{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:21:59Z","timestamp":1789572119331,"version":"build-2803163510"},"reference-count":107,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000070","name":"NIBIB","doi-asserted-by":"publisher","award":["R01 EB022075"],"award-info":[{"award-number":["R01 EB022075"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.semradonc.2019.08.005","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T19:10:58Z","timestamp":1573499458000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Transarterial Radioembolization for Hepatocellular Carcinoma and Hepatic Metastases: Clinical Aspects and Dosimetry Models"],"prefix":"10.1016","volume":"30","author":[{"given":"Justin K.","family":"Mikell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuni K.","family":"Dewaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semradonc.2019.08.005_bib0001","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2214\/AJR.15.14802","article-title":"Transarterial chemoembolization and (90)Y radioembolization for hepatocellular carcinoma: Review of current applications beyond intermediate-stage disease","volume":"205","author":"Fidelman","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0002","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.semradonc.2011.05.004","article-title":"Radioembolization for primary and metastatic liver cancer","volume":"21","author":"Memon","year":"2011","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0003","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40336-016-0172-0","article-title":"The role of (90)Y-radioembolization in downstaging primary and secondary hepatic malignancies: A systematic review","volume":"4","author":"Braat","year":"2016","journal-title":"Clin Transl Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0004","doi-asserted-by":"crossref","first-page":"860","DOI":"10.21037\/jgo.2016.08.04","article-title":"Radioembolization with (90)Y glass microspheres for the treatment of unresectable metastatic liver disease from chemotherapy-refractory gastrointestinal cancers: Final report of a prospective pilot study","volume":"7","author":"Fidelman","year":"2016","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0005","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2013.06.015","article-title":"Radiation lobectomy: Time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection","volume":"59","author":"Vouche","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0006","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijrobp.2009.10.062","article-title":"Radiation segmentectomy: A novel approach to increase safety and efficacy of radioembolization","volume":"79","author":"Riaz","year":"2011","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0007","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1148\/radiol.2018171768","article-title":"Radiation segmentectomy: Potential curative therapy for early hepatocellular carcinoma","volume":"287","author":"Lewandowski","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0008","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1245\/s10434-017-5950-z","article-title":"The Post-SIR-Spheres Surgery Study (P4S): Retrospective analysis of safety following hepatic resection or transplantation in patients previously treated with selective internal radiation therapy with yttrium-90 resin microspheres","volume":"24","author":"Pardo","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0009","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1245\/s10434-007-9553-y","article-title":"Preoperative portal vein embolization and surgical resection in patients with hepatocellular carcinoma and small future liver remnant volume: Comparison with transarterial chemoembolization","volume":"14","author":"Seo","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0010","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1007\/s00464-016-5225-y","article-title":"Technical feasibility and safety of laparoscopic right hepatectomy for hepatocellular carcinoma following sequential TACE-PVE: A comparative study","volume":"31","author":"Goumard","year":"2017","journal-title":"Surg Endosc"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0011","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00270-012-0440-y","article-title":"Portal vein embolization before liver resection: A systematic review","volume":"36","author":"van Lienden","year":"2013","journal-title":"Cardiovasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvir.2018.06.027","article-title":"Outcomes of surgical resection after radioembolization for hepatocellular carcinoma","volume":"29","author":"Gabr","year":"2018","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0013","doi-asserted-by":"crossref","first-page":"E43","DOI":"10.21037\/jgo.2017.01.26","article-title":"Neoadjuvant transarterial radiation lobectomy for colorectal hepatic metastases: A small cohort analysis on safety, efficacy, and radiopathologic correlation","volume":"8","author":"Shah","year":"2017","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0014","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jso.24269","article-title":"90Y radiation lobectomy: Outcomes following surgical resection in patients with hepatic tumors and small future liver remnant volumes","volume":"114","author":"Lewandowski","year":"2016","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.crad.2013.09.009","article-title":"Hepatic volume changes after lobar selective internal radiation therapy (SIRT) of hepatocellular carcinoma","volume":"69","author":"Theysohn","year":"2014","journal-title":"Clin Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0016","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1055\/s-0035-1564708","article-title":"Planning arteriography for yttrium-90 microsphere radioembolization","volume":"32","author":"Gaba","year":"2015","journal-title":"Semin Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0017","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.hpb.2015.07.002","article-title":"A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90","volume":"18","author":"Teo","year":"2016","journal-title":"HPB"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0018","doi-asserted-by":"crossref","first-page":"215","DOI":"10.12659\/AOT.902595","article-title":"Long-term outcome after liver transplantation for hepatocellular carcinoma following yttrium-90 radioembolization bridging treatment","volume":"22","author":"Radunz","year":"2017","journal-title":"Ann Transpl"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0019","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00268-016-3682-z","article-title":"Yttrium-90 radioembolization for hepatocellular carcinoma prior to liver transplantation","volume":"41","author":"Ettorre","year":"2017","journal-title":"World J Surg"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0020","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S1470-2045(17)30683-6","article-title":"Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): An open-label randomised controlled phase 3 trial","volume":"18","author":"Vilgrain","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0021","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1200\/JCO.2017.76.0892","article-title":"SIRveNIB: Selective internal radiation therapy versus sorafenib in Asia-pacific patients with hepatocellular carcinoma","volume":"36","author":"Chow","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0022","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jhep.2012.06.014","article-title":"Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial","volume":"57","author":"Bruix","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0023","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.2196\/resprot.7016","article-title":"VESPRO: An individual patient data prospective meta-analysis of selective internal radiation therapy versus sorafenib for advanced, locally advanced, or recurrent hepatocellular carcinoma of the SARAH and SIRveNIB trials","volume":"6","author":"Gebski","year":"2017","journal-title":"JMIR Res Protoc"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0024","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/hep.29480","article-title":"Radioembolization for hepatocellular carcinoma: Statistical confirmation of improved survival in responders by landmark analyses","volume":"67","author":"Riaz","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0025","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00270-018-2008-y","article-title":"Radioembolization super survivors: Extended survival in non-operative hepatocellular carcinoma","volume":"41","author":"Gordon","year":"2018","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0026","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1148\/radiol.2016160718","article-title":"Radiation segmentectomy versus TACE combined with microwave ablation for unresectable solitary hepatocellular carcinoma up to 3 cm: A propensity score matching study","volume":"283","author":"Biederman","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0027","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1200\/JCO.2015.61.4925","article-title":"Outcomes after stereotactic body radiotherapy or radiofrequency ablation for hepatocellular carcinoma","volume":"34","author":"Wahl","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0028","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2016.07.020","article-title":"Stereotactic body radiotherapy for primary hepatic malignancies\u2014Report of a phase I\/II institutional study","volume":"121","author":"Weiner","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0029","doi-asserted-by":"crossref","first-page":"261","DOI":"10.14694\/EdBook_AM.2012.32.171","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma","author":"Dawson","year":"2012","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jamaoncol.2017.2303","article-title":"Individualized adaptive stereotactic body radiotherapy for liver tumors in patients at high risk for liver damage: A phase 2 clinical trial","volume":"4","author":"Feng","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0031","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/jgh.13028","article-title":"Percutaneous thermal ablation for primary hepatocellular carcinoma: A systematic review and meta-analysis","volume":"31","author":"Chinnaratha","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0032","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jhep.2018.02.027","article-title":"Validation of response to yttrium-90 radioembolization for hepatocellular carcinoma with portal vein invasion","volume":"69","author":"Mosconi","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0033","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jhep.2017.12.026","article-title":"Development of a prognostic score to predict response to yttrium-90 radioembolization for hepatocellular carcinoma with portal vein invasion","volume":"68","author":"Spreafico","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0034","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s00259-015-3068-8","article-title":"Radioembolization of hepatocarcinoma with 90Y glass microspheres: Development of an individualized treatment planning strategy based on dosimetry and radiobiology","volume":"42","author":"Chiesa","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0035","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/liv.13098","article-title":"A comparison of survival in patients with hepatocellular carcinoma and portal vein invasion treated by radioembolization or sorafenib","volume":"36","author":"de la Torre","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0036","article-title":"Radioembolization is a safe and effective treatment for hepatocellular carcinoma with portal vein thrombosis: A propensity score analysis","volume":"11","author":"Cho","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0037","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000343855","article-title":"Radiotherapeutic options for hepatocellular carcinoma with portal vein tumor thrombosis","volume":"3","author":"Lee","year":"2014","journal-title":"Liver Cancer"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0038","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1200\/JCO.2015.66.1181","article-title":"SIRFLOX: Randomized phase III trial comparing first-line mFOLFOX6 (plus or minus bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer","volume":"34","author":"van Hazel","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0039","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S1470-2045(17)30457-6","article-title":"First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): A combined analysis of three multicentre, randomised, phase 3 trials","volume":"18","author":"Wasan","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0040","doi-asserted-by":"crossref","first-page":"e11545","DOI":"10.2196\/11545","article-title":"TheraSphere Yttrium-90 glass microspheres combined with chemotherapy versus chemotherapy alone in second-line treatment of patients with metastatic colorectal carcinoma of the liver: Protocol for the EPOCH Phase 3 randomized clinical trial","volume":"8","author":"Chauhan","year":"2019","journal-title":"JMIR Res Protoc"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0041","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00270-018-2148-0","article-title":"Radioembolization with (90)Y resin microspheres of neuroendocrine liver metastases: International multicenter study on efficacy and toxicity","volume":"42","author":"Braat","year":"2019","journal-title":"Cardiovasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0042","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejrad.2018.01.012","article-title":"Yttrium-90 radioembolization for unresectable metastatic neuroendocrine liver tumor: A systematic review","volume":"100","author":"Jia","year":"2018","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0043","unstructured":"Therasphere (TM). Biocompatibles UK Ltd: package insert; 2014."},{"key":"10.1016\/j.semradonc.2019.08.005_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2014.00198","article-title":"Side effects of yttrium-90 radioembolization","volume":"4","author":"Riaz","year":"2014","journal-title":"Front Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MEG.0000000000000772","article-title":"Radioembolization-induced liver disease: A systematic review","volume":"29","author":"Braat","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0046","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1186\/s12885-016-2868-y","article-title":"Single administration of Selective Internal Radiation Therapy versus continuous treatment with sorafeNIB in locally advanced hepatocellular carcinoma (SIRveNIB): Study protocol for a phase iii randomized controlled trial","volume":"16","author":"Gandhi","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0047","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/COC.0b013e318168ef65","article-title":"Incidence of radiation pneumonitis after hepatic intra-arterial radiotherapy with yttrium-90 microspheres assuming uniform lung distribution","volume":"31","author":"Salem","year":"2008","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0048","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0360-3016(95)00039-3","article-title":"Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors","volume":"33","author":"Leung","year":"1995","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0049","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s00330-017-4998-2","article-title":"Safety analysis of holmium-166 microsphere scout dose imaging during radioembolisation work-up: A cohort study","volume":"28","author":"Braat","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0050","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1118\/1.3608909","article-title":"Recommendations of the American Association of Physicists in Medicine on dosimetry, imaging, and quality assurance procedures for [sup 90]Y microsphere brachytherapy in the treatment of hepatic malignancies","volume":"38","author":"Dezarn","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0051","article-title":"Radiation safety concerns associated with preparing the dosage, treating and releasing the patient, and managing radioactive waste","author":"Erwin","year":"2016","journal-title":"Handbook of Radioembolization"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0052","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00259-011-1812-2","article-title":"EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds","volume":"38","author":"Giammarile","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0053","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/jbm.820271010","article-title":"Chemical durability of Y2O3-Al2O3-SiO2 glasses for the in vivo delivery of beta radiation","volume":"27","author":"Erbe","year":"1993","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0054","unstructured":"SIR-Sphere (TM). Sirtex Medical Inc.: package insert; 2011."},{"key":"10.1016\/j.semradonc.2019.08.005_bib0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13550-015-0133-z","article-title":"Evaluation of the delivered activity of yttrium-90 resin microspheres using sterile water and 5 % glucose during administration","volume":"5","author":"Ahmadzadehfar","year":"2015","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0056","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijrobp.2010.08.015","article-title":"Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres","volume":"82","author":"Lau","year":"2012","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0057","article-title":"Yttrium-90 hepatic radioembolization: An update on current practice and recent developments","volume":"115","author":"Braat","year":"2015","journal-title":"J Nucl Med jnumed."},{"key":"10.1016\/j.semradonc.2019.08.005_bib0058","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijrobp.2006.11.060","article-title":"Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: A consensus panel report from the radioembolization brachytherapy oncology consortium","volume":"68","author":"Kennedy","year":"2007","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0059","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ijrobp.2008.10.005","article-title":"Treatment parameters and outcome in 680 treatments of internal radiation with resin 90y-microspheres for unresectable hepatic tumors","volume":"74","author":"Kennedy","year":"2009","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0060","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12149-011-0499-6","article-title":"Clinical implications of the body surface area method versus partition model dosimetry for yttrium-90 radioembolization using resin microspheres: A technical review","volume":"25","author":"Kao","year":"2011","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0061","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jvir.2013.11.018","article-title":"Limitations of body surface area-based activity calculation for radioembolization of hepatic metastases in colorectal cancer","volume":"25","author":"Lam","year":"2014","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0062","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ejmp.2014.05.004","article-title":"Liver selective internal radiation therapy with 90Y resin microspheres: Comparison between pre-treatment activity calculation methods","volume":"30","author":"Bernardini","year":"2014","journal-title":"Phys Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0063","first-page":"1209","article-title":"Dosimetric techniques in 90Y-microsphere therapy of liver cancer: The MIRD equations for dose calculations","volume":"47","author":"Gulec","year":"2006","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0064","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0360-3016(91)90797-8","article-title":"Dose distribution following selective internal radiation therapy","volume":"21","author":"Fox","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0065","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1088\/0031-9155\/45\/4\/316","article-title":"Analysis of the distribution of intra-arterial microspheres in human liver following hepatic yttrium-90 microsphere therapy","volume":"45","author":"Campbell","year":"2000","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0066","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.ijrobp.2004.09.004","article-title":"Pathologic response and microdosimetry of 90Y microspheres in man: Review of four explanted whole livers","volume":"60","author":"Kennedy","year":"2004","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0067","first-page":"293","article-title":"Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer","volume":"24","author":"Ho","year":"1997","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0068","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/BF01084369","article-title":"Partition model for estimating radiation doses from yttrium-90 microspheres in treating hepatic tumours","volume":"23","author":"Ho","year":"1996","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0069","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2967\/jnumed.111.097469","article-title":"Image-guided personalized predictive dosimetry by artery-specific SPECT\/CT partition modeling for safe and effective 90Y radioembolization","volume":"53","author":"Kao","year":"2012","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0070","article-title":"MIRD pamphlet no. 17: The dosimetry of nonuniform activity distributions-radionuclide S values at the voxel level","volume":"40","author":"Bolch","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0071","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ijrobp.2016.07.021","article-title":"Selective internal radiation therapy with yttrium-90 glass microspheres: Biases and uncertainties in absorbed dose calculations between clinical dosimetry models","volume":"96","author":"Mikell","year":"2016","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0072","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jvir.2018.07.006","article-title":"Tumor targeting and three-dimensional voxel-based dosimetry to predict tumor response, toxicity, and survival after yttrium-90 resin microsphere radioembolization in hepatocellular carcinoma","volume":"29","author":"Allimant","year":"2018","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0073","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40658-015-0119-y","article-title":"Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90 Y microsphere selective internal radiation therapy","volume":"2","author":"Mikell","year":"2015","journal-title":"EJNMMI Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0074","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2967\/jnumed.112.105825","article-title":"Study of the impact of tissue density heterogeneities on 3-dimensional abdominal dosimetry: Comparison between dose kernel convolution and direct Monte Carlo methods","volume":"54","author":"Dieudonn\u00e9","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0075","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2967\/jnumed.106.038000","article-title":"Three-dimensional radiobiologic dosimetry: Application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry","volume":"48","author":"Prideaux","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0076","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1109\/TMI.2009.2022753","article-title":"Effect of voxel size and computation method on Tc-99m MAA SPECT\/CT-based dose estimation for Y-90 microsphere therapy","volume":"28","author":"Pasciak","year":"2009","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0077","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1088\/0031-9155\/57\/2\/517","article-title":"A free database of radionuclide voxel S values for the dosimetry of nonuniform activity distributions","volume":"57","author":"Lanconelli","year":"2012","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0078","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2967\/jnumed.110.077149","article-title":"Fine-resolution voxel S values for constructing absorbed dose distributions at variable voxel size","volume":"51","author":"Dieudonne","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0079","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1088\/0031-9155\/59\/17\/4769","article-title":"A new approach for dose calculation in targeted radionuclide therapy (TRT) based on collapsed cone superposition: Validation with 90Y","volume":"59","author":"Sanchez-Garcia","year":"2014","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0080","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1002\/mp.12483","article-title":"Impact of respiratory motion and acquisition settings on SPECT liver dosimetry for radioembolization","volume":"44","author":"Bastiaannet","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0081","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40658-018-0221-z","article-title":"The physics of radioembolization","volume":"5","author":"Bastiaannet","year":"2018","journal-title":"EJNMMI Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0082","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1053\/j.tvir.2018.07.002","article-title":"Interventional oncology: Optimizing transarterial therapies for the treatment of hepatic malignancy","volume":"21","author":"Kouri","year":"2018","journal-title":"Tech Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0083","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/j.tvir.2007.08.001","article-title":"Technical aspects of radioembolization with 90Y microspheres","volume":"10","author":"Salem","year":"2007","journal-title":"Tech Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0084","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/01.RVI.0000177063.92678.21","article-title":"The effect of catheter-directed CT angiography on yttrium-90 radioembolization treatment of hepatocellular carcinoma","volume":"16","author":"Rhee","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13550-018-0402-8","article-title":"The value of 99mTc-MAA SPECT\/CT for lung shunt estimation in 90Y radioembolization: A phantom and patient study","volume":"8","author":"Allred","year":"2018","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0086","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13550-014-0033-7","article-title":"Personalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT\/CT for yttrium-90 radioembolization","volume":"4","author":"Kao","year":"2014","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0087","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.2967\/jnumed.112.117614","article-title":"99mTc-macroaggregated albumin poorly predicts the intrahepatic distribution of 90Y resin microspheres in hepatic radioembolization","volume":"54","author":"Wondergem","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0088","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2967\/jnumed.112.112508","article-title":"Predictive value of intratumoral 99mTc-macroaggregated albumin uptake in patients with colorectal liver metastases scheduled for radioembolization with 90Y-microspheres","volume":"54","author":"Ulrich","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0089","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.2967\/jnumed.116.173104","article-title":"Partition model-based 99mTc-MAA SPECT\/CT predictive dosimetry compared with 90Y TOF PET\/CT posttreatment dosimetry in radioembolization of hepatocellular carcinoma: A quantitative agreement comparison","volume":"57","author":"Gnesin","year":"2016","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/153303461000900304","article-title":"Quantitative comparison of yttrium-90 (90Y)-microspheres and technetium-99m (99mTc)-macroaggregated albumin SPECT images for planning90Y therapy of liver cancer","volume":"9","author":"Kne\u0161aurek","year":"2010","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0091","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jvir.2016.12.1221","article-title":"Correlation of technetium-99m macroaggregated albumin and yttrium-90 glass microsphere biodistribution in hepatocellular carcinoma: A retrospective review of pretreatment single photon emission CT and posttreatment positron emission tomography\/CT","volume":"28","author":"Haste","year":"2017","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0092","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.2967\/jnumed.115.162685","article-title":"Predictive value of 99mTc-MAA SPECT for 90Y-labeled resin microsphere distribution in radioembolization of primary and secondary hepatic tumors","volume":"56","author":"Ilhan","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0093","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00259-013-2675-5","article-title":"The role of SPECT\/CT in radioembolization of liver tumours","volume":"41","author":"Ahmadzadehfar","year":"2014","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0094","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17229\/jdit.2015-0428-016","article-title":"A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy","volume":"2","author":"O\u2019 Doherty","year":"2015","journal-title":"J Diagn Imaging Ther"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0095","doi-asserted-by":"crossref","unstructured":"Dewaraja YK, Frey EC, Sgouros G, et al. MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy. Available at: http:\/\/jnm.snmjournals.org. Accessed January 18, 2013.","DOI":"10.2967\/jnumed.111.100123"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0096","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-009-1210-1","article-title":"Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT","volume":"36","author":"Lhommel","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0097","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.apradiso.2006.08.009","article-title":"A new internal pair production branching ratio of 90Y: The development of a non-destructive assay for 90Y and 90Sr","volume":"65","author":"Selwyn","year":"2007","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0098","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1118\/1.4922685","article-title":"90Y-PET imaging: Exploring limitations and accuracy under conditions of low counts and high random fraction","volume":"42","author":"Carlier","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0099","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/s00259-015-3059-9","article-title":"A multicentre comparison of quantitative 90Y PET\/CT for dosimetric purposes after radioembolization with resin microspheres","volume":"42","author":"Willowson","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0100","doi-asserted-by":"crossref","DOI":"10.1053\/j.semnuclmed.2019.01.005","article-title":"Dosimetry of Y-90 microspheres utilizing Tc-99m SPECT and Y-90 PET","author":"Tafti","year":"2019","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0101","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13550-017-0292-1","article-title":"Clinical and imaging-based prognostic factors in radioembolisation of liver metastases from colorectal cancer: A retrospective exploratory analysis","volume":"7","author":"Willowson","year":"2017","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0102","article-title":"90 Y TOF-PET based EUD reunifies patient survival prediction in resin and glass microspheres radioembolization of HCC tumours","volume":"63","author":"d'Abadie","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/2191-219X-3-57","article-title":"Post-radioembolization yttrium-90 PET\/CT\u2014Part 2: Dose-response and tumor predictive dosimetry for resin microspheres","volume":"3","author":"Kao","year":"2013","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0104","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijrobp.2018.01.116","article-title":"Prospective trial using internal pair-production positron emission tomography to establish the yttrium-90 radioembolization dose required for response of hepatocellular carcinoma","volume":"101","author":"Chan","year":"2018","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0105","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00270-018-1949-5","article-title":"Hepatotoxic dose thresholds by positron-emission tomography after yttrium-90 radioembolization of liver tumors: A prospective single-arm observational study","volume":"41","author":"Chan","year":"2018","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0106","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2967\/jnumed.113.135301","article-title":"A hepatic dose-toxicity model opening the way toward individualized radioembolization planning","volume":"55","author":"Walrand","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.semradonc.2019.08.005_bib0107","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1109\/TRPMS.2018.2842463","article-title":"Development of a customizable hepatic arterial tree and particle transport model for use in treatment planning","volume":"3","author":"Crookston","year":"2019","journal-title":"IEEE Trans Radiat Plasma Med Sci"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429619300591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429619300591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:51:29Z","timestamp":1760950289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429619300591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":107,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1053429619300591"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2019.08.005","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transarterial Radioembolization for Hepatocellular Carcinoma and Hepatic Metastases: Clinical Aspects and Dosimetry Models","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2019.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}