703612","article-title":"Post-dilution on line haemodiafiltration with citrate dialysate: First clinical experience in chronic dialysis patients","volume":"2013","author":"Panichi","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9185413","article-title":"Is anticoagulation discontinuation achievable with citrate dialysate during HDF sessions?","volume":"2016","author":"Dolley-Hitze","year":"2016","journal-title":"Int J Nephrol"},{"issue":"3-4","key":"10.1016\/j.semnephrol.2023.151481_bib0037","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000345342","article-title":"Safe use of citric acid-based dialysate and heparin removal in postdilution online hemodiafiltration","volume":"34","author":"Aniort","year":"2012","journal-title":"Blood Purif"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0038","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1471-2369-15-104","article-title":"Avoidance of systemic anticoagulation during intermittent haemodialysis with heparin-grafted polyacrilonitrile membrane and citrate-enriched dialysate: A retrospective cohort study","volume":"15","author":"Francois","year":"2014","journal-title":"BMC Nephrol"},{"issue":"4","key":"10.1016\/j.semnephrol.2023.151481_bib0039","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/ndt\/gfw461","article-title":"A noninferiority trial comparing a heparin-grafted membrane plus citrate-containing dialysate versus regional citrate anticoagulation: Results of the CiTED study","volume":"32","author":"Meijers","year":"2017","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.semnephrol.2023.151481_bib0040","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/ckj\/sfaa228","article-title":"Strategies for asymmetrical triacetate dialyser heparin-free effective haemodialysis: The SAFE study","volume":"14","author":"Vandenbosch","year":"2021","journal-title":"Clin Kidney J"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0041","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1053\/j.ajkd.2021.04.004","article-title":"Dialyzer performance during hemodialysis without systemic anticoagulation using a heparin-grafted dialyzer combined with a citrate-enriched dialysate: Results of the randomized crossover noninferiority EvoCit study","volume":"79","author":"Fran\u00e7ois","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151483","article-title":"Avoiding systemic heparinization during Q1 hemodialysis: how the dialysis setup might help","author":"Janssens","year":"2023","journal-title":"Semin Nephrol"},{"issue":"11","key":"10.1016\/j.semnephrol.2023.151481_bib0043","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/ndt\/8.11.1228","article-title":"Citrate versus heparin anticoagulation in chronic haemodialysis patients","volume":"8","author":"Janssen","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0044","first-page":"S237","article-title":"Extracorporeal management of acute renal failure patients at high risk of bleeding","volume":"41","author":"Ward","year":"1993","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12882-018-0879-4","article-title":"A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: Safety, efficacy, and cost","volume":"19","author":"Wen","year":"2018","journal-title":"BMC Nephrol"},{"issue":"2","key":"10.1016\/j.semnephrol.2023.151481_bib0046","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0272-6386(87)80092-6","article-title":"Reducing the hemorrhagic complications of hemodialysis: A controlled comparison of low-dose heparin and citrate anticoagulation","volume":"9","author":"Flanigan","year":"1987","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.semnephrol.2023.151481_bib0047","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ki.1996.112","article-title":"Citrate compared to low molecular weight heparin anticoagulation in chronic hemodialysis patients","volume":"49","author":"Janssen","year":"1996","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.semnephrol.2023.151481_bib0048","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1046\/j.1523-1755.1999.00671.x","article-title":"Effect of anticoagulation on blood membrane interactions during hemodialysis","volume":"56","author":"Hofbauer","year":"1999","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0049","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000507874","article-title":"Efficacy and safety of regional anticoagulation with 4% trisodium citrate versus heparin in extended hemodialysis among critical patients with cancer and acute kidney injury","volume":"50","author":"Moura","year":"2021","journal-title":"Blood Purif"},{"issue":"16","key":"10.1016\/j.semnephrol.2023.151481_bib0050","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/jama.2020.18618","article-title":"Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: A randomized clinical trial","volume":"324","author":"Zarbock","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0051","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/ndt\/gfq575","article-title":"Regional citrate versus systemic heparin for anticoagulation in critically ill patients on continuous venovenous haemofiltration: A prospective randomized multicentre trial","volume":"26","author":"Hetzel","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0052","article-title":"Regional citrate anticoagulation in continuous renal replacement therapy: Is metabolic fear the enemy of logic? A systematic review and meta-analysis of randomised controlled trials","volume":"13","author":"Jacobs","year":"2023","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0053","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1525-1594.2010.01038.x","article-title":"Evaluation of three different methods to prevent dialyzer clotting without causing systemic anticoagulation effect","volume":"35","author":"Richtrova","year":"2011","journal-title":"Artif Organs"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0054","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.ajkd.2007.02.001","article-title":"Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: A prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding","volume":"49","author":"Evenepoel","year":"2007","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0055","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1177\/039139880803100507","article-title":"Regional citrate anticoagulation for hemodialysis: Calcium-free vs. calcium containing dialysate\u2014a randomized trial","volume":"31","author":"Buturovic-Ponikvar","year":"2008","journal-title":"Int J Artif Organs"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0056","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/cc11180","article-title":"A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the molecular adsorbents recirculating system","volume":"16","author":"Meijers","year":"2012","journal-title":"Crit Care"},{"issue":"11","key":"10.1016\/j.semnephrol.2023.151481_bib0057","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1631\/jzus.B2200082","article-title":"Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis: A prospective multicenter randomized controlled trial","volume":"23","author":"Tang","year":"2022","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151473","article-title":"Clotting of the extracorporeal circuit in hemodialysis: beyond contact-activated Q1 coagulation","author":"Engelen","year":"2023","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0059","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fimmu.2018.00071","article-title":"The complement system in dialysis: A forgotten story?","volume":"9","author":"Poppelaars","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.semnephrol.2023.151481_bib0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1681\/ASN.V72234","article-title":"Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: Dissociation of complement activation and neutropenia from neutrophil degranulation","volume":"7","author":"B\u00f6hler","year":"1996","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0061","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ckj\/sfu127","article-title":"Low concentrations of citrate reduce complement and granulocyte activation in vitro in human blood","volume":"8","author":"Huang","year":"2015","journal-title":"Clin Kidney J"},{"issue":"7","key":"10.1016\/j.semnephrol.2023.151481_bib0062","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/ndt\/13.7.1752","article-title":"Citrate anticoagulation does not correct cuprophane bioincompatibility as evaluated by the expression of leukocyte surface molecules","volume":"13","author":"Dhondt","year":"1998","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.semnephrol.2023.151481_bib0063","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000045683","article-title":"Effect of regional citrate anticoagulation on leukopenia, complement activation, and expression of leukocyte surface molecules during hemodialysis with unmodified cellulose membranes","volume":"85","author":"Dhondt","year":"2000","journal-title":"Nephron"},{"issue":"7","key":"10.1016\/j.semnephrol.2023.151481_bib0064","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/ndt\/12.7.1387","article-title":"Low polymorphonuclear cell degranulation during citrate anticoagulation: A comparison between citrate and heparin dialysis","volume":"12","author":"Bos","year":"1997","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/ndt\/gfi069","article-title":"Citrate anticoagulation abolishes degranulation of polymorphonuclear cells and platelets and reduces oxidative stress during haemodialysis","volume":"21","author":"Gritters","year":"2006","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0066","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/ckj\/sfaa131","article-title":"A high magnesium concentration in citrate dialysate prevents oxidative stress and damage in human monocytes in vitro","volume":"14","author":"Vida","year":"2021","journal-title":"Clin Kidney J"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0067","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s40620-020-00943-6","article-title":"Citrate high volume on-line hemodiafiltration modulates serum interleukin-6 and klotho levels: The multicenter randomized controlled study \u201cHephaestus.\u201d","volume":"34","author":"Pizzarelli","year":"2021","journal-title":"J Nephrol"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0068","doi-asserted-by":"crossref","first-page":"10622","DOI":"10.1038\/s41598-019-47040-8","article-title":"Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents chemerin-mediated microvascular injury","volume":"9","author":"Dellepiane","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0069","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000342258","article-title":"Effects of acetate-free citrate dialysate on glycoxidation and lipid peroxidation products in hemodialysis patients","volume":"2","author":"Masuda","year":"2012","journal-title":"Nephron Extra"},{"issue":"3","key":"10.1016\/j.semnephrol.2023.151481_bib0070","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1186\/cc11363","article-title":"Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients","volume":"16","author":"Link","year":"2012","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0071","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13054-019-2317-9","article-title":"Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: A systematic review and meta-analysis","volume":"23","author":"Zhang","year":"2019","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0072","doi-asserted-by":"crossref","first-page":"100","DOI":"10.23876\/j.krcp.18.0045","article-title":"Conversion from acetate dialysate to citrate dialysate in a central delivery system for maintenance hemodialysis patients","volume":"38","author":"Park","year":"2019","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0073","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2369-14-216","article-title":"Replacement of acetate with citrate in dialysis fluid: A randomized clinical trial of short term safety and fluid biocompatibility","volume":"14","author":"Grundstr\u00f6m","year":"2013","journal-title":"BMC Nephrol"},{"issue":"1","key":"10.1016\/j.semnephrol.2023.151481_bib0074","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000368478","article-title":"Changes of serum calcium, magnesium and parathyroid hormone induced by hemodialysis with citrate-enriched dialysis solution","volume":"40","author":"\u0160afr\u00e1nek","year":"2015","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2369-14-18","article-title":"Acetate free citrate-containing dialysate increase intact-PTH and BAP levels in the patients with low intact-PTH","volume":"14","author":"Kuragano","year":"2013","journal-title":"BMC Nephrol"},{"issue":"12","key":"10.1016\/j.semnephrol.2023.151481_bib0076","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225824","article-title":"Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial","volume":"14","author":"Ter Meulen","year":"2019","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.semnephrol.2023.151481_bib0077","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/ndt\/gfy134","article-title":"Acetate-free, citrate-acidified bicarbonate dialysis improves serum calcification propensity\u2014a preliminary study","volume":"33","author":"Lorenz","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0078","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1013335","article-title":"The metabolomic differential plasma profile between dialysates. Pursuing to understand the mechanisms of citrate dialysate clinical benefits","volume":"13","author":"Broseta","year":"2022","journal-title":"Front Physiol"},{"issue":"19","key":"10.1016\/j.semnephrol.2023.151481_bib0079","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911693","article-title":"Impact of acetate versus citrate dialysates on intermediary metabolism\u2014a targeted metabolomics approach","volume":"23","author":"Broseta","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.semnephrol.2023.151481_bib0080","article-title":"Advantages of the use of citrate over acetate as a stabilizer in hemodialysis fluid: A randomized ABC-treat study","author":"de Sequera","year":"2021","journal-title":"Nefrologia (Engl Ed)"},{"issue":"5","key":"10.1016\/j.semnephrol.2023.151481_bib0081","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1744-9987.2011.00976.x","article-title":"Comparison of acetate-free citrate hemodialysis and bicarbonate hemodialysis regarding the effect of intra-dialysis hypotension and post-dialysis malaise","volume":"15","author":"Daimon","year":"2011","journal-title":"Ther Apher Dial"},{"issue":"6","key":"10.1016\/j.semnephrol.2023.151481_bib0082","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1159\/000502939","article-title":"Impact of long-term citrate dialysate use on survival in haemodialysis patients","volume":"49","author":"S\u00e9ret","year":"2020","journal-title":"Blood Purif"},{"issue":"7","key":"10.1016\/j.semnephrol.2023.151481_bib0083","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ndt\/gfaa089","article-title":"Long-term mortality risk associated with citric acid- and acetic acid-based bicarbonate haemodialysis: A historical cohort propensity score-matched study in a large, multicentre, population-based study","volume":"35","author":"Neri","year":"2020","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1016\/j.semnephrol.2023.151481_bib0084","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/ndt\/gfaa168","article-title":"Impact of the dialysate acid component on haemodialysis mortality rates","volume":"35","author":"Couchoud","year":"2020","journal-title":"Nephrol Dial Transplant"}],"container-title":["Seminars in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929523001912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0270929523001912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:20:24Z","timestamp":1762280424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0270929523001912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0270929523001912"],"URL":"https:\/\/doi.org\/10.1016\/j.semnephrol.2023.151481","relation":{},"ISSN":["0270-9295"],"issn-type":[{"value":"0270-9295","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional Citrate Anticoagulation: A Tale of More Than Two Stories","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nephrology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semnephrol.2023.151481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151481"}}