{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:12:17Z","timestamp":1793473937999,"version":"4.5.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.semradonc.2025.02.009","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:15:48Z","timestamp":1741936548000},"page":"243-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reirradiation for Locally Recurrent Head and Neck Cancer: State-of-the-Art and Future Directions"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-6004","authenticated-orcid":false,"given":"Jack","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Spiotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Newcomm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Garden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semradonc.2025.02.009_bib0001","unstructured":"Phan J, and Garden A.S. Sataloff Text Book Radiation Oncology. Chapter 2: Principles of Radiation Oncology."},{"key":"10.1016\/j.semradonc.2025.02.009_bib0002","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.radonc.2014.04.018","article-title":"High-dose reirradiation with intensity-modulated radiotherapy for recurrent head-and-neck cancer: disease control, survival and toxicity","volume":"111","author":"Duprez","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0003","first-page":"1464","article-title":"Re-irradiation for head and neck cancer: balancing curative intent with risk for complication","volume":"66","author":"Salama","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.semradonc.2025.02.009_bib0004","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-0039-1694052","article-title":"Patient outcomes after reirradiation of small skull base tumors using stereotactic Body Radiotherapy, Intensity modulated Radiotherapy, or Proton Therapy","volume":"81","author":"Ng","year":"2020","journal-title":"J Neurol Surg"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0005","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1002\/hed.26384","article-title":"Highly conformal reirradiation in patients with prior oropharyngeal radiation: clinical efficacy and toxicity outcomes","volume":"42","author":"Bagley","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0006","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1200\/JCO.1998.16.11.3556","article-title":"Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients","volume":"16","author":"De Crevoisier","year":"1998","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0007","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1200\/JCO.2008.20.0691","article-title":"Prognostic factors for survival after salvage reirradiation of head and neck cancer","volume":"27","author":"Tanvetyanon","year":"2009","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0008","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijrobp.2005.07.005","article-title":"Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma","volume":"64","author":"Salama","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0009","first-page":"3065","article-title":"Radiation therapy for head and neck cancers: a history and update on advances","volume":"32","author":"Barker","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0010","first-page":"733","article-title":"Intensity-modulated radiation therapy in head and neck cancers: The University of Chicago experience","volume":"52","author":"Chao","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0011","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.radonc.2014.04.018","article-title":"High-dose reirradiation with intensity-modulated radiotherapy for recurrent head-and-neck cancer: disease control, survival and toxicity","volume":"111","author":"Duprez","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0012","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/hed.20332","article-title":"Intensity-modulated radiation therapy in head and neck cancers: an update","volume":"29","author":"Lee","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0013","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1002\/hed.25180","article-title":"Reirradiation of head and neck cancer using modern highly conformal techniques","volume":"40","author":"Ho","year":"2018","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0014","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijrobp.2017.06.012","article-title":"Multi-institution reirradiation (MIRI) Collaborative. Refining patient selection for reirradiation of head and neck squamous carcinoma in the IMRT era: A Multi-institution cohort study by the MIRI Collaborative","volume":"100","author":"Ward","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0015","first-page":"1031","article-title":"Intensity-modulated radiotherapy-based reirradiation for head and Neck cancer: A multi-institutional study by Korean Radiation Oncology Group (KROG 1707)","volume":"52","author":"Lee","year":"2020","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0016","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijrobp.2008.04.021","article-title":"IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes","volume":"73","author":"Sulman","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0017","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.ijrobp.2016.03.015","article-title":"Reirradiation of head and neck cancers with intensity modulated radiation therapy: out- comes and analyses","volume":"95","author":"Takiar","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0018","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/hed.26264","article-title":"Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: meta-analysis and systematic review","volume":"42","author":"Lee","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2024.106875","article-title":"Proton therapy re-irradiation outcomes and genomic landscape of patients with recurrent head and neck cancer","volume":"154","author":"Krc","year":"2024","journal-title":"Oral Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijrobp.2016.02.036","article-title":"Proton beam reirradiation for recurrent head and neck cancer: multi-institutional report on feasibility and early outcomes","volume":"95","author":"Romesser","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0021","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ijrobp.2016.07.037","article-title":"Reirradiation of recurrent and second primary head and neck cancer with proton therapy","volume":"96","author":"McDonald","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0022","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.50607","article-title":"Evaluation of proton therapy reirradiation for patients with recurrent head and neck squamous cell carcinoma","volume":"6","author":"Lee","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0023","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1002\/hed.25180","article-title":"Reirradiation of head and neck cancer using modern highly conformal techniques","volume":"40","author":"Ho","year":"2018","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0024","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11912-017-0639-9","article-title":"Reirradiation of skull base tumors with advanced highly conformal techniques","volume":"19","author":"Ho","year":"2017","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0025","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3390\/jcm13113020","article-title":"Stereotactic body radiotherapy in recurrent and oligometastatic head and neck tumours","volume":"13","author":"Tham","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0026","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.ijrobp.2016.03.015","article-title":"Reirradiation of head and neck cancers with intensity modulated radiation therapy: outcomes and analyses","volume":"95","author":"Takiar","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0027","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2016.03.053","article-title":"Reirradiation of head and neck cancers with proton therapy: outcomes and analyses","volume":"96","author":"Phan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104757","article-title":"Reirradiation using stereotactic body radiotherapy in the management of recurrent or second primary head and neck cancer: A meta-analysis and systematic review","volume":"107","author":"Lee","year":"2020","journal-title":"Oral Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0029","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijrobp.2017.06.012","article-title":"Refining patient selection for reirradiation of head and neck squamous carcinoma in the IMRT era: A multi-institution cohort study by the MIRI Collaborative","volume":"100","author":"Ward","year":"2017","journal-title":"Int J Ra- diation Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0030","first-page":"82","article-title":"A multi-institution analysis of staged stereotactic body radiotherapy (SBRT) reirradiation for recurrent, previously-irradiated head and neck cancer: an analysis of the International RadioSurgery Oncology Consortium for head and Neck cancer (IROC-HNC)","volume":"148","author":"Vargo","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0031","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1200\/JCO.1998.16.11.3556","article-title":"Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients","volume":"16","author":"De Crevoisier","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0032","first-page":"1163","article-title":"Reirradiation for recurrent head and neck cancer: the current State of Reirradiation studies and future directions","volume":"100","author":"Ward","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0033","first-page":"521","article-title":"Proton therapy for head and neck cancer: A critical review of evidence","volume":"37","author":"Holliday","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0034","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1002\/hed.26820","article-title":"Stereotactic body ablative radiotherapy for reirradiation of small volume head and neck cancers is associated with prolonged survival: large, single-institution, modern cohort study","volume":"43","author":"Diao","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/hed.20332","article-title":"Intensity-modulated radiation therapy in head and neck cancers: an update","volume":"29","author":"Lee","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0036","doi-asserted-by":"crossref","first-page":"E1962","DOI":"10.1002\/hed.24355","article-title":"Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience","volume":"38","author":"Sandulache","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0037","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0360-3016(01)01745-X","article-title":"RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck","volume":"51","author":"Spencer","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0038","unstructured":"C.J. Langer, J. Harris, E.M. Horwitz, et al: Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of radiation therapy oncology group protocol 9911"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0039","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1038\/s41598-024-53438-w","article-title":"Re-irradiation for isolated neck recurrence in head and neck tumor: impact of rN category","volume":"14","author":"Yamazaki","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0040","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1200\/JCO.2008.20.0691","article-title":"Prognostic factors for survival after salvage reirradiation of head and neck cancer","volume":"27","author":"Tanvetyanon","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0041","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.oraloncology.2016.06.017","article-title":"Predictors of severe long-term toxicity after re-irradiation for head and neck cancer","volume":"60","author":"Lee","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0042","doi-asserted-by":"crossref","unstructured":"Phan J, and Garden A.S.: Sataloff Text Book Radiation Oncology. Chapter 2: Principles of Radiation Oncology. https:\/\/doi.org\/10.5005\/jp\/books\/12710_3.","DOI":"10.5005\/jp\/books\/12710_3"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0043","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1120\/jacmp.v17i3.6038","article-title":"Improved setup and positioning accuracy using a three-point customized cushion\/mask\/bite-block immobilization system for stereotactic reirradiation of head and neck cancer","volume":"17","author":"Wang","year":"2016","journal-title":"J Appl Clin Med Phys"},{"issue":"10380","key":"10.1016\/j.semradonc.2025.02.009_bib0044","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0140-6736(23)00269-6","article-title":"Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial","volume":"401","author":"You","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0045","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/hed.26037","article-title":"A prospective evaluation of health-related quality of life after skull base re-irradiation","volume":"42","author":"Bahig","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0046","article-title":"Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation","volume":"44","author":"Mohamed","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0047","doi-asserted-by":"crossref","first-page":"131","DOI":"10.14338\/IJPT-20-00064.1","article-title":"A systematic review on re-irradiation with charged particle beam therapy in the management of locally recurrent skull base and head and neck tumors","volume":"8","author":"Gamez","year":"2021","journal-title":"Int J Part Ther"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0048","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hed.26920","article-title":"Reply to letter to the Editor regarding 'Stereotactic radiotherapy for reirradiation of head and neck cancer: dosimetric details matter'","volume":"44","author":"Diao","year":"2022","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0049","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.radonc.2014.04.018","article-title":"High-dose reirradiation with intensity-modulated radiotherapy for recurrent head and neck cancer: disease control, survival and toxicity","volume":"111","author":"Duprez","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0050","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ijrobp.2014.11.023","article-title":"A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck","volume":"91","author":"Vargo","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0051","unstructured":"National Comprehensive Cancer Network. Available at https:\/\/www.nccn.org. Accessed August 27, 2024."},{"key":"10.1016\/j.semradonc.2025.02.009_bib0052","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ijrobp.2008.12.075","article-title":"Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial","volume":"75","author":"Heron","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0053","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijrobp.2011.11.054","article-title":"Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study","volume":"84","author":"Comet","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0054","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/COC.0b013e3181e84dc0","article-title":"The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy","volume":"34","author":"Rwigema","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0055","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1118\/1.4926037","article-title":"Outcomes of hypofractionated treatments\u2014Results of the WGSBRT: recurrent HNC treated with SBRT TCP-based outcomes estimates","volume":"42","author":"Yorke","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0056","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/COC.0b013e3181dbb73e","article-title":"Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: a single institution matched case-control study","volume":"34","author":"Heron","year":"2011","journal-title":"Am J clinical Oncol"},{"issue":"2","key":"10.1016\/j.semradonc.2025.02.009_bib0057","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijrobp.2023.04.007","article-title":"Phase 1 dose escalation of stereotactic body radiation therapy and concurrent cisplatin for reirradiation of unresectable, recurrent squamous cell carcinoma of the head and neck","volume":"117","author":"Echevarria","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0058","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.radonc.2013.08.012","article-title":"Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer","volume":"109","author":"Lartigau","year":"2013","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0059","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1002\/hed.26384","article-title":"Highly conformal reirradiation in patients with prior oropharyngeal radiation: clinical efficacy and toxicity outcomes","volume":"42","author":"Bagley","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0060","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-0039-1694052","article-title":"Patient outcomes after reirradiation of small skull base tumors using stereotactic Body Radiotherapy, Intensity modulated Radiotherapy, or Proton Therapy","volume":"81","author":"Ng","year":"2020","journal-title":"J Neurol Surg, Part B, Skull base"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0061","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/hed.27887","article-title":"A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma","volume":"47","author":"Goodman","year":"2024","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0062","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1002\/hed.26820","article-title":"Stereotactic body ablative radiotherapy for reirradiation of small volume head and neck cancers is associated with prolonged survival: large, single-institution, modern cohort study","volume":"43","author":"Diao","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0063","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1002\/cncr.24595","article-title":"The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx","volume":"115","author":"Zafereo","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0064","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.radonc.2012.04.020","article-title":"Prospective evaluation of patient-reported quality-of-life outcomes following SBRT \u00b1 cetuximab for locally-recurrent, previously-irradiated head and neck cancer","volume":"104","author":"Vargo","year":"2012","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0065","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/medicina58081074","article-title":"Salvage post-operative stereotatic ablative radiotherapy for re-current squamous cell carcinoma of head and neck","volume":"58","author":"Pellizzon","year":"2022","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0066","unstructured":"M.D. Anderson: 3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial (NCT05674396), 2023, ClinicalTrials.gov https:\/\/clinicaltrials.gov\/study\/NCT05674396."},{"key":"10.1016\/j.semradonc.2025.02.009_bib0067","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3171\/2017.11.JNS172084","article-title":"Stereotactic radiosurgery for trigeminal pain secondary to recurrent malignant skull base tumors","volume":"130","author":"Phan","year":"2019","journal-title":"J Neurosurg"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0068","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijrobp.2018.01.044","article-title":"Head and neck tumor control probability: radiation dose-volume effects in stereotactic body radiation therapy for locally recurrent previously-irradiated Head and neck cancer: report of the AAPM Working Group","volume":"110","author":"Vargo","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0069","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.radonc.2013.05.005","article-title":"outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife: a multi-institutional study","volume":"107","author":"Yamazaki","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1126\/scitranslmed.3000864","article-title":"A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy","volume":"2","author":"Wang","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0071","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1088\/0031-9155\/51\/11\/009","article-title":"Fitting the linear-quadratic model to detailed data sets for different dose ranges","volume":"51","author":"Garcia","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0072","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.semradonc.2008.04.005","article-title":"The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery","volume":"18","author":"Kirkpatrick","year":"2008","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0073","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2307\/3576798","article-title":"Lethal and potentially lethal lesions induced by radiation\u2013a unified repair model","volume":"106","author":"Curtis","year":"1986","journal-title":"Radiat Res"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0074","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1088\/0031-9155\/49\/20\/012","article-title":"Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy","volume":"49","author":"Guerrero","year":"2004","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.semradonc.2008.04.004","article-title":"The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction","volume":"18","author":"Brenner","year":"2008","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0076","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.radonc.2019.07.008","article-title":"Estimation of the alpha\/beta ratio of non-small cell lung cancer treated with stereotactic body radiotherapy","volume":"142","author":"Klement","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0077","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejmp.2016.12.012","article-title":"Optimal dose and fraction number in SBRT of lung tumours: A radiobiological analysis","volume":"44","author":"Ruggieri","year":"2017","journal-title":"Phys Med"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0078","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ijrobp.2012.11.003","article-title":"Dose escalation, not \"new biology,\" can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer","volume":"85","author":"Brown","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0079","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ijrobp.2008.02.008","article-title":"Early mucosal reactions during and after head-and-neck radiotherapy: dependence of treatment tolerance on radiation dose and schedule duration","volume":"71","author":"Fenwick","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0167-8140(03)00231-7","article-title":"Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedules","volume":"69","author":"Fowler","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0081","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ijrobp.2012.02.004","article-title":"A new model for predicting acute mucosal toxicity in head-and-neck cancer patients undergoing radiotherapy with altered schedules","volume":"83","author":"Trigari","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0082","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.clon.2015.02.001","article-title":"The radiobiology of hypofractionation","volume":"27","author":"Nahum","year":"2015","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0083","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijrobp.2017.04.017","article-title":"A multi-institutional comparison of SBRT and IMRT for definitive reirradiation of recurrent or second primary head and Neck cancer","volume":"100","author":"Vargo","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0084","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ijrobp.2008.12.075","article-title":"Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial","volume":"75","author":"Heron","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0085","first-page":"1349","article-title":"Examining tumor control and toxicity after stereotactic body radiotherapy in locally recurrent previously irradiated head and neck cancers: implications of treatment duration and tumor volume","volume":"36","author":"Vargo","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0086","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.ijrobp.2008.10.013","article-title":"Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer","volume":"74","author":"Roh","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0087","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ijrobp.2016.02.049","article-title":"Risk of severe toxicity according to site of recurrence in patients treated with stereotactic body radiation therapy for recurrent head and neck cancer","volume":"95","author":"Ling","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0088","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.semradonc.2015.11.008","article-title":"Dose-response modeling of the visual pathway tolerance to single-fraction and hypofractionated stereotactic radiosurgery","volume":"26","author":"Hiniker","year":"2016","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0089","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20190170","article-title":"Physiological motion of the optic chiasm and its impact on stereotactic radiosurgery dose","volume":"92","author":"Xiang","year":"2019","journal-title":"Br J Radiol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijrobp.2019.09.038","article-title":"Spinal cord dose tolerance to stereotactic body radiation therapy","volume":"110","author":"Sahgal","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0091","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijrobp.2020.12.037","article-title":"Initial data pooling for radiation dose-volume tolerance for carotid artery blowout and other bleeding events in hypofractionated head and neck retreatments","volume":"110","author":"Grimm","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0092","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1120\/jacmp.v17i3.6038","article-title":"Improved setup and positioning accuracy using a three-point customized cushion\/mask\/bite-block immobilization system for stereotactic reirradiation of head and neck cancer","volume":"17","author":"Wang","year":"2016","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0093","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phro.2020.04.001","article-title":"Comparison of tumor delineation using dual energy computed tomography versus magnetic resonance imaging in head and neck cancer re-irradiation cases","volume":"14","author":"Ng","year":"2020","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0094","first-page":"102","article-title":"Conventionally fractionated large volume head and neck re-irradiation using multileaf collimator-based robotic technique: A feasibility study","volume":"24","author":"Bahig","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0095","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.prro.2020.02.016","article-title":"SABR for skull base malignancies: A systematic analysis of set-up and positioning accuracy","volume":"10","author":"Mesko","year":"2020","journal-title":"Prac Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0096","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijrobp.2019.09.010","article-title":"Estimating PTV margins in head and neck stereotactic ablative radiation therapy (SABR) through target site analysis of positioning and intrafractional accuracy","volume":"106","author":"Mesko","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0097","unstructured":"M.K. Harishankar, S. Prince, A.M. Mohan, et al: Association of Notch4 with metastasis in human oral squamous cell carcinoma"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0098","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(18)31999-8","article-title":"Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0099","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for recurrent squamous-cell carcinoma of the head and neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0100","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0101","first-page":"826","article-title":"The 2017 American Society for Radiation Oncology (ASTRO) guidelines on palliative radiotherapy for patients with cancer","volume":"97","author":"Weichselbaum","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0102","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2015.02.021","article-title":"Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife: A multi-institutional matched-cohort analysis","volume":"115","author":"Yamazaki","year":"2015","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0103","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1038\/s41598-023-29459-2","article-title":"Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study","volume":"13","author":"Yamazaki","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0104","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ijrobp.2010.08.029","article-title":"Risk of carotid blowout after reirradiation of the head and neck: a systematic review","volume":"82","author":"McDonald","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103088","article-title":"Carotid blowout syndrome after reirradiation for head and neck malignancies: a comprehensive systematic review for a pragmatic multidisciplinary approach","volume":"155","author":"Alterio","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0106","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1269\/jrr.10086","article-title":"Stereotactic body radiation therapy for head and neck tumor: disease control and morbidity outcomes","volume":"52","author":"Kodani","year":"2011","journal-title":"J Radiat Res"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0107","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijrobp.2017.11.045","article-title":"Carotid dosimetry and the risk of carotid blowout syndrome after re-irradiation with head and neck stereotactic body radiation therapy","volume":"101","author":"Gebhardt","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.semradonc.2025.02.009_bib0108","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/hed.20697","article-title":"Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck","volume":"30","author":"Spencer","year":"2008","journal-title":"Head Neck"},{"issue":"6","key":"10.1016\/j.semradonc.2025.02.009_bib0109","doi-asserted-by":"crossref","first-page":"516","DOI":"10.5301\/tj.5000614","article-title":"Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: single-institution experience and systematic review","volume":"103","author":"Tagliaferri","year":"2017","journal-title":"Tumori"},{"issue":"11","key":"10.1016\/j.semradonc.2025.02.009_bib0110","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.3390\/curroncol29110655","article-title":"Magnetic resonance-guided radiation therapy for head and neck cancers","volume":"29","author":"Lavigne","year":"2022","journal-title":"Current Oncology"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0111","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.critrevonc.2019.01.011","article-title":"Positron emission tomography with computed tomography imaging (PET\/CT) for the radiotherapy planning definition of the biological target volume: PART 1","volume":"140","author":"Alongi","year":"2019","journal-title":"Critic Rev Oncol\/Hematol"},{"issue":"10","key":"10.1016\/j.semradonc.2025.02.009_bib0112","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/hed.23763","article-title":"Safety and efficacy of hypo- fractionated stereotactic body reirradiation in head and neck can- cer: long-term follow-up of a large series","volume":"37","author":"Kress","year":"2015","journal-title":"Head Neck"},{"issue":"5","key":"10.1016\/j.semradonc.2025.02.009_bib0113","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.ijrobp.2008.10.013","article-title":"Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer","volume":"74","author":"Roh","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.semradonc.2025.02.009_bib0114","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ijrobp.2008.09.022","article-title":"Stereotactic body radiation therapy for primary, recurrent, and metastatic tumors in the head-and-neck region","volume":"74","author":"Siddiqui","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.semradonc.2025.02.009_bib0115","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/COC.0b013e3181e84dc0","article-title":"The impact of tumor volume and radiotherapy dose on outcome in previously irradi- ated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy","volume":"34","author":"Rwigema","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0116","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijrobp.2017.11.045","article-title":"Carotid dosimetry and the risk of carotid blowout syndrome after re-irradiation with head and neck stereotactic body radiation therapy","volume":"101","author":"Gebhardt","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.semradonc.2025.02.009_bib0117","first-page":"975","article-title":"Preliminary experience with endovascular reconstruction for the management of carotid blowout syndrome","volume":"24","author":"Lesley","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"10.1016\/j.semradonc.2025.02.009_bib0118","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.adro.2017.05.007","article-title":"Risk of carotid blowout after reirradiation with particle therapy","volume":"2","author":"Dale","year":"2017","journal-title":"Adv Radiat Oncol"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0119","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.50607","article-title":"Evaluation of proton therapy reirradiation for patients with recurrent head and neck squamous cell carcinoma","volume":"6","author":"Lee","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"8","key":"10.1016\/j.semradonc.2025.02.009_bib0120","first-page":"e43500","article-title":"Effectiveness of robotic stereotactic radiotherapy in patients undergoing re-irradiation: A review","volume":"15","author":"Mohamed Yoosuf","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.semradonc.2025.02.009_bib0121","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3171\/2017.11.JNS172084","article-title":"Stereotactic radiosurgery for trigeminal pain secondary to recurrent malignant skull base tumors","volume":"130","author":"Phan","year":"2019","journal-title":"J Neurosurg"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0122","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1038\/s41598-018-26556-5","article-title":"Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates","volume":"8","author":"Matsuya","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0123","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijrobp.2010.04.027","article-title":"Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors","volume":"81","author":"Cengiz","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0124","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1748-717X-8-242","article-title":"A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers","volume":"8","author":"Yazici","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0125","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ijrobp.2016.02.049","article-title":"Risk of severe toxicity according to site of recurrence in patients treated with stereotactic body radiation therapy for recurrent head and neck cancer","volume":"95","author":"Ling","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 5","key":"10.1016\/j.semradonc.2025.02.009_bib0126","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1245\/s10434-016-5492-9","article-title":"Impact of flap reconstruction on radiotoxicity after salvage surgery and reirradiation for recurrent head and neck cancer","volume":"23","author":"Ho","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.semradonc.2025.02.009_bib0127","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.ijrobp.2007.04.057","article-title":"Intensity-modulated radiotherapy with concurrent chemotherapy for previously irradi- ated, recurrent head and neck cancer","volume":"69","author":"Biagioli","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"20","key":"10.1016\/j.semradonc.2025.02.009_bib0128","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1002\/cncr.25305","article-title":"Efficacy and toxicity of reirradiation using intensity-modulated radiotherapy for recur- rent or second primary head and neck cancer","volume":"116","author":"Sher","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40463-015-0084-4","article-title":"A retrospective study of head and neck re-irradiation for patients with recurrent or second primary head and neck cancer: the McGill University experience","volume":"44","author":"Al-Wassia","year":"2015","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.semradonc.2025.02.009_bib0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13014-016-0630-x","article-title":"Outcomes of patients with loco-regionally recurrent or new primary squamous cell car- cinomas of the head and neck treated with curative intent reirra- diation at Mayo Clinic","volume":"11","author":"Curtis","year":"2016","journal-title":"Radiat Oncol"},{"issue":"4","key":"10.1016\/j.semradonc.2025.02.009_bib0131","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ijrobp.2016.07.037","article-title":"Reirradia- tion of recurrent and second primary head and neck cancer with proton therapy","volume":"96","author":"McDonald","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.semradonc.2025.02.009_bib0132","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijrobp.2020.08.013","article-title":"Single- and multifraction stereotactic radiosurgery dose\/volume tolerances of the brain","volume":"110","author":"Milano","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.semradonc.2025.02.009_bib133","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/hed.24872","article-title":"Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis","volume":"39","author":"Pollard","year":"2017","journal-title":"Head Neck"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105342962500013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105342962500013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:54:43Z","timestamp":1741938883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105342962500013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":133,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S105342962500013X"],"URL":"https:\/\/doi.org\/10.1016\/j.semradonc.2025.02.009","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reirradiation for Locally Recurrent Head and Neck Cancer: State-of-the-Art and Future Directions","name":"articletitle","label":"Article Title"},{"value":"Seminars in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semradonc.2025.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}