{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:11:53Z","timestamp":1788757913628,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.semperi.2026.152280","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:10:22Z","timestamp":1784067022000},"page":"152280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The uprise of congenital syphilis in the United States: a preventable failure of perinatal systems"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-3392","authenticated-orcid":false,"given":"Jana","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.semperi.2026.152280_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.semperi.2026.152280_bib0002","series-title":"Global Guidance on Criteria and Processes for Validation: Elimination of Mother-to-Child Transmission of HIV and Syphilis","year":"2017"},{"key":"10.1016\/j.semperi.2026.152280_bib0003","series-title":"Sexually Transmitted Infections Surveillance, 2024 (Provisional)","year":"2025"},{"issue":"4","key":"10.1016\/j.semperi.2026.152280_bib0004","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/AOG.0000000000005700","article-title":"Rising stillbirth rates related to congenital syphilis in the United States from 2016 to 2022","volume":"144","author":"Machefsky","year":"2024","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.semperi.2026.152280_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.73","article-title":"Syphilis","volume":"3","author":"Peeling","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.semperi.2026.152280_bib0006","series-title":"Elimination of mother-to-child transmission of syphilis","year":"2016"},{"key":"10.1016\/j.semperi.2026.152280_bib0007","series-title":"Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases","article-title":"Syphilis","year":"2024"},{"key":"10.1016\/j.semperi.2026.152280_bib0008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<119::AID-PD39>3.0.CO;2-T","article-title":"In utero infection with Treponema pallidum in early pregnancy","volume":"17","author":"Nathan","year":"1997","journal-title":"Prenat Diagn."},{"key":"10.1016\/j.semperi.2026.152280_bib0009","series-title":"Textbook of Pediatric Infectious Diseases","first-page":"1724","article-title":"Syphilis","author":"S\u00e1nchez","year":"1998"},{"key":"10.1016\/j.semperi.2026.152280_bib0010","unstructured":"American Academy of Pediatrics. Congenital Syphilis Evaluation and Treatment Guide. https:\/\/www.aap.org\/en\/patient-care\/congenital-syphilis\/congenital-syphilis-evaluation-and-treatment-guide\/. Accessed 2026."},{"issue":"9","key":"10.1016\/j.semperi.2026.152280_bib0011","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/OLQ.0000000000002187","article-title":"Trends in syphilis prevalence by race and ethnicity among pregnant persons, 2016\u20132023","volume":"52","author":"Liang","year":"2025","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.semperi.2026.152280_bib0012","first-page":"661","article-title":"Missed opportunities for prevention of congenital syphilis\u2014United States, 2018","volume":"69","author":"Kimball","year":"2020","journal-title":"MMWR"},{"issue":"Suppl 2","key":"10.1016\/j.semperi.2026.152280_bib0013","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/00333549141291S206","article-title":"The social determinants of health","volume":"129","author":"Braveman","year":"2014","journal-title":"Public Health Rep"},{"key":"10.1016\/j.semperi.2026.152280_bib0014","first-page":"1269","article-title":"Vital signs: missed opportunities for preventing congenital syphilis\u2014United States, 2022","volume":"72","author":"McDonald","year":"2023","journal-title":"MMWR"},{"issue":"5","key":"10.1016\/j.semperi.2026.152280_bib0015","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/OLQ.0000000000001298","article-title":"Maternal reinfection during pregnancy and congenital syphilis","volume":"48","author":"Matthias","year":"2021","journal-title":"Sex Transm Dis"},{"issue":"2","key":"10.1016\/j.semperi.2026.152280_bib0016","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/00007435-200102000-00006","article-title":"Missed opportunities for congenital syphilis prevention","volume":"28","author":"Warner","year":"2001","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.semperi.2026.152280_bib0017","first-page":"1088","article-title":"Factors contributing to congenital syphilis cases\u2014NYC 2010\u20132016","volume":"67","author":"Slutsker","year":"2018","journal-title":"MMWR"},{"key":"10.1016\/j.semperi.2026.152280_bib0018","first-page":"67","article-title":"Substance use among persons with syphilis during pregnancy\u2014Arizona and Georgia, 2018\u20132021","volume":"72","year":"2023","journal-title":"MMWR"},{"key":"10.1016\/j.semperi.2026.152280_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2022.100595","article-title":"Disparities in state-mandated third-trimester testing for syphilis","volume":"4","author":"Clement","year":"2022","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.semperi.2026.152280_bib0020","unstructured":"Centers for Disease Control and Prevention Division of STD Prevention (DSTDP). State statutory and regulatory language regarding prenatal syphilis screenings in the United States. https:\/\/www.cdc.gov\/syphilis\/media\/pdfs\/2025\/09\/Prenatal-Syphilis-Screening-Laws-2025.pdf. Accessed July 3, 2026."},{"key":"10.1016\/j.semperi.2026.152280_bib0021","unstructured":"American College of Obstetricians and Gynecologists. Screening for syphilis in pregnancy. https:\/\/www.acog.org\/clinical\/clinical-guidance\/practice-advisory\/articles\/2024\/04\/screening-for-syphilis-in-pregnancy. Accessed July 3, 2026."},{"key":"10.1016\/j.semperi.2026.152280_bib0022","unstructured":"American Society of Health-System Pharmacists. Benzathine penicillin G shortage update. 2026."},{"key":"10.1016\/j.semperi.2026.152280_bib0023","series-title":"The Impact of Chronic Underfunding on America\u2019s Public Health System","year":"2024"},{"key":"10.1016\/j.semperi.2026.152280_bib0024","article-title":"Medicaid expansion and maternal health outcomes","author":"Daw","year":"2020","journal-title":"Health Aff"},{"key":"10.1016\/j.semperi.2026.152280_bib0025","article-title":"Improvement in universal prenatal syphilis screening after legislation","author":"Diesel","year":"2025","journal-title":"Pregnancy"},{"issue":"5","key":"10.1016\/j.semperi.2026.152280_bib0026","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/phn.12784","article-title":"Trauma-informed care in STD clinics","volume":"37","author":"Brewer","year":"2020","journal-title":"Public Health Nurs"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:29:37Z","timestamp":1788755377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000526000698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0146000526000698"],"URL":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152280","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The uprise of congenital syphilis in the United States: a preventable failure of perinatal systems","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152280"}}