{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:19:54Z","timestamp":1785453594140,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.siny.2021.101269","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T12:44:49Z","timestamp":1626266689000},"page":"101269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Subcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia"],"prefix":"10.1016","volume":"26","author":[{"given":"Celia","family":"Rodd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Schwieger-Briel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Hagmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2021.101269_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/pde.13640","article-title":"Subcutaneous fat necrosis of the newborn and associated hypercalcemia: a systematic review of the literature","volume":"36","author":"Stefanko","year":"2019","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib2","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1001\/archderm.1984.01650470123027","article-title":"Subcutaneous fat necrosis of the newborn","volume":"120","author":"Katz","year":"1984","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1042\/bj0200084","article-title":"The chemical nature of the subcutaneous fat in the normal and sclerematous infant","volume":"20","author":"Channon","year":"1926","journal-title":"Biochem J"},{"key":"10.1016\/j.siny.2021.101269_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dc.21622","article-title":"Fine-needle aspiration cytology of subcutaneous fat necrosis of the newborn: the cytology spectrum with review of the literature","volume":"40","author":"Schubert","year":"2012","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.siny.2021.101269_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000494501","article-title":"Subcutaneous fat necrosis of the newborn: is fine needle aspiration cytology diagnostic?","volume":"63","author":"Agarwal","year":"2019","journal-title":"Acta Cytol"},{"key":"10.1016\/j.siny.2021.101269_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-231458","article-title":"Subcutaneous fat necrosis of the newborn","volume":"12","author":"O' Brien","year":"2019","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.siny.2021.101269_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2133.2007.07782.x","article-title":"Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children","volume":"156","author":"Mahe","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-234360","article-title":"Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia","volume":"13","author":"Elsayed","year":"2020","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.siny.2021.101269_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000497176","article-title":"Report of 2 novel presentations of subcutaneous fat necrosis of the newborn","volume":"6","author":"Kannenberg","year":"2019","journal-title":"Dermatopathology (Basel)"},{"key":"10.1016\/j.siny.2021.101269_bib10","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1542\/peds.2010-3508","article-title":"Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates","volume":"128","author":"Strohm","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101269_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpra.2017.10.006","article-title":"Subcutaneous fat necrosis requiring plastic surgical intervention in an infant treated with whole-body cooling","volume":"15","author":"Heskin","year":"2018","journal-title":"JPRAS Open"},{"key":"10.1016\/j.siny.2021.101269_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1525-1470.1987.tb00764.x","article-title":"Sclerema neonatorum and subcutaneous fat necrosis of the newborn","volume":"4","author":"Fretzin","year":"1987","journal-title":"Pediatr Dermatol"},{"issue":"vii","key":"10.1016\/j.siny.2021.101269_bib13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.det.2008.05.015","article-title":"Cold panniculitis","volume":"26","author":"Quesada-Cortes","year":"2008","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.siny.2021.101269_bib14","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1111\/apa.13463","article-title":"Macrosomia and haemodynamic instability may represent risk factors for subcutaneous fat necrosis in asphyxiated newborns treated with hypothermia","volume":"105","author":"Courteau","year":"2016","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.siny.2021.101269_bib15","first-page":"145","article-title":"Diminished reproduction, failure to thrive, and altered immunologic function in a colony of T-cell receptor transgenic mice: possible role of Citrobacter rodentium","volume":"48","author":"Maggio-Price","year":"1998","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.siny.2021.101269_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12887-015-0395-7","article-title":"Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register","volume":"15","author":"Grass","year":"2015","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.siny.2021.101269_bib17","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1111\/j.1442-200X.2012.03730.x","article-title":"Subcutaneous fat necrosis after selective head cooling in an infant","volume":"55","author":"Kuboi","year":"2013","journal-title":"Pediatr Int"},{"key":"10.1016\/j.siny.2021.101269_bib18","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archdermatol.2010.176","article-title":"Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia","volume":"146","author":"Oza","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib19","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3109\/14767058.2012.683898","article-title":"Strategies for reducing the incidence of skin complications in newborns treated with whole-body hypothermia","volume":"25","author":"Filippi","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.siny.2021.101269_bib20","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1111\/pde.12973","article-title":"Subcutaneous fat necrosis of the newborn: a 20-year retrospective study","volume":"33","author":"Del Pozzo-Magana","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1525-1470.1993.tb00375.x","article-title":"Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature","volume":"10","author":"Hicks","year":"1993","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib22","article-title":"Subcutaneous fat necrosis and hypercalcemia after therapeutic hypothermia in patients with hypoxic-ischemic encephalopathy: a case series","volume":"10","author":"Verma","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.siny.2021.101269_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1525-1470.2011.01716.x","article-title":"Hypercalcemia due to subcutaneous fat necrosis in a newborn after total body cooling","volume":"30","author":"Akcay","year":"2013","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.siny.2021.101269_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0022-3476(99)70462-2","article-title":"Etidronate therapy for hypercalcemia in subcutaneous fat necrosis of the newborn","volume":"134","author":"Rice","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2021.101269_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s004670050654","article-title":"Hypercalcemia of the newborn: etiology, evaluation, and management","volume":"13","author":"Rodd","year":"1999","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.siny.2021.101269_bib26","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jbmr.3296","article-title":"Hypercalcemic disorders in children","volume":"32","author":"Stokes","year":"2017","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.siny.2021.101269_bib27","first-page":"289","article-title":"Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis","volume":"65","author":"Alos","year":"2006","journal-title":"Horm Res"},{"key":"10.1016\/j.siny.2021.101269_bib28","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1055\/s-0034-1395987","article-title":"Neonatal hypercalcemia secondary to subcutaneous fat necrosis successfully treated with pamidronate: a case series and literature review","volume":"4","author":"Samedi","year":"2014","journal-title":"AJP Rep"},{"key":"10.1016\/j.siny.2021.101269_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ccr3.855","article-title":"Zoledronic acid for neonatal subcutaneous fat necrosis","volume":"5","author":"Di Bari","year":"2017","journal-title":"Clin Case Rep"},{"key":"10.1016\/j.siny.2021.101269_bib30","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1055\/s-0039-1691777","article-title":"Use of zoledronic acid in a neonate with subcutaneous fat necrosis complicated with severe, refractory hypercalcemia","volume":"36","author":"Militello","year":"2019","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.siny.2021.101269_bib31","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1515\/jpm-2019-0172","article-title":"Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia","volume":"47","author":"Alsaleem","year":"2019","journal-title":"J Perinat Med"},{"key":"10.1016\/j.siny.2021.101269_bib32","unstructured":"Steele S. Database (CALIPER) [Internet]. CALIPER Project. [cited 2021 May 6]. Available from: https:\/\/caliperproject.ca\/caliper\/database\/."},{"key":"10.1016\/j.siny.2021.101269_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clinbiochem.2014.07.012","article-title":"Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada","volume":"47","author":"Gallo","year":"2014","journal-title":"Clin Biochem"},{"key":"10.1016\/j.siny.2021.101269_bib34","doi-asserted-by":"crossref","first-page":"F419","DOI":"10.1136\/archdischild-2014-306069","article-title":"Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications","volume":"99","author":"Shumer","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.siny.2021.101269_bib35","doi-asserted-by":"crossref","first-page":"F343","DOI":"10.1136\/fn.88.4.F343","article-title":"Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification","volume":"88","author":"Dudink","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:46:37Z","timestamp":1761677197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X21000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1744165X21000779"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2021.101269","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2021.101269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101269"}}