{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:21:12Z","timestamp":1790720472645,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.semperi.2024.151987","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T21:45:46Z","timestamp":1728596746000},"page":"151987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic emergencies in the NICU"],"prefix":"10.1016","volume":"48","author":[{"given":"Ruby","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swosti","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Asghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.semperi.2024.151987_bib0002","doi-asserted-by":"crossref","first-page":"e649","DOI":"10.1542\/neo.21-10-e649","article-title":"Neonatal presentations of metabolic disorders","volume":"21","author":"Md","year":"2020","journal-title":"Neoreviews"},{"issue":"3","key":"10.1016\/j.semperi.2024.151987_bib0003","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2010-3851","article-title":"Newborn. Postnatal glucose homeostasis in late-preterm and term infants","volume":"127","author":"Adamkin","year":"2011","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.semperi.2024.151987_bib0004","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations from the pediatric endocrine society for evaluation and management of persistent hypoglycemia in neonates, infants, and children","volume":"167","author":"Thornton","year":"2015","journal-title":"J Pediatr"},{"issue":"Suppl 2","key":"10.1016\/j.semperi.2024.151987_bib0005","first-page":"69","article-title":"Congenital hyperinsulinism: diagnosis and treatment update","volume":"9","author":"Demirbilek","year":"2017","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"2","key":"10.1016\/j.semperi.2024.151987_bib0006","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.clp.2015.02.010","article-title":"Inborn errors of metabolism","volume":"42","author":"El-Hattab","year":"2015","journal-title":"Clin Perinatol"},{"issue":"12","key":"10.1016\/j.semperi.2024.151987_bib0007","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/jama.2022.2363","article-title":"Prophylactic oral dextrose gel and neurosensory impairment at 2-year follow-up of participants in the hPOD randomized trial","volume":"327","author":"Edwards","year":"2022","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.semperi.2024.151987_bib0008","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0022-3476(80)80499-9","article-title":"Treatment of neonatal hypoglycemia with minibolus and intravenous glucose infusion","volume":"97","author":"Lilien","year":"1980","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.semperi.2024.151987_bib0010","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1210\/jc.2018-01613","article-title":"Prevalence of adverse events in children with congenital hyperinsulinism treated with diazoxide","volume":"103","author":"Herrera","year":"2018","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0011","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1542\/peds.111.1.220","article-title":"Glucagon infusion for treatment of hypoglycemia: efficacy and safety in sick, preterm infants","volume":"111","author":"Charsha","year":"2003","journal-title":"Pediatrics"},{"issue":"3 Spec No","key":"10.1016\/j.semperi.2024.151987_bib0012","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/adc.68.3_Spec_No.255","article-title":"Neonatal blood glucose concentrations: metabolic effects of intravenous glucagon and intragastric medium chain triglyceride","volume":"68","author":"Hawdon","year":"1993","journal-title":"Arch Dis Child"},{"issue":"10","key":"10.1016\/j.semperi.2024.151987_bib0013","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1001\/archpedi.156.10.999","article-title":"Experience with intravenous glucagon infusions as a treatment for resistant neonatal hypoglycemia","volume":"156","author":"Miralles","year":"2002","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"7 Spec No","key":"10.1016\/j.semperi.2024.151987_bib0014","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/adc.67.7_Spec_No.767","article-title":"Metabolic acidosis in newborn infants","volume":"67","author":"Walter","year":"1992","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.semperi.2024.151987_bib0015","unstructured":"Tschudy MMEA, Kristin M. (Ed.), ed. The Harriet Lane Handbook: A Manual For Pediatric House Officers. 16th ed. Mosby; 2002."},{"key":"10.1016\/j.semperi.2024.151987_bib0016","doi-asserted-by":"crossref","unstructured":"Mandell I. Serum anion gap in metabolic acidosis. Neonatal Network. (4):252\u2013254. doi:10.1891\/0730-0832.28.4.252.","DOI":"10.1891\/0730-0832.28.4.252"},{"issue":"6","key":"10.1016\/j.semperi.2024.151987_bib0017","doi-asserted-by":"crossref","DOI":"10.1542\/peds.102.6.e69","article-title":"Inborn errors of metabolism in infancy: a guide to diagnosis","volume":"102","author":"Burton","year":"1998","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.semperi.2024.151987_bib0018","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/adc.56.6.425","article-title":"Factors associated with periventricular haemorrhage in very low birthweight infants","volume":"56","author":"Cooke","year":"1981","journal-title":"Arch Dis Child"},{"issue":"13","key":"10.1016\/j.semperi.2024.151987_bib0019","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.3390\/nu14132755","article-title":"Recommendations for the diagnosis and therapeutic management of hyperammonaemia in paediatric and adult patients","volume":"14","author":"B\u00e9langer-Quintana","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00431-010-1369-2","article-title":"Clinical practice: the management of hyperammonemia","volume":"170","author":"H\u00e4berle","year":"2011","journal-title":"Eur J Pediatr"},{"issue":"8","key":"10.1016\/j.semperi.2024.151987_bib0021","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41581-020-0267-8","article-title":"Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy","volume":"16","author":"Raina","year":"2020","journal-title":"Nature Reviews Nephrol"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0022","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0733-8619(03)00060-4","article-title":"Neurologic manifestations of electrolyte disturbances","volume":"20","author":"Riggs","year":"2002","journal-title":"Neurol Clin"},{"issue":"20","key":"10.1016\/j.semperi.2024.151987_bib0023","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJM200005183422006","volume":"342","author":"Adrogue","year":"2000","journal-title":"New England J Medicine"},{"issue":"8","key":"10.1016\/j.semperi.2024.151987_bib0024","first-page":"503","article-title":"Treatment of hyperkalaemia by altering the transcellular gradient in patients with renal failure: effect of various therapeutic approaches","volume":"74","author":"Ngugi","year":"1997","journal-title":"East Afr Med J"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1067\/mpd.2002.125229","article-title":"Efficacy of albuterol inhalation in treatment of hyperkalemia in premature neonates","volume":"141","author":"Singh","year":"2002","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0026","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0025-7125(16)30085-2","article-title":"Hypercalcemic crisis","volume":"79","author":"Edelson","year":"1995","journal-title":"Med Clin North Am"},{"issue":"5","key":"10.1016\/j.semperi.2024.151987_bib0027","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0272-6386(12)80667-6","article-title":"Magnesium deficiency: pathophysiologic and clinical overview","volume":"24","author":"Al-Ghamdi","year":"1994","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"10.1016\/j.semperi.2024.151987_bib0028","first-page":"609","article-title":"Plasma potassium, serum magnesium and ventricular fibrillation: a prospective study","volume":"86","author":"Higham","year":"1993","journal-title":"Q J Med"},{"issue":"3","key":"10.1016\/j.semperi.2024.151987_bib0029","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/pir.36-3-92","article-title":"Adrenal insufficiency","volume":"36","author":"Auron","year":"2015","journal-title":"Pediatr Rev"},{"issue":"4","key":"10.1016\/j.semperi.2024.151987_bib0030","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.beem.2018.05.010","article-title":"Primary adrenal insufficiency in children: diagnosis and management","volume":"32","author":"Kirkgoz","year":"2018","journal-title":"Best Practice Res Clin Endocrinol Metabol"},{"issue":"2","key":"10.1016\/j.semperi.2024.151987_bib0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pcl.2018.12.007","article-title":"The current state of newborn screening in the United States","volume":"66","author":"Fabie","year":"2019","journal-title":"Pediatr Clin North Am"},{"issue":"10372","key":"10.1016\/j.semperi.2024.151987_bib0031","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(22)01330-7","article-title":"Congenital adrenal hyperplasia","volume":"401","author":"Auer","year":"2023","journal-title":"The Lancet"},{"issue":"4","key":"10.1016\/j.semperi.2024.151987_bib0032","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.beem.2018.03.012","article-title":"Central adrenal insufficiency in children and adolescents","volume":"32","author":"Patti","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"key":"10.1016\/j.semperi.2024.151987_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1309053","article-title":"X-linked adrenoleukodystrophy and primary adrenal insufficiency","volume":"14","author":"Cappa","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.semperi.2024.151987_bib0034","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00431-019-03348-1","article-title":"Adrenal crises in children with adrenal insufficiency: epidemiology and risk factors","volume":"178","author":"Eyal","year":"2019","journal-title":"Eur J Pediatr"},{"issue":"4","key":"10.1016\/j.semperi.2024.151987_bib0036","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000525075","article-title":"Management of acute adrenal insufficiency-related adverse events in children with congenital adrenal hyperplasia: results of an international survey of specialist centres","volume":"95","author":"Ali","year":"2022","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"10.1016\/j.semperi.2024.151987_bib0037","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/archdischild-2022-325156","article-title":"Emergency and perioperative management of adrenal insufficiency in children and young people: british Society for Paediatric Endocrinology and Diabetes consensus guidance","volume":"108","author":"Mushtaq","year":"2023","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.semperi.2024.151987_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.757566","article-title":"Acute illness and death in children with adrenal insufficiency","volume":"12","author":"Worth","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.semperi.2024.151987_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1198519","article-title":"Hypoglycaemia in adrenal insufficiency","volume":"14","author":"Lee","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1016\/j.semperi.2024.151987_bib0039","article-title":"Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia","author":"Ng","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.semperi.2024.151987_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1133376","article-title":"Adrenal crisis in infants and young children with adrenal insufficiency: management and prevention","volume":"14","author":"Bizzarri","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.semperi.2024.151987_bib0042","series-title":"Disease of the Fetus and Infant","author":"Martin","year":"2020"},{"issue":"3","key":"10.1016\/j.semperi.2024.151987_bib0001","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-058859","article-title":"Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"150","author":"Kemper","year":"2022","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.semperi.2024.151987_bib0043","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/jp.2008.211","article-title":"Clinical report from the pilot USA Kernicterus Registry (1992 to 2004)","volume":"29","author":"Johnson","year":"2009","journal-title":"J Perinatol"},{"key":"10.1016\/j.semperi.2024.151987_bib0044","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcmd.2018.05.002","article-title":"Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018","volume":"72","author":"Christensen","year":"2018","journal-title":"Blood Cells Mol Dis."},{"issue":"2","key":"10.1016\/j.semperi.2024.151987_bib0045","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.75.2.393","article-title":"Efficacy of phototherapy in prevention and management of neonatal hyperbilirubinemia","volume":"75","author":"Brown","year":"1985","journal-title":"Pediatrics"},{"issue":"18","key":"10.1016\/j.semperi.2024.151987_bib0046","article-title":"The effect of immunoglobulin treatment for hemolysis on the incidence of necrotizing enterocolitis-a meta-analysis","volume":"20","author":"Yang","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000524001216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000524001216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:18:19Z","timestamp":1733998699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000524001216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0146000524001216"],"URL":"https:\/\/doi.org\/10.1016\/j.semperi.2024.151987","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic emergencies in the NICU","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semperi.2024.151987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151987"}}