{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:48:48Z","timestamp":1784843328932,"version":"3.55.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.semperi.2023.151725","type":"journal-article","created":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T22:39:27Z","timestamp":1678660767000},"page":"151725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions"],"prefix":"10.1016","volume":"47","author":[{"given":"Kevin","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Shuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Hare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semperi.2023.151725_bib0001","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/1752-1947-7-276","article-title":"Fetal hypoplastic left heart syndrome and maternal liver transplantation for Wilson's disease: a case report","volume":"7","author":"Wenners","year":"2013","journal-title":"J Med Case Rep"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0002","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1471-0528.1992.tb14503.x","article-title":"Results of a 2 1\/2-year study in the South East Thames Region","volume":"99","author":"Sharland","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0003","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1651-2227.2006.00023.x","article-title":"Prenatal diagnosis of congenital heart defects - a population based study","volume":"96","author":"Nikkila","year":"2007","journal-title":"Acta Paediatr"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0004","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.echo.2004.04.011","article-title":"American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram","volume":"17","author":"Rychik","year":"2004","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0005","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/hrt.69.6.551","article-title":"Stenting of the arterial duct combined with banding of the pulmonary arteries and atrial septectomy or septostomy: a new approach to palliation for the hypoplastic left heart syndrome","volume":"69","author":"Gibbs","year":"1993","journal-title":"Br Heart J"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0006","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.athoracsur.2015.06.098","article-title":"Hybrid Procedure for Neonates With Hypoplastic Left Heart Syndrome at High-Risk for Norwood: Midterm Outcomes","volume":"100","author":"Murphy","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0007","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ejcts.2007.12.042","article-title":"Improving the outcome of high-risk neonates with hypoplastic left heart syndrome: hybrid procedure or conventional surgical palliation?","volume":"33","author":"Pizarro","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0008","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtcvs.2005.07.053","article-title":"Single-ventricle palliation for high-risk neonates: the emergence of an alternative hybrid stage I strategy","volume":"131","author":"Bacha","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"12","key":"10.1016\/j.semperi.2023.151725_bib0009","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/echo.13667","article-title":"Fetal interventions for structural heart disease","volume":"34","author":"Schidlow","year":"2017","journal-title":"Echocardiography"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0010","first-page":"86","article-title":"Hypoplastic left heart syndrome: a review","volume":"23","author":"Gobergs","year":"2016","journal-title":"Acta Med Litu"},{"issue":"8","key":"10.1016\/j.semperi.2023.151725_bib0011","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.semperi.2023.151725_bib0012","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.jacc.2022.03.336","article-title":"Burden of Pediatric Heart Failure in the United States","volume":"79","author":"Amdani","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.semperi.2023.151725_bib0013","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/bdr2.1589","article-title":"National population-based estimates for major birth defects, 2010-2014","volume":"111","author":"Mai","year":"2019","journal-title":"Birth Defects Res"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0014","doi-asserted-by":"crossref","first-page":"e1181","DOI":"10.1542\/peds.2010-3742","article-title":"Inpatient costs and charges for surgical treatment of hypoplastic left heart syndrome","volume":"128","author":"Dean","year":"2011","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0015","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0022-5223(00)70007-9","article-title":"Hypoplastic left heart syndrome: valuingthe survival","volume":"119","author":"Williams","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0016","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s002469900314","article-title":"Current status of staged reconstruction for hypoplastic left heart syndrome","volume":"19","author":"Bove","year":"1998","journal-title":"Pediatr Cardiol"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0017","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/CIRCULATIONAHA.105.548016","article-title":"Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study","volume":"114","author":"Bernstein","year":"2006","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.semperi.2023.151725_bib0018","first-page":"1255","article-title":"Outcome of listing for heart transplantation in infants younger than six months: predictors of death and interval to transplantation. The Pediatric Heart Transplantation Study Group","volume":"16","author":"Morrow","year":"1997","journal-title":"J Heart Lung Transplant"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0019","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0002-8703(96)90093-9","article-title":"Fontan palliation versus heart transplantation: a comparison of charges","volume":"131","author":"Gajarski","year":"1996","journal-title":"Am Heart J"},{"issue":"21","key":"10.1016\/j.semperi.2023.151725_bib0020","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1056\/NEJMoa0912461","article-title":"Comparison of shunt types in the Norwood procedure for single-ventricle lesions","volume":"362","author":"Ohye","year":"2010","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.semperi.2023.151725_bib0021","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/heartjnl-2015-307467","article-title":"The Fontan circulation after 45\u2005years: update in physiology","volume":"102","author":"Gewillig","year":"2016","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0022","article-title":"The pathophysiology and complications of Fontan circulation","volume":"92","author":"Mazza","year":"2021","journal-title":"Acta Biomed"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0023","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000902","article-title":"Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology","volume":"5","author":"Erikssen","year":"2018","journal-title":"Open Heart"},{"issue":"10","key":"10.1016\/j.semperi.2023.151725_bib0024","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/hc1002.105182","article-title":"Heart failure and ventricular dysfunction in patients with single or systemic right ventricles","volume":"105","author":"Piran","year":"2002","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0025","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.pcl.2020.06.008","article-title":"Outcomes in Hypoplastic Left Heart Syndrome","volume":"67","author":"Metcalf","year":"2020","journal-title":"Pediatr Clin North Am"},{"issue":"8","key":"10.1016\/j.semperi.2023.151725_bib0026","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.healun.2014.02.030","article-title":"Gene expression and \u03b2-adrenergic signaling are altered in hypoplastic left heart syndrome","volume":"33","author":"Miyamoto","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0027","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1067\/mtc.2003.183","article-title":"Outcomes after the Norwood operation in neonates with critical aortic stenosis or aortic valve atresia","volume":"125","author":"Ashburn","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0028","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-4975(96)00251-2","article-title":"Surgical management of hypoplastic left heart syndrome","volume":"62","author":"Bando","year":"1996","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"10.1016\/j.semperi.2023.151725_bib0029","doi-asserted-by":"crossref","first-page":"II262","DOI":"10.1161\/01.CIR.92.9.262","article-title":"Ten-year institutional experience with palliative surgery for hypoplastic left heart syndrome. Risk factors related to stage I mortality","volume":"92","author":"Forbess","year":"1995","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0030","first-page":"IV199","article-title":"Hypoplastic left heart syndrome. Outcome after initial reconstruction and before modified Fontan procedure","volume":"82","author":"Murdison","year":"1990","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.semperi.2023.151725_bib0031","first-page":"I82","article-title":"Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients","volume":"106","author":"Tweddell","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0032","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0022-5223(95)70346-2","article-title":"The Norwood operation and subsequent Fontan operation in infants with complex congenital heart disease","volume":"109","author":"Weldner","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0033","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/0003-4975(91)90011-E","article-title":"Results of the Fontan procedure for patients with univentricular heart","volume":"52","author":"Cohen","year":"1991","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"10.1016\/j.semperi.2023.151725_bib0034","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0002-9149(00)01131-0","article-title":"Two-dimensional echocardiographic assessment of right ventricular function as a predictor of outcome in hypoplastic left heart syndrome","volume":"86","author":"Altmann","year":"2000","journal-title":"Am J Cardiol"},{"issue":"21","key":"10.1016\/j.semperi.2023.151725_bib0035","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1161\/CIRCULATIONAHA.105.543686","article-title":"Cardiac magnetic resonance imaging after stage I Norwood operation for hypoplastic left heart syndrome","volume":"112","author":"Muthurangu","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0036","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.athoracsur.2006.05.020","article-title":"Impaired power output and cardiac index with hypoplastic left heart syndrome: a magnetic resonance imaging study","volume":"82","author":"Sundareswaran","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.semperi.2023.151725_bib0037","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijcard.2020.03.085","article-title":"Serial changes in longitudinal strain are associated with outcome in children with hypoplastic left heart syndrome","volume":"317","author":"Borrelli","year":"2020","journal-title":"Int J Cardiol"},{"issue":"8","key":"10.1016\/j.semperi.2023.151725_bib0038","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1007\/s00246-020-02433-9","article-title":"Loss of Ventricular Function After Bidirectional Cavopulmonary Connection: Who Is at Risk?","volume":"41","author":"Vincenti","year":"2020","journal-title":"Pediatr Cardiol"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0039","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/2150135120947692","article-title":"Tricuspid Valve and Right Ventricular Function Throughout the Hybrid Palliation Strategy for Hypoplastic Left Heart Syndrome and Variants","volume":"12","author":"Carrillo","year":"2021","journal-title":"World J Pediatr Congenit Heart Surg"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0040","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.siny.2005.08.006","article-title":"Hypoplastic left heart syndrome: from in-utero diagnosis to school age","volume":"10","author":"Rychik","year":"2005","journal-title":"Semin Fetal Neonatal Med"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0041","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cjca.2022.04.028","article-title":"Hypoplastic Left Heart Syndrome Across the Lifespan: Clinical Considerations for Care of the Fetus, Child, and Adult","volume":"38","author":"Wald","year":"2022","journal-title":"Can J Cardiol"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0042","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004809","article-title":"Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study","volume":"6","author":"Goldberg","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0043","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.jtcvs.2013.06.011","article-title":"Abnormalities in blood coagulation, fibrinolysis, and platelet activation in adult patients after the Fontan procedure","volume":"147","author":"Tomkiewicz-Pajak","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0044","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1177\/1076029613520464","article-title":"Thrombosis and thromboembolic complications in fontan patients: a literature review","volume":"20","author":"Firdouse","year":"2014","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.semperi.2023.151725_bib0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bone.2015.04.012","article-title":"Deficits in bone density and structure in children and young adults following Fontan palliation","volume":"77","author":"Avitabile","year":"2015","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0046","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jtcvs.2009.02.018","article-title":"Skeletal myoblast sheet transplantation improves the diastolic function of a pressure-overloaded right heart","volume":"138","author":"Hoashi","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"8","key":"10.1016\/j.semperi.2023.151725_bib0047","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3727\/096368909X471170","article-title":"Autologous umbilical cord blood mononuclear cell transplantation preserves right ventricular function in a novel model of chronic right ventricular volume overload","volume":"18","author":"Yerebakan","year":"2009","journal-title":"Cell Transplant"},{"issue":"11","key":"10.1016\/j.semperi.2023.151725_bib0048","doi-asserted-by":"crossref","first-page":"H1816","DOI":"10.1152\/ajpheart.00955.2015","article-title":"Mesenchymal stem cells preserve neonatal right ventricular function in a porcine model of pressure overload","volume":"310","author":"Wehman","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0049","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.athoracsur.2009.10.035","article-title":"Human cord blood stem cells enhance neonatal right ventricular function in an ovine model of right ventricular training","volume":"89","author":"Davies","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0050","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41598-020-57694-4","article-title":"Induction of left ventricular hypoplasia by occluding the foramen ovale in the fetal lamb","volume":"10","author":"Wong","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0051","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9149(73)90810-2","article-title":"Experimental production of hypoplastic left heart syndrome in the chick embryo","volume":"31","author":"Harh","year":"1973","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0052","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ng.3870","article-title":"The complex genetics of hypoplastic left heart syndrome","volume":"49","author":"Liu","year":"2017","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.semperi.2023.151725_bib0053","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049077","article-title":"A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow","volume":"14","author":"Rahman","year":"2021","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.semperi.2023.151725_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.674180","article-title":"Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration","volume":"9","author":"Elde","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0055","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.118.311217","article-title":"Clinical studies of cell therapy in cardiovascular medicine recent developments and future directions","volume":"123","author":"Banerjee","year":"2018","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0056","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ejhf.2178","article-title":"A Phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial","volume":"23","author":"Bolli","year":"2021","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0057","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1139\/cjpp-2020-0406","article-title":"After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease","volume":"99","author":"Bolli","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0058","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/CIRCULATIONAHA.112.001075","article-title":"Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy","volume":"128","author":"Bolli","year":"2013","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0059","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","article-title":"Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy: POSEIDON-DCM Trial","volume":"69","author":"Hare","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"10.1016\/j.semperi.2023.151725_bib0060","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial","volume":"308","author":"Hare","year":"2012","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0061","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial","volume":"116","author":"Ishigami","year":"2015","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.semperi.2023.151725_bib0062","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3727\/096368913X665602","article-title":"Improvement of cardiac stem cell sheet therapy for chronic ischemic injury by adding endothelial progenitor cell transplantation: analysis of layer-specific regional cardiac function","volume":"23","author":"Kamata","year":"2014","journal-title":"Cell Transplant"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0063","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.jtcvs.2014.10.093","article-title":"Regenerative therapy for hypoplastic left heart syndrome: first report of intraoperative intramyocardial injection of autologous umbilical-cord blood-derived cells","volume":"149","author":"Burkhart","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0064","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jtcvs.2019.06.001","article-title":"Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections","volume":"158","author":"Burkhart","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0065","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/CIRCRESAHA.116.310253","article-title":"Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial","volume":"120","author":"Ishigami","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0066","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.mayocpiqo.2017.07.002","article-title":"Cell-Based Therapy for Myocardial Dysfunction After Fontan Operation in Hypoplastic Left Heart Syndrome","volume":"1","author":"Qureshi","year":"2017","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0067","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.healun.2009.10.006","article-title":"A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells","volume":"29","author":"Rupp","year":"2010","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0068","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"5411","key":"10.1016\/j.semperi.2023.151725_bib0069","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0070","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jacbts.2019.02.001","article-title":"Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine","volume":"4","author":"Albertario","year":"2019","journal-title":"JACC Basic Transl Sci"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0071","article-title":"Human Neonatal Thymus Mesenchymal Stem\/Stromal Cells and Chronic Right Ventricle Pressure Overload","volume":"6","author":"Chery","year":"2019","journal-title":"Bioengineering (Basel)"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0072","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cardiores.2004.12.013","article-title":"Human cord blood cells induce angiogenesis following myocardial infarction in NOD\/scid-mice","volume":"66","author":"Ma","year":"2005","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0073","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"Smith","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0074","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/1074248418784287","article-title":"Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis","volume":"24","author":"Nana-Leventaki","year":"2019","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0075","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1073\/pnas.0808920106","article-title":"c-kit expression identifies cardiovascular precursors in the neonatal heart","volume":"106","author":"Tallini","year":"2009","journal-title":"Proc Natl Acad Sci U S A,"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0076","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCULATIONAHA.110.971622","article-title":"Characterization and functionality of cardiac progenitor cells in congenital heart patients","volume":"123","author":"Mishra","year":"2011","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0077","doi-asserted-by":"crossref","first-page":"883","DOI":"10.5966\/sctm.2015-0241","article-title":"Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure","volume":"5","author":"Agarwal","year":"2016","journal-title":"Stem Cells Transl Med"},{"issue":"4","key":"10.1016\/j.semperi.2023.151725_bib0078","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/CIRCRESAHA.118.313845","article-title":"Aggregation of Child Cardiac Progenitor Cells Into Spheres Activates Notch Signaling and Improves Treatment of Right Ventricular Heart Failure","volume":"124","author":"Trac","year":"2019","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0079","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.athoracsur.2017.04.058","article-title":"Cardiac Progenitor Cells Enhance Neonatal Right Ventricular Function After Pulmonary Artery Banding","volume":"104","author":"Wehman","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.semperi.2023.151725_bib0080","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen Med"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0081","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.athoracsur.2015.04.130","article-title":"Safety of Intracoronary Human Cord Blood Stem Cells in a Lamb Model of Infant Cardiopulmonary Bypass","volume":"100","author":"Brizard","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"24","key":"10.1016\/j.semperi.2023.151725_bib0082","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1161\/01.CIR.0000070948.37545.E0","article-title":"Noncultured, autologous, skeletal muscle cells can successfully engraft into ovine myocardium","volume":"107","author":"Borenstein","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0083","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jtcvs.2015.06.076","article-title":"Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: Three-year follow-up of the Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single-Ventricle Physiology (TICAP) trial","volume":"150","author":"Tarui","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.semperi.2023.151725_bib0084","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ahj.2017.06.009","article-title":"Study design and rationale for ELPIS: A phase I\/IIb randomized pilot study of allogeneic human mesenchymal stem cell injection in patients with hypoplastic left heart syndrome","volume":"192","author":"Kaushal","year":"2017","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0085","doi-asserted-by":"crossref","DOI":"10.1093\/ehjopen\/oead002","article-title":"Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial","volume":"3","author":"Kaushal","year":"2023","journal-title":"Eur Heart J Open"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0086","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00246-022-02872-6","article-title":"Autologous Cardiac Stem Cell Injection in Patients with Hypoplastic Left Heart Syndrome (CHILD Study)","volume":"43","author":"Kaushal","year":"2022","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.semperi.2023.151725_bib0087","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9628536","article-title":"Challenges and Controversies in Human Mesenchymal Stem Cell Therapy","volume":"2019","author":"Lukomska","year":"2019","journal-title":"Stem Cells Int"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0088","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4070\/kcj.2020.0518","article-title":"Challenges and Limitations of Strategies to Promote Therapeutic Potential of Human Mesenchymal Stem Cells for Cell-Based Cardiac Repair","volume":"51","author":"Bui","year":"2021","journal-title":"Korean Circ J"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0089","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.109.210682","article-title":"Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice","volume":"106","author":"Chimenti","year":"2010","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0090","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","article-title":"Exosomes as critical agents of cardiac regeneration triggered by cell therapy","volume":"2","author":"Ibrahim","year":"2014","journal-title":"Stem Cell Reports"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0091","doi-asserted-by":"crossref","first-page":"337","DOI":"10.15252\/emmm.201606924","article-title":"Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion","volume":"9","author":"Cambier","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"12","key":"10.1016\/j.semperi.2023.151725_bib0092","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.108.816058","article-title":"Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy","volume":"120","author":"Johnston","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.semperi.2023.151725_bib0093","first-page":"201","article-title":"Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction","volume":"38","author":"Gallet","year":"2017","journal-title":"Eur Heart J"},{"issue":"7504","key":"10.1016\/j.semperi.2023.151725_bib0094","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","article-title":"Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts","volume":"510","author":"Chong","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/CBM-160609","article-title":"Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid","volume":"17","author":"Akers","year":"2016","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.semperi.2023.151725_bib0096","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/960926","article-title":"Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy","volume":"2015","author":"Vandergriff","year":"2015","journal-title":"Stem Cells Int"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0097","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s13402-017-0335-7","article-title":"MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR\/HIF-1\u03b1\/VEGF signaling axis in breast cancer cells","volume":"40","author":"Pakravan","year":"2017","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.semperi.2023.151725_bib0098","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jconrel.2022.06.026","article-title":"Stem cell membrane, stem cell-derived exosomes and hybrid stem cell camouflaged nanoparticles: A promising biomimetic nanoplatforms for cancer theranostics","volume":"348","author":"Khosravi","year":"2022","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0099","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.gendis.2014.07.003","article-title":"The potential and challenges of using stem cells for cardiovascular repair and regeneration","volume":"1","author":"Sun","year":"2014","journal-title":"Genes Dis"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0100","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.semperi.2023.151725_bib0101","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/CIRCRESAHA.121.318183","article-title":"Cardiac Tissues From Stem Cells: New Routes to Maturation and Cardiac Regeneration","volume":"128","author":"Campostrini","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.semperi.2023.151725_bib0102","doi-asserted-by":"crossref","first-page":"e5805","DOI":"10.7717\/peerj.5805","article-title":"Recent advances and challenges on application of tissue engineering for treatment of congenital heart disease","volume":"6","author":"Mantakaki","year":"2018","journal-title":"PeerJ"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0103","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJM200102153440717","article-title":"Transplantation of a tissue-engineered pulmonary artery","volume":"344","author":"Shin'oka","year":"2001","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0104","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jtcvs.2009.09.057","article-title":"Late-term results of tissue-engineered vascular grafts in humans","volume":"139","author":"Hibino","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.semperi.2023.151725_bib0105","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1017\/S1047951112000066","article-title":"Intracoronary bone marrow cell application for terminal heart failure in children","volume":"22","author":"Rupp","year":"2012","journal-title":"Cardiol Young"},{"issue":"2","key":"10.1016\/j.semperi.2023.151725_bib0106","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.athoracsur.2009.10.035","article-title":"Human cord blood stem cells enhance neonatal right ventricular function in an ovine model of right ventricular training","volume":"89","author":"Davies","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.semperi.2023.151725_bib0107","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13239-013-0167-1","article-title":"Cardiac fibroblast-derived 3D extracellular matrix seeded with mesenchymal stem cells as a novel device to transfer cells to the ischemic myocardium","volume":"5","author":"Schmuck","year":"2014","journal-title":"Cardiovasc Eng Technol"},{"issue":"7","key":"10.1016\/j.semperi.2023.151725_bib0108","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1161\/CIRCRESAHA.117.312311","article-title":"Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease","volume":"122","author":"Sano","year":"2018","journal-title":"Circ Res"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000523000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000523000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T21:13:22Z","timestamp":1711142002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000523000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":108,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0146000523000289"],"URL":"https:\/\/doi.org\/10.1016\/j.semperi.2023.151725","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semperi.2023.151725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151725"}}