{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:30Z","timestamp":1791229470101,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.semradonc.2008.09.007","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T07:01:15Z","timestamp":1227682875000},"page":"35-42","source":"Crossref","is-referenced-by-count":215,"title":["Dysphagia in Head and Neck Cancer Patients Treated With Radiation: Assessment, Sequelae, and Rehabilitation"],"prefix":"10.1016","volume":"19","author":[{"given":"Barbara A.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semradonc.2008.09.007_bib1","series-title":"Dysphagia Assessment and Treatment Planning","first-page":"27","article-title":"Anatomy and physiology of deglutition","author":"Kendall","year":"2008"},{"key":"10.1016\/j.semradonc.2008.09.007_bib2","first-page":"15","article-title":"Anatomy and function of the swallowing mechanism, in Clinical Management of Swallowing Disorders","author":"Murray","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib3","series-title":"Comprehensive Management of Swallowing Disorders","first-page":"23","article-title":"The normal swallow","author":"Aviv","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib4","first-page":"1","article-title":"Anatomy and Physiology of Deglutition","author":"Kendall","year":"2008"},{"key":"10.1016\/j.semradonc.2008.09.007_bib6","series-title":"Dysphagia Assessment and Treatment Planning","first-page":"103","article-title":"Clinical swallow evaluation","author":"Goodrich","year":"2008"},{"key":"10.1016\/j.semradonc.2008.09.007_bib7","series-title":"Comprehensive Management of Swallowing Disorders","first-page":"59","article-title":"Clinical evaluation of swallowing: The nutritionist's perspective","author":"Molseed","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib8","first-page":"95","article-title":"Evaluation of dysphagia, in Clinical Management of Swallowing Disorders","author":"Murry","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/000348940511400301","article-title":"Fleximble endoscpopic evaluation of swallowing with sensory testing: patient characteristics and analysis of safety in 1,340 consecutive examinations","volume":"114","author":"Aviv","year":"2005","journal-title":"Ann Otol Rhinol Laryngeal"},{"key":"10.1016\/j.semradonc.2008.09.007_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00005537-200301000-00004","article-title":"The safety of flexible endoscopic evaluation of swallowing with sensory testing in an outpatient otolaryngology setting","volume":"113","author":"Cohen","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.semradonc.2008.09.007_bib11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/1097-0142(197909)44:3<1095::AID-CNCR2820440344>3.0.CO;2-C","article-title":"Swallowing disorders in three types of head and neck surgical patients","volume":"44","author":"Logemann","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.semradonc.2008.09.007_bib12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/00016489709113476","article-title":"Prognostic factors for swallowing rehabilitation following head and neck cancer surgery","volume":"117","author":"Denk","year":"1997","journal-title":"Acta Otolaryngology"},{"key":"10.1016\/j.semradonc.2008.09.007_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1288\/00005537-199401000-00015","article-title":"Surgical variables affecting postoperative swallowing efficiency in oral cancer patients: A pilot study","volume":"104","author":"McConnel","year":"1994","journal-title":"Laryngoscope"},{"key":"10.1016\/j.semradonc.2008.09.007_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/014556139707600708","article-title":"Swallow and pharyngeal function in post-operative cancer patients","volume":"76","author":"Martini","year":"1997","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.semradonc.2008.09.007_bib15","first-page":"13","article-title":"Clinical and economic consequences of mucositis indicued by chemotherapy and\/or radiation therapy","volume":"5","author":"Murphy","year":"2007","journal-title":"J Support Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib16","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer Supp"},{"key":"10.1016\/j.semradonc.2008.09.007_bib17","first-page":"289","article-title":"Oral mucositis (OM) related morbidity and resource utilization is a prospective study of head and neck cancer (HNC) patients","volume":"24","author":"Isitt","year":"2006","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib18","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2006.06.0079","article-title":"Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer","volume":"24","author":"Rosenthal","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib20","first-page":"286","article-title":"Swallowing function for patients treated on E2399: A phase II trial of function preservation with induction paclitaxel\/carboplatin followed by radiation plus weekly paclitxel","volume":"24","author":"Murphy","year":"2006","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archotol.126.3.371","article-title":"Swallowing function in patients with head and neck cancer prior to treatment","volume":"126","author":"Stenson","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2008.09.007_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/hed.20299","article-title":"Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation","volume":"28","author":"Logemann","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2008.09.007_bib23","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0360-3016(03)01454-8","article-title":"Swallowing dysfunction\u2014Preventative and rehabilitation strategies in patients with head-and-neck cancers treated with surgery, radiotherapy, and chemotherapy: A critical review","volume":"57","author":"Mittal","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib24","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/hed.20427","article-title":"Risk factors for hypopharyngeal\/upper esophageal stricture formation after concurrent chemoradiation","volume":"28","author":"Lee","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2008.09.007_bib25","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.ijrobp.2007.02.049","article-title":"Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: Early dose-effect relationships for swallowing structures","volume":"68","author":"Feng","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib26","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijrobp.2004.05.050","article-title":"Dysphagia and aspiration after chemoradiotherapy for head and neck cancer: Which anatomic structures are affected and can they be spared by IMRT?","volume":"60","author":"Eisbruch","year":"2004","journal-title":"Int J Radiation Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib27","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijrobp.2006.10.028","article-title":"Intensity-modulated radiotherapy for nasopharyngeal carcinoma: clinical correlation of dose to the pharyngo-esophageal axis and dysphagia","volume":"67","author":"Fua","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib30","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0360-3016(96)00434-8","article-title":"The use of radiologically placed gastrostomy tubes in head and neck cancer patients receiving radiotherapy","volume":"36","author":"Tyldesley","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1207\/s15327914nc5201_4","article-title":"Early percutaneous endoscopic gastrostomy insertion maintains nutritional state in patients with aerodigestive tract caner","volume":"52","author":"Beer","year":"2005","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.semradonc.2008.09.007_bib32","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.3.CO;2-T","article-title":"Enteral nutrition during the treatment of head and neck carcinoma: Is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube?","volume":"91","author":"Mekhail","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.semradonc.2008.09.007_bib33","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/hed.20607","article-title":"Loss of lean body mass and associated physcial function decline in the context of increased energy expenditure and inflammatorys tate in head and neck cancer patients undergoing concurrent chemo-rediation therapy","volume":"29","author":"Silver","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2008.09.007_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0360-3016(96)00604-9","article-title":"Mastication and swallowing in patients with postirradiation xerostomia","volume":"37","author":"Hamlet","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib35","first-page":"186","article-title":"Neck dissection following organ preservation protocols prolongs feeding tube dependence in patients with advanced head and neck cancer","volume":"24","author":"Lango","year":"2006","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib36","series-title":"Clinical Management of Swallowing Disorders","first-page":"38","article-title":"The abnormal swallow: Conditions and diseases","author":"Murry","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0360-3016(02)02712-8","article-title":"Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer","volume":"53","author":"Eisbruch","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib38","first-page":"1669","article-title":"Aspiration occurence during chemoradiation for head and neck cancer","volume":"3B","author":"Nguyen","year":"2007","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.semradonc.2008.09.007_bib39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/annonc\/mdh101","article-title":"Dysphagia following chemoradiation for locally advanced head and neck cancer","volume":"15","author":"Nguyen","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archoto.2007.43","article-title":"Changes in quality of life over 1 year in patients with head and neck cancer","volume":"134","author":"Ronis","year":"2008","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2008.09.007_bib41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archotol.132.6.655","article-title":"Variables associated with feeding tube placement in head and neck cancer","volume":"132","author":"Cheng","year":"2006","journal-title":"Arch Otolaryngol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib42","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archotol.131.9.762","article-title":"Breathing and swallowing dynamics across the adult lifespan","volume":"131","author":"Martin-Harris","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2008.09.007_bib43","first-page":"932","article-title":"Dietary intake and adapations in head and neck cancer patients treated with chemoradiation","volume":"21","author":"Murphy","year":"2002","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2008.09.007_bib44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hed.10092","article-title":"Swallow function and perception of dysphagia in patients with head and neck cancer","volume":"24","author":"Pauloski","year":"2002","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2008.09.007_bib45","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijrobp.2005.07.966","article-title":"Influence of intravenous amifostine on xerostomia, tumor control and survival after radiotherapy for head and neck cancer: 2-year follow-up of a prospective, randomized phase III trial","volume":"63","author":"Wasserman","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib46","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ijrobp.2005.06.023","article-title":"Amifostine reduces side effects and improves complete response rate during radiotherapy: Results of a meta-analysis","volume":"64","author":"Sasse","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2008.09.007_bib47","series-title":"Evaluation and Treatment of Swallowing Disorders","first-page":"181","article-title":"Evaluation of swallowing disorders","author":"Logemann","year":"1998"},{"key":"10.1016\/j.semradonc.2008.09.007_bib48","series-title":"Dysphagia Assessment and Treatment Planning","first-page":"304","article-title":"The treatment plan","author":"Leonard","year":"2008"},{"key":"10.1016\/j.semradonc.2008.09.007_bib49","series-title":"Comprehensive Management of Swallowing Disorders","first-page":"244","article-title":"Therapeutic intervention for swallowing disorders","author":"Murry","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib50","series-title":"Clinical Management of Swallowing Disorders","first-page":"152","article-title":"Nonsurgical treatment of swallowing disorders","author":"Murry","year":"2006"},{"key":"10.1016\/j.semradonc.2008.09.007_bib51","first-page":"301","article-title":"The treatment plan: Dysphagia Assessment and Treatment Planning","author":"eonard","year":"2008"},{"key":"10.1016\/j.semradonc.2008.09.007_bib52","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archotol.133.6.564","article-title":"Examining the evidence on neuromuscular electrical stimulation for swallowing: A meta-analysis","volume":"133","author":"Carnaby-Mann","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2008.09.007_bib53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/hed.20672","article-title":"Swallowing disorders in the first year after radiation and chemoradiation","volume":"30","author":"Logemann","year":"2008","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2008.09.007_bib54","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/019459989411000212","article-title":"Effects of postural change on aspiration in head and neck surgical patients","volume":"110","author":"Logemann","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2008.09.007_bib55","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1053\/gast.2002.32999","article-title":"Rehabilitation of swallowing by exercise in tube-fed patients with pharyngeal dysphagia secondary to abnormal UES opening","volume":"122","author":"Shaker","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.semradonc.2008.09.007_bib56","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/00005537-200408000-00008","article-title":"Swallowing-related quality of life after head and neck cancer treatment","volume":"114","author":"Gillespie","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.semradonc.2008.09.007_bib57","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/01.mlg.0000217278.96901.fc","article-title":"Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life","volume":"116","author":"Kulbersh","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.semradonc.2008.09.007_bib58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/MLG.0b013e31815659b0","article-title":"Pretreatment swallowing exercises improve swallow function after chemoradiation","volume":"118","author":"Carroll","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.semradonc.2008.09.007_bib59","series-title":"Assessment of Dysphagia in Adults","first-page":"16","article-title":"Normal swallow","author":"Provencio-Arambula","year":"2007"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429608000623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429608000623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T05:43:04Z","timestamp":1589175784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429608000623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1053429608000623"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2008.09.007","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}