{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:55:07Z","timestamp":1773420907159,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.siny.2008.08.008","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T09:31:59Z","timestamp":1222939919000},"page":"35-41","source":"Crossref","is-referenced-by-count":26,"title":["Automated respiratory support in newborn infants"],"prefix":"10.1016","volume":"14","author":[{"given":"Nelson","family":"Claure","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Bancalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2008.08.008_bib1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0146-0005(03)00056-9","article-title":"Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network","volume":"27","author":"St John","year":"2003","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0146-0005(03)00055-7","article-title":"The NICHD neonatal research network: changes in practice and outcomes during the first 15 years","volume":"27","author":"Fanaroff","year":"2003","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib3","first-page":"241","article-title":"Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease","volume":"82","author":"Taghizadeh","year":"1976","journal-title":"Am J Pathol"},{"key":"10.1016\/j.siny.2008.08.008_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-3476(05)80746-2","article-title":"Multivariate assessment of traditional risk factors for chronic lung disease in very low birth weight neonates","volume":"119","author":"Palta","year":"1991","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib5","first-page":"819","article-title":"Chronic lung disease: the role of oxidative stress","volume":"87","author":"Saugstad","year":"1998","journal-title":"Biol Neonat"},{"key":"10.1016\/j.siny.2008.08.008_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1084-2756(98)80008-0","article-title":"Free radical disease in neonatology","volume":"3","author":"Saugstad","year":"1998","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.siny.2008.08.008_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1203\/00006450-199103000-00014","article-title":"Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: increased susceptibility to pulmonary oxygen toxicity compared with term rabbits","volume":"29","author":"Frank","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2008.08.008_bib8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0095-5108(18)30683-3","article-title":"Retinopathy of prematurity: what causes it?","volume":"15","author":"Avery","year":"1988","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib9","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1542\/peds.2005-0249","article-title":"Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia","volume":"116","author":"Ehrenkranz","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib10","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jpeds.2005.01.047","article-title":"National Institutes of Child Health and Human Development Neonatal Research Network. Extremely low birth weight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomes","volume":"146","author":"Walsh","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib11","first-page":"127","article-title":"Neurodevelopmental status of low birth weight infants with bronchopulmonary dysplasia requiring prolonged oxygen supplementation","volume":"7","author":"Lifschitz","year":"1987","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib12","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jama.289.9.1124","article-title":"Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms","volume":"289","author":"Schmidt","year":"2003","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.siny.2008.08.008_bib13","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0022-3476(97)70042-8","article-title":"Computer controlled minute ventilation in preterm infants undergoing mechanical ventilation","volume":"131","author":"Claure","year":"1997","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.jp.7211371","article-title":"A crossover analysis of mandatory minute ventilation compared to synchronized intermittent mandatory ventilation in neonates","volume":"25","author":"Guthrie","year":"2005","journal-title":"J Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00134-005-0003-7","article-title":"Adaptive mechanical backup ventilation for preterm infants on respiratory assist modes \u2013 a pilot study","volume":"32","author":"Herber-Jonat","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.siny.2008.08.008_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0022-3476(95)70171-0","article-title":"Mechanisms for episodes of hypoxemia in preterm infants undergoing mechanical ventilation","volume":"127","author":"Bolivar","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000102056","article-title":"The role of abdominal muscle activity on the duration and severity of hypoxemia episodes in mechanically ventilated preterm infants","volume":"92","author":"Esquer","year":"2007","journal-title":"Neonatology"},{"key":"10.1016\/j.siny.2008.08.008_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00134-006-0079-8","article-title":"Volume-controlled intermittent mandatory ventilation in preterm infants with hypoxemic episodes","volume":"32","author":"Hummler","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.siny.2008.08.008_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000088198","article-title":"Effects of volume-targeted synchronized intermittent mandatory ventilation on spontaneous episodes of hypoxemia in preterm infants","volume":"89","author":"Polimeni","year":"2006","journal-title":"Biol Neonate"},{"key":"10.1016\/j.siny.2008.08.008_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000153097","article-title":"Targeted minute ventilation and tidal volume in an animal model of acute changes in lung mechanics and episodes of hypoxemia","volume":"95","author":"Claure","year":"2009","journal-title":"Neonatology"},{"key":"10.1016\/j.siny.2008.08.008_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.jp.7211500","article-title":"Pulse oximetry in very low birth weight infants: can oxygen saturation be maintained in the desired range?","volume":"26","author":"Laptook","year":"2006","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.siny.2008.08.008_bib22","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1542\/peds.2005-0413","article-title":"AVIOx Study Group. Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study","volume":"118","author":"Hagadorn","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1542\/peds.2006-3099","article-title":"Compliance with alarm limits for pulse oximetry in very preterm infants","volume":"119","author":"Clucas","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib24","first-page":"635","article-title":"Clinically unsuspected hypoxia during sleep and feeding in infants with bronchopulmonary dysplasia","volume":"81","author":"Garg","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/ppul.1950130303","article-title":"Spontaneous desaturations in intubated very low birth weight infants with acute and chronic lung disease","volume":"13","author":"Durand","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.siny.2008.08.008_bib26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-3476(97)70242-7","article-title":"Characteristics of hypoxemic episodes in very low birth weight infants on ventilatory support","volume":"130","author":"Dimaguila","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1067\/mpd.2002.127277","article-title":"Relation of sleep state to hypoxemic episodes in ventilated extremely-low-birth-weight infants","volume":"141","author":"Lehtonen","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1203\/00006450-199412000-00007","article-title":"Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat","volume":"36","author":"Penn","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2008.08.008_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00920938","article-title":"The progression of retinopathy of prematurity and fluctuation in blood gas tension","volume":"231","author":"Saito","year":"1993","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.siny.2008.08.008_bib30","first-page":"3169","article-title":"Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat","volume":"35","author":"Reynaud","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.siny.2008.08.008_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.73.1.1","article-title":"Effects of marginal hypoxemia on recovery from oxygen-induced retinopathy in the kitten model","volume":"73","author":"Phelps","year":"1984","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib32","first-page":"4275","article-title":"A novel model of retinopathy of prematurity simulating preterm oxygen variability in the rat","volume":"41","author":"Cunningham","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.siny.2008.08.008_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1203\/01.PDR.0000099772.66376.02","article-title":"Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity","volume":"55","author":"McColm","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2008.08.008_bib34","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0022-3476(89)80855-8","article-title":"Hypoxic airway constriction in infants of very low birth weight recovering from moderate to severe bronchopulmonary dysplasia","volume":"115","author":"Tay-Uyboco","year":"1989","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1152\/jappl.1977.43.4.662","article-title":"Potentiation of pulmonary vasoconstrictor response with repeated intermittent hypoxia","volume":"43","author":"Unger","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.siny.2008.08.008_bib36","first-page":"326","article-title":"Influence of alveolar oxygen on pulmonary vasoconstriction in newborn lambs versus sheep","volume":"132","author":"Custer","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.siny.2008.08.008_bib37","first-page":"687","article-title":"Importance of multiple episodes of hypoxia or cold stress on the development of enterocolitis in an animal model","volume":"77","author":"Barlow","year":"1975","journal-title":"Surgery"},{"key":"10.1016\/j.siny.2008.08.008_bib38","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/adc.54.4.278","article-title":"New technique for servo-control of arterial oxygen tension in preterm infants","volume":"54","author":"Beddis","year":"1979","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.siny.2008.08.008_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1088\/0143-0815\/9\/4\/001","article-title":"Closed-loop control of the partial pressure of arterial oxygen in neonates","volume":"9","author":"Dugdale","year":"1988","journal-title":"Clin Phys Physiol Meas"},{"key":"10.1016\/j.siny.2008.08.008_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ppul.1950140209","article-title":"Adaptive control of the inspired oxygen delivery to the neonate","volume":"14","author":"Bhutani","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.siny.2008.08.008_bib41","first-page":"117","article-title":"Closed-loop control of SaO2 in the neonate","volume":"26","author":"Morozoff","year":"1992","journal-title":"Biomed Instrum Technol"},{"key":"10.1016\/j.siny.2008.08.008_bib42","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0022-3476(97)70107-0","article-title":"Computer-assisted adjustment of inspired oxygen concentration improves control of oxygen saturation in newborn infants requiring mechanical ventilation","volume":"131","author":"Sun","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2008.08.008_bib43","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1542\/peds.107.5.1120","article-title":"Closed-loop controlled inspired oxygen concentration for mechanically ventilated very low birth weight infants with frequent episodes of hypoxemia","volume":"107","author":"Claure","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib44","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1164\/rccm.200407-929OC","article-title":"Automatic control of the inspired oxygen fraction in preterm infants: a randomized crossover trial","volume":"170","author":"Urschitz","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2008.08.008_bib45","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1542\/peds.112.6.1415","article-title":"Resolving our uncertainty about oxygen therapy","volume":"112","author":"Cole","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib46","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1542\/peds.2006-2200","article-title":"Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research","volume":"119","author":"Higgins","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2008.08.008_bib47_1","doi-asserted-by":"crossref","first-page":"F143","DOI":"10.1136\/adc.2005.092726","article-title":"Optimum oxygen therapy in preterm babies","volume":"92","author":"Tin","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X08001066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X08001066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T06:15:49Z","timestamp":1684563349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X08001066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1744165X08001066"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2008.08.008","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}