{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:23:39Z","timestamp":1791897819315,"version":"4.3.4"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.siny.2021.101200","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T06:44:58Z","timestamp":1611297898000},"page":"101200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["When to say no to inhaled nitric oxide in neonates?"],"prefix":"10.1016","volume":"26","author":[{"given":"Praveen","family":"Chandrasekharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Abman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2021.101200_bib1","series-title":"Center for drug evaluation and research - application number: NDA 20845: approval letter","author":"FDA","year":"1999"},{"key":"10.1016\/j.siny.2021.101200_bib2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1542\/peds.99.6.838","article-title":"Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS)","volume":"99","author":"The Neonatal Inhaled Nitric Oxide Study Group","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa043927","article-title":"Inhaled nitric oxide for premature infants with severe respiratory failure","volume":"353","author":"Van Meurs","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2021.101200_bib4","first-page":"146","article-title":"Early hypoxic respiratory failure in extreme prematurity: mortality and neurodevelopmental outcomes","author":"Chandrasekharan","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib5","article-title":"Initial oxygen use for preterm newborn resuscitation: a systematic review with meta-analysis","volume":"143","author":"Welsford","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM199702273360901","article-title":"Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure","volume":"336","author":"Neonatal Inhaled Nitric Oxide Study","year":"1997","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2021.101200_bib7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199702273360902","article-title":"Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group","volume":"336","author":"Roberts","year":"1997","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2021.101200_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-3476(97)70124-0","article-title":"Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn","volume":"131","author":"Kinsella","year":"1997","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpeds.2016.08.063","article-title":"Prominent intrapulmonary bronchopulmonary anastomoses and abnormal lung development in infants and children with down syndrome","volume":"180","author":"Bush","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jpeds.2014.09.010","article-title":"Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia","volume":"166","author":"Acker","year":"2015","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.clp.2012.06.006","article-title":"The pulmonary circulation in neonatal respiratory failure","volume":"39","author":"Lakshminrusimha","year":"2012","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.siny.2021.101200_bib12","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1542\/neo.16-12-e680","article-title":"Persistent pulmonary hypertension of the newborn","volume":"16","author":"Lakshminrusimha","year":"2015","journal-title":"NeoReviews"},{"key":"10.1016\/j.siny.2021.101200_bib13","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","article-title":"Pediatric pulmonary hypertension: guidelines from the American heart association and American thoracic society","volume":"132","author":"Abman","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.siny.2021.101200_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa061088","article-title":"Inhaled nitric oxide in preterm infants undergoing mechanical ventilation","volume":"355","author":"Ballard","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2021.101200_bib15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJMoa060442","article-title":"Early inhaled nitric oxide therapy in premature newborns with respiratory failure","volume":"355","author":"Kinsella","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.siny.2021.101200_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1542\/peds.2010-3507","article-title":"NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants","volume":"127","author":"Cole","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1542\/peds.2013-3444","article-title":"Newborn, American Academy of P. Use of inhaled nitric oxide in preterm infants","volume":"133","author":"Kumar","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1542\/peds.2013-3444","article-title":"Use of inhaled nitric oxide in preterm infants","volume":"133","author":"Kumar","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1542\/peds.2014-3290","article-title":"Off-label use of inhaled nitric oxide after release of NIH consensus statement","volume":"135","author":"Ellsworth","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jpeds.2015.11.050","article-title":"Recommendations for the use of inhaled nitric oxide therapy in premature newborns with severe pulmonary hypertension","volume":"170","author":"Kinsella","year":"2016","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib21","first-page":"CD000509","article-title":"Inhaled nitric oxide for respiratory failure in preterm infants","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.siny.2021.101200_bib22","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2018.2895","article-title":"Association of early inhaled nitric oxide with the survival of preterm neonates with pulmonary hypoplasia","volume":"172","author":"Ellsworth","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib23","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1111\/apa.14436","article-title":"Treatment with nitric oxide in the neonatal intensive care unit is associated with increased risk of childhood cancer","volume":"107","author":"Dixon","year":"1992","journal-title":"Acta paediatrica (Oslo, Norway"},{"key":"10.1016\/j.siny.2021.101200_bib24","series-title":"Free radical damage can cause serious long-lasting effects. Acta paediatrica (Oslo, Norway","author":"Vali","year":"1992"},{"key":"10.1016\/j.siny.2021.101200_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2018.02.040","article-title":"The left ventricle in congenital diaphragmatic hernia: implications for the management of pulmonary hypertension","author":"Kinsella","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpeds.2019.12.037","article-title":"Implications of atrial-level shunting by echocardiography in newborns with congenital diaphragmatic hernia","volume":"219","author":"Wehrmann","year":"2020","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.earlhumdev.2008.08.002","article-title":"Inhaled nitric oxide in the term newborn","volume":"84","author":"Kinsella","year":"2008","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.siny.2021.101200_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/PCC.0b013e318250af44","article-title":"Inodilators in nitric oxide resistant persistent pulmonary hypertension of the newborn","volume":"14","author":"Lakshminrusimha","year":"2013","journal-title":"Pediatr Crit Care Med : J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc"},{"key":"10.1016\/j.siny.2021.101200_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/NPM-180082","article-title":"Methemoglobin and the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn","volume":"13","author":"Dadiz","year":"2020","journal-title":"J\u00a0Neonatal Perinat Med"},{"key":"10.1016\/j.siny.2021.101200_bib30","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0140-6736(05)64067-6","article-title":"Methaemoglobinaemia after inhalation of nitric oxide in infant with pulmonary hypertension","volume":"350","author":"Nakajima","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2021.101200_bib31","article-title":"Factors influencing decision making in neonatology: inhaled nitric oxide in preterm infants","author":"Manja","year":"2018","journal-title":"J\u00a0Perinatol : Off J Calif Perinat Assoc"},{"key":"10.1016\/j.siny.2021.101200_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpeds.2019.10.063","article-title":"Just say No to iNO in preterms-really?","volume":"218","author":"Lakshminrusimha","year":"2020","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2017.05.029","article-title":"Evaluation and management of pulmonary hypertension in children with bronchopulmonary dysplasia","author":"Krishnan","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/jp.2015.126","article-title":"Sildenafil and retinopathy of prematurity risk in very low birth weight infants","volume":"36","author":"Samiee-Zafarghandy","year":"2016","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.siny.2021.101200_bib35","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.healun.2019.06.022","article-title":"Updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: the European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT","volume":"38","author":"Hansmann","year":"2019","journal-title":"J\u00a0Heart Lung Transplant : Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.siny.2021.101200_bib36","first-page":"428","article-title":"Early use of inhaled nitric oxide in preterm infants: is there a rationale for selective approach?","volume":"34","author":"Chandrasekharan","year":"2017","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.siny.2021.101200_bib37","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/jp.2015.2","article-title":"Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series","volume":"35","author":"Semberova","year":"2015","journal-title":"J\u00a0Perinatol : Off J Calif Perinat Assoc"},{"key":"10.1016\/j.siny.2021.101200_bib38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jpeds.2012.03.008","article-title":"Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure","volume":"161","author":"Aikio","year":"2012","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-0028-1104743","article-title":"Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia","volume":"26","author":"Chock","year":"2009","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.siny.2021.101200_bib40","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0022-3476(95)70467-1","article-title":"Inhaled nitric oxide for premature infants after prolonged rupture of the membranes","volume":"126","author":"Peliowski","year":"1995","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0140-6736(00)03548-0","article-title":"Inhaled nitric oxide in neonates with persistent pulmonary hypertension","volume":"357","author":"Tworetzky","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2021.101200_bib42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1203\/00006450-199804001-01724","article-title":"Soluble guanylate cyclase mRNA expression change during ovine lung development","volume":"43","author":"Mensah","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101200_bib43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.jp.7211673","article-title":"Characteristics of pulmonary hypertension in preterm neonates","volume":"27","author":"Kumar","year":"2007","journal-title":"J\u00a0Perinatol : Off J Calif Perinat Assoc"},{"key":"10.1016\/j.siny.2021.101200_bib44","article-title":"Pulmonary hypertension in bronchopulmonary dysplasia","author":"Hansmann","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101200_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jpeds.2007.02.010","article-title":"Inhaled nitric oxide in the premature newborn","volume":"151","author":"Kinsella","year":"2007","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib46","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0140-6736(10)60664-2","article-title":"Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial","volume":"376","author":"Mercier","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2021.101200_bib47","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0022-3476(05)81551-3","article-title":"Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide","volume":"123","author":"Kinsella","year":"1993","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib48","first-page":"CD000399","article-title":"Nitric oxide for respiratory failure in infants born at or near term","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.siny.2021.101200_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40748-017-0066-9","article-title":"Milrinone in congenital diaphragmatic hernia - a randomized pilot trial: study protocol, review of literature and survey of current practices","volume":"3","author":"Lakshminrusimha","year":"2017","journal-title":"Matern Health Neonatol Perinatol"},{"key":"10.1016\/j.siny.2021.101200_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/pch\/21.4.183","article-title":"The Canadian pediatric surgery network congenital diaphragmatic hernia evidence review project: developing national guidelines for care","volume":"21","author":"Puligandla","year":"2016","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.siny.2021.101200_bib51","doi-asserted-by":"crossref","unstructured":"Gitto E, Pellegrino S, Aversa S, Romeo C, Trimarchi G, Barberi I, et\u00a0al. Oxidative stress and persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide and different oxygen concentrations. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2012.","DOI":"10.3109\/14767058.2012.663020"},{"key":"10.1016\/j.siny.2021.101200_bib52","first-page":"H1849","article-title":"Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension","volume":"277","author":"Black","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.siny.2021.101200_bib53","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/01.pdr.0000191136.69142.8c","article-title":"Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation","volume":"59","author":"Lakshminrusimha","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101200_bib54","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1089\/ars.2013.5785","article-title":"Role of reactive oxygen species in neonatal pulmonary vascular disease","volume":"21","author":"Wedgwood","year":"2014","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.siny.2021.101200_bib55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpeds.2018.07.009","article-title":"The oxygen load supplied during delivery room stabilization of preterm infants modifies the DNA methylation profile","volume":"202","author":"Lorente-Pozo","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib56","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3168","article-title":"Oxygen redux","volume":"138","author":"Soll","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101200_bib57","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1164\/rccm.200605-676OC","article-title":"Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension","volume":"174","author":"Lakshminrusimha","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2021.101200_bib58","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/japplphysiol.00711.2011","article-title":"Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen","volume":"111","author":"Lakshminrusimha","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.siny.2021.101200_bib59","doi-asserted-by":"crossref","first-page":"H1491","DOI":"10.1152\/ajpheart.00185.2007","article-title":"The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow","volume":"293","author":"Lakshminrusimha","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.siny.2021.101200_bib60","doi-asserted-by":"crossref","first-page":"44049","DOI":"10.1074\/jbc.M305895200","article-title":"Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals","volume":"278","author":"Romero","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.siny.2021.101200_bib61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1067\/mpd.2003.140","article-title":"Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia","volume":"142","author":"Kinsella","year":"2003","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib62","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41390-019-0643-x","article-title":"Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial","volume":"87","author":"Sekar","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101200_bib63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jpeds.2018.12.004","article-title":"Acute vasoreactivity testing during cardiac catheterization of neonates with bronchopulmonary dysplasia-associated pulmonary hypertension","volume":"208","author":"Frank","year":"2019","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.siny.2021.101200_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/children4080063","article-title":"Persistent pulmonary hypertension in the newborn","volume":"4","author":"Mathew","year":"2017","journal-title":"Children"},{"key":"10.1016\/j.siny.2021.101200_bib65","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1164\/rccm.200907-1126OC","article-title":"Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity","volume":"182","author":"Keller","year":"2010","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:45:41Z","timestamp":1761677141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X21000081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1744165X21000081"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2021.101200","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"When to say no to inhaled nitric oxide in neonates?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2021.101200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101200"}}