{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:06Z","timestamp":1792173366090,"version":"4.4.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.semradonc.2021.09.008","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T21:27:14Z","timestamp":1638307634000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients"],"prefix":"10.1016","volume":"32","author":[{"given":"Mar\u00eda E. Guerra","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Kirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"Reitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semradonc.2021.09.008_bib0001","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1056\/NEJM199509073331014","article-title":"Ataxia-telangiectasia\u2013broad implications for a rare disorder","volume":"333","author":"Kastan","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0002","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41580-019-0152-0","article-title":"DNA double-strand break repair-pathway choice in somatic mammalian cells","volume":"20","author":"Scully","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0003","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0004","doi-asserted-by":"crossref","first-page":"13436","DOI":"10.1074\/jbc.M115.708263","article-title":"The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization","volume":"291","author":"Sawicka","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0005","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","article-title":"Requirement of the MRN complex for ATM activation by DNA damage","volume":"22","author":"Uziel","year":"2003","journal-title":"Embo j"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0006","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0007","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1093\/emboj\/cdg630","article-title":"The Mre11 complex is required for ATM activation and the G2\/M checkpoint","volume":"22","author":"Carson","year":"2003","journal-title":"Embo j"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0008","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature03442","article-title":"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage","volume":"434","author":"Falck","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0009","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0010","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.molcel.2013.10.019","article-title":"Replication stress and chromatin context link ATM activation to a role in DNA replication","volume":"52","author":"Olcina","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0011","doi-asserted-by":"crossref","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","article-title":"Substrate specificities and identification of putative substrates of ATM kinase family members","volume":"274","author":"Kim","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0012","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0013","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1038\/sj.emboj.7601231","article-title":"Involvement of novel autophosphorylation sites in ATM activation","volume":"25","author":"Kozlov","year":"2006","journal-title":"Embo j"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0014","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nsmb1090","article-title":"Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex","volume":"13","author":"Dupr\u00e9","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0015","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.200805154","article-title":"Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo","volume":"183","author":"Daniel","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0016","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature05112","article-title":"Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo","volume":"443","author":"Pellegrini","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0017","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/15384101.2016.1158362","article-title":"Structure of the human dimeric ATM kinase","volume":"15","author":"Lau","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0018","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0019","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0020","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ng1297-453","article-title":"Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways","volume":"17","author":"Barlow","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0021","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0022","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4161\/cc.9.3.10556","article-title":"Mechanism of p53 stabilization by ATM after DNA damage","volume":"9","author":"Cheng","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0023","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature06337","article-title":"Human CtIP promotes DNA end resection","volume":"450","author":"Sartori","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0024","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/emboj.2011.27","article-title":"Factors determining DNA double-strand break repair pathway choice in G2 phase","volume":"30","author":"Shibata","year":"2011","journal-title":"Embo j"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003277","article-title":"The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0026","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","article-title":"A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci","volume":"16","author":"Riballo","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0027","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2008.05.017","article-title":"ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin","volume":"31","author":"Goodarzi","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0028","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1038\/ncomms4347","article-title":"ATM specifically mediates repair of double-strand breaks with blocked DNA ends","volume":"5","author":"\u00c1lvarez-Quil\u00f3n","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0029","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpedi.1967.02090270073006","article-title":"Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis","volume":"114","author":"Gotoff","year":"1967","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/258427a0","article-title":"Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity","volume":"258","author":"Taylor","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0031","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1200\/JCO.2014.56.5101","article-title":"Incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: a report from the French national registry of primary immune deficiencies","volume":"33","author":"Suarez","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0032","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1093\/nar\/8.16.3709","article-title":"Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells","volume":"8","author":"Houldsworth","year":"1980","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0033","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1073\/pnas.77.12.7315","article-title":"Radiosensitivity in ataxia-telangiectasia: a new explanation","volume":"77","author":"Painter","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0034","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0009-2797(83)90167-9","article-title":"Responses of Huntington's disease and ataxia telangiectasia lymphoblastoid cells to bleomycin","volume":"47","author":"Imray","year":"1983","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0027-5107(83)90054-4","article-title":"Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts","volume":"109","author":"Nagasawa","year":"1983","journal-title":"Mutat Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0036","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/09553008114550651","article-title":"Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation","volume":"39","author":"Zampetti-Bosseler","year":"1981","journal-title":"Int J Radiat Biol Relat Stud Phys Chem Med"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0037","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","article-title":"A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia","volume":"71","author":"Kastan","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0038","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1158\/1535-7163.MCT-15-0945","article-title":"ATM Mutations in Cancer: Therapeutic Implications","volume":"15","author":"Choi","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0039","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijrobp.2007.04.012","article-title":"Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy","volume":"69","author":"Ho","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1200\/PO.20.00334","article-title":"Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants","author":"Modlin","year":"2021","journal-title":"JCO Precision Oncology"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0041","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.1038\/onc.2008.280","article-title":"Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background","volume":"27","author":"Mao","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0042","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1200\/JCO.1999.17.4.1259","article-title":"Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease","volume":"17","author":"Nichols","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0043","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0044","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/jcp.54.7.512","article-title":"Ataxia telangiectasia gene mutations in leukaemia and lymphoma","volume":"54","author":"Boultwood","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0045","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.onc.1201603","article-title":"ATM is usually rearranged in T-cell prolymphocytic leukaemia","volume":"16","author":"Yuille","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0046","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood.V99.1.238","article-title":"ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances","volume":"99","author":"Camacho","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0047","article-title":"Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy","author":"Pitter","year":"2020","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0048","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0049","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1073\/pnas.97.7.3336","article-title":"Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice","volume":"97","author":"Borghesani","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0050","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1667\/RR3073","article-title":"Effect of Atm disruption on spontaneously arising and radiation-induced deletion mutations in mouse liver","volume":"160","author":"Furuno-Fukushi","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0051","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.280.5366.1089","article-title":"Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system","volume":"280","author":"Herzog","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0052","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.201204035","article-title":"Loss of ATM kinase activity leads to embryonic lethality in mice","volume":"198","author":"Daniel","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0053","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.201204098","article-title":"Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice","volume":"198","author":"Yamamoto","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0054","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13578-020-0376-x","article-title":"ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition\u2009\u2260\u2009deletion","volume":"10","author":"Menolfi","year":"2020","journal-title":"Cell Biosci"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0055","first-page":"5637","article-title":"Loss of atm radiosensitizes multiple p53 null tissues","volume":"58","author":"Westphal","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0056","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ng0897-397","article-title":"atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity","volume":"16","author":"Westphal","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0057","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1073\/pnas.162349699","article-title":"Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts","volume":"99","author":"Worgul","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0058","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1523\/JNEUROSCI.4213-15.2016","article-title":"DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis","volume":"37","author":"Enriquez-Rios","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0059","doi-asserted-by":"crossref","DOI":"10.21037\/tcr.2017.06.19","article-title":"Genetically engineered mouse models for studying radiation biology","volume":"6","author":"Castle","year":"2017","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0060","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1172\/JCI73932","article-title":"Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium","volume":"124","author":"Moding","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0061","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa4214","article-title":"Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy","volume":"7","author":"Moding","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0062","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1158\/0008-5472.CAN-17-3103","article-title":"Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma","volume":"79","author":"Torok","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0063","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142158","article-title":"Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models","volume":"131","author":"Deland","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0064","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1158\/1541-7786.MCR-16-0389","article-title":"Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG","volume":"15","author":"Cordero","year":"2017","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.01.052","article-title":"Cooperation of the ATM and Fanconi Anemia\/BRCA Pathways in Double-Strand Break End Resection","volume":"30","author":"Cai","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0066","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jmedchem.6b00519","article-title":"Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase","volume":"59","author":"Degorce","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0067","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1021\/acs.jmedchem.7b01896","volume":"61","author":"Pike","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0068","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1158\/1535-7163.MCT-18-1394","article-title":"Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically","volume":"19","author":"Riches","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0069","doi-asserted-by":"crossref","first-page":"eaat1719","DOI":"10.1126\/sciadv.aat1719","article-title":"The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models","volume":"4","author":"Durant","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0070","article-title":"Brain exposure of the ATM inhibitor AZD1390 in humans - a positron emission tomography (PET) study","author":"Jucaite","year":"2020","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0071","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1158\/1538-7445.AM2018-338","article-title":"Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models","volume":"78","author":"Zimmermann","year":"2018","journal-title":"Cancer Research"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0072","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0073","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1073\/pnas.051632098","article-title":"Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development","volume":"98","author":"Sekiguchi","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0074","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.molcel.2009.04.025","article-title":"Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes","volume":"34","author":"Call\u00e9n","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0075","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1073\/pnas.1019293108","article-title":"Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions","volume":"108","author":"Zha","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0076","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1073\/pnas.1013295108","article-title":"Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation","volume":"108","author":"Gapud","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0077","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0960-9822(01)00048-3","article-title":"Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis","volume":"11","author":"Gurley","year":"2001","journal-title":"Curr Biol"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0078","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1158\/1535-7163.MCT-16-0378","article-title":"AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells","volume":"16","author":"Min","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0079","doi-asserted-by":"crossref","first-page":"44289","DOI":"10.18632\/oncotarget.6247","article-title":"The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo","volume":"6","author":"Vendetti","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0080","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1158\/0008-5472.CAN-16-3398","article-title":"ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma","volume":"77","author":"Schmitt","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0081","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nature03443","article-title":"Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase","volume":"434","author":"Bryant","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0082","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03445","article-title":"Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy","volume":"434","author":"Farmer","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0083","doi-asserted-by":"crossref","first-page":"8109","DOI":"10.1158\/0008-5472.CAN-06-0140","article-title":"Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition","volume":"66","author":"McCabe","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0084","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41467-018-07729-2","article-title":"ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks","volume":"10","author":"Balmus","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0085","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.aam7344","article-title":"PARP inhibitors: Synthetic lethality in the clinic","volume":"355","author":"Lord","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0086","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030687","article-title":"ATM-Deficient Cancers Provide New Opportunities for Precision Oncology","volume":"12","author":"Jette","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0087","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41416-019-0565-8","article-title":"Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated\/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells","volume":"121","author":"Jette","year":"2019","journal-title":"Br J Cancer"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0088","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.molcel.2020.04.035","article-title":"Biomarker-Guided Development of DNA Repair Inhibitors","volume":"78","author":"Cleary","year":"2020","journal-title":"Mol Cell"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0089","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature14184","article-title":"Homologous-recombination-deficient tumours are dependent on Pol\u03b8-mediated repair","volume":"518","author":"Ceccaldi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0090","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1158\/1078-0432.CCR-12-3408","article-title":"ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation","volume":"19","author":"Biddlestone-Thorpe","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0091","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"H\u00e4rtlova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0092","first-page":"443","article-title":"Elevation of interferon beta-inducible proteins in ataxia telangiectasia cells","volume":"56","author":"Siddoo-Atwal","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0093","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1158\/1541-7786.MCR-10-0358","article-title":"Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway","volume":"9","author":"Sugihara","year":"2011","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0094","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-19-0761","article-title":"Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy","volume":"79","author":"Zhang","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0095","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139333","article-title":"ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS\/STING activation","volume":"131","author":"Hu","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semradonc.2021.09.008_bib0096","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/(SICI)1096-8628(20000529)92:3<170::AID-AJMG3>3.0.CO;2-#","article-title":"Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients","volume":"92","author":"Li","year":"2000","journal-title":"Am J Med Genet"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429621000588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429621000588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:51:53Z","timestamp":1760950313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429621000588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1053429621000588"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2021.09.008","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2021.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}