{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:47:03Z","timestamp":1781678823502,"version":"3.54.5"},"reference-count":83,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["semradonc.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.semradonc.2017.04.008","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:49:29Z","timestamp":1504486169000},"page":"340-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Management of Radiation Toxicity in Head and Neck Cancers"],"prefix":"10.1016","volume":"27","author":[{"given":"Farzan","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Movsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib2","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijrobp.2011.06.2000","article-title":"Effect of radiotherapy and chemotherapy on the risk of mucositis during intensity-modulated radiation therapy for oropharyngeal cancer","volume":"83","author":"Sanguineti","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hed.21165","article-title":"Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity-modulated radiation therapy","volume":"32","author":"Bar Ad","year":"2010","journal-title":"Head Neck"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.anorl.2014.07.001","article-title":"Management of somatic pain induced by head and neck cancer treatment: Pain following radiation therapy and chemotherapy. Guidelines of the French Otorhinolaryngology Head and Neck Surgery Society (SFORL)","volume":"131","author":"Blanchard","year":"2014","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.semradonc.2017.04.008_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.critrevonc.2016.01.010","article-title":"Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements","volume":"100","author":"De Sanctis","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/1097-0142(20010815)92:4<875::AID-CNCR1396>3.0.CO;2-1","article-title":"Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: Results from a multicenter, randomized, double-blind, placebo-controlled clinical trial","volume":"92","author":"Epstein","year":"2001","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2354.2008.00943.x","article-title":"Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: A double-blind placebo-controlled randomized clinical trial","volume":"18","author":"Kazemian","year":"2009","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"11","key":"10.1016\/j.semradonc.2017.04.008_bib10","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s00520-013-1847-y","article-title":"Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients","volume":"21","author":"Nicolatou-Galitis","year":"2013","journal-title":"Support Care Cancer"},{"issue":"20","key":"10.1016\/j.semradonc.2017.04.008_bib11","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1200\/JCO.2010.32.4095","article-title":"Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: A randomized, placebo-controlled study","volume":"29","author":"Le","year":"2011","journal-title":"J Clin Oncol"},{"issue":"20","key":"10.1016\/j.semradonc.2017.04.008_bib12","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1200\/JCO.2010.32.4103","article-title":"Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: A randomized, placebo-controlled trial","volume":"29","author":"Henke","year":"2011","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.semradonc.2017.04.008_bib13","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1007\/s00520-016-3153-y","article-title":"Low-level laser therapy\/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: Part 2: Proposed applications and treatment protocols","volume":"24","author":"Zecha","year":"2016","journal-title":"Support Care Cancer"},{"issue":"6","key":"10.1016\/j.semradonc.2017.04.008_bib14","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1007\/s00520-016-3152-z","article-title":"Low level laser therapy\/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: Part 1: Mechanisms of action, dosimetric, and safety considerations","volume":"24","author":"Zecha","year":"2016","journal-title":"Support Care Cancer"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.radonc.2012.06.011","article-title":"Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients\u2014A triple blinded randomized controlled trial","volume":"104","author":"Gautam","year":"2012","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00520-012-1684-4","article-title":"Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy\u2014A randomized controlled trial","volume":"21","author":"Gautam","year":"2013","journal-title":"Support Care Cancer"},{"issue":"9","key":"10.1016\/j.semradonc.2017.04.008_bib17","doi-asserted-by":"crossref","first-page":"e107418","DOI":"10.1371\/journal.pone.0107418","article-title":"Effect of prophylactic low level laser therapy on oral mucositis: A systematic review and meta-analysis","volume":"9","author":"Oberoi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.semradonc.2017.04.008_bib18","doi-asserted-by":"crossref","first-page":"i69","DOI":"10.1093\/jrr\/rrw047","article-title":"IMRT for head and neck cancer: Reducing xerostomia and dysphagia","volume":"57","author":"Wang","year":"2016","journal-title":"J Radiat Res"},{"issue":"6","key":"10.1016\/j.semradonc.2017.04.008_bib19","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/cam4.609","article-title":"The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer","volume":"5","author":"Nevens","year":"2016","journal-title":"Cancer Med"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.radonc.2012.10.010","article-title":"Adaptive radiotherapy for head and neck cancer--dosimetric results from a prospective clinical trial","volume":"106","author":"Schwartz","year":"2013","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2005.07.957","article-title":"Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer","volume":"64","author":"Hansen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ijrobp.2010.06.052","article-title":"Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: Successes and barriers","volume":"78","author":"Vissink","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.semradonc.2017.04.008_bib23","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/00005537-200106000-00012","article-title":"Hyperthermic, supersaturated humidification in the treatment of xerostomia","volume":"111","author":"Criswell","year":"2001","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.adaj.2015.09.014","article-title":"Efficacy and safety of pilocarpine for radiation-induced xerostomia in patients with head and neck cancer: A systematic review and meta-analysis","volume":"147","author":"Cheng","year":"2016","journal-title":"J Am Dent Assoc"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijrobp.2015.11.012","article-title":"Is pilocarpine effective in preventing radiation-induced xerostomia? A systematic review and meta-analysis","volume":"94","author":"Yang","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib26","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ijrobp.2007.01.019","article-title":"Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer","volume":"68","author":"Chambers","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"10.1016\/j.semradonc.2017.04.008_bib27","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/hed.21894","article-title":"Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia","volume":"34","author":"Witsell","year":"2012","journal-title":"Head Neck"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/aim.2010.002733","article-title":"Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: A systematic review","volume":"28","author":"O'Sullivan","year":"2010","journal-title":"Acupunct Med"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijrobp.2015.01.050","article-title":"Acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating radiation-induced xerostomia: Results of RTOG 0537 phase 3 study","volume":"92","author":"Wong","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2017.04.008_bib30","doi-asserted-by":"crossref","first-page":"16776","DOI":"10.1038\/srep16776","article-title":"Effectiveness of acupuncture and related therapies for palliative care of cancer: Overview of systematic reviews","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib31","doi-asserted-by":"crossref","first-page":"e95968","DOI":"10.1371\/journal.pone.0095968","article-title":"Effect of amifostine in head and neck cancer patients treated with radiotherapy: A systematic review and meta-analysis based on randomized controlled trials","volume":"9","author":"Gu","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00520-012-1613-6","article-title":"Systematic review of amifostine for the management of oral mucositis in cancer patients","volume":"21","author":"Nicolatou-Galitis","year":"2013","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.oooo.2016.03.002","article-title":"Xerostomia: Current streams of investigation","volume":"122","author":"Quock","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0167-8140(02)00025-7","article-title":"De Gustibus: Time scale of loss and recovery of tastes caused by radiotherapy","volume":"63","author":"Maes","year":"2002","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.semradonc.2017.04.008_bib35","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ctrv.2014.06.011","article-title":"Treatment-related dysgeusia in head and neck cancer patients","volume":"40","author":"Irune","year":"2014","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijrobp.2016.05.011","article-title":"Predictors of dysgeusia in patients with oropharyngeal cancer treated with chemotherapy and intensity modulated radiation therapy","volume":"96","author":"Sapir","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib37","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.ijrobp.2006.08.037","article-title":"Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer","volume":"66","author":"Yamashita","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib38","first-page":"123","article-title":"Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial","volume":"18","author":"Najafizade","year":"2013","journal-title":"J Res Med Sci"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib39","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.ijrobp.2006.10.046","article-title":"Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4)","volume":"67","author":"Halyard","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.semradonc.2017.04.008_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2334\/josnusd.51.565","article-title":"A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: A secondary analysis","volume":"51","author":"Jham","year":"2009","journal-title":"J Oral Sci"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.critrevonc.2015.06.001","article-title":"Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus","volume":"96","author":"Russi","year":"2015","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib42","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0360-3016(02)02756-6","article-title":"Skin toxicity due to intensity-modulated radiotherapy for head-and-neck carcinoma","volume":"53","author":"Lee","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.semradonc.2017.04.008_bib43","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.breast.2013.07.047","article-title":"Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer","volume":"22","author":"Sharp","year":"2013","journal-title":"Breast"},{"issue":"10","key":"10.1016\/j.semradonc.2017.04.008_bib44","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1007\/s00520-013-1896-2","article-title":"Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group","volume":"21","author":"Wong","year":"2013","journal-title":"Support Care Cancer"},{"issue":"2-4","key":"10.1016\/j.semradonc.2017.04.008_bib45","first-page":"141","article-title":"The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers\u2014A clinical phase-III randomized trial","volume":"36","author":"Kaul","year":"1999","journal-title":"Indian J Cancer"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib46","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ijrobp.2006.01.015","article-title":"Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: A double-blind, randomized study","volume":"65","author":"Lin","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.otohns.2003.08.015","article-title":"Prophylactic effect of pentoxifylline on radiotherapy complications: A clinical study","volume":"130","author":"Aygenc","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"10.1016\/j.semradonc.2017.04.008_bib48","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1200\/JCO.1999.17.10.3283","article-title":"Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol","volume":"17","author":"Delanian","year":"1999","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.semradonc.2017.04.008_bib49","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1200\/JCO.2004.09.101","article-title":"Pentoxifylline in the treatment of radiation-induced fibrosis","volume":"22","author":"Okunieff","year":"2004","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.semradonc.2017.04.008_bib50","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00520-011-1197-6","article-title":"Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities","volume":"19","author":"Lacouture","year":"2011","journal-title":"Support Care Cancer"},{"issue":"10","key":"10.1016\/j.semradonc.2017.04.008_bib51","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/annonc\/mdr139","article-title":"Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: Proposals for a revised grading system and consensus management guidelines","volume":"22","author":"Bernier","year":"2011","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/0975-5950.183870","article-title":"Radiation-induced dental caries, prevention and treatment - A systematic review","volume":"6","author":"Gupta","year":"2015","journal-title":"Natl J Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.surge.2014.07.003","article-title":"The management of osteoradionecrosis of the jaws\u2014A review","volume":"13","author":"Rice","year":"2015","journal-title":"Surgeon"},{"key":"10.1016\/j.semradonc.2017.04.008_bib54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.critrevonc.2015.08.010","article-title":"Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Dental pathologies and osteoradionecrosis (Part 1) literature review and consensus statement","volume":"97","author":"Buglione","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1079-2104(97)90287-0","article-title":"Conservative management of osteoradionecrosis","volume":"84","author":"Wong","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.semradonc.2017.04.008_bib56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.critrevonc.2016.08.017","article-title":"Osteoradionecrosis and intensity modulated radiation therapy: An overview","volume":"107","author":"De Felice","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002560050028","article-title":"CT findings in osteoradionecrosis of the mandible","volume":"25","author":"Hermans","year":"1996","journal-title":"Skeletal Radiol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib58","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijrobp.2006.11.059","article-title":"Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: Likely contributions of both dental care and improved dose distributions","volume":"68","author":"Ben-David","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijrobp.2010.10.041","article-title":"Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: An update of the Memorial Sloan-Kettering Cancer Center experience","volume":"82","author":"Setton","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib60","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijrobp.2012.05.032","article-title":"Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer","volume":"85","author":"Tsai","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.semradonc.2017.04.008_bib61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14219\/jada.archive.1985.0074","article-title":"Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin","volume":"111","author":"Marx","year":"1985","journal-title":"J Am Dent Assoc"},{"issue":"24","key":"10.1016\/j.semradonc.2017.04.008_bib62","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1200\/JCO.2004.09.006","article-title":"Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 study group","volume":"22","author":"Annane","year":"2004","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.semradonc.2017.04.008_bib63","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hed.24495","article-title":"New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review","volume":"38","author":"Costa","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2017.04.008_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005005.pub4","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury","volume":"4","author":"Bennett","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib65","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ijrobp.2010.03.029","article-title":"Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): A phase II trial","volume":"80","author":"Delanian","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"16","key":"10.1016\/j.semradonc.2017.04.008_bib66","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1200\/JCO.2009.24.6199","article-title":"Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: Clinical and functional results","volume":"28","author":"Feng","year":"2010","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib67","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00455-016-9710-1","article-title":"Pathophysiology of radiation-induced dysphagia in head and neck cancer","volume":"31","author":"King","year":"2016","journal-title":"Dysphagia"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib68","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.radonc.2011.05.015","article-title":"Delineation of organs at risk involved in swallowing for radiotherapy treatment planning","volume":"101","author":"Christianen","year":"2011","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib69","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.critrevonc.2015.06.005","article-title":"Dysphagia in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus","volume":"96","author":"Schindler","year":"2015","journal-title":"Crit Rev Oncol Hematol"},{"issue":"11","key":"10.1016\/j.semradonc.2017.04.008_bib70","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/jamaoto.2013.4715","article-title":"Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: Use it or lose it","volume":"139","author":"Hutcheson","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib71","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00455-014-9592-z","article-title":"The effect of prophylactic percutaneous endoscopic gastrostomy (PEG) tube placement on swallowing and swallow-related outcomes in patients undergoing radiotherapy for head and neck cancer: A systematic review","volume":"30","author":"Shaw","year":"2015","journal-title":"Dysphagia"},{"issue":"3","key":"10.1016\/j.semradonc.2017.04.008_bib72","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hed.23251","article-title":"Strategies to reduce long-term postchemoradiation dysphagia in patients with head and neck cancer: An evidence-based review","volume":"36","author":"Paleri","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2017.04.008_bib73","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1002\/hed.24197","article-title":"Efficacy of electrical stimulation and exercise for dysphagia in patients with head and neck cancer: A randomized clinical trial","volume":"38","author":"Langmore","year":"2016","journal-title":"Head Neck"},{"issue":"26","key":"10.1016\/j.semradonc.2017.04.008_bib74","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1200\/JCO.2014.55.0707","article-title":"Patient-reported outcomes and survivorship in radiation oncology: Overcoming the cons","volume":"32","author":"Siddiqui","year":"2014","journal-title":"J Clin Oncol"},{"issue":"24","key":"10.1016\/j.semradonc.2017.04.008_bib75","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/jnci\/djr485","article-title":"Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival","volume":"103","author":"Quinten","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"10.1016\/j.semradonc.2017.04.008_bib76","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/jamaoncol.2015.2639","article-title":"Validity and reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)","volume":"1","author":"Dueck","year":"2015","journal-title":"JAMA Oncol"},{"issue":"8","key":"10.1016\/j.semradonc.2017.04.008_bib77","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jamaoncol.2015.2689","article-title":"PROceeding with the Patient-Reported Outcomes (Pros) Version of the Common Terminology Criteria for Adverse Events","volume":"1","author":"Movsas","year":"2015","journal-title":"JAMA Oncol"},{"issue":"7","key":"10.1016\/j.semradonc.2017.04.008_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju127","article-title":"Recommended patient-reported core set of symptoms to measure in head and neck cancer treatment trials","volume":"106","author":"Chera","year":"2014","journal-title":"J Natl Cancer Inst"},{"issue":"23","key":"10.1016\/j.semradonc.2017.04.008_bib79","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1001\/jama.288.23.3027","article-title":"Health-related quality-of-life assessments and patient-physician communication: A randomized controlled trial","volume":"288","author":"Detmar","year":"2002","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.semradonc.2017.04.008_bib80","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejca.2015.12.025","article-title":"Patient-reported outcomes in head and neck and thyroid cancer randomised controlled trials: A systematic review of completeness of reporting and impact on interpretation","volume":"56","author":"Mercieca-Bebber","year":"2016","journal-title":"Eur J Cancer"},{"issue":"31","key":"10.1016\/j.semradonc.2017.04.008_bib81","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1200\/JCO.2007.11.5501","article-title":"Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients","volume":"25","author":"Kam","year":"2007","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2017.04.008_bib82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.semradonc.2017.04.008_bib83","doi-asserted-by":"crossref","first-page":"E1481","DOI":"10.1002\/hed.24263","article-title":"Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results","volume":"38","author":"Ghosh-Laskar","year":"2016","journal-title":"Head Neck"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429617300395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429617300395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T17:52:04Z","timestamp":1719424324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429617300395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1053429617300395"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2017.04.008","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Radiation Toxicity in Head and Neck Cancers","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2017.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}