{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:47:59Z","timestamp":1792219679054,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","sfnmjournal.com","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.siny.2017.11.005","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T08:25:51Z","timestamp":1512807951000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"title":["First and second trimester screening for fetal structural anomalies"],"prefix":"10.1016","volume":"23","author":[{"given":"Lindsay","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2017.11.005_bib1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0002-9378(94)70040-0","article-title":"A\u00a0randomized trial of prenatal ultrasonographic screening: impact on the detection, management and outcome of anomalous fetuses. The RADIUS Study Group","volume":"171","author":"Crane","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0002-9378(99)70577-6","article-title":"The performance of routine ultrasonographic screening of pregnancies in the Eurofetus Study","volume":"181","author":"Grandjean","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/aogs.13037","article-title":"Detection of fetal abnormalities by second-trimester ultrasound screening in a non-selected population","volume":"96","author":"Rydberg","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.siny.2017.11.005_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/bdra.23353","article-title":"Advances in ultrasound imaging for congenital malformations during early gestation","volume":"103","author":"Rayburn","year":"2015","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.siny.2017.11.005_bib5","first-page":"CD007058","article-title":"Ultrasound for fetal assessment in early pregnancy","volume":"7","author":"Whitworth","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.siny.2017.11.005_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.semperi.2015.11.009","article-title":"Ultrasound screening: status of markers and efficacy of screening for structural abnormalities","volume":"40","author":"Rao","year":"2016","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.siny.2017.11.005_bib7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/uog.10116","article-title":"Barriers to prenatal detection of congenital heart disease: a population-based study","volume":"40","author":"Pinto","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib8","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/AOG.0000000000000015","article-title":"Accuracy of ultrasonography at 11\u201314 weeks of gestation for detection of fetal structural anomalies: a systematic review","volume":"122","author":"Rossi","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib9","article-title":"Systematic review of first trimester ultrasound screening in detecting fetal structural anomalies and factors affecting screening performance","author":"Karim","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib10","article-title":"Yield of a 12\u201313 week scan for the early diagnosis of fetal congenital anomalies in the cell-free DNA era","author":"Kenkhuis","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/uog.12342","article-title":"ISUOG Practice Guidelines: performance of first-trimester fetal ultrasound scan","volume":"41","author":"Salomon","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/uog.9026","article-title":"ISUOG statement on the safe use of Doppler in the 11 to 13+6 week fetal ultrasound examination","volume":"37","author":"Salvesen","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/pd.588","article-title":"Integrated ultrasound and biochemical screening for trisomy 21 at 11 to 14 weeks","volume":"23","author":"Cicero","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2017.11.005_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/pd.2637","article-title":"Screening for fetal aneuploidies at 11 to 13 weeks","volume":"31","author":"Nicolaides","year":"2011","journal-title":"Prenat Diag"},{"key":"10.1016\/j.siny.2017.11.005_bib15","series-title":"The 11\u201313+6 weeks scan","author":"Nicolaides","year":"2004"},{"key":"10.1016\/j.siny.2017.11.005_bib16","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1046\/j.0960-7692.2001.00584.x","article-title":"Incidence of major structural cardiac defects associated with increased nuchal translucency but normal karyotype","volume":"18","author":"Ghi","year":"2001","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ajog.2014.06.025","article-title":"Risk of selected structural abnormalities in infants after increased nuchal translucency measurement","volume":"211","author":"Baer","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/pd.2642","article-title":"Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11\u201313 weeks","volume":"31","author":"Syngelaki","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2017.11.005_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/uog.10070","article-title":"First trimester detection of structural abnormalities and the role of aneuploidy markers","volume":"39","author":"Grande","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/uog.12489","article-title":"Improved detection rate of structural abnormalities in the first trimester using an extended examination protocol","volume":"42","author":"Iliescu","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/uog.7444","article-title":"13\u201314 week fetal anatomy scan: a 5-year prospective study","volume":"35","author":"Ebrashy","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/uog.5232","article-title":"Comparison of nuchal and detailed morphology ultrasound examinations in early pregnancy for fetal structural abnormality screening: a randomized controlled trial","volume":"31","author":"Chen","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1471-0528.2006.00953.x","article-title":"Detection of malformations in chromosomally normal fetuses by routine ultrasound at 12 or 18 weeks of gestation \u2013 a randomised controlled trial in 39,572 pregnancies","volume":"113","author":"Saltvedt","year":"2006","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.siny.2017.11.005_bib24","author":"Kirwan","year":"2010"},{"key":"10.1016\/j.siny.2017.11.005_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajog.2014.02.028","volume":"210","author":"Reddy","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib26","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1701-2163(16)34307-9","article-title":"Society of Obstetricians and Gynaecologists of Canada. Evaluation of prenatally diagnosed structural congenital anomalies","volume":"31","author":"Gagnon","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Can"},{"key":"10.1016\/j.siny.2017.11.005_bib27","series-title":"Prenatal assessment of fetal structural conditions (C-Obs 60)","author":"HGSA\/RANZCOG Joint Committee on Prenatal Diagnosis and Screening","year":"2015"},{"key":"10.1016\/j.siny.2017.11.005_bib28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/uog.8831","article-title":"ISUOG Clinical Standards Committee. Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan","volume":"37","author":"Salomon","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.7863\/ultra.33.2.189","article-title":"Consensus report on the detailed fetal anatomic ultrasound examination: indications, components, and qualifications","volume":"33","author":"Wax","year":"2014","journal-title":"J\u00a0Ultrasound Med"},{"key":"10.1016\/j.siny.2017.11.005_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/uog.19","article-title":"Nasal bone hypoplasia in trisomy 21 at 15 to 22 weeks' gestation","volume":"21","author":"Cicero","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/uog.12364","article-title":"Meta-analysis of second trimester markers for trisomy 21","volume":"41","author":"Agathokleous","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/pd.4329","article-title":"Role of the second-trimester \u2018genetic sonogram\u2019 for Down syndrome screen in the era of first-trimester screening and noninvasive prenatal testing","volume":"34","author":"Odibo","year":"2014","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.siny.2017.11.005_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/uog.13393","article-title":"ISUOG consensus statement on the impact of non-invasive prenatal testing (NIPT) on prenatal ultrasound practice","volume":"44","author":"Salomon","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/uog.13269","article-title":"Impact of introduction of 20-week ultrasound scan on prevalence of fetal and neonatal outcomes in cases of selected severe congenital heart defects in The Netherlands","volume":"44","author":"Baardman","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pd.306","article-title":"Ultrasound in prenatal diagnosis: polemics around routine ultrasound screening for second trimester fetal malformations","volume":"22","author":"Levi","year":"2002","journal-title":"Prenat Diag"},{"key":"10.1016\/j.siny.2017.11.005_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/uog.10059","article-title":"Increased nuchal translucency and normal karyotype: perinatal and pediatric outcomes at 2 years of age","volume":"39","author":"Mula","year":"2012","journal-title":"Ultrasound Obstet Gynceol"},{"key":"10.1016\/j.siny.2017.11.005_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/AOG.0000000000000336","article-title":"Association of copy number variants with specific ultrasonographically detected fetal anomalies","volume":"124","author":"Donnelly","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib38","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/AOG.0b013e3181c33cad","article-title":"Array comparative genomic hybridization in prenatal diagnosis","volume":"114","author":"American College of Obstetricians and Gynecologists Committee Opinion No 446","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib39","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/uog.6401","article-title":"Fetal anatomic evaluation in the overweight and obese gravida","volume":"33","author":"Thornburg","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib40","first-page":"795","article-title":"Limitations of aneuploidy and anomaly detection in the obese patient","volume":"3","author":"Zozzaro-Smith","year":"2014","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.siny.2017.11.005_bib41","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/uog.6393","article-title":"Sonography in obese and overweight pregnant women: clinical, medicolegal and technical issues","volume":"33","author":"Paladini","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/uog.7472","article-title":"Diagnostic accuracy of transabdominal ultrasound in detecting prenatal cleft lip and palate: a systematic review","volume":"35","author":"Maarse","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/uog.7639","article-title":"Fetal micrognathia: almost always an ominous finding","volume":"35","author":"Paladini","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.1016","article-title":"Fetal brain imaging: a comparison between magnetic resonance imaging and dedicated neurosonography","volume":"23","author":"Malinger","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib45","first-page":"188","article-title":"Accuracy of neurosonography and MRI in clinical management of fetuses referred with central nervous system abnormalities","volume":"44","author":"Paladini","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/uog.3909","article-title":"Sonographic examination of the fetal central nervous system: guidelines for performing the \u2018basic examination\u2019 and the \u2018fetal neurosonogram\u2019","volume":"29","author":"International Society of Ultrasound in Obstetrics & Gynecology Education Committee","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/uog.12506","article-title":"Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age","volume":"42","author":"Paladini","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib48","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/uog.13429","article-title":"Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature","volume":"44","author":"Rossi","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib49","author":"American College of Radiology"},{"key":"10.1016\/j.siny.2017.11.005_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/uog.17412","article-title":"ISUOG Practice Guidelines: performance of fetal magnetic resonance imaging","volume":"49","author":"Prayer","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2214\/ajr.182.5.1821111","article-title":"American College of Radiology white paper on MR safety: 2004 update and revisions","volume":"182","author":"Kanal","year":"2004","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.siny.2017.11.005_bib52","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/uog.13271","article-title":"Comparison of ultrasound and magnetic resonance imaging parameters in predicting survival in isolated left-sided congenital diaphragmatic hernia","volume":"46","author":"Bebbington","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajog.2008.06.062","article-title":"Intracranial magnetic resonance imaging findings in the surviving fetus after spontaneous monochorionic cotwin demise","volume":"199","author":"Jelin","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000097106","article-title":"Evolving indications for the EXIT procedure: the usefulness of combining ultrasound and fetal MRI","volume":"22","author":"Mota","year":"2007","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.siny.2017.11.005_bib55","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/01.AOG.0000233155.62906.6d","article-title":"Accuracy of ultrasonography and magnetic resonance imaging in the diagnosis of placenta accreta","volume":"108","author":"Warshak","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.siny.2017.11.005_bib56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/uog.15774","article-title":"Diagnostic accuracy of ultrasonography and magnetic resonance imaging for the detection of fetal anomalies: a blinded case\u2013control study","volume":"48","author":"Goncalves","year":"2016","journal-title":"Ultrasound Obstet Gynceol"},{"key":"10.1016\/j.siny.2017.11.005_bib57","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMoa1203382","article-title":"Chromosomal microarray versus karyotyping for prenatal diagnosis","volume":"367","author":"Wapner","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2017.11.005_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/gim.2017.55","article-title":"Population-based impact of noninvasive prenatal screening (NIPS) on screening and diagnostic testing for fetal aneuploidy","author":"Hui","year":"2017","journal-title":"Genet Med"},{"key":"10.1016\/j.siny.2017.11.005_bib59","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejogrb.2016.02.042","article-title":"Noninvasive prenatal testing: more caution in counseling is needed in high risk pregnancies with ultrasound abnormalities","volume":"200","author":"Oneda","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X17301361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X17301361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T06:06:37Z","timestamp":1535177197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X17301361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1744165X17301361"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2017.11.005","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First and second trimester screening for fetal structural anomalies","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2017.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}