{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:39:46Z","timestamp":1787996386295,"version":"build-2784847793"},"reference-count":98,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS102617"],"award-info":[{"award-number":["R01NS102617"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.siny.2021.101273","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T04:30:17Z","timestamp":1627446617000},"page":"101273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bedside and laboratory neuromonitoring in neonatal encephalopathy"],"prefix":"10.1016","volume":"26","author":[{"given":"L.","family":"Chalak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hellstrom-Westas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El-Dib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An.N.","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-8453","authenticated-orcid":false,"given":"A.","family":"Garcia-Alix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.siny.2018.02.003","article-title":"Amplitude-integrated electroencephalography for seizure detection in newborn infants","volume":"23","author":"Hellstrom-Westas","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib2","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","article-title":"Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants","volume":"72","author":"Hellstrom-Westas","year":"1995","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"8","key":"10.1016\/j.siny.2021.101273_bib3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00431-015-2490-z","article-title":"Early amplitude-integrated EEG monitoring 6 h after birth predicts long-term neurodevelopment of asphyxiated late preterm infants","volume":"174","author":"Jiang","year":"2015","journal-title":"Eur J Pediatr"},{"issue":"6 Pt 1","key":"10.1016\/j.siny.2021.101273_bib4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1542\/peds.103.6.1263","article-title":"Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography","volume":"103","author":"al Naqeeb","year":"1999","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.siny.2006.07.011","article-title":"Continuous brain-function monitoring: state of the art in clinical practice","volume":"11","author":"Hellstrom-Westas","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib6","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1542\/peds.2004-0863","article-title":"Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy","volume":"115","author":"Osredkar","year":"2005","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jpeds.2011.01.006","article-title":"Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy","volume":"159","author":"Takenouchi","year":"2011","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000339570","article-title":"aEEG evolution during therapeutic hypothermia and prediction of NICU outcome in encephalopathic neonates","volume":"102","author":"Massaro","year":"2012","journal-title":"Neonatology."},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.siny.2014.12.011","article-title":"Impact of hypothermia on predictors of poor outcome: how do we decide to redirect care?","volume":"20","author":"Bonifacio","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0013-4694(72)90063-6","article-title":"The neonatal EEG: statistical studies and prognostic value in full-term and pre-term babies","volume":"32","author":"Monod","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"5\u20136","key":"10.1016\/j.siny.2021.101273_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/0013-4694(80)90402-2","article-title":"Behavioral state cycles, background EEGs and prognosis of newborns with perinatal hypoxia","volume":"49","author":"Watanabe","year":"1980","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib13","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0659","article-title":"Early EEG grade and outcome at 5 Years after mild neonatal hypoxic ischemic encephalopathy","author":"Murray","year":"2016","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e31820af91a","article-title":"Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"76","author":"Nash","year":"2011","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neucli.2010.11.002","article-title":"Influence of hypothermia on the prognostic value of early EEG in full-term neonates with hypoxic ischemic encephalopathy","volume":"41","author":"Hamelin","year":"2010","journal-title":"Neurophysiol Clin"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00004691-199307000-00008","article-title":"Prognostic value of background patterns in the neonatal EEG","volume":"10","author":"Holmes","year":"1993","journal-title":"J Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib17","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1542\/peds.2008-2190","article-title":"Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years","volume":"124","author":"Murray","year":"2009","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0387-7604(89)80079-8","article-title":"The EEG evolution and neurological prognosis of neonates with perinatal hypoxia [corrected]","volume":"11","author":"Takeuchi","year":"1989","journal-title":"Brain Dev"},{"issue":"10","key":"10.1016\/j.siny.2021.101273_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib20","doi-asserted-by":"crossref","first-page":"F267","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: an observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ejpn.2016.06.003","article-title":"Role of EEG background activity, seizure burden and MRI in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischaemic encephalopathy in the era of therapeutic hypothermia","volume":"20","author":"Weeke","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/0883073810390036","article-title":"Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"26","author":"Wusthoff","year":"2011","journal-title":"J Child Neurol"},{"issue":"14","key":"10.1016\/j.siny.2021.101273_bib23","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1212\/WNL.0000000000000282","article-title":"Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study","volume":"82","author":"Glass","year":"2014","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/WNP.0b013e31823e96d7","article-title":"The American clinical Neurophysiology society's guideline on continuous electroencephalography monitoring in neonates","volume":"28","author":"Shellhaas","year":"2011","journal-title":"J Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-200110000-00005","article-title":"Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage","volume":"50","author":"Wirrell","year":"2001","journal-title":"Pediatr Res"},{"issue":"12","key":"10.1016\/j.siny.2021.101273_bib26","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/dmcn.13215","article-title":"Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy","volume":"58","author":"Kharoshankaya","year":"2016","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib27","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.1542\/peds.2014-3777","article-title":"Treating EEG seizures in hypoxic ischemic encephalopathy: a randomized controlled trial","volume":"136","author":"Srinivasakumar","year":"2015","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib28","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1542\/peds.2009-0136","article-title":"Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial","volume":"125","author":"van Rooij","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/cc11230","article-title":"Quantitative EEG for the detection of brain ischemia","volume":"16","author":"Foreman","year":"2012","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib30","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2004-1695","article-title":"Rebound seizures during rewarming","volume":"114","author":"Battin","year":"2004","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib31","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.clp.2008.07.018","article-title":"Supportive care during neuroprotective hypothermia in the term newborn: adverse effects and their prevention","volume":"35","author":"Thoresen","year":"2008","journal-title":"Clin Perinatol"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pediatrneurol.2009.05.004","article-title":"Seizures are common in term infants undergoing head cooling","volume":"41","author":"Yap","year":"2009","journal-title":"Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41390-018-0040-x","article-title":"Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia","volume":"84","author":"Cornet","year":"2018","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101273_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.compbiomed.2015.05.017","article-title":"Multimodal predictor of neurodevelopmental outcome in newborns with hypoxic-ischaemic encephalopathy","volume":"63","author":"Temko","year":"2015","journal-title":"Comput Biol Med"},{"issue":"11","key":"10.1016\/j.siny.2021.101273_bib35","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1469-8749.1990.tb08122.x","article-title":"Power spectral analysis of the EEG of term infants following birth asphyxia","volume":"32","author":"Bell","year":"1990","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.clinph.2016.10.094","article-title":"Does relative or absolute EEG power have prognostic value in HIE setting?","volume":"128","author":"Govindan","year":"2017","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.clinph.2015.05.024","article-title":"Grading hypoxic-ischemic encephalopathy severity in neonatal EEG using GMM supervectors and the support vector machine","volume":"127","author":"Ahmed","year":"2016","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.siny.2021.101273_bib38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-444-64029-1.00014-X","article-title":"Monitoring and management of brain hemodynamics and oxygenation","volume":"162","author":"El-Dib","year":"2019","journal-title":"Handb Clin Neurol"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000101063","article-title":"Use of tissue oxygenation index and fractional tissue oxygen extraction as non-invasive parameters for cerebral oxygenation: a validation study in piglets","volume":"92","author":"Naulaers","year":"2007","journal-title":"Neonatology."},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib40","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1152\/jappl.1990.68.3.1086","article-title":"Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy","volume":"68","author":"Wyatt","year":"1990","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/hbm.20868","article-title":"Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life","volume":"31","author":"Roche-Labarbe","year":"2010","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib42","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.jpeds.2013.07.007","article-title":"Reference ranges for regional cerebral tissue oxygen saturation and fractional oxygen extraction in neonates during immediate transition after birth","volume":"163","author":"Pichler","year":"2013","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/pr.2015.186","article-title":"Reference values of regional cerebral oxygen saturation during the first 3 days of life in preterm neonates","volume":"79","author":"Alderliesten","year":"2016","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1203\/PDR.0b013e31822a36db","article-title":"Cerebral oxygenation during the first days of life in preterm and term neonates: differences between different brain regions","volume":"70","author":"Wijbenga","year":"2011","journal-title":"Pediatr Res"},{"issue":"1 Pt 1","key":"10.1016\/j.siny.2021.101273_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(05)72459-8","article-title":"Vasoparalysis associated with brain damage in asphyxiated term infants","volume":"117","author":"Pryds","year":"1990","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1542\/peds.2005-0987","article-title":"Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome","volume":"117","author":"Toet","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2021.101273_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101939","article-title":"Changes in brain perfusion in successive arterial spin labeling MRI scans in neonates with hypoxic-ischemic encephalopathy","volume":"24","author":"Proisy","year":"2019","journal-title":"NeuroImage Clin"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.siny.2021.101273_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.00393","article-title":"Cerebral near infrared spectroscopy monitoring in term infants with hypoxic ischemic encephalopathy-A systematic review","volume":"11","author":"Mitra","year":"2020","journal-title":"Front Neurol"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib50","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1055\/s-0034-1396692","article-title":"Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment?","volume":"32","author":"Peng","year":"2015","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.siny.2021.101273_bib51","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuroimage.2013.04.072","article-title":"Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"85","author":"Wintermark","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.siny.2021.101273_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.earlhumdev.2017.07.008","article-title":"Cerebral regional oxygen saturation trends in infants with hypoxic-ischemic encephalopathy","volume":"113","author":"Jain","year":"2017","journal-title":"Early Hum Dev"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00221-002-1030-z","article-title":"Changes in cerebral haemodynamics, regional oxygen saturation and amplitude-integrated continuous EEG during hypoxia-ischaemia and reperfusion in newborn piglets","volume":"144","author":"Ioroi","year":"2002","journal-title":"Exp Brain Res"},{"issue":"8","key":"10.1016\/j.siny.2021.101273_bib54","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.clinph.2011.10.051","article-title":"The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig","volume":"123","author":"Zhang","year":"2012","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib55","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1152\/japplphysiol.91156.2008","article-title":"Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets","volume":"106","author":"Tichauer","year":"2009","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib56","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1388-2457(00)00499-5","article-title":"Electrocortical brain activity, cerebral haemodynamics and oxygenation during progressive hypotension in newborn piglets","volume":"112","author":"Gavilanes","year":"2001","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00004647-200203000-00011","article-title":"Near-infrared spectroscopy cerebral oxygen saturation thresholds for hypoxia-ischemia in piglets","volume":"22","author":"Kurth","year":"2002","journal-title":"J Cerebr Blood Flow Metabol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000468976","article-title":"Prediction of outcome in neonates with hypoxic-ischemic encephalopathy II: role of amplitude-integrated electroencephalography and cerebral oxygen saturation measured by near-infrared spectroscopy","volume":"112","author":"Goeral","year":"2017","journal-title":"Neonatology."},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib59","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/pr.2013.84","article-title":"Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value?","volume":"74","author":"Lemmers","year":"2013","journal-title":"Pediatr Res"},{"issue":"9","key":"10.1016\/j.siny.2021.101273_bib60","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1055\/s-0038-1626712","article-title":"Amplitude-integrated EEG and cerebral near-infrared spectroscopy in cooled, asphyxiated infants","volume":"35","author":"Niezen","year":"2018","journal-title":"Am J Perinatol"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib61","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.siny.2021.101273_bib62","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1097\/CCM.0b013e318223b910","article-title":"Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia","volume":"39","author":"Lee","year":"2011","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib63","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.expneurol.2011.11.025","article-title":"Cerebral blood flow during reperfusion predicts later brain damage in a mouse and a rat model of neonatal hypoxic-ischemic encephalopathy","volume":"233","author":"Ohshima","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.siny.2021.101273_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2014.00266","article-title":"Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia","volume":"8","author":"Govindan","year":"2014","journal-title":"Front Hum Neurosci"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib65","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1152\/jn.00353.2015","article-title":"Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"114","author":"Massaro","year":"2015","journal-title":"J Neurophysiol"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib66","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/pr.2013.132","article-title":"Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy","volume":"74","author":"Howlett","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2021.101273_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-015-0464-4","article-title":"A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia","volume":"15","author":"Burton","year":"2015","journal-title":"BMC Neurol"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib68","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3174\/ajnr.A4083","article-title":"Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury","volume":"36","author":"Tekes","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.siny.2021.101273_bib69","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000452833","article-title":"Optimizing cerebral autoregulation may decrease neonatal regional hypoxic-ischemic brain injury","volume":"39","author":"Lee","year":"2016","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.siny.2021.101273_bib70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nicl.2016.01.020","article-title":"Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy","volume":"11","author":"Tian","year":"2016","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.siny.2021.101273_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/srep45958","article-title":"Novel wavelet real time analysis of neurovascular coupling in neonatal encephalopathy","volume":"7","author":"Chalak","year":"2017","journal-title":"Sci Rep"},{"issue":"1\u20134","key":"10.1016\/j.siny.2021.101273_bib72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000457833","article-title":"New wavelet neurovascular bundle for bedside evaluation of cerebral autoregulation and neurovascular coupling in newborns with hypoxic-ischemic encephalopathy","volume":"39","author":"Chalak","year":"2017","journal-title":"Dev Neurosci"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/jcbfm.2013.165","article-title":"Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia","volume":"34","author":"Dehaes","year":"2014","journal-title":"J Cerebr Blood Flow Metabol"},{"key":"10.1016\/j.siny.2021.101273_bib74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-444-64029-1.00013-8","article-title":"Biomarkers in neonatal hypoxic-ischemic encephalopathy-Review of the literature to date and future directions for research","volume":"162","author":"Murray","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.siny.2021.101273_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2012.00144","article-title":"Biomarkers of hypoxic-ischemic encephalopathy in newborns","volume":"3","author":"Douglas-Escobar","year":"2012","journal-title":"Front Neurol"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib76","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jpeds.2012.02.047","article-title":"Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia","volume":"161","author":"Massaro","year":"2012","journal-title":"J Pediatr"},{"issue":"7","key":"10.1016\/j.siny.2021.101273_bib77","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/PCC.0000000000000155","article-title":"Biomarkers S100B and neuron-specific enolase predict outcome in hypothermia-treated encephalopathic newborns*","volume":"15","author":"Massaro","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"4","key":"10.1016\/j.siny.2021.101273_bib78","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1203\/00006450-200104000-00011","article-title":"Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia","volume":"49","author":"Nagdyman","year":"2001","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib79","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1203\/01.PDR.0000072518.98189.A0","article-title":"Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia","volume":"54","author":"Nagdyman","year":"2003","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1651-2227.2011.02480.x","article-title":"Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia","volume":"101","author":"Roka","year":"2012","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib81","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/PCC.0b013e3182720642","article-title":"Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study","volume":"14","author":"Massaro","year":"2013","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib82","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1203\/PDR.0b013e3181f85a03","article-title":"A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy","volume":"68","author":"Douglas-Escobar","year":"2010","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib83","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","article-title":"Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy","volume":"164","author":"Chalak","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2021.101273_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2014.00273","article-title":"UCH-L1 and GFAP serum levels in neonates with hypoxic-ischemic encephalopathy: a single center pilot study","volume":"5","author":"Douglas-Escobar","year":"2014","journal-title":"Front Neurol"},{"key":"10.1016\/j.siny.2021.101273_bib85","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpeds.2017.10.060","article-title":"Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy","volume":"194","author":"Massaro","year":"2018","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib86","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1016\/j.ajog.2011.06.025","article-title":"Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling","volume":"205","author":"Ennen","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"8","key":"10.1016\/j.siny.2021.101273_bib87","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.braindev.2013.10.007","article-title":"Serum tau protein level serves as a predictive factor for neurological prognosis in neonatal asphyxia","volume":"36","author":"Takahashi","year":"2014","journal-title":"Brain Dev"},{"issue":"1","key":"10.1016\/j.siny.2021.101273_bib88","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/etm.2016.3911","article-title":"SBDPs and Tau proteins for diagnosis and hypothermia therapy in neonatal hypoxic ischemic encephalopathy","volume":"13","author":"Wu","year":"2017","journal-title":"Exp Therapeut Med"},{"issue":"S0022\u20133476(20)","key":"10.1016\/j.siny.2021.101273_bib89","first-page":"30832","article-title":"Plasma and CSF candidate biomarkers of neonatal encephalopathy severity and neurodevelopmental outcomes","volume":"1","author":"Dietrick","year":"2020","journal-title":"J Pediatr"},{"issue":"5","key":"10.1016\/j.siny.2021.101273_bib90","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/pr.2015.280","article-title":"Association of brain injury and neonatal cytokine response during therapeutic hypothermia in newborns with hypoxic-ischemic encephalopathy","volume":"79","author":"Orrock","year":"2016","journal-title":"Pediatr Res"},{"issue":"10","key":"10.1016\/j.siny.2021.101273_bib91","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/jcbfm.2012.83","article-title":"Serum cytokines in a clinical trial of hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"32","author":"Jenkins","year":"2012","journal-title":"J Cerebr Blood Flow Metabol"},{"issue":"1055\/s-0040","key":"10.1016\/j.siny.2021.101273_bib92","first-page":"1717072","article-title":"Blood biomarkers and 6- to 7-year childhood outcomes following neonatal encephalopathy","volume":"10","author":"Pappas","year":"2020","journal-title":"Am J Perinatol"},{"issue":"6","key":"10.1016\/j.siny.2021.101273_bib93","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s41372-020-00850-5","article-title":"Blood biomarkers for neonatal hypoxic-ischemic encephalopathy in the presence and absence of sentinel events","volume":"41","author":"Broni","year":"2020","journal-title":"J Perinatol"},{"issue":"2","key":"10.1016\/j.siny.2021.101273_bib94","doi-asserted-by":"crossref","DOI":"10.1161\/01.STR.26.2.290","article-title":"Neuron-specific enolase in gerbil brain and serum after transient cerebral ischemia","volume":"26","author":"Horn","year":"1995","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.siny.2021.101273_bib95","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/cns.12127","article-title":"Biomarkers for the clinical differential diagnosis in traumatic brain injury\u2013a systematic review","volume":"19","author":"Yokobori","year":"2013","journal-title":"CNS Neurosci Ther"},{"issue":"10","key":"10.1016\/j.siny.2021.101273_bib96","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1651-2227.2001.tb03249.x","article-title":"Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants","volume":"90","author":"Blennow","year":"2001","journal-title":"Acta Paediatr"},{"issue":"8","key":"10.1016\/j.siny.2021.101273_bib97","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1111\/j.1651-2227.2012.02679.x","article-title":"Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic\/ischaemic brain damage","volume":"101","author":"Sun","year":"2012","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.1016\/j.siny.2021.101273_bib98","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1203\/00006450-199503000-00002","article-title":"Glial fibrillary acidic protein in the cerebrospinal fluid: a possible indicator of prognosis in full-term asphyxiated newborn infants?","volume":"37","author":"Blennow","year":"1995","journal-title":"Pediatr Res"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X21000810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:45:45Z","timestamp":1761677145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X21000810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1744165X21000810"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2021.101273","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bedside and laboratory neuromonitoring in neonatal encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2021.101273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101273"}}