{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:58:19Z","timestamp":1792022299365,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["structuralheartjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structural Heart"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.shj.2022.100089","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T04:30:21Z","timestamp":1663216221000},"page":"100089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Left Ventricular Systolic Dysfunction in Aortic Stenosis: Pathophysiology, Diagnosis, Management, and Future Directions"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-1459","authenticated-orcid":false,"given":"Nikolaos","family":"Spilias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trejeeve","family":"Martyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-085X","authenticated-orcid":false,"given":"Kara J.","family":"Denby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge C.","family":"Harb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran B.","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.shj.2022.100089_bib1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1161\/01.CIR.0000015343.76143.13","article-title":"Evaluation and management of patients with aortic stenosis","volume":"105","author":"Carabello","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.hfc.2006.09.010","article-title":"The epidemiology of valvular heart disease: a growing public health problem","volume":"2","author":"Supino","year":"2006","journal-title":"Heart Fail Clin"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/CIRCINTERVENTIONS.113.000650","article-title":"Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the placement of aortic transcatheter valves (PARTNER) trial (cohort A)","volume":"6","author":"Elmariah","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005809","article-title":"Effect of baseline left ventricular ejection fraction on 2-year outcomes after transcatheter aortic valve replacement: analysis of the PARTNER 2 trials","volume":"12","author":"Furer","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.shj.2022.100089_bib5","first-page":"132","article-title":"Transcatheter aortic valve implantation in patients with LV dysfunction: impact on mortality and predictors of LV function recovery","volume":"26","author":"Elhmidi","year":"2014","journal-title":"J\u00a0Invasive Cardiol"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.shj.2022.100089_bib7","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.athoracsur.2009.05.078","article-title":"Aortic valve replacement for aortic stenosis in patients with left ventricular dysfunction","volume":"88","author":"Halkos","year":"2009","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/heartjnl-2014-306737","article-title":"Transcatheter aortic valve replacement and standard therapy in inoperable patients with aortic stenosis and low EF","volume":"101","author":"Passeri","year":"2015","journal-title":"Heart"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.003425","article-title":"Early recovery of left ventricular systolic function after CoreValve transcatheter aortic valve replacement","volume":"9","author":"Dauerman","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"issue":"19","key":"10.1016\/j.shj.2022.100089_bib10","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2017.03.023","article-title":"Prognostic implications of moderate aortic stenosis in patients with left ventricular systolic dysfunction","volume":"69","author":"van Gils","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"22","key":"10.1016\/j.shj.2022.100089_bib11","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/j.jacc.2021.04.014","article-title":"Moderate aortic stenosis in patients with heart failure and reduced ejection fraction","volume":"77","author":"Jean","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.shj.2022.100089_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-039961","article-title":"Impact of transcatheter aortic valve implantation on left ventricular function recovery, mass regression and outcome in patients with aortic stenosis: protocol of the TAVI-NOR prospective study","volume":"11","author":"Mohamed Ali","year":"2021","journal-title":"BMJ Open"},{"issue":"18","key":"10.1016\/j.shj.2022.100089_bib13","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.jcin.2020.04.008","article-title":"Left ventricular hemodynamic changes during transcatheter aortic valve replacement assessed by real-time pressure-volume loops","volume":"13","author":"Yin","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"issue":"1","key":"10.1016\/j.shj.2022.100089_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jaccas.2020.11.041","article-title":"First-in-Man 4-Chamber pressure-volume analysis during transcatheter aortic valve replacement for bicuspid aortic valve disease","volume":"3","author":"Sarraf","year":"2021","journal-title":"JACC Case Rep"},{"issue":"9","key":"10.1016\/j.shj.2022.100089_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nrcardio.2011.80","article-title":"Assessment of left ventricular function in aortic stenosis","volume":"8","author":"Ozkan","year":"2011","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/hrt.2010.192997","article-title":"Prognostic effect of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis","volume":"97","author":"Cioffi","year":"2011","journal-title":"Heart"},{"issue":"19","key":"10.1016\/j.shj.2022.100089_bib17","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and the myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.shj.2022.100089_bib18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","article-title":"Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms","volume":"107","author":"Hein","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/hrt.2005.062422","article-title":"Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: a transthoracic Doppler and myocardial contrast echocardiography study","volume":"92","author":"Galiuto","year":"2006","journal-title":"Heart"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.81.2.187","article-title":"Hemodynamic regulation of tumor necrosis factor-alpha gene and protein expression in adult feline myocardium","volume":"81","author":"Kapadia","year":"1997","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.shj.2022.100089_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0735-1097(00)00721-X","article-title":"Elevated circulating levels of serum tumor necrosis factor-alpha in patients with hemodynamically significant pressure and volume overload","volume":"36","author":"Kapadia","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib22","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/CIRCULATIONAHA.104.516963","article-title":"Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart","volume":"112","author":"Heymans","year":"2005","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.shj.2022.100089_bib23","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jcmg.2016.10.007","article-title":"Myocardial fibrosis and cardiac decompensation in aortic stenosis","volume":"10","author":"Chin","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"issue":"8 Pt 1","key":"10.1016\/j.shj.2022.100089_bib24","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jcmg.2019.02.034","article-title":"Multimodality imaging markers of adverse myocardial remodeling in aortic stenosis","volume":"12","author":"Treibel","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"5","key":"10.1016\/j.shj.2022.100089_bib25","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.ijcard.2012.06.012","article-title":"Longitudinal left ventricular 2D strain is superior to ejection fraction in predicting myocardial recovery and symptomatic improvement after aortic valve implantation","volume":"167","author":"Kempny","year":"2013","journal-title":"Int J Cardiol"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib26","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/CIRCIMAGING.114.002041","article-title":"Incremental prognostic value of left ventricular global longitudinal strain in patients with aortic stenosis and preserved ejection fraction","volume":"7","author":"Kusunose","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"issue":"11","key":"10.1016\/j.shj.2022.100089_bib27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.echo.2014.07.001","article-title":"Recovery of left ventricular mechanics after transcatheter aortic valve implantation: effects of baseline ventricular function and postprocedural aortic regurgitation","volume":"27","author":"Poulin","year":"2014","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.shj.2022.100089_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.777206","article-title":"Left ventricular mechanics differ in subtypes of aortic stenosis following transcatheter aortic valve replacement","volume":"8","author":"Wani","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"19","key":"10.1016\/j.shj.2022.100089_bib29","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.jacc.2020.03.042","article-title":"Regression of left ventricular mass after transcatheter aortic valve replacement: the PARTNER trials and registries","volume":"75","author":"Chau","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.shj.2022.100089_bib30","first-page":"847","article-title":"Predictors of left ventricular ejection fraction recovery after transcatheter aortic valve replacement (TAVR)","volume":"42","author":"Aventin","year":"2021","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.shj.2022.100089_bib31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s10554-018-1401-6","article-title":"Less pronounced reverse left ventricular remodeling in patients with bicuspid aortic stenosis treated with transcatheter aortic valve replacement compared to tricuspid aortic stenosis","volume":"34","author":"Xiong","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"issue":"14","key":"10.1016\/j.shj.2022.100089_bib32","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1161\/CIRCULATIONAHA.105.568824","article-title":"Influence of preoperative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis","volume":"113","author":"Quere","year":"2006","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.shj.2022.100089_bib33","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jacc.2018.01.054","article-title":"Transcatheter aortic valve replacement in patients with low-flow, low-gradient aortic stenosis: the TOPAS-TAVI registry","volume":"71","author":"Ribeiro","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib34","article-title":"Contemporary outcomes in low-gradient aortic stenosis patients who underwent dobutamine stress echocardiography","volume":"8","author":"Sato","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.shj.2022.100089_bib35","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1253\/circj.CJ-15-1309","article-title":"Native T1 relaxation time and extracellular volume fraction as accurate markers of diffuse myocardial fibrosis in heart valve disease - comparison with targeted left ventricular myocardial biopsy","volume":"80","author":"Kockova","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.shj.2022.100089_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijcard.2018.02.029","article-title":"Role of T2 mapping in left ventricular reverse remodeling after TAVR","volume":"266","author":"Gastl","year":"2018","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jacc.2020.11.006","article-title":"Prevalence and outcomes of concomitant aortic stenosis and cardiac amyloidosis","volume":"77","author":"Nitsche","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"38","key":"10.1016\/j.shj.2022.100089_bib38","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Casta\u00f1o","year":"2017","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/ehjci\/jeaa310","article-title":"Computed tomography angiography-derived extracellular volume fraction predicts early recovery of left ventricular systolic function after transcatheter aortic valve replacement","volume":"22","author":"Han","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib40","first-page":"346","article-title":"Prognostic impact of electrocardiographic left ventricular hypertrophy following transcatheter aortic valve replacement","volume":"77","author":"Tanaka","year":"2021","journal-title":"J\u00a0Cardiol"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib41","article-title":"Implication of different ECG left ventricular hypertrophy in patients undergoing transcatheter aortic valve replacement","volume":"11","author":"Yang","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.shj.2022.100089_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.amjcard.2015.03.054","article-title":"Impact on left ventricular function and remodeling and on 1-year outcome in patients with left bundle branch block after transcatheter aortic valve implantation","volume":"116","author":"Carrabba","year":"2015","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/clc.23138","article-title":"B-type natriuretic peptide is associated with remodeling and exercise capacity after transcatheter aortic valve replacement for aortic stenosis","volume":"42","author":"Sato","year":"2019","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.shj.2022.100089_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijcard.2018.05.020","article-title":"Cytokines profile of reverse cardiac remodeling following transcatheter aortic valve replacement","volume":"270","author":"Kim","year":"2018","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.shj.2022.100089_bib45","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/jamacardio.2021.2082","article-title":"Prevention and mitigation of heart failure in the treatment of calcific aortic stenosis: a unifying therapeutic principle","volume":"6","author":"Lindman","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"9386","key":"10.1016\/j.shj.2022.100089_bib46","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(03)14285-7","article-title":"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-preserved trial","volume":"362","author":"Yusuf","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.shj.2022.100089_bib47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"325","author":"Yusuf","year":"1991","journal-title":"N\u00a0Engl J Med"},{"issue":"23","key":"10.1016\/j.shj.2022.100089_bib48","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198706043162301","article-title":"Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)","volume":"316","year":"1987","journal-title":"N\u00a0Engl J Med"},{"issue":"18","key":"10.1016\/j.shj.2022.100089_bib49","article-title":"Renin-angiotensin system blockade in aortic stenosis: implications before and after aortic valve replacement","volume":"9","author":"Goel","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib50","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jacc.2017.12.035","article-title":"Reverse myocardial remodeling following valve replacement in patients with aortic stenosis","volume":"71","author":"Treibel","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.shj.2022.100089_bib51","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.amjcard.2010.04.028","article-title":"Effect of candesartan treatment on left ventricular remodeling after aortic valve replacement for aortic stenosis","volume":"106","author":"Dahl","year":"2010","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.shj.2022.100089_bib52","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jcmg.2019.09.005","article-title":"Plasma ACE2 activity predicts mortality in aortic stenosis and is associated with severe myocardial fibrosis","volume":"13","author":"Ramchand","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.shj.2022.100089_bib53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cardfail.2009.01.014","article-title":"Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes","volume":"15","author":"Epelman","year":"2009","journal-title":"J\u00a0Card Fail"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib54","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/archinte.165.8.858","article-title":"Angiotensin-converting enzyme inhibitors and change in aortic valve calcium","volume":"165","author":"O'Brien","year":"2005","journal-title":"Arch Intern Med"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib55","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/ehjci\/jev043","article-title":"A\u00a0prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor ramipril in aortic stenosis (RIAS trial)","volume":"16","author":"Bull","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"8","key":"10.1016\/j.shj.2022.100089_bib56","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/heartjnl-2017-311738","article-title":"Renin-angiotensin system blockade therapy after transcatheter aortic valve implantation","volume":"104","author":"Ochiai","year":"2018","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.shj.2022.100089_bib57","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jacc.2019.05.055","article-title":"Renin-angiotensin system inhibition following transcatheter aortic valve replacement","volume":"74","author":"Rodriguez-Gabella","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"21","key":"10.1016\/j.shj.2022.100089_bib58","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1001\/jama.2018.18077","article-title":"Association of renin-angiotensin inhibitor treatment with mortality and heart failure readmission in patients with transcatheter aortic valve replacement","volume":"320","author":"Inohara","year":"2018","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.shj.2022.100089_bib59","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020255","article-title":"Impact of renin-angiotensin system inhibitors on clinical outcomes and ventricular remodelling after transcatheter aortic valve implantation: rationale and design of the RASTAVI randomised multicentre study","volume":"8","author":"Amat-Santos","year":"2018","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.shj.2022.100089_bib60","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ejhf.2370","article-title":"Dapagliflozin after transcatheter aortic valve implantation (DapaTAVI) Investigators. Rationale and design of the dapagliflozin after transcatheter aortic valve implantation (DapaTAVI) randomized trial","volume":"24","author":"Amat-Santos","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"45","key":"10.1016\/j.shj.2022.100089_bib61","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"issue":"28","key":"10.1016\/j.shj.2022.100089_bib62","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1093\/eurheartj\/ehv701","article-title":"Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction","volume":"37","author":"Samad","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.shj.2022.100089_bib63","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ahj.2016.08.009","article-title":"Rationale and design of the Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure (TAVR UNLOAD) trial","volume":"182","author":"Spitzer","year":"2016","journal-title":"Am Heart J"},{"issue":"6","key":"10.1016\/j.shj.2022.100089_bib64","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.athoracsur.2006.07.043","article-title":"Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement","volume":"82","author":"Pai","year":"2006","journal-title":"Ann Thorac Surg"},{"issue":"25","key":"10.1016\/j.shj.2022.100089_bib65","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.jacc.2015.10.001","article-title":"Initial surgical versus conservative strategies in patients with asymptomatic severe aortic stenosis","volume":"66","author":"Taniguchi","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.shj.2022.100089_bib66","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcmg.2018.11.005","article-title":"Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta-analysis","volume":"12","author":"Magne","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.shj.2022.100089_bib67","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009958","article-title":"Left ventricular global longitudinal strain is associated with long-term outcomes in moderate aortic stenosis","volume":"13","author":"Zhu","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"issue":"34","key":"10.1016\/j.shj.2022.100089_bib68","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/eurheartj\/ehu189","article-title":"High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis","volume":"35","author":"Chin","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.shj.2022.100089_bib69","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ahj.2019.02.018","article-title":"Rationale and design of the randomized, controlled early valve replacement guided by biomarkers of left ventricular decompensation in asymptomatic patients with severe aortic stenosis (EVOLVED) trial","volume":"212","author":"Bing","year":"2019","journal-title":"Am Heart J"},{"issue":"2 Pt 1","key":"10.1016\/j.shj.2022.100089_bib70","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jcmg.2019.01.036","article-title":"Management of asymptomatic severe aortic stenosis: evolving concepts in timing of valve replacement","volume":"13","author":"Lindman","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"11","key":"10.1016\/j.shj.2022.100089_bib71","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamacardio.2018.3152","article-title":"Outcomes of patients with asymptomatic aortic stenosis followed up in heart valve clinics","volume":"3","author":"Lancellotti","year":"2018","journal-title":"JAMA Cardiol"}],"container-title":["Structural Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2474870622018796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2474870622018796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:15:09Z","timestamp":1762863309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2474870622018796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2474870622018796"],"URL":"https:\/\/doi.org\/10.1016\/j.shj.2022.100089","relation":{},"ISSN":["2474-8706"],"issn-type":[{"value":"2474-8706","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left Ventricular Systolic Dysfunction in Aortic Stenosis: Pathophysiology, Diagnosis, Management, and Future Directions","name":"articletitle","label":"Article Title"},{"value":"Structural Heart","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.shj.2022.100089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc. on behalf of Cardiovascular Research Foundation.","name":"copyright","label":"Copyright"}],"article-number":"100089"}}