{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:15:49Z","timestamp":1789078549367,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.siny.2008.02.006","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T19:37:47Z","timestamp":1207942667000},"page":"215-222","source":"Crossref","is-referenced-by-count":29,"title":["Alpha-thalassaemia"],"prefix":"10.1016","volume":"13","author":[{"given":"W.C.","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.Y.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.Y.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2008.02.006_bib1","unstructured":"Bouljenkov V. Epidemiology of haemoglobinopathies. In WHO Regional Working Group on the Prevention and Control of Thalassemia in Asia, Bangkok, Thailand; 1994."},{"key":"10.1016\/j.siny.2008.02.006_bib2","series-title":"Disorders of hemoglobin: genetics, pathophysiology and clinical management","first-page":"117","article-title":"Molecular genetics of the human globin genes","author":"Forget","year":"2001"},{"key":"10.1016\/j.siny.2008.02.006_bib3","series-title":"Disorders of hemoglobin: genetics, pathophysiology and clinical management","first-page":"405","article-title":"Molecular mechanisms of \u03b1-thalassemia","author":"Higgs","year":"2001"},{"key":"10.1016\/j.siny.2008.02.006_bib4","series-title":"Disorders of hemoglobin: genetics, pathophysiology and clinical management","first-page":"431","article-title":"Clinical and laboratory features of the \u03b1-thalassemia syndromes","author":"Higgs","year":"2001"},{"key":"10.1016\/j.siny.2008.02.006_bib5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJM200008243430804","article-title":"Genetic and clinical features of hemoglobin H disease in Chinese patients","volume":"343","author":"Chen","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2008.02.006_bib6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1182\/blood.V59.2.370.370","article-title":"Hb Bart's level in cord blood and deletions of \u03b1-globin genes","volume":"59","author":"Lie-Injo","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.siny.2008.02.006_bib7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1471-0528.1985.tb01447.x","article-title":"Homozygous alpha-thalassaemia: clinical presentation, diagnosis and management. A review of 46 cases","volume":"92","author":"Liang","year":"1985","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.siny.2008.02.006_bib8","unstructured":"World Health Organization. Hereditary disease programme database. http:\/\/www.who.int\/ncd\/hgn\/."},{"key":"10.1016\/j.siny.2008.02.006_bib9","first-page":"244","article-title":"Prevention of beta-thalassemia major and Hb Bart's hydrops fetalis syndrome","volume":"32","author":"Beris","year":"1995","journal-title":"Semin Hematol"},{"key":"10.1016\/j.siny.2008.02.006_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1447-0756.2000.tb01312.x","article-title":"Ten years' experience of antenatal mean corpuscular volume screening and prenatal diagnosis for thalassaemias in Hong Kong","volume":"26","author":"Sin","year":"2000","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.siny.2008.02.006_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0002-9378(84)80134-9","article-title":"A screening protocol for a prenatal population at risk for hemoglobin disorders. Results of its application to a group of southeast Asians and blacks","volume":"150","author":"Stein","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0002-9378(79)90648-3","article-title":"Thalassemia and pregnancy: result of an antenatal screening program","volume":"134","author":"Alger","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib13","first-page":"1310","article-title":"Thalassaemia screening based on red cell indices in the Chinese","volume":"86","author":"Ma","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.siny.2008.02.006_bib14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/jcp.48.9.861","article-title":"Comparison of haemoglobin H inclusion bodies with embryonic zeta globin in screening for alpha thalassaemia","volume":"48","author":"Chan","year":"1995","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.siny.2008.02.006_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1182\/blood.V66.1.224.224","article-title":"Hydrops fetalis due to an unusual form of Hb H disease","volume":"66","author":"Chan","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.siny.2008.02.006_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1365-2141.1997.d01-2017.x","article-title":"Molecular defects in Hb H hydrops fetalis","volume":"96","author":"Chan","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.siny.2008.02.006_bib17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2002-07-1975","article-title":"Hemoglobin H disease: not necessarily a benign disorder","volume":"101","author":"Chui","year":"2003","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.siny.2008.02.006_bib18","first-page":"1","article-title":"Prenatal diagnosis and screening of common genetic diseases in Hong Kong","volume":"26","author":"Chan","year":"1995","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.siny.2008.02.006_bib19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJM197405092901908","article-title":"In utero diagnosis of hemoglobinopathies. Technic for obtaining fetal blood","volume":"290","author":"Hobbins","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2008.02.006_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0140-6736(74)92293-4","article-title":"Fetal blood-sampling in utero","volume":"1","author":"Kan","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2008.02.006_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2141.1980.tb05914.x","article-title":"Prenatal diagnosis of beta thalassaemia by fetal red cell enrichment with NH4-Cl-NH4HCO3 differential lysis of maternal cells","volume":"44","author":"Furbetta","year":"1980","journal-title":"Br J Haematol"},{"key":"10.1016\/j.siny.2008.02.006_bib22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1974.tb20579.x","article-title":"Intrauterine diagnosis of thalassemia","volume":"232","author":"Kan","year":"1974","journal-title":"Ann N Y Acad Sci"},{"issue":"26","key":"10.1016\/j.siny.2008.02.006_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1182\/blood.V64.2.329.329","article-title":"Advances in the prenatal diagnosis of hematologic diseases","volume":"64","author":"Alter","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.siny.2008.02.006_bib24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jama.236.13.1471","article-title":"Mid-trimester amniocentesis for prenatal diagnosis","volume":"236","author":"NICHD National registry for amniocentesis study group","year":"1976","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.siny.2008.02.006_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJM197807272990403","article-title":"Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion","volume":"299","author":"Orkin","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2008.02.006_bib26","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nprot.2006.73","article-title":"Southern blotting","volume":"1","author":"Southern","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.siny.2008.02.006_bib27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/bmj.288.6427.1327","article-title":"Prenatal diagnosis of homozygous alpha thalassaemia by direct DNA analysis of uncultured amniotic fluid cells","volume":"288","author":"Chan","year":"1984","journal-title":"Br Med J"},{"key":"10.1016\/j.siny.2008.02.006_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1399-0004.1995.tb03972.x","article-title":"Detection of alpha-thalassemia-1 (Southeast Asian type) and its application for prenatal diagnosis","volume":"47","author":"Winichagoon","year":"1995","journal-title":"Clin Genet"},{"key":"10.1016\/j.siny.2008.02.006_bib29","first-page":"173","article-title":"Prenatal diagnosis of common single gene disorders by DNA technology","volume":"3","author":"Chan","year":"1997","journal-title":"Hong Kong Med J"},{"key":"10.1016\/j.siny.2008.02.006_bib30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/(SICI)1097-0223(199706)17:6<505::AID-PD104>3.0.CO;2-R","article-title":"Misdiagnosis of homozygous alpha-thalassaemia 1 may occur if polymerase chain reaction alone is used in prenatal diagnosis","volume":"17","author":"Ko","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2141.2001.03112.x","article-title":"Quantitative polymerase chain reaction for the rapid prenatal diagnosis of homozygous alpha-thalassaemia (Hb Bart's hydrops fetalis)","volume":"115","author":"Chan","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.siny.2008.02.006_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2141.2000.01870.x","article-title":"Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions","volume":"108","author":"Liu","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.siny.2008.02.006_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<327::AID-PD67>3.0.CO;2-N","article-title":"Early ultrasound prediction of pregnancies affected by homozygous \u03b1-thalassemia-1","volume":"17","author":"Lam","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0002-9378(99)70165-1","article-title":"Prenatal ultrasonographic prediction of homozygous type 1 alpha-thalassemia at 12\u201313 weeks of gestation","volume":"180","author":"Lam","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/uog.2720","article-title":"A new strategy for prenatal diagnosis of homozygous alpha-thalassaemia","volume":"28","author":"Leung","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib36","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/pd.1035","article-title":"Cost-effectiveness of prenatal screening for thalassemia in Hong Kong","volume":"24","author":"Leung","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/uog.1829","article-title":"Prenatal diagnosis of alpha-thalassaemia in a twin pregnancy","volume":"25","author":"Leung","year":"2005","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib38","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/pd.1550","article-title":"Experience in preimplantation genetic diagnosis for exclusion of homozygous \u03b1\u00b0 thalassemia","volume":"26","author":"Chan","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/pd.1970070503","article-title":"Ultrasound evaluation of pregnancies at risk for homozygous alpha-thalassaemia-1","volume":"7","author":"Ghosh","year":"1987","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0140-6736(94)91644-6","article-title":"Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous \u03b1-thalassemia-1","volume":"344","author":"Ghosh","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2008.02.006_bib41","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1027::AID-PD691>3.0.CO;2-C","article-title":"Placental thickness at midpregnancy as a predictor of Hb Bart's disease","volume":"19","author":"Tongsong","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.7863\/jum.1999.18.12.807","article-title":"Fetal sonographic cardiothoracic ratio at midpregnancy as a predictor of Hb Bart disease","volume":"18","author":"Tongsong","year":"1999","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.siny.2008.02.006_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.7863\/jum.2004.23.1.49","article-title":"Sonographic markers of hemoglobin Bart disease at midpregnancy","volume":"23","author":"Tongsong","year":"2004","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.siny.2008.02.006_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/pd.237","article-title":"Middle cerebral artery Doppler study in fetuses with homozygous \u03b1-thalassemia-1 at 12\u201313 weeks of gestation","volume":"22","author":"Lam","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib45","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/uog.1009","article-title":"Fetal middle cerebral artery peak systolic velocity in the investigation of non-immune hydrops","volume":"23","author":"Hernandez-Andrade","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.0960-7692.2001.00498.x","article-title":"Serial sonographic findings of four fetuses with homozygous alpha-thalassemia-1 from 21 weeks onwards","volume":"19","author":"Leung","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib47","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/uog.2721","article-title":"Use of placental volume measured by three-dimensional ultrasound for the prediction of fetal Hb-Bart's disease: a preliminary report","volume":"28","author":"Chen","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/uog.1051","article-title":"Detection of increased middle cerebral artery peak systolic velocity in fetuses affected by hemoglobin H Quong Sze disease","volume":"23","author":"Leung","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2008.02.006_bib49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/pd.1096","article-title":"Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood","volume":"25","author":"Lau","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib50","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1073\/pnas.81.19.6188","article-title":"Human embryonic zeta-globin chains in adult patients with alpha-thalassemias","volume":"81","author":"Chung","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.siny.2008.02.006_bib51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1373\/clinchem.2006.075085","article-title":"Microsatellite markers within-SEA breakpoints for prenatal diagnosis of Hb Barts hydrops fetalis","volume":"53","author":"Ho","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.siny.2008.02.006_bib52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1471-4914(00)01867-0","article-title":"Preimplantation genetic diagnosis: applications for molecular medicine","volume":"7","author":"Wells","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.siny.2008.02.006_bib53","first-page":"203","article-title":"Preimplantation genetic diagnosis of alpha-thalassemia by blastomere aspiration and polymerase chain reaction: preliminary experience","volume":"95","author":"Chang","year":"1996","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.siny.2008.02.006_bib54","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/pd.170","article-title":"Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR","volume":"21","author":"Piyamongkol","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib55","unstructured":"Li XH, Zhuang GL, Zhou CQ, Cheng G, Shu YM, Zeng RP. Preimplantation genetic diagnosis of human embryos with \u03b1-thalassemia. The first conference of reproductive medicine of Mainland China, Hong Kong and Taiwan, Zhuhai, China; 2000; p. 0\u201310."},{"key":"10.1016\/j.siny.2008.02.006_bib56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01130810","article-title":"Reliability of gender determination using the polymerase chain reaction (PCR) for single cells","volume":"8","author":"Strom","year":"1991","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"10.1016\/j.siny.2008.02.006_bib57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/molehr\/2.3.213","article-title":"Increasing the denaturation temperature during the first cycles of amplification reduces allele dropout from single cells for preimplantation genetic diagnosis","volume":"2","author":"Ray","year":"1996","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib58","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(05)60535-1","article-title":"Diagnosis of spinal muscular atrophy from fetal normoblasts in maternal blood","volume":"352","author":"Chan","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2008.02.006_bib59","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/molehr\/gah101","article-title":"Isothermal whole genome amplification from single and small numbers of cells: a new era for preimplantation genetic diagnosis of inherited disease","volume":"10","author":"Handyside","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib60","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/molehr\/gah114","article-title":"Multiple displacement amplification on single cell and possible PGD applications","volume":"10","author":"Hellani","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib61","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/oxfordjournals.humrep.a137173","article-title":"Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage","volume":"5","author":"Hardy","year":"1990","journal-title":"Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib62","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/pd.1051","article-title":"Preimplantation genetic diagnosis for beta-thalassaemia: the Sardinian experience","volume":"24","author":"Monni","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2008.02.006_bib63","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/del402","article-title":"ESHRE PGD consortium data collection VI: cycles from January to December 2003 with pregnancy follow-up to October 2004","volume":"22","author":"Sermon","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib64","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.fertnstert.2003.09.082","article-title":"Over a decade of experience with preimplantation genetic diagnosis: a multicenter report","volume":"82","author":"Verlinsky","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.siny.2008.02.006_bib65","doi-asserted-by":"crossref","unstructured":"Verlinsky Y, Kuliev A. Present status of preimplantation diagnosis. In international seminar on preimplantation HLA typing and stem cell transplantation, Cyprus, March 2004, Abs 0\u20135.","DOI":"10.1201\/b14655"},{"key":"10.1016\/j.siny.2008.02.006_bib66","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/molehr\/8.5.502","article-title":"Single cell CGH analysis reveals a high degree of mosaicism in human embryos from patients with balanced structural chromosome aberrations","volume":"8","author":"Malmgren","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.siny.2008.02.006_bib67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000204686","article-title":"Long-term survival of a baby with homozygous alpha-thalassaemia-1","volume":"88","author":"Lam","year":"1992","journal-title":"Acta Haematol"},{"key":"10.1016\/j.siny.2008.02.006_bib68","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.1651-2227.2005.tb02096.x","article-title":"Neurodevelopmental outcome and haematological course of a long-time survivor with homozygous alpha-thalassaemia: case report and review of the literature","volume":"94","author":"Lucke","year":"2005","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.siny.2008.02.006_bib69","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/sj.bmt.1703104","article-title":"Successful mismatched sibling cord blood transplant in Hb Bart's disease","volume":"28","author":"Zhou","year":"2001","journal-title":"Bone Marrow Transplant"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X0800022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X0800022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:19:50Z","timestamp":1684343990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X0800022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1744165X0800022X"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2008.02.006","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}