{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:39:53Z","timestamp":1780731593410,"version":"3.54.1"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["088208"],"award-info":[{"award-number":["088208"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCLH Charity"},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["305823"],"award-info":[{"award-number":["305823"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008721","name":"University College London Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Research Centre (A.L.D.)"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","sfnmjournal.com","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.siny.2017.04.005","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T13:31:18Z","timestamp":1494855078000},"page":"415-422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Placenta-directed gene therapy for fetal growth restriction"],"prefix":"10.1016","volume":"22","author":[{"given":"Tara","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2017.04.005_bib1","first-page":"115","article-title":"Gene medicine for cancer treatment: commercially available medicine and accumulated clinical data in China","volume":"2","author":"Ma","year":"2008","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jgm.2698","article-title":"Gene therapy clinical trials worldwide to 2012 \u2013 an update","volume":"15","author":"Ginn","year":"2013","journal-title":"J\u00a0Gene Med"},{"key":"10.1016\/j.siny.2017.04.005_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/pd.2787","article-title":"Organ targeted prenatal gene therapy \u2013 how far are we?","volume":"31","author":"Mehta","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2017.04.005_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/pd.4401","article-title":"Treatment of poor placentation and the prevention of associated adverse outcomes \u2013 what does the future hold?","volume":"34","author":"Spencer","year":"2014","journal-title":"Prenat Diagn"},{"issue":"9774","key":"10.1016\/j.siny.2017.04.005_bib5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(10)62233-7","article-title":"Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis","volume":"377","author":"Flenady","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2017.04.005_bib6","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/HYPERTENSIONAHA.113.01892","article-title":"Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome","volume":"62","author":"Lyall","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.siny.2017.04.005_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1471-0528.2003.t01-1-02163.x","article-title":"Longitudinal quantification of uterine artery blood volume flow changes during gestation in pregnancies complicated by intrauterine growth restriction","volume":"110","author":"Konje","year":"2003","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.siny.2017.04.005_bib8","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.ajog.2006.03.065","article-title":"Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction","volume":"195","author":"Savvidou","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.04.005_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1210\/jc.2007-1042","article-title":"Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction","volume":"93","author":"Nevo","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.siny.2017.04.005_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa041367","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth","volume":"352","author":"Marlow","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"2 Pt 1","key":"10.1016\/j.siny.2017.04.005_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.AOG.0000253215.79121.75","article-title":"Predictors of neonatal outcome in early-onset placental dysfunction","volume":"109","author":"Baschat","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.04.005_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13059-015-0859-y","article-title":"Towards a new era in medicine: therapeutic genome editing","volume":"16","author":"Porteus","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.siny.2017.04.005_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1089\/hum.2015.095","article-title":"Recent advancements in cardiovascular gene therapy and vascular biology","volume":"26","author":"Laakkonen","year":"2015","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bpobgyn.2007.08.008","article-title":"Gene therapy for the fetus: is there a future?","volume":"22","author":"David","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.siny.2017.04.005_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/85664","article-title":"Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in\u00a0vivo","volume":"19","author":"Kobinger","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.siny.2017.04.005_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.molmed.2008.07.003","article-title":"Gene transfer: the challenge of regulated gene expression","volume":"14","author":"Guo","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.siny.2017.04.005_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/hum.2007.013","article-title":"Use of nonintegrating lentiviral vectors for gene therapy","volume":"18","author":"Philpott","year":"2007","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib18","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.CIR.0000115519.03688.A2","article-title":"Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart","volume":"109","author":"Rutanen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.siny.2017.04.005_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling \u2013 in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.siny.2017.04.005_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/380435a0","article-title":"Development and lethality in embryos lacking a single VEGF allele","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature"},{"issue":"6573","key":"10.1016\/j.siny.2017.04.005_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.siny.2017.04.005_bib22","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/gt.2008.102","article-title":"Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep","volume":"15","author":"David","year":"2008","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/gt.2011.158","article-title":"Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A(165) in the uterine arteries of pregnant sheep","volume":"19","author":"Mehta","year":"2012","journal-title":"Gene Ther"},{"issue":"6","key":"10.1016\/j.siny.2017.04.005_bib24","doi-asserted-by":"crossref","first-page":"e100021","DOI":"10.1371\/journal.pone.0100021","article-title":"Local over-expression of VEGF-DDeltaNDeltaC in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis","volume":"9","author":"Mehta","year":"2014","journal-title":"PloS One"},{"issue":"Suppl A","key":"10.1016\/j.siny.2017.04.005_bib25","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.placenta.2005.12.002","article-title":"Nutritional modulation of adolescent pregnancy outcome \u2013 a review","volume":"27","author":"Wallace","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.siny.2017.04.005_bib26","first-page":"379","article-title":"Studies on experimental growth retardation in sheep. The effect of removal of endometrial caruncles on fetal size and metabolism","volume":"1","author":"Robinson","year":"1979","journal-title":"J\u00a0Dev Physiol"},{"key":"10.1016\/j.siny.2017.04.005_bib27","first-page":"A128","article-title":"Prenatal Ad.VEGF gene therapy \u2013 a promising new treatment for fetal growth restriction","volume":"22","author":"Carr","year":"2011","journal-title":"Hum Gene Ther"},{"issue":"4","key":"10.1016\/j.siny.2017.04.005_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/hum.2013.214","article-title":"Uteroplacental adenovirus VEGF gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies","volume":"25","author":"Carr","year":"2014","journal-title":"Hum Gene Ther"},{"issue":"3 Suppl","key":"10.1016\/j.siny.2017.04.005_bib29","first-page":"269A","article-title":"Maternal delivery of Ad.VEGF gene therapy increases fetal growth velocity in an ovine paradigm of fetal growth restriction","volume":"18","author":"Carr","year":"2011","journal-title":"Reprod Sci"},{"key":"10.1016\/j.siny.2017.04.005_bib30","doi-asserted-by":"crossref","first-page":"Fa7","DOI":"10.1136\/adc.2011.300160.20","article-title":"Alterations in postnatal growth and metabolism following prenatal treatment of intrauterine growth restriction with Ad.VEGF gene therapy in the sheep","volume":"96","author":"Carr","year":"2011","journal-title":"Archs Dis Childh Fetal Neonatal Ed"},{"key":"10.1016\/j.siny.2017.04.005_bib31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.placenta.2015.03.003","article-title":"Animal models of fetal growth restriction: considerations for translational medicine","volume":"36","author":"Swanson","year":"2015","journal-title":"Placenta"},{"issue":"Suppl A","key":"10.1016\/j.siny.2017.04.005_bib32","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation \u2013 a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.siny.2017.04.005_bib33","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.placenta.2007.02.005","article-title":"The Guinea pig placenta: model of placental growth dynamics","volume":"28","author":"Mess","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.siny.2017.04.005_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/plac.2000.0602","article-title":"Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the Guinea-pig","volume":"22","author":"Roberts","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.siny.2017.04.005_bib35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0023677216637506","article-title":"The use of ultrasound to assess fetal growth in a Guinea pig model of fetal growth restriction","volume":"51","author":"Swanson","year":"2017","journal-title":"Lab Anim"},{"key":"10.1016\/j.siny.2017.04.005_bib36","first-page":"78A","article-title":"Local administration of Ad.VEGF-A165 to the uteroplacental circulation enhances fetal growth and reduces brain sparing in an FGR model of Guinea pig pregnancy","volume":"19","author":"Mehta","year":"2012","journal-title":"Reprod Sci"},{"key":"10.1016\/j.siny.2017.04.005_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/hum.2016.046","article-title":"Maternal therapy with Ad. VEGF-A165 increases fetal weight at term in a Guinea-pig model of fetal growth restriction","volume":"27","author":"Swanson","year":"2016","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ymgme.2005.07.028","article-title":"The role of the insulin-like growth factor system in prenatal growth","volume":"86","author":"Randhawa","year":"2005","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.siny.2017.04.005_bib39","first-page":"129","article-title":"The IGF axis and placental function. a mini review","volume":"69","author":"Forbes","year":"2008","journal-title":"Horm Res"},{"issue":"6892","key":"10.1016\/j.siny.2017.04.005_bib40","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature00819","article-title":"Placental-specific IGF-II is a major modulator of placental and fetal growth","volume":"417","author":"Const\u00e2ncia","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.siny.2017.04.005_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1023\/A:1020957809082","article-title":"Insulin-like growth factor (IGF)-I gene deletion","volume":"3","author":"Camacho-H\u00fcbner","year":"2002","journal-title":"Rev Endocr Metab Dis"},{"issue":"S423","key":"10.1016\/j.siny.2017.04.005_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1651-2227.1997.tb18367.x","article-title":"Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature","volume":"86","author":"Woods","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.siny.2017.04.005_bib43","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1210\/en.2006-1701","article-title":"Fetal and amniotic insulin-like growth factor-I supplements improve growth rate in intrauterine growth restriction fetal sheep","volume":"148","author":"Eremia","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.siny.2017.04.005_bib44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/jc.2004-1052","article-title":"Adenovirally mediated expression of insulin-like growth factors enhances the function of first trimester placental fibroblasts","volume":"90","author":"Miller","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.siny.2017.04.005_bib45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.placenta.2013.11.012","article-title":"Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in\u00a0vivo and the human trophoblast line BeWo in\u00a0vitro","volume":"35","author":"Jones","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.siny.2017.04.005_bib46","doi-asserted-by":"crossref","first-page":"e74632","DOI":"10.1371\/journal.pone.0074632","article-title":"Adenoviral-mediated placental gene transfer of IGF-1 corrects placental insufficiency via enhanced placental glucose transport mechanisms","volume":"8","author":"Jones","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.siny.2017.04.005_bib47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1089\/hum.2014.065","article-title":"Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction","volume":"26","author":"Keswani","year":"2015","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib48","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0968-0004(91)90102-2","article-title":"Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?","volume":"16","author":"Vlodavsky","year":"1991","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.siny.2017.04.005_bib49","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0090-4295(00)00457-X","article-title":"Fibroblast growth factor 2: its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions","volume":"55","author":"Dow","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.siny.2017.04.005_bib50","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/gt.2008.102","article-title":"Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep","volume":"15","author":"David","year":"2008","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib51","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/gt.2011.158","article-title":"Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A165 in the uterine arteries of pregnant sheep","volume":"19","author":"Mehta","year":"2012","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib52","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1016\/j.biomaterials.2011.02.038","article-title":"Enhanced in\u00a0vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector","volume":"32","author":"Katayama","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.siny.2017.04.005_bib53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/10430340050016247","article-title":"Comparative in\u00a0vivo approaches for selective adenovirus-mediated gene delivery to the placenta","volume":"11","author":"Xing","year":"2000","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib54","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.gt.3301444","article-title":"Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid\/liposomes and plasmid\/polyethyleneimine complexes","volume":"8","author":"Heikkil\u00e4","year":"2001","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib55","series-title":"Presented at: ESGCT and NVGCT collaborative congress","article-title":"Human placental ex\u00a0vivo studies to support an adenovirus-mediated vascular endothelial growth factor (VEGF) gene medicine for the treatment of severe early onset fetal growth restriction (FGR)","author":"Brownbill","year":"2014"},{"key":"10.1016\/j.siny.2017.04.005_bib56","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s00270-011-0166-2","article-title":"Perioperative temporary occlusion of the internal iliac arteries as prophylaxis in cesarean section at risk of hemorrhage in placenta accreta","volume":"34","author":"Carnevale","year":"2011","journal-title":"Cardiovasc Interv Radiol"},{"key":"10.1016\/j.siny.2017.04.005_bib57","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1161\/01.CIR.96.10.3561","article-title":"In utero cardiac gene transfer via intraplacental delivery of recombinant adenovirus","volume":"96","author":"Woo","year":"1997","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.siny.2017.04.005_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/sj.gt.3301007","article-title":"Intrauterine gene transfer: gestational stage-specific gene delivery in mice","volume":"6","author":"T\u00fcrkay","year":"1999","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/mgme.2000.2984","article-title":"Adenovirus-mediated in utero gene transfer in mice and Guinea pigs: tissue distribution of recombinant adenovirus determined by quantitative TaqMan\u2013polymerase chain reaction assay","volume":"69","author":"Senoo","year":"2000","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.siny.2017.04.005_bib60","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/hum.2007.120","article-title":"Factors determining the risk of inadvertent retroviral transduction of male germ cells after in utero gene transfer in sheep","volume":"20","author":"Park","year":"2009","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib61","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1089\/hum.2005.16.417","article-title":"Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta)","volume":"16","author":"Lee","year":"2005","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib62","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.gt.3301444","article-title":"Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid\/liposomes and plasmid\/polyethyleneimine complexes","volume":"8","author":"Heikkila","year":"2001","journal-title":"Gene Ther"},{"key":"10.1016\/j.siny.2017.04.005_bib63","first-page":"373","article-title":"Declaration of Helsinki. Ethical principles for medical research involving human subjects","volume":"79","author":"World Medical Association","year":"2001","journal-title":"Bull WHO"},{"issue":"3 Pt 2","key":"10.1016\/j.siny.2017.04.005_bib64","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ajog.2005.06.020","article-title":"A\u00a0comprehensive ethical framework for responsibly designing and conducting pharmacologic research that involves pregnant women","volume":"193","author":"McCullough","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.siny.2017.04.005_bib65","first-page":"38","article-title":"Pregnancy and clinical research","author":"Lyerly","year":"2008","journal-title":"Hastings Cent Rep"},{"key":"10.1016\/j.siny.2017.04.005_bib66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3138\/ijfab.5.2.82","article-title":"How are pregnant women vulnerable research participants?","volume":"5","author":"Wild","year":"2012","journal-title":"Int J Fem Approaches Bioeth"},{"key":"10.1016\/j.siny.2017.04.005_bib67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3138\/ijfab.5.2.82","article-title":"How are pregnant women vulnerable research participants?","volume":"5","author":"Wild","year":"2012","journal-title":"Int J Fem Approaches Bioeth"},{"key":"10.1016\/j.siny.2017.04.005_bib68","series-title":"International ethical guidelines for biomedical research involving human subjects","author":"Council for International Organizations of Medical Sciences (CIOMS)","year":"2002"},{"key":"10.1016\/j.siny.2017.04.005_bib69","series-title":"Code of federal regulations title 45: public welfare department of health and human services; Part 46: protection of human subjects","author":"US Department of Health and Human Services","year":"2009"},{"key":"10.1016\/j.siny.2017.04.005_bib70","series-title":"Consent: patients and doctors making decisions together","author":"General Medical Council","year":"2008"},{"key":"10.1016\/j.siny.2017.04.005_bib71","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ajog.2010.08.054","article-title":"Long-term developmental follow-up of infants who participated in a randomized clinical trial of amniocentesis vs laser photocoagulation for the treatment of twin-to-twin transfusion syndrome","volume":"203","author":"Salomon","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.04.005_bib72","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A\u00a0randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2017.04.005_bib74","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/humc.2015.2518","article-title":"Introduction: gene therapy and gene transfer projects of the 7th framework Programme for research and technological development of the European union (second part)","volume":"26","author":"Gancberg","year":"2015","journal-title":"Hum Gene Ther Clin Dev"},{"key":"10.1016\/j.siny.2017.04.005_bib75","series-title":"Public summary of opinion on orphan designation \u2013 adenoviral vector serotype 5 containing the vascular endothelial growth factor D isoform (preprocessed short form) from a CMV promoter for the treatment of placental insufficiency","author":"European Medicines Agency","year":"2015"},{"key":"10.1016\/j.siny.2017.04.005_bib76","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/uog.15880","article-title":"Ethics and social acceptability of a proposed clinical trial using maternal gene therapy to treat severe early-onset fetal growth restriction","volume":"47","author":"Sheppard","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.04.005_bib77","series-title":"Additional protocol to the convention on human rights and biomedicine, concerning biomedical research","author":"Council of Europe","year":"2005"},{"key":"10.1016\/j.siny.2017.04.005_bib78","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/15265161.2011.562595","article-title":"An ethically justified framework for clinical investigation to benefit pregnant and fetal patients","volume":"11","author":"Chervenak","year":"2011","journal-title":"Am J Bioeth"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X1730046X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X1730046X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T19:11:23Z","timestamp":1602097883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X1730046X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1744165X1730046X"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2017.04.005","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placenta-directed gene therapy for fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2017.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}