{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:33:11Z","timestamp":1790685191162,"version":"4.1.0"},"reference-count":143,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002655","name":"Terry Fox Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["semradonc.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.semradonc.2015.05.004","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T02:06:52Z","timestamp":1431655612000},"page":"260-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Hypoxia and Predicting Radiation Response"],"prefix":"10.1016","volume":"25","author":[{"given":"Richard P.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Bristow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Fyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Koritzinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradly G.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"312","key":"10.1016\/j.semradonc.2015.05.004_bib1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1259\/0007-1285-26-312-638","article-title":"The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy","volume":"26","author":"Gray","year":"1953","journal-title":"Br J Radiol"},{"issue":"4540","key":"10.1016\/j.semradonc.2015.05.004_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/178978a0","article-title":"Role of oxygen in modifying the radiosensitivity of E. coli B","volume":"178","author":"Alper","year":"1956","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2307\/3570739","article-title":"Influence of oxygen tension on x-ray-induced chromosomal damage in Ehrlich ascites tumor cells irradiated in vitro and in vivo","volume":"11","author":"Deschner","year":"1959","journal-title":"Radiat Res"},{"key":"10.1016\/j.semradonc.2015.05.004_bib4","first-page":"803","article-title":"Radiobiologic basis of oxygen as a modifying factor in radiation therapy","volume":"85","author":"Gray","year":"1961","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0360-3016(86)90223-3","article-title":"Sensitizers and radiation dose fractionation: Results and interpretations","volume":"12","author":"Hill","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0167-8140(97)00186-2","article-title":"Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays","volume":"46","author":"Chapman","year":"1998","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0360-3016(86)90273-7","article-title":"Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia","volume":"12","author":"Urtasun","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrc3064","article-title":"Targeting hypoxia in cancer therapy","volume":"11","author":"Wilson","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/j.semnuclmed.2014.11.002","article-title":"The clinical significance of hypoxia in human cancers","volume":"45","author":"Dhani","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clon.2014.02.002","article-title":"The meaning, measurement and modification of hypoxia in the laboratory and the clinic","volume":"26","author":"Hammond","year":"2014","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"23","key":"10.1016\/j.semradonc.2015.05.004_bib12","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2015.05.004_bib13","series-title":"The Basic Science of Oncology 5th Edition","author":"Hill","year":"2013"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2174\/156652409788167050","article-title":"Tumor hypoxia as a modifier of DNA strand break and cross-link repair","volume":"9","author":"Chan","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.semradonc.2015.05.004_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1634\/theoncologist.9-90005-10","article-title":"The role of hypoxia-induced factors in tumor progression","volume":"9","author":"Vaupel","year":"2004","journal-title":"Oncologist"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism. hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1158\/1078-0432.CCR-06-1967","article-title":"Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis","volume":"13","author":"Rofstad","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.semnuclmed.2014.10.004","article-title":"Optimizing hypoxia detection and treatment strategies","volume":"45","author":"Koch","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-07-5472","article-title":"Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance","volume":"68","author":"Chan","year":"2008","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.prp.2007.10.009","article-title":"Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcoma","volume":"204","author":"Maseide","year":"2008","journal-title":"Pathol Res Pract"},{"issue":"10","key":"10.1016\/j.semradonc.2015.05.004_bib21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"issue":"5516","key":"10.1016\/j.semradonc.2015.05.004_bib22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"issue":"5516","key":"10.1016\/j.semradonc.2015.05.004_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2007.04.001","article-title":"HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity","volume":"11","author":"Zhang","year":"2007","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2013.11.022","article-title":"Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth","volume":"19","author":"Sun","year":"2014","journal-title":"Cell Metab"},{"issue":"38","key":"10.1016\/j.semradonc.2015.05.004_bib27","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1","volume":"269","author":"Semenza","year":"1994","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib28","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/01.RES.77.3.638","article-title":"Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5\u05f3 enhancer","volume":"77","author":"Liu","year":"1995","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib29","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","article-title":"A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol Cell Biol"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1158\/1541-7786.MCR-06-0150","article-title":"Translating tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways","volume":"4","author":"Koumenis","year":"2006","journal-title":"Mol Cancer Res"},{"issue":"11","key":"10.1016\/j.semradonc.2015.05.004_bib31","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nrc2501","article-title":"Hypoxia signalling through mTOR and the unfolded protein response in cancer","volume":"8","author":"Wouters","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2006.01.010","article-title":"Hypoxia-induced energy stress regulates mRNA translation and cell growth","volume":"21","author":"Liu","year":"2006","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib33","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.emboj.7600998","article-title":"Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control","volume":"25","author":"Koritzinsky","year":"2006","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.201307185","article-title":"Two phases of disulfide bond formation have differing requirements for oxygen","volume":"203","author":"Koritzinsky","year":"2013","journal-title":"J Cell Biol"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"21","key":"10.1016\/j.semradonc.2015.05.004_bib36","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1128\/MCB.22.21.7405-7416.2002","article-title":"Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha","volume":"22","author":"Koumenis","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"17","key":"10.1016\/j.semradonc.2015.05.004_bib37","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1158\/0008-5472.CAN-04-1606","article-title":"XBP1 is essential for survival under hypoxic conditions and is required for tumor growth","volume":"64","author":"Romero-Ramirez","year":"2004","journal-title":"Cancer Res"},{"issue":"19","key":"10.1016\/j.semradonc.2015.05.004_bib38","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/sj.emboj.7600777","article-title":"ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth","volume":"24","author":"Bi","year":"2005","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib39","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.radonc.2013.06.005","article-title":"New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1alpha signaling is essential for promoting adaptation and survival to hypoxia","volume":"108","author":"Cojocari","year":"2013","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.radonc.2007.04.031","article-title":"Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia","volume":"83","author":"Koritzinsky","year":"2007","journal-title":"Radiother Oncol"},{"issue":"6716","key":"10.1016\/j.semradonc.2015.05.004_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib42","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.semradonc.2013.05.006","article-title":"The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia","volume":"23","author":"Koritzinsky","year":"2013","journal-title":"Semin Radiat Oncol"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib45","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1073\/pnas.1210633110","article-title":"PERK\/eIF2alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS","volume":"110","author":"Rouschop","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2015.05.004_bib46","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1038\/ncomms6203","article-title":"Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER","volume":"5","author":"van den Beucken","year":"2014","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib47","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/path.4099","article-title":"Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma","volume":"229","author":"Mito","year":"2013","journal-title":"J Pathol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib48","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.radonc.2011.05.044","article-title":"E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells","volume":"99","author":"Theys","year":"2011","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.semradonc.2015.05.004_bib49","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ncb3013","article-title":"ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1","volume":"16","author":"Zhang","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib50","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.radonc.2014.03.014","article-title":"Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cells","volume":"111","author":"Al-Assar","year":"2014","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2013.08.001","article-title":"Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma","volume":"24","author":"Bhat","year":"2013","journal-title":"Cancer Cell"},{"issue":"7100","key":"10.1016\/j.semradonc.2015.05.004_bib52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib53","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/BJ20121155","article-title":"Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase","volume":"449","author":"Sanchez-Fernandez","year":"2013","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib54","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0360-3016(90)90407-B","article-title":"The role of the H-ras oncogene in radiation resistance and metastasis","volume":"18","author":"McKenna","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"506","key":"10.1016\/j.semradonc.2015.05.004_bib55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1259\/0007-1285-43-506-81","article-title":"Radiosensitivity and the oxygen effect for mammalian cells cultured in vitro in stationary phase","volume":"43","author":"Berry","year":"1970","journal-title":"Br J Radiol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib56","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijrobp.2005.09.031","article-title":"Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status","volume":"64","author":"Sprong","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib57","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1667\/3474.1","article-title":"Growth of V79 cells as xenograft tumors promotes multicellular resistance but does not increase spontaneous or radiation-induced mutant frequency","volume":"164","author":"Banath","year":"2005","journal-title":"Radiat Res"},{"issue":"10","key":"10.1016\/j.semradonc.2015.05.004_bib58","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1158\/1541-7786.MCR-14-0246","article-title":"Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells","volume":"12","author":"Chan","year":"2014","journal-title":"Mol Cancer Res"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib59","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2041-9414-4-5","article-title":"Tumor hypoxia as a driving force in genetic instability","volume":"4","author":"Luoto","year":"2013","journal-title":"Genome Integrity"},{"issue":"Pt 1","key":"10.1016\/j.semradonc.2015.05.004_bib60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/jcs.092262","article-title":"Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability","volume":"125","author":"Kumareswaran","year":"2012","journal-title":"J Cell Sci"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib61","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2307\/3579108","article-title":"Radiation-induced DNA damage in tumors and normal tissues. II. Influence of dose, residual DNA damage and physiological factors in oxygenated cells","volume":"140","author":"Zhang","year":"1994","journal-title":"Radiat Res"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib62","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2307\/3579024","article-title":"Radiation-induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks","volume":"142","author":"Zhang","year":"1995","journal-title":"Radiat Res"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib63","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1200\/JCO.20.3.680","article-title":"Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer","volume":"20","author":"Fyles","year":"2002","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib65","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1158\/1078-0432.CCR-11-2711","article-title":"Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer","volume":"18","author":"Milosevic","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib66","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0167-8140(00)00223-1","article-title":"A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy","volume":"57","author":"Nordsmark","year":"2000","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib67","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.radonc.2006.07.014","article-title":"Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer","volume":"80","author":"Fyles","year":"2006","journal-title":"Radiother Oncol"},{"issue":"18","key":"10.1016\/j.semradonc.2015.05.004_bib68","first-page":"4525","article-title":"Hypoxic cervical cancers with low apoptotic index are highly aggressive","volume":"59","author":"Hockel","year":"1999","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-8140(99)00139-5","article-title":"Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix","volume":"53","author":"Knocke","year":"1999","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib70","first-page":"1104","article-title":"Disease control of uterine cervical cancer: Relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy","volume":"6","author":"Lyng","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"19","key":"10.1016\/j.semradonc.2015.05.004_bib71","first-page":"4509","article-title":"Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix","volume":"56","author":"Hockel","year":"1996","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib72","first-page":"941","article-title":"Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma","volume":"56","author":"Brizel","year":"1996","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib73","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2174\/1566524033479447","article-title":"Molecular mechanisms of tumor invasion and metastasis: An integrated view","volume":"3","author":"Cairns","year":"2003","journal-title":"Curr Mol Med"},{"issue":"13","key":"10.1016\/j.semradonc.2015.05.004_bib74","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S1470-2045(14)71021-6","article-title":"Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: A retrospective cohort study","volume":"15","author":"Lalonde","year":"2014","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib75","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1200\/JCO.2005.02.7474","article-title":"Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial","volume":"24","author":"Koukourakis","year":"2006","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib76","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0360-3016(02)02815-8","article-title":"Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: Correlation with tumor oxygenation","volume":"53","author":"Haugland","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"15","key":"10.1016\/j.semradonc.2015.05.004_bib77","first-page":"5666","article-title":"Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas","volume":"9","author":"Hedley","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib78","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/labinvest.3700680","article-title":"Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX","volume":"87","author":"Iakovlev","year":"2007","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib79","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","article-title":"HIF-1: Upstream and downstream of cancer metabolism","volume":"20","author":"Semenza","year":"2010","journal-title":"Curr Opin Genet Dev"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib80","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrc2397","article-title":"Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response","volume":"8","author":"Dewhirst","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib81","first-page":"2416","article-title":"Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor\/phosphatidylinositol 3\u2032-kinase\/protein kinase B in prostate cancer cells","volume":"9","author":"Mabjeesh","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib82","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1470-2045(08)70076-7","article-title":"Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: A retrospective analysis of two randomised radiotherapy trials and one surgical cohort study","volume":"9","author":"Vergis","year":"2008","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semnuclmed.2014.10.003","article-title":"Evaluation of hypoxia with copper-labeled diacetyl-bis(N-methylthiosemicarbazone)","volume":"45","author":"Lapi","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib84","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1053\/j.semnuclmed.2014.10.006","article-title":"F-18 fluoromisonidazole for imaging tumor hypoxia: Imaging the microenvironment for personalized cancer therapy","volume":"45","author":"Rajendran","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib85","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.semnuclmed.2014.10.005","article-title":"The chemistry and radiochemistry of hypoxia-specific, radiohalogenated nitroaromatic imaging probes","volume":"45","author":"Kumar","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib86","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1053\/j.semnuclmed.2014.10.001","article-title":"Hypoxia imaging in gliomas with F-fluoromisonidazole PET: Toward clinical translation","volume":"45","author":"Bell","year":"2015","journal-title":"Semin Nucl Med"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radonc.2012.09.015","article-title":"FAZA PET\/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial","volume":"105","author":"Mortensen","year":"2012","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib88","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2012.08.019","article-title":"Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer","volume":"105","author":"Zips","year":"2012","journal-title":"Radiother Oncol"},{"issue":"13","key":"10.1016\/j.semradonc.2015.05.004_bib89","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1200\/JCO.2005.05.2878","volume":"24","author":"Rischin","year":"2006","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.semradonc.2015.05.004_bib90","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1007\/s00259-011-1876-z","article-title":"Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET\/CT utilizing multimodality fusion techniques","volume":"38","author":"Garcia-Parra","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib91","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrclinonc.2012.171","article-title":"Imaging hypoxia to improve radiotherapy outcome","volume":"9","author":"Horsman","year":"2012","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib92","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1371\/journal.pmed.0030047","article-title":"Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers","volume":"3","author":"Chi","year":"2006","journal-title":"PLoS Med"},{"issue":"8","key":"10.1016\/j.semradonc.2015.05.004_bib93","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1158\/1078-0432.CCR-13-2958","article-title":"Hypoxia-driven gene expression is an independent prognostic factor in stage II and III colon cancer patients","volume":"20","author":"Dekervel","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib94","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1158\/0008-5472.CAN-06-3322","article-title":"Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers","volume":"67","author":"Winter","year":"2007","journal-title":"Cancer Res"},{"issue":"20","key":"10.1016\/j.semradonc.2015.05.004_bib95","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1158\/0008-5472.CAN-12-1085","article-title":"Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI","volume":"72","author":"Halle","year":"2012","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib96","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/bjc.2014.604","article-title":"The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer","volume":"112","author":"Ragnum","year":"2015","journal-title":"Br J Cancer"},{"issue":"17","key":"10.1016\/j.semradonc.2015.05.004_bib97","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1158\/0008-5472.CAN-11-1182","article-title":"Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer","volume":"71","author":"Toustrup","year":"2011","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib98","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.radonc.2011.09.010","article-title":"Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck","volume":"102","author":"Toustrup","year":"2012","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib99","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(97)00220-X","article-title":"A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85","volume":"46","author":"Overgaard","year":"1998","journal-title":"Radiother Oncol"},{"issue":"26","key":"10.1016\/j.semradonc.2015.05.004_bib100","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1200\/JCO.2007.12.7878","article-title":"Hypoxic radiosensitization: Adored and ignored","volume":"25","author":"Overgaard","year":"2007","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib101","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.radonc.2011.03.004","article-title":"Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck\u2014A systematic review and meta-analysis","volume":"100","author":"Overgaard","year":"2011","journal-title":"Radiother Oncol"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib102","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1470-2045(02)00929-4","article-title":"ARCON: A novel biology-based approach in radiotherapy","volume":"3","author":"Kaanders","year":"2002","journal-title":"Lancet Oncol"},{"issue":"15","key":"10.1016\/j.semradonc.2015.05.004_bib103","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1200\/JCO.2011.35.9315","article-title":"Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial","volume":"30","author":"Janssens","year":"2012","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib104","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.radonc.2013.04.022","article-title":"Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial","volume":"108","author":"Rademakers","year":"2013","journal-title":"Radiother Oncol"},{"issue":"33","key":"10.1016\/j.semradonc.2015.05.004_bib105","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1200\/JCO.2010.28.4950","article-title":"Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma","volume":"28","author":"Hoskin","year":"2010","journal-title":"J Clin Oncol"},{"issue":"17","key":"10.1016\/j.semradonc.2015.05.004_bib106","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1158\/1078-0432.CCR-13-0542","article-title":"A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer","volume":"19","author":"Eustace","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"1035","key":"10.1016\/j.semradonc.2015.05.004_bib107","doi-asserted-by":"crossref","first-page":"20130753","DOI":"10.1259\/bjr.20130753","article-title":"An arranged marriage for precision medicine: Hypoxia and genomic assays in localized prostate cancer radiotherapy","volume":"87","author":"Bristow","year":"2014","journal-title":"Br J Radiol"},{"issue":"18","key":"10.1016\/j.semradonc.2015.05.004_bib108","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1200\/JCO.2009.27.4449","article-title":"Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group","volume":"28","author":"Rischin","year":"2010","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib109","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1200\/JCO.2013.51.4265","article-title":"Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis: A Gynecologic Oncology Group study","volume":"32","author":"DiSilvestro","year":"2014","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1016\/j.semradonc.2015.05.004_bib110","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1200\/JCO.2009.27.4498","article-title":"Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: Results from TROG 02.02","volume":"28","author":"Peters","year":"2010","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib111","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"10.1016\/j.semradonc.2015.05.004_bib112","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1200\/JCO.2008.20.2853","article-title":"Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck","volume":"27","author":"Lassen","year":"2009","journal-title":"J Clin Oncol"},{"issue":"27","key":"10.1016\/j.semradonc.2015.05.004_bib113","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1200\/JCO.2010.29.2904","article-title":"Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial","volume":"28","author":"Rischin","year":"2010","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.semradonc.2015.05.004_bib114","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nm0512-636b","article-title":"Targeting hypoxia brings breath of fresh air to cancer therapy","volume":"18","author":"Moyer","year":"2012","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib115","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijrobp.2013.07.022","article-title":"The tumor radiobiology of SRS and SBRT: Are more than the 5 Rs involved?","volume":"88","author":"Brown","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"19","key":"10.1016\/j.semradonc.2015.05.004_bib116","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1158\/0008-5472.CAN-06-3126","article-title":"Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells","volume":"66","author":"Clarke","year":"2006","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib117","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semradonc.2008.11.001","article-title":"Cancer stem cells in solid tumors: An overview","volume":"19","author":"O\u05f3Brien","year":"2009","journal-title":"Semin Radiat Oncol"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib118","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrc2419","article-title":"Exploring the role of cancer stem cells in radioresistance","volume":"8","author":"Baumann","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib119","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.radonc.2007.04.020","article-title":"Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation","volume":"83","author":"Yaromina","year":"2007","journal-title":"Radiother Oncol"},{"issue":"21","key":"10.1016\/j.semradonc.2015.05.004_bib120","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1158\/1078-0432.CCR-10-2244","article-title":"CD44: A cancer stem cell-related biomarker with predictive potential for radiotherapy","volume":"16","author":"Baumann","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.semradonc.2015.05.004_bib121","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcancer.2014.07.001","article-title":"Cancer stem cells, cancer cell plasticity and radiation therapy","volume":"31C","author":"Vlashi","year":"2015","journal-title":"Semin Cancer Biol"},{"issue":"8","key":"10.1016\/j.semradonc.2015.05.004_bib122","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3109\/09553002.2014.892227","article-title":"Cancer stem cells and radioresistance","volume":"90","author":"Rycaj","year":"2014","journal-title":"Int J Radiat Biol"},{"issue":"7120","key":"10.1016\/j.semradonc.2015.05.004_bib123","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"issue":"7239","key":"10.1016\/j.semradonc.2015.05.004_bib124","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature07733","article-title":"Association of reactive oxygen species levels and radioresistance in cancer stem cells","volume":"458","author":"Diehn","year":"2009","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1593\/tlo.10247","article-title":"Ablation of breast cancer stem cells with radiation","volume":"4","author":"Zielske","year":"2011","journal-title":"Transl Oncol"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib126","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/bjc.1993.434","article-title":"Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix","volume":"68","author":"West","year":"1993","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2006.09.037","article-title":"Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia","volume":"67","author":"Blazek","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib128","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.canlet.2007.09.012","article-title":"Influence of oxygen tension on CD133 phenotype in human glioma cell cultures","volume":"258","author":"Platet","year":"2007","journal-title":"Cancer Lett"},{"issue":"6","key":"10.1016\/j.semradonc.2015.05.004_bib129","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","article-title":"Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells","volume":"15","author":"Li","year":"2009","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.semradonc.2015.05.004_bib130","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3109\/09553002.2014.916841","article-title":"Hypoxia as a biomarker for radioresistant cancer stem cells","volume":"90","author":"Peitzsch","year":"2014","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"10.1016\/j.semradonc.2015.05.004_bib131","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1667\/0033-7587(2001)156[0388:TKMFRO]2.0.CO;2","article-title":"The K(m) for radiosensitization of human tumor cells by oxygen is much greater than 3mmHg and is further increased by elevated levels of cysteine","volume":"156","author":"Horan","year":"2001","journal-title":"Radiat Res"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib132","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.radonc.2013.06.011","article-title":"Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells","volume":"108","author":"Sorensen","year":"2013","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib133","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/1754-9485.12155","article-title":"Correlation of p16 status, hypoxic imaging using [18F]-misonidazole positron emission tomography and outcome in patients with loco-regionally advanced head and neck cancer","volume":"58","author":"Trinkaus","year":"2014","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"24","key":"10.1016\/j.semradonc.2015.05.004_bib134","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1158\/1078-0432.CCR-13-1787","article-title":"Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response","volume":"19","author":"Zannella","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.semradonc.2015.05.004_bib135","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2478\/tumor-2013-0003","article-title":"Selective radiosensitization of hypoxic cells using BCCA621C: A novel hypoxia activated prodrug targeting DNA-dependent protein kinase","volume":"1","author":"Lindquist","year":"2013","journal-title":"Tumor Microenvironment Ther"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib136","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1021\/cb4001537","article-title":"CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia\/reoxygenation through inhibition of Chk1 and Aurora A","volume":"8","author":"Cazares-Korner","year":"2013","journal-title":"ACS Chem Biol"},{"issue":"2","key":"10.1016\/j.semradonc.2015.05.004_bib137","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijrobp.2014.09.045","article-title":"A comparative study of the hypoxia PET tracers [(1)(8)F]HX4, [(1)(8)F]FAZA, and [(1)(8)F]FMISO in a preclinical tumor model","volume":"91","author":"Peeters","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib138","doi-asserted-by":"crossref","first-page":"556","DOI":"10.18632\/oncotarget.2785","article-title":"Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia","volume":"6","author":"Cortese","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.semradonc.2015.05.004_bib139","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.bjc.6605491","article-title":"Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype","volume":"102","author":"Ameri","year":"2010","journal-title":"Br J Cancer"},{"issue":"7","key":"10.1016\/j.semradonc.2015.05.004_bib140","doi-asserted-by":"crossref","first-page":"e69239","DOI":"10.1371\/journal.pone.0069239","article-title":"Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia","volume":"8","author":"Cheng","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.semradonc.2015.05.004_bib141","doi-asserted-by":"crossref","first-page":"e76508","DOI":"10.1371\/journal.pone.0076508","article-title":"Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers","volume":"8","author":"Grandjean","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.semradonc.2015.05.004_bib142","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4614-5915-6_9","article-title":"Intratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancer","volume":"772","author":"Taiakina","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.semradonc.2015.05.004_bib143","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10585-008-9182-2","article-title":"The tumor microenvironment and metastatic disease","volume":"26","author":"Lunt","year":"2009","journal-title":"Clin Exp Metastasis"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429615000570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429615000570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T05:10:28Z","timestamp":1651986628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429615000570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":143,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1053429615000570"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2015.05.004","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia and Predicting Radiation Response","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2015.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}