{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:06:44Z","timestamp":1789589204754,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["10940012510013"],"award-info":[{"award-number":["10940012510013"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.semperi.2026.152295","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:50:26Z","timestamp":1788493826000},"page":"152295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Measuring total bilirubin for clinical decision making: are we treating at the right number?"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5745-1501","authenticated-orcid":false,"given":"Isabel V.","family":"Dupont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0652-669X","authenticated-orcid":false,"given":"Stanley F.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-648X","authenticated-orcid":false,"given":"Peter H.","family":"Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-7501","authenticated-orcid":false,"given":"Christian V.","family":"Hulzebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semperi.2026.152295_bib0001","unstructured":"Wong R.J.B., Vinod K., Unconjugated hyperbilirubinemia in newborns \u226535 weeks of gestation: initial management and phototherapy. https:\/\/www.uptodate.cn\/contents\/unconjugated-hyperbilirubinemia-in-newborns-35-weeks-of-gestation-initial-management-and-phototherapy, 2025 (accessed 16 August 2026)."},{"key":"10.1016\/j.semperi.2026.152295_bib0002","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.pcl.2004.03.011","article-title":"Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week","volume":"51","author":"Bhutani","year":"2004","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.semperi.2026.152295_bib0003","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1056\/NEJMct0708376","article-title":"Phototherapy for neonatal jaundice","volume":"358","author":"Maisels","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0004","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","article-title":"Neonatal hyperbilirubinaemia: a global perspective","volume":"2","author":"Olusanya","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.semperi.2026.152295_bib0005","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1056\/NEJMe068053","article-title":"Neonatal hyperbilirubinemia\u2013what are the risks?","volume":"354","author":"Watchko","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0006","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(58)91849-X","article-title":"Influence of light on the hyperbilirubinaemia of infants","volume":"1","author":"Cremer","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/j.semperi.2026.152295_bib0007","series-title":"Jaundice in newborn babies under 28 days","year":"2023"},{"key":"10.1016\/j.semperi.2026.152295_bib0008","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-058859","article-title":"Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"150","author":"Kemper","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0009","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1373\/clinchem.2008.121269","article-title":"Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice","volume":"55","author":"Ahlfors","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0010","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0022-2275(20)39768-6","article-title":"Structure and binding of unconjugated bilirubin: relevance for physiological and pathophysiological function","volume":"35","author":"Ostrow","year":"1994","journal-title":"J Lipid Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0011","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/j.semperi.2011.02.007","article-title":"Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates","volume":"35","author":"Amin","year":"2011","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.semperi.2020.151352","article-title":"Treatment criteria for infants with hyperbilirubinemia in Japan","volume":"45","author":"Morioka","year":"2021","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0013","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1080\/14767058.2020.1761318","article-title":"Unbound bilirubin measurements in term and late-preterm infants","volume":"35","author":"Hegyi","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0014","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1373\/clinchem.2011.176412","article-title":"Fluorescence sensor for the quantification of unbound bilirubin concentrations","volume":"58","author":"Huber","year":"2012","journal-title":"Clin Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0015","doi-asserted-by":"crossref","first-page":"F384","DOI":"10.1136\/adc.2007.134056","article-title":"Usefulness of the bilirubin\/albumin ratio for predicting bilirubin-induced neurotoxicity in premature infants","volume":"93","author":"Hulzebos","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.semperi.2026.152295_bib0016","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/s41390-025-04638-1","article-title":"Need for accurate and actionable neonatal bilirubin test results","volume":"99","author":"Bhutani","year":"2026","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0017","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/clinchem\/hvaf144","article-title":"Evaluation of total bilirubin in a national quality program","volume":"72","author":"Westenberg","year":"2025","journal-title":"Clin Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0018","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/clinchem\/hvaf175","article-title":"The analytical performance of neonatal total bilirubin assays does not meet the clinical need","volume":"72","author":"Oostendorp","year":"2026","journal-title":"Clin Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0019","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1515\/cclm-2024-0620","article-title":"Bilirubin measurements in neonates: uniform neonatal treatment can only be achieved by improved standardization","volume":"62","author":"Hulzebos","year":"2024","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1124\/mol.116.107524","article-title":"Developmental, genetic, dietary, and xenobiotic influences on neonatal hyperbilirubinemia","volume":"91","author":"Yueh","year":"2017","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.semperi.2026.152295_bib0021","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1067\/mpd.2000.108566","article-title":"Unbound bilirubin associated with kernicterus: a historical approach","volume":"137","author":"Ahlfors","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.semperi.2026.152295_bib0022","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1542\/peds.2005-0395","article-title":"Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns","volume":"117","author":"Wennberg","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0023","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1053\/j.semperi.2004.09.002","article-title":"Bilirubin-albumin binding and neonatal jaundice","volume":"28","author":"Ahlfors","year":"2004","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0024","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/ped.13635","article-title":"Hyperbilirubinemia in preterm infants in Japan: New treatment criteria","volume":"60","author":"Morioka","year":"2018","journal-title":"Pediatr Int"},{"key":"10.1016\/j.semperi.2026.152295_bib0025","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.siny.2014.12.002","article-title":"Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities","volume":"20","author":"Brites","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0026","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1046\/j.1365-2362.2003.01261.x","article-title":"New concepts in bilirubin encephalopathy","volume":"33","author":"Ostrow","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.semperi.2026.152295_bib0027","doi-asserted-by":"crossref","first-page":"10852","DOI":"10.1074\/jbc.274.16.10852","article-title":"Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes","volume":"274","author":"Zucker","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0028","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/s41390-022-02351-x","article-title":"Models of bilirubin neurological damage: lessons learned and new challenges","volume":"93","author":"Gazzin","year":"2023","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0029","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.siny.2009.12.004","article-title":"Chronic bilirubin encephalopathy: diagnosis and outcome","volume":"15","author":"Shapiro","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0030","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1442-200X.1992.tb01024.x","article-title":"Determination of serum unbound bilirubin for prediction of kernicterus in low birthweight infants","volume":"34","author":"Nakamura","year":"1992","journal-title":"Acta Paediatr Jpn"},{"key":"10.1016\/j.semperi.2026.152295_bib0031","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.earlhumdev.2011.04.004","article-title":"Bartrial study group NNRN. Uniform treatment thresholds for hyperbilirubinemia in preterm infants: background and synopsis of a national guideline","volume":"87","author":"van Imhoff","year":"2011","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.semperi.2026.152295_bib0032","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-058865","article-title":"Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation","volume":"150","author":"Slaughter","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0033","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/archdischild-2021-322891","article-title":"Severe neonatal hyperbilirubinaemia: lessons learnt from a national perinatal audit","volume":"107","author":"van der Geest","year":"2022","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.semperi.2026.152295_bib0034","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/jp.2012.71","article-title":"An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation","volume":"32","author":"Maisels","year":"2012","journal-title":"J Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0035","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1542\/peds.75.4.703","article-title":"Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia","volume":"75","author":"Nakamura","year":"1985","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0036","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1542\/peds.107.4.664","article-title":"Bilirubin and serial auditory brainstem responses in premature infants","volume":"107","author":"Amin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0037","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/dmcn.13284","article-title":"Auditory toxicity in late preterm and term neonates with severe jaundice","volume":"59","author":"Amin","year":"2017","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.semperi.2026.152295_bib0038","first-page":"140","article-title":"Chronic auditory toxicity in late preterm and term infants with significant hyperbilirubinemia","author":"Amin","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0039","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.siny.2014.11.001","article-title":"Disorders of bilirubin binding to albumin and bilirubin-induced neurologic dysfunction","volume":"20","author":"Morioka","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0040","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1542\/neo.17-3-e124","article-title":"International perspectives: clinical kernicterus in preterm infants in Japan","volume":"17","author":"Morioka","year":"2016","journal-title":"NeoReviews"},{"key":"10.1016\/j.semperi.2026.152295_bib0041","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1442-200X.2009.02878.x","article-title":"The significance of measurement of serum unbound bilirubin concentrations in high-risk infants","volume":"51","author":"Lee","year":"2009","journal-title":"Pediatr Int"},{"key":"10.1016\/j.semperi.2026.152295_bib0042","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1038\/s41390-025-04667-w","article-title":"Unbound bilirubin: a call to reframe neonatal care and clinical decision-making","volume":"99","author":"Hegyi","year":"2026","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0043","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-025-04702-w","article-title":"Bilirubin-albumin molar ratio for screening high unbound bilirubin across gestational ages","author":"Iwatani","year":"2025","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0044","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/clinchem\/24.9.1491","article-title":"Bilirubin-protein interactions monitored by difference spectroscopy","volume":"24","author":"Ash","year":"1978","journal-title":"Clin Chem"},{"key":"10.1016\/j.semperi.2026.152295_bib0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0773.1978.tb02184.x","article-title":"Determination of the vacant amount of high-affinity bilirubin binding site on serum albumin","volume":"42","author":"Brodersen","year":"1978","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"10.1016\/j.semperi.2026.152295_bib0046","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0009-8981(80)90388-5","article-title":"Reserve bilirubin binding capacity assessed by difference spectroscopy: assay statistics and results on newborn sera","volume":"104","author":"Ash","year":"1980","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.semperi.2026.152295_bib0047","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.semperi.2004.09.005","article-title":"Clinical assessment of bilirubin-induced neurotoxicity in premature infants","volume":"28","author":"Amin","year":"2004","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099466","article-title":"The bilirubin albumin ratio in the management of hyperbilirubinemia in preterm infants to improve neurodevelopmental outcome: a randomized controlled trial\u2013BARTrial","volume":"9","author":"Hulzebos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semperi.2026.152295_bib0049","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1442-200X.2011.03457.x","article-title":"Is bilirubin\/albumin ratio correlated with unbound bilirubin concentration?","volume":"54","author":"Sato","year":"2012","journal-title":"Pediatr Int"},{"key":"10.1016\/j.semperi.2026.152295_bib0050","doi-asserted-by":"crossref","first-page":"e1330","DOI":"10.1542\/peds.2013-1764","article-title":"Serum bilirubin and bilirubin\/albumin ratio as predictors of bilirubin encephalopathy","volume":"134","author":"Iskander","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0051","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1542\/peds.112.4.773","article-title":"Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants","volume":"112","author":"Oh","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030900","article-title":"Hyperbilirubinemia and neurodevelopmental outcome of very low birthweight infants: results from the LIFT cohort","volume":"7","author":"Mazeiras","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.semperi.2026.152295_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2023.113458","article-title":"Hyperbilirubinemia among infants born preterm: peak levels and association with neurodevelopmental outcomes","volume":"259","author":"Solis-Garcia","year":"2023","journal-title":"J Pediatr"},{"key":"10.1016\/j.semperi.2026.152295_bib0054","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1542\/peds.90.6.888","article-title":"Serum bilirubin levels, intracranial hemorrhage, and the risk of developmental problems in very low birth weight neonates","volume":"90","author":"O'Shea","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0055","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1542\/peds.102.6.1426","article-title":"Outcomes of extremely premature infants related to their peak serum bilirubin concentrations and exposure to phototherapy","volume":"102","author":"Yeo","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0056","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.90.5.707","article-title":"Kernicterus in preterm newborns: past, present, and future","volume":"90","author":"Watchko","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0057","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1136\/fn.88.6.F455","article-title":"Jaundice in low birthweight infants: pathobiology and outcome","volume":"88","author":"Watchko","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.semperi.2026.152295_bib0058","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1542\/peds.112.6.1256","article-title":"Changes in globus pallidus with (pre)term kernicterus","volume":"112","author":"Govaert","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0059","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1542\/peds.49.5.652","article-title":"Kernicterus in small sick premature infants receiving phototherapy","volume":"49","author":"Keenan","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000302719","article-title":"Are recommended phototherapy thresholds safe enough for extremely low birth weight (ELBW) infants? A report on 2 ELBW infants with kernicterus despite only moderate hyperbilirubinemia","volume":"99","author":"Moll","year":"2011","journal-title":"Neonatology"},{"key":"10.1016\/j.semperi.2026.152295_bib0061","doi-asserted-by":"crossref","first-page":"F323","DOI":"10.1136\/adc.2008.147686","article-title":"Range of UK practice regarding thresholds for phototherapy and exchange transfusion in neonatal hyperbilirubinaemia","volume":"94","author":"Rennie","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.semperi.2026.152295_bib0062","unstructured":"The Hospital for Sick Children. Phototherapy and Exchange transfusion guidelines for preterm infants <35 weeks gestational age: the hospital for sick children; 2019."},{"key":"10.1016\/j.semperi.2026.152295_bib0063","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13052-025-02104-6","article-title":"Mother infant zero separation for neonatal jaundice: we are getting closer","volume":"51","author":"Davanzo","year":"2025","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.semperi.2026.152295_bib0064","first-page":"10","article-title":"Light\" on phototherapy-complications and strategies for shortening its duration, a review of the literature","author":"Shoris","year":"2023","journal-title":"Children"},{"key":"10.1016\/j.semperi.2026.152295_bib0065","first-page":"142","article-title":"Childhood seizures after phototherapy","author":"Newman","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.semperi.2026.152295_bib0066","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/jp.2012.64","article-title":"Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns?","volume":"32","author":"Tyson","year":"2012","journal-title":"J Perinatol"},{"key":"10.1016\/j.semperi.2026.152295_bib0067","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2026.14107","article-title":"Phototherapy, morbidity, and mortality in very preterm newborns","volume":"9","author":"Deschmann","year":"2026","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.semperi.2026.152295_bib0068","unstructured":"Bilirubin thresholds in preterm infants on neonatal intensive CarE Units: The B-NICE Trial (B-NICE). https:\/\/clinicaltrials.gov\/study\/NCT07674537, ClinicalTrials. gov, (accessed 29 June 2026)."},{"key":"10.1016\/j.semperi.2026.152295_bib0069","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/10408363.2022.2038074","article-title":"Current and emerging technologies for the timely screening and diagnosis of neonatal jaundice","volume":"59","author":"Thomas","year":"2022","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.semperi.2026.152295_bib0070","unstructured":"NSW Health, Variations in Serum Bilirubin assay method and results in neonates. https:\/\/www.health.nsw.gov.au\/sabs\/Documents\/2025-si-012.pdf, 2025 (accessed 11 August 2026)."},{"key":"10.1016\/j.semperi.2026.152295_bib0071","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/jamapediatrics.2015.4944","article-title":"Association between laboratory calibration of a serum bilirubin assay, neonatal bilirubin levels, and phototherapy use","volume":"170","author":"Kuzniewicz","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.semperi.2026.152295_bib0072","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.5858\/arpa.2022-0478-OA","article-title":"A significant increase in the incidence of neonatal hyperbilirubinemia and phototherapy treatment due to a routine change in laboratory equipment","volume":"148","author":"Oostendorp","year":"2024","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.semperi.2026.152295_bib0073","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/apa.14316","article-title":"Identification of risk for neonatal haemolysis","volume":"107","author":"Bhutani","year":"2018","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.semperi.2026.152295_bib0074","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-026-05246-3","article-title":"Predictive ability of postnatal total bilirubin rate of rise endures","author":"Bhutani","year":"2026","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0075","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41390-019-0469-6","article-title":"Repetitive bilirubin measurements in preterm infants prior to phototherapy: is it wise to use the rate of rise?","volume":"87","author":"Hulzebos","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.semperi.2026.152295_bib0076","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamapediatrics.2016.0279","article-title":"Laboratory accuracy in neonatal bilirubin: the search for truth in laboratory medicine","volume":"170","author":"Lo","year":"2016","journal-title":"JAMA Pediatr"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000526000844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:46:47Z","timestamp":1789588007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000526000844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":76,"alternative-id":["S0146000526000844"],"URL":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152295","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Measuring total bilirubin for clinical decision making: are we treating at the right number?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semperi.2026.152295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152295"}}