{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:06:29Z","timestamp":1761681989894,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.siny.2011.07.002","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T16:54:06Z","timestamp":1312649646000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Old and new antithrombotic drugs in neonates and infants"],"prefix":"10.1016","volume":"16","author":[{"given":"Guy","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2011.07.002_bib1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.thromres.2010.10.009","article-title":"Neonatal systemic venous thrombosis","volume":"126","author":"Yank","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.siny.2011.07.002_bib2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1542\/peds.2009-0768","article-title":"Dramatic increase in venous thromboembolism in children\u2019s hospitals in the United States from 2001\u20132007","volume":"124","author":"Raffini","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2011.07.002_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1378\/chest.08-0762","article-title":"Antithrombotic therapy in neonates and children: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"133","author":"Monagle","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.siny.2011.07.002_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/014860710803200188","article-title":"Thromboembolism in infants and children with gastrointestinal failure receiving long-term parenteral nutrition","volume":"32","author":"Kakzanov","year":"2008","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.siny.2011.07.002_bib5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1160\/TH04-02-0131","article-title":"A\u00a0case series of 72 infants with renal vein thrombosis. Data from the 1-800-NO-CLOTS registry","volume":"92","author":"Kuhle","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.siny.2011.07.002_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1055\/s-2007-996103","article-title":"Heparin therapy in pediatric patients","volume":"23","author":"Sutor","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.siny.2011.07.002_bib7","doi-asserted-by":"crossref","first-page":"e510","DOI":"10.1542\/peds.2008-2052","article-title":"Unfractionated heparin therapy in infants and children","volume":"123","author":"Newall","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2011.07.002_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2141.2010.08302.x","article-title":"Clinical use of unfractionated heparin therapy in children: time for a change?","volume":"150","author":"Newall","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.siny.2011.07.002_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00001721-200011020-00004","article-title":"Monitoring unfractionated heparin therapy: relationship between eight anti-Xa assays and a protamine titration assay","volume":"11","author":"Kitchen","year":"2000","journal-title":"Blood Coag Fibrin"},{"key":"10.1016\/j.siny.2011.07.002_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2001-15259","article-title":"Heparin-induced thrombocytopenia in pediatrics","volume":"27","author":"Severin","year":"2001","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.siny.2011.07.002_bib11","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa0803200","article-title":"Contaminated heparin associated with adverse clinical events and activation of the contact system","volume":"358","author":"Kishimoto","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2011.07.002_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V79.1.1.1","article-title":"Low molecular weight heparin","volume":"79","author":"Hirsh","year":"1992","journal-title":"Blood"},{"issue":"Suppl.","key":"10.1016\/j.siny.2011.07.002_bib13","first-page":"131","article-title":"Comparative pharmacokinetics of LMWHs","volume":"26","author":"Samama","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.siny.2011.07.002_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0049-3848(03)00100-2","article-title":"Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin-sodium) in pediatric patients","volume":"109","author":"Massicotte","year":"2003","journal-title":"Thromb Res"},{"key":"10.1016\/j.siny.2011.07.002_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0022-3476(96)70273-1","article-title":"Low-molecular-weight heparin in pediatric patients with thrombotic disease: a dose finding study","volume":"128","author":"Massicotte","year":"1996","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2011.07.002_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00043426-200003000-00011","article-title":"Low-molecular-weight heparin in thrombotic disease in children and adolescents","volume":"22","author":"Punzalan","year":"2000","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.siny.2011.07.002_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00431-001-0873-9","article-title":"Low molecular weight heparin in children","volume":"161","author":"Albisetti","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2011.07.002_bib18","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1538-7836.2007.02624.x","article-title":"Once-daily enoxaparin in pediatric thromboembolism: a dose finding and pharmacodynamics\/pharmacokinetics study","volume":"5","author":"O\u2019Brien","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.siny.2011.07.002_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.thromres.2006.10.025","article-title":"The effects of heparin and low molecular weight heparin on bone","volume":"122","author":"Rajgopal","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.siny.2011.07.002_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00043426-200003000-00002","article-title":"Low-molecular-weight heparin therapy in children","volume":"22","author":"Massicotte","year":"2000","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"issue":"Suppl. 3","key":"10.1016\/j.siny.2011.07.002_bib21","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1007\/PL00014339","article-title":"The low molecular weight heparin dalteparin for prophylaxis and therapy of thrombosis in childhood: a report on 48 cases","volume":"158","author":"Nohe","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2011.07.002_bib22","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1160\/TH05-03-0215","article-title":"Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events","volume":"94","author":"Kuhle","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.siny.2011.07.002_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0038-1642427","article-title":"Oral anticoagulation therapy in pediatric patients: a prospective study","volume":"71","author":"Andrew","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.siny.2011.07.002_bib24","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V94.9.3007","article-title":"Analysis of warfarin therapy in pediatric patients: a prospective cohort study of 319 patients","volume":"94","author":"Streif","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.siny.2011.07.002_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0049-3848(86)90258-6","article-title":"Antithrombotic therapy in children and adolescents","volume":"42","author":"Woods","year":"1986","journal-title":"Thromb Res"},{"key":"10.1016\/j.siny.2011.07.002_bib26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1010-7940(00)00353-5","article-title":"Mitral-valve replacement in children under 6 years of age","volume":"17","author":"Gunther","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"issue":"Suppl. 3","key":"10.1016\/j.siny.2011.07.002_bib27","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1007\/PL00014345","article-title":"Severe protein C deficiency and aseptic osteonecrosis of the hip joint: a case report","volume":"158","author":"Wermes","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2011.07.002_bib28","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1056\/NEJM199106273242606","article-title":"Oral anticoagulant drugs","volume":"324","author":"Hirsh","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2011.07.002_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1182\/asheducation-2008.1.245","article-title":"New anticoagulants in children","volume":"1","author":"Young","year":"2008","journal-title":"Hematol Am Soc Educ Program"},{"key":"10.1016\/j.siny.2011.07.002_bib30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MBC.0b013e328335f1d2","article-title":"Novel paediatric anticoagulants: a review of the current literature","volume":"21","author":"Chan","year":"2010","journal-title":"Blood Coag Fibrin"},{"key":"10.1016\/j.siny.2011.07.002_bib31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1067\/mpd.2002.121384","article-title":"Lepirudin anticoagulation for heparin-induced thrombocytopenia","volume":"140","author":"Deitcher","year":"2002","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2011.07.002_bib32","first-page":"147","article-title":"Argatroban use during pediatric interventional cardiac catheterization","volume":"61","author":"Cetta","year":"2004","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.siny.2011.07.002_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0889-8588(05)70144-1","article-title":"Clinical application of argatroban as an alternative anticoagulant for extracorporeal circulation","volume":"14","author":"Kawada","year":"2000","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.siny.2011.07.002_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1055\/s-2002-35285","article-title":"Anticoagulation with recombinant hirudin and danaparoid sodium in pediatric patients","volume":"28","author":"Severin","year":"2002","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.siny.2011.07.002_bib35","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/j.1538-7836.2007.02623.x","article-title":"Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis","volume":"5","author":"Young","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.siny.2011.07.002_bib36","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/pbc.21731","article-title":"Bivalirudin for anticoagulation in children","volume":"51","author":"Rayapudi","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.siny.2011.07.002_bib37","first-page":"671","article-title":"Bivalirudin as a procedural anticoagulant in the pediatric population undergoing intravascular procedures for congenital heart disease","volume":"77","author":"Forbes","year":"2011","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.siny.2011.07.002_bib38","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pbc.22852","article-title":"Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open label, safety, efficacy, and pharmacokinetic study","volume":"56","author":"Young","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.siny.2011.07.002_bib39","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/archinte.163.15.1849","article-title":"Argatroban anticoagulation in patients with heparin-induced thrombocytopenia","volume":"163","author":"Lewis","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.siny.2011.07.002_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0091270010365550","article-title":"Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics","volume":"51","author":"Madabushi","year":"2011","journal-title":"J\u00a0Clin Pharm"},{"key":"10.1016\/j.siny.2011.07.002_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/ATVBAHA.108.162677","article-title":"New anticoagulants for treatment of venous thromboembolism","volume":"28","author":"Gross","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"Suppl.","key":"10.1016\/j.siny.2011.07.002_bib42","first-page":"542","article-title":"Use of argatroban and fondaparinux in a child with heparin-induced thrombocytopenia","volume":"42","author":"Young","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.siny.2011.07.002_bib43","doi-asserted-by":"crossref","first-page":"S2355","DOI":"10.1016\/j.athoracsur.2006.02.075","article-title":"Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients","volume":"81","author":"Boshkov","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.siny.2011.07.002_bib44","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood.V108.11.916.916","article-title":"Pediatric experience with fondaparinux in deep vein thrombosis","volume":"108","author":"Grabowski","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.siny.2011.07.002_bib45","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MPH.0b013e3181256ba5","article-title":"Treatment of thrombosis with fondaparinux (Arixtra) in a patient with end-stage renal disease receiving hemodialysis therapy","volume":"29","author":"Sharatkumar","year":"2007","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.siny.2011.07.002_bib46","unstructured":"Young G, Yee DL, O\u2019Brien S, Khanna R, Nugent DJ. FondaKIDS: a prospective dose-finding, pharmacokinetic, and safety study of fondaparinux in children between 1\u201318 years of age."},{"key":"10.1016\/j.siny.2011.07.002_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood-2009-09-241851","article-title":"The new oral anticoagulants","volume":"115","author":"Garcia","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.siny.2011.07.002_bib48","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.healun.2006.08.005","article-title":"Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia","volume":"25","author":"Almond","year":"2006","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.siny.2011.07.002_bib49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1160\/TH07-04-0252","article-title":"Fondaparinux for the treatment of patients with acute heparin-induced thrombocytopenia","volume":"99","author":"Lobo","year":"2008","journal-title":"Thromb Haemost"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X11000655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X11000655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:41:13Z","timestamp":1761676873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X11000655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1744165X11000655"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2011.07.002","relation":{},"ISSN":["1744-165X"],"issn-type":[{"type":"print","value":"1744-165X"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Old and new antithrombotic drugs in neonates and infants","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2011.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}