{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:53:02Z","timestamp":1791409982793,"version":"4.3.3"},"reference-count":3,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","structuralheartjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structural Heart"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.shj.2026.101126","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:16:49Z","timestamp":1789024609000},"page":"101126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimands in Cardiovascular Device Trials: What Are They and Why Do They Matter?"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-5014","authenticated-orcid":false,"given":"Andrew D.","family":"Althouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-0054","authenticated-orcid":false,"given":"Graeme L.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.shj.2026.101126_bib1","unstructured":"ICH E9 Statistical Principles for Clinical Trials. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-e-9-statistical-principles-clinical-trials-step-5_en.pdf"},{"key":"10.1016\/j.shj.2026.101126_bib2","unstructured":"ICH E9 (R1) Addendum on Estimands and Sensitivity Analysis in Clinical Trials to the Guideline on Statistical Principles for Clinical Trials. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-e9-r1-addendum-estimands-sensitivity-analysis-clinical-trials-guideline-statistical-principles_en.pdf"},{"key":"10.1016\/j.shj.2026.101126_bib3","unstructured":"ISO 14155:2026 - Clinical investigation of medical devices for human subjects - Good clinical practice (4th ed.). Geneva: International Organization for Standardization. Available from: https:\/\/www.iso.org\/standard\/83968.html."}],"container-title":["Structural Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2474870626003350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2474870626003350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:34:28Z","timestamp":1791408868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2474870626003350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":3,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2474870626003350"],"URL":"https:\/\/doi.org\/10.1016\/j.shj.2026.101126","relation":{},"ISSN":["2474-8706"],"issn-type":[{"value":"2474-8706","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estimands in Cardiovascular Device Trials: What Are They and Why Do They Matter?","name":"articletitle","label":"Article Title"},{"value":"Structural Heart","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.shj.2026.101126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Cardiovascular Research Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101126"}}