{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:51:11Z","timestamp":1770490271588,"version":"3.49.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.semradonc.2021.11.006","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T16:45:33Z","timestamp":1647535533000},"page":"155-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Evolving Role of Whole Breast Hypofractionation in Older Patients With Early Breast Cancer"],"prefix":"10.1016","volume":"32","author":[{"given":"Ian","family":"Kunkler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.semradonc.2021.11.006_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(20)30741-5","article-title":"Updated recommendations regarding the management of older patients with breast cancer: A joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG)","author":"Biganzoli","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0002","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1200\/JCO.20.01243","article-title":"Hypofractionated breast irradiation: What's next?","volume":"38","author":"Whelan","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0003","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK standardisation of breast radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow up results of two randomised trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0004","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/94.15.1143","article-title":"Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer","volume":"94","author":"Whelan","year":"2002","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0005","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1200\/JCO.20.01363","article-title":"Hypofractionated versus standard fractionated radiotherapy in patients with early breast cancer or ductal carcinoma in situ in a randomized phase III Trial: The DBCG HYPO Trial","volume":"31","author":"Offersen","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0006","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1200\/JCO.20.01024","article-title":"F. Hypofractionated versus conventional fractionated radiotherapy after breast-conserving surgery in the modern treatment era: A multicenter, randomized controlled trial from China","volume":"38","author":"Wang","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0007","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1200\/JCO.19.02750","article-title":"Ten-year results of the randomised FAST: A randomized controlled trial of 5-fraction whole-breast radiotherapy for early breast cancer","volume":"38","author":"Brunt","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0008","first-page":"1603","article-title":"FAST Phase III RCT of radiotherapy hypofractionation for treatment of early breast cancer: 10-year results (CRUKE\/04\/015)","volume":"102","author":"Brunt","year":"2018","journal-title":"IJROBP"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0009","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward):5 year efficacy and late normal tissue effects results from a multicentre non-inferiority, randomised phase 3 trial","volume":"395","author":"Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00066-020-01744-3","article-title":"Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward","volume":"197","author":"Krug","year":"2021","journal-title":"Strahlether Onkol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0011","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0140-6736(20)30978-8","article-title":"1-week hypofractionated adjuvant whole-breast radiotherapy: Towards a new standard?","volume":"395","author":"Livy","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0012","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1200\/JCO.20.02389","article-title":"Hypofractionated-whole breast irradiation: Case closed?","volume":"38","author":"Recht","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0013","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.clon.2020.03.006","article-title":"International Guidelines on Radiation Therapy for Breast Cancer duringthe COVID-19 Pandemic","volume":"32","author":"Coles","year":"2020","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0014","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijrobp.2020.06.054","article-title":"Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development","volume":"108","author":"Thompson","year":"2020","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2021.11.006_bib0015","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429621000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429621000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:52:39Z","timestamp":1760950359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429621000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1053429621000746"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2021.11.006","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Evolving Role of Whole Breast Hypofractionation in Older Patients With Early Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2021.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}