{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:32:44Z","timestamp":1793068364528,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.semperi.2026.152268","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:27:15Z","timestamp":1781868435000},"page":"152268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-dose aspirin in pregnancy: 81 mg vs 162 mg \u2014 Is there a role for personalized medicine?"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6568-299X","authenticated-orcid":false,"given":"Annabeth","family":"Brewton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Rood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.semperi.2026.152268_bib0001","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/AOG.0000000000002114","article-title":"Pregnancy-related mortality in the United States, 2011-2013","volume":"130","author":"Creanga","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"18","key":"10.1016\/j.semperi.2026.152268_bib0002","doi-asserted-by":"crossref","first-page":"423","DOI":"10.15585\/mmwr.mm6818e1","article-title":"Vital signs: pregnancy-related deaths, United States, 2011-2015, and Strategies for prevention, 13 States, 2013-2017","volume":"68","author":"Petersen","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0003","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.semperi.2026.152268_bib0004","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and future cardiovascular health: a systematic review and meta-analysis","volume":"10","author":"Wu","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"12","key":"10.1016\/j.semperi.2026.152268_bib0005","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1001\/jama.2021.8551","article-title":"Aspirin use to prevent preeclampsia and related morbidity and mortality: updated evidence report and systematic review for the US preventive services task force","volume":"326","author":"Henderson","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.semperi.2026.152268_bib0006","article-title":"ACOG committee opinion No. 743: low-dose aspirin use during pregnancy","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0007","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus Placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semperi.2026.152268_bib0008","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.placenta.2008.11.021","article-title":"Placental stress and pre-eclampsia: a revised view","volume":"30","author":"Redman","year":"2009","journal-title":"Placenta"},{"issue":"Suppl A","key":"10.1016\/j.semperi.2026.152268_bib0009","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"issue":"5\u20136","key":"10.1016\/j.semperi.2026.152268_bib0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","article-title":"The mechanism of action of aspirin","volume":"110","author":"Vane","year":"2003","journal-title":"Thromb Res"},{"issue":"5","key":"10.1016\/j.semperi.2026.152268_bib0011","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7503","key":"10.1016\/j.semperi.2026.152268_bib0012","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0013","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0014","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.semperi.2026.152268_bib0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.semperi.2026.152268_bib0016","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/uog.18899","article-title":"Early screening and prevention of preterm pre-eclampsia with aspirin: time for clinical implementation","volume":"50","author":"Rolnik","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0017","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajog.2017.01.034","article-title":"Antiplatelet therapy before or after 16 weeks' gestation for preventing preeclampsia","volume":"216","author":"Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"1\u20132","key":"10.1016\/j.semperi.2026.152268_bib0018","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/07420528.2012.717455","article-title":"Chronotherapy with low-dose aspirin for prevention of complications in pregnancy","volume":"30","author":"Ayala","year":"2013","journal-title":"Chronobiol Int"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0019","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jacc.2004.08.071","article-title":"Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients","volume":"46","author":"Hermida","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"2 Pt 1","key":"10.1016\/j.semperi.2026.152268_bib0020","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2017.11.561","article-title":"Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis","volume":"218","author":"Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.semperi.2026.152268_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.semperi.2026.152268_bib0023","unstructured":"in hypertension in pregnancy: diagnosis and management. 2019: London."},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2024.06.038","article-title":"Aspirin 162 mg vs 81 mg for preeclampsia prophylaxis in high-risk obese individuals: a comparative effectiveness open-label randomized trial (ASPREO)","volume":"232","author":"Amro","year":"2025","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.semperi.2026.152268_bib0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/AOG.0000000000006100","article-title":"Comparison of 162 mg and 81 mg aspirin for prevention of preeclampsia: a randomized controlled trial","volume":"147","author":"Khander","year":"2026","journal-title":"Obstet Gynecol"},{"issue":"10220","key":"10.1016\/j.semperi.2026.152268_bib0026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0140-6736(19)32973-3","article-title":"Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial","volume":"395","author":"Hoffman","year":"2020","journal-title":"Lancet"},{"issue":"9937","key":"10.1016\/j.semperi.2026.152268_bib0027","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(14)60157-4","article-title":"Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial","volume":"384","author":"Schisterman","year":"2014","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.semperi.2026.152268_bib0028","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.30804","article-title":"Use of a smartphone app to explore potential underuse of prophylactic aspirin for preeclampsia","volume":"4","author":"Krishnamurti","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2017.01.017","article-title":"Reduction of severe maternal morbidity from hemorrhage using a state perinatal quality collaborative","volume":"216","author":"Main","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.semperi.2026.152268_bib0030","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1186\/s12884-023-05922-w","article-title":"Leveraging quality improvement to promote health equity: standardization of prenatal aspirin recommendations","volume":"23","author":"Gross","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"issue":"15","key":"10.1016\/j.semperi.2026.152268_bib0031","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/jama.282.15.1458","article-title":"Why don't physicians follow clinical practice guidelines? A framework for improvement","volume":"282","author":"Cabana","year":"1999","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.semperi.2026.152268_bib0032","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/GRF.0000000000000349","article-title":"Reducing disparities in severe maternal morbidity and mortality","volume":"61","author":"Howell","year":"2018","journal-title":"Clin Obstet Gynecol"},{"issue":"35","key":"10.1016\/j.semperi.2026.152268_bib0033","doi-asserted-by":"crossref","first-page":"762","DOI":"10.15585\/mmwr.mm6835a3","article-title":"Racial\/ethnic disparities in pregnancy-related deaths - United States, 2007-2016","volume":"68","author":"Petersen","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0034","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.21792","article-title":"Utility of the US preventive services task force for preeclampsia risk assessment and aspirin prophylaxis","volume":"8","author":"McElrath","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"7893","key":"10.1016\/j.semperi.2026.152268_bib0035","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41586-021-04249-w","article-title":"RNA profiles reveal signatures of future health and disease in pregnancy","volume":"601","author":"Rasmussen","year":"2022","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0036","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/uog.17399","article-title":"Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation","volume":"49","author":"O'Gorman","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0037","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/uog.17455","article-title":"Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations","volume":"49","author":"O'Gorman","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2017.08.110","article-title":"Aspirin for Evidence-based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia","volume":"217","author":"Wright","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0039","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.112.117283","article-title":"Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin","volume":"127","author":"Grosser","year":"2013","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0040","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1538-7836.2012.04723.x","article-title":"The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes","volume":"10","author":"Rocca","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"11","key":"10.1016\/j.semperi.2026.152268_bib0041","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S1701-2163(16)34346-8","article-title":"Low-dose ASA response using the PFA-100 in women with high-risk pregnancy","volume":"31","author":"Caron","year":"2009","journal-title":"J Obstet Gynaecol Can"},{"issue":"4","key":"10.1016\/j.semperi.2026.152268_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2019.01.222","article-title":"Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin","volume":"220","author":"Finneran","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.semperi.2026.152268_bib0043","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1471-0528.2012.03312.x","article-title":"Prediction of recurrence of hypertensive disorders of pregnancy between 34 and 37 weeks of gestation: a retrospective cohort study","volume":"119","author":"van Oostwaard","year":"2012","journal-title":"BJOG"},{"issue":"12","key":"10.1016\/j.semperi.2026.152268_bib0044","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1001\/jama.2021.14781","article-title":"Aspirin use to prevent preeclampsia and related morbidity and mortality: US preventive services task force recommendation statement","volume":"326","author":"Force","year":"2021","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.semperi.2026.152268_bib0045","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s40265-023-01842-3","article-title":"Aspirin for the prevention of early and severe pre-eclampsia recurrence: a real-world population-based study","volume":"83","author":"Lailler","year":"2023","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.semperi.2026.152268_bib0046","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ajog.2007.10.783","article-title":"Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?","volume":"198","author":"Bdolah","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.semperi.2026.152268_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2024.12.030","article-title":"Comparison of two aspirin doses for the prophylaxis of pre-eclampsia in twin pregnancy: a multicenter retrospective study with propensity score matching","volume":"233","author":"Zorzato","year":"2025","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.semperi.2026.152268_bib0048","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ajog.2020.03.005","article-title":"The role of aspirin in prevention of preeclampsia in twin pregnancies: does the dose matter?","volume":"223","author":"Kalafat","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.semperi.2026.152268_bib0049","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ajog.2022.09.046","article-title":"Low-dose aspirin for the prevention of superimposed preeclampsia in women with chronic hypertension: a systematic review and meta-analysis","volume":"228","author":"Richards","year":"2023","journal-title":"Am J Obstet Gynecol"},{"issue":"2S","key":"10.1016\/j.semperi.2026.152268_bib0050","doi-asserted-by":"crossref","first-page":"S1182","DOI":"10.1016\/j.ajog.2020.11.029","article-title":"Chronic hypertension and superimposed preeclampsia: screening and diagnosis","volume":"226","author":"Kametas","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.semperi.2026.152268_bib0051","article-title":"ACOG practice bulletin No. 201: pregestational Diabetes Mellitus","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"Supplement_1","key":"10.1016\/j.semperi.2026.152268_bib0052","doi-asserted-by":"crossref","first-page":"S321","DOI":"10.2337\/dc26-S015","article-title":"15. Management of diabetes in pregnancy: standards of care in diabetes-2026","volume":"49","year":"2026","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.semperi.2026.152268_bib0053","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12882-019-1560-2","article-title":"Clinical practice guideline on pregnancy and renal disease","volume":"20","author":"Wiles","year":"2019","journal-title":"BMC Nephrol"},{"issue":"5","key":"10.1016\/j.semperi.2026.152268_bib0054","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s40620-021-01049-3","article-title":"Low-dose aspirin for the prevention of severe preeclampsia in patients with chronic kidney disease: a retrospective study: this is the study for kidney and pregnancy","volume":"34","author":"Wang","year":"2021","journal-title":"J Nephrol"},{"issue":"9","key":"10.1016\/j.semperi.2026.152268_bib0055","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1056\/NEJMms2004740","article-title":"Hidden in plain sight - reconsidering the use of race correction in clinical algorithms","volume":"383","author":"Vyas","year":"2020","journal-title":"N Engl J Med"},{"issue":"6273","key":"10.1016\/j.semperi.2026.152268_bib0056","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1126\/science.aac4951","article-title":"Science and society. Taking race out of human genetics","volume":"351","author":"Yudell","year":"2016","journal-title":"Science"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:54:12Z","timestamp":1793066052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000526000571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0146000526000571"],"URL":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152268","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose aspirin in pregnancy: 81 mg vs 162 mg \u2014 Is there a role for personalized medicine?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152268"}}