{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:17Z","timestamp":1790801117545,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.siny.2022.101347","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T02:09:53Z","timestamp":1650334193000},"page":"101347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pulmonary hypertension and oxidative stress: Where is the link?"],"prefix":"10.1016","volume":"27","author":[{"given":"Munmun","family":"Rawat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ppul.25073","article-title":"Persistent pulmonary hypertension of the newborn","volume":"56","author":"Mandell","year":"2021","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0022-3476(81)80605-1","article-title":"The structural basis of persistent pulmonary hypertension of the newborn infant","volume":"98","author":"Murphy","year":"1981","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2022.101347_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2019.03.035","article-title":"Oxygen radical disease in the newborn, revisited: oxidative stress and disease in the newborn period","volume":"142","author":"Perez","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1203\/00006450-198403000-00004","article-title":"Preparation for birth into an O2-rich environment: the antioxidant enzymes in the developing rabbit lung","volume":"18","author":"Frank","year":"1984","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2022.101347_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.acc.2020.08.011","article-title":"Oxidative stress biomarkers in the preterm infant","volume":"102","author":"Sanchez-Illana","year":"2021","journal-title":"Adv Clin Chem"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1203\/pdr.0b013e318030d5b9","article-title":"Aortopulmonary transposition in the fetus: speculation on pathophysiology and therapy","volume":"61","author":"Rudolph","year":"2007","journal-title":"Pediatr Res"},{"issue":"8","key":"10.1016\/j.siny.2022.101347_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/children4080063","article-title":"Persistent pulmonary hypertension in the newborn","volume":"4","author":"Mathew","year":"2017","journal-title":"Children"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0095-5108(18)30039-3","article-title":"Pulmonary vascular biology during neonatal transition","volume":"26","author":"Lakshminrusimha","year":"1999","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.siny.2022.101347_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.freeradbiomed.2019.04.001","article-title":"Optimal oxygenation and role of free radicals in PPHN","volume":"142","author":"Wedgwood","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1203\/00006450-199205000-00007","article-title":"Adenosine triphosphate and adenosine increase the pulmonary blood flow to postnatal levels in fetal lambs","volume":"31","author":"Konduri","year":"1992","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.PCC.0000144715.03515.55","article-title":"Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn","volume":"5","author":"Pierce","year":"2004","journal-title":"Pediatr Crit Care Med : J Soc Critic Care Med World Fed Pediatr Intens Critic Care Soc"},{"issue":"5 Pt 2","key":"10.1016\/j.siny.2022.101347_bib12","first-page":"H2001","article-title":"Endothelium-dependent relaxations to adenosine in juvenile rabbit pulmonary arteries and veins","volume":"266","author":"Steinhorn","year":"1994","journal-title":"Am J Physiol"},{"issue":"9","key":"10.1016\/j.siny.2022.101347_bib13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1089\/ars.2015.6247","article-title":"The redox code","volume":"23","author":"Jones","year":"2015","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.siny.2022.101347_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.siny.2022.101347_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology","author":"Sies","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.siny.2022.101347_bib16","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"10.1016\/j.siny.2022.101347_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/antiox7110168","article-title":"The plasma membrane: a platform for intra- and intercellular redox signaling","volume":"7","author":"Nordzieke","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.siny.2022.101347_bib18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fped.2018.00369","article-title":"Oxidative stress as a primary risk factor for brain damage in preterm newborns","volume":"6","author":"Panfoli","year":"2018","journal-title":"Front Pediatr"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib19","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.RES.59.6.612","article-title":"PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH","volume":"59","author":"Kukreja","year":"1986","journal-title":"Circ Res"},{"key":"10.1016\/j.siny.2022.101347_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/physiol.00004.2006","article-title":"Modulation of vascular smooth muscle signaling by reactive oxygen species","volume":"21","author":"Lyle","year":"2006","journal-title":"Physiology"},{"key":"10.1016\/j.siny.2022.101347_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.redox.2013.04.005","article-title":"Sites of reactive oxygen species generation by mitochondria oxidizing different substrates","volume":"1","author":"Quinlan","year":"2013","journal-title":"Redox Biol"},{"issue":"23","key":"10.1016\/j.siny.2022.101347_bib22","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41390-019-0649-4","article-title":"Nitric oxide and preterm resuscitation: some words of caution","volume":"87","author":"Vento","year":"2020","journal-title":"Pediatr Res"},{"issue":"7","key":"10.1016\/j.siny.2022.101347_bib24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1089\/ars.2017.7162","article-title":"The conundrum of hydrogen peroxide signaling and the emerging role of peroxiredoxins as redox relay hubs","volume":"28","author":"Stocker","year":"2018","journal-title":"Antioxidants Redox Signal"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014564","article-title":"Hydrogen peroxide probes directed to different cellular compartments","volume":"6","author":"Malinouski","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.siny.2022.101347_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/ars.2015.6262","article-title":"Urinary lipid peroxidation byproducts: are they relevant for predicting neonatal morbidity in preterm infants?","volume":"23","author":"Kuligowski","year":"2015","journal-title":"Antioxidants Redox Signal"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbalip.2014.10.007","article-title":"The isoprostanes--25 years later","volume":"1851","author":"Milne","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib28","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1542\/peds.2009-0434","article-title":"Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease","volume":"124","author":"Vento","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093703","article-title":"Assessment of oxidative damage to proteins and DNA in urine of newborn infants by a validated UPLC-MS\/MS approach","volume":"9","author":"Kuligowski","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.siny.2022.101347_bib30","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.freeradbiomed.2015.09.014","article-title":"Novel biomarkers in amniotic fluid for early assessment of intraamniotic infection","volume":"89","author":"Chafer-Pericas","year":"2015","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1471-4914(03)00031-5","article-title":"Protein carbonylation in human diseases","volume":"9","author":"Dalle-Donne","year":"2003","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.siny.2022.101347_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2019.03.034","article-title":"Biomarkers of oxidative stress in the fetus and in the newborn","volume":"142","author":"Perrone","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"10.1016\/j.siny.2022.101347_bib33","first-page":"BC17","article-title":"Circulating protein carbonyls, antioxidant enzymes and related trace minerals among preterms with respiratory distress syndrome","volume":"11","author":"Ahmed","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.siny.2022.101347_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.freeradbiomed.2021.12.310","article-title":"A UPLC-MS\/MS method for the determination of oxidative stress biomarkers in amniotic fluid","volume":"179","author":"Cascant-Vilaplana","year":"2022","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib35","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1089\/ars.2010.3630","article-title":"Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension","volume":"15","author":"Wedgwood","year":"2011","journal-title":"Antioxidants Redox Signal"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.resp.2010.08.018","article-title":"Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn","volume":"174","author":"Farrow","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib37","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2011.4184","article-title":"Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells","volume":"17","author":"Farrow","year":"2012","journal-title":"Antioxidants Redox Signal"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib38","doi-asserted-by":"crossref","first-page":"L660","DOI":"10.1152\/ajplung.00369.2004","article-title":"Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn","volume":"289","author":"Wedgwood","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12","key":"10.1016\/j.siny.2022.101347_bib39","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1139\/y90-241","article-title":"Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle","volume":"68","author":"Rhoades","year":"1990","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.siny.2022.101347_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.ph.57.030195.000555","article-title":"Regulation of pulmonary vascular tone in the perinatal period","volume":"57","author":"Fineman","year":"1995","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib41","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(90)90221-Q","article-title":"Modulatory role of endogenous nitric oxide in pulmonary circulation in vivo","volume":"185","author":"Wiklund","year":"1990","journal-title":"Eur J Pharmacol"},{"issue":"6174","key":"10.1016\/j.siny.2022.101347_bib42","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib43","doi-asserted-by":"crossref","first-page":"L1058","DOI":"10.1152\/ajplung.2001.281.5.L1058","article-title":"ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species","volume":"281","author":"Wedgwood","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.siny.2022.101347_bib44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/bbrc.1993.1240","article-title":"Functionally distinct endothelin B receptors in vascular endothelium and smooth muscle","volume":"191","author":"Shetty","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005344-200107000-00006","article-title":"Oxidative stress increases endothelin-1 synthesis in human coronary artery smooth muscle cells","volume":"38","author":"K\u00e4hler","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib46","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1203\/00006450-199812000-00001","article-title":"Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs","volume":"44","author":"Black","year":"1998","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/01.pdr.0000191136.69142.8c","article-title":"Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation","volume":"59","author":"Lakshminrusimha","year":"2006","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib48","doi-asserted-by":"crossref","first-page":"L473","DOI":"10.1152\/ajplung.00313.2005","article-title":"Adjacent bronchus attenuates pulmonary arterial contractility","volume":"291","author":"Lakshminrusimha","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/japplphysiol.01382.2005","article-title":"Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation","volume":"101","author":"Lakshminrusimha","year":"2006","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib50","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/japplphysiol.00711.2011","article-title":"Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen","volume":"111","author":"Lakshminrusimha","year":"2011","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1203\/PDR.0b013e3181bab0c7","article-title":"Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension","volume":"66","author":"Lakshminrusimha","year":"2009","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib52","first-page":"428","article-title":"Early use of inhaled nitric oxide in preterm infants: is there a rationale for selective approach?","volume":"34","author":"Chandrasekharan","year":"2017","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib53","doi-asserted-by":"crossref","first-page":"H1812","DOI":"10.1152\/ajpheart.00425.2006","article-title":"Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension","volume":"292","author":"Konduri","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.siny.2022.101347_bib54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCRESAHA.107.161463","article-title":"Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells","volume":"102","author":"Farrow","year":"2008","journal-title":"Circ Res"},{"issue":"5 Pt 1","key":"10.1016\/j.siny.2022.101347_bib55","first-page":"L1005","article-title":"Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension","volume":"272","author":"Shaul","year":"1997","journal-title":"Am J Physiol"},{"issue":"4 Pt 2","key":"10.1016\/j.siny.2022.101347_bib56","first-page":"H1483","article-title":"Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension","volume":"268","author":"Steinhorn","year":"1995","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib57","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1203\/00006450-199603000-00010","article-title":"Chronic intrauterine pulmonary hypertension alters endothelin receptor activity in the ovine fetal lung","volume":"39","author":"Ivy","year":"1996","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib58","doi-asserted-by":"crossref","first-page":"L480","DOI":"10.1152\/ajplung.00283.2004","article-title":"Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide","volume":"288","author":"Wedgwood","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12","key":"10.1016\/j.siny.2022.101347_bib59","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2018.7720","article-title":"Biomechanical forces and oxidative stress: implications for pulmonary vascular disease","volume":"31","author":"Zemskov","year":"2019","journal-title":"Antioxidants Redox Signal"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib60","doi-asserted-by":"crossref","first-page":"L1069","DOI":"10.1152\/ajplung.00408.2005","article-title":"Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase","volume":"290","author":"Grobe","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.siny.2022.101347_bib61","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/HYPERTENSIONAHA.110.166819","article-title":"Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase","volume":"58","author":"Xu","year":"2011","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib62","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3892\/etm.2017.4243","article-title":"Effects of 17beta-estradiol and 2-methoxyestradiol on the oxidative stress-hypoxia inducible factor-1 pathway in hypoxic pulmonary hypertensive rats","volume":"13","author":"Wang","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.siny.2022.101347_bib63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.toxlet.2018.07.010","article-title":"Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats","volume":"295","author":"Bertoli","year":"2018","journal-title":"Toxicol Lett"},{"issue":"14","key":"10.1016\/j.siny.2022.101347_bib64","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1089\/ars.2012.4766","article-title":"Increased p22(phox)\/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn","volume":"18","author":"Wedgwood","year":"2013","journal-title":"Antioxidants Redox Signal"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib65","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/01.RES.70.3.593","article-title":"Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression","volume":"70","author":"Rao","year":"1992","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.siny.2010.04.001","article-title":"Maturation of the antioxidant system and the effects on preterm birth","volume":"15","author":"Davis","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"issue":"13","key":"10.1016\/j.siny.2022.101347_bib67","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1089\/ars.2013.5515","article-title":"Developmental regulation of antioxidant enzymes and their impact on neonatal lung disease","volume":"21","author":"Berkelhamer","year":"2014","journal-title":"Antioxidants Redox Signal"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib68","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0891-5849(97)00384-5","article-title":"Development of glutathione synthesis and gamma-glutamyltranspeptidase activities in tissues from newborn infants","volume":"24","author":"Lavoie","year":"1998","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib69","doi-asserted-by":"crossref","first-page":"L616","DOI":"10.1152\/ajplung.00064.2011","article-title":"Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn","volume":"302","author":"Wedgwood","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.siny.2022.101347_bib70","doi-asserted-by":"crossref","first-page":"L979","DOI":"10.1152\/ajplung.90238.2008","article-title":"Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension","volume":"295","author":"Farrow","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12","key":"10.1016\/j.siny.2022.101347_bib71","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1164\/rccm.200605-676OC","article-title":"Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension","volume":"174","author":"Lakshminrusimha","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib72","doi-asserted-by":"crossref","first-page":"L109","DOI":"10.1152\/ajplung.00309.2009","article-title":"SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension","volume":"299","author":"Farrow","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"10.1016\/j.siny.2022.101347_bib73","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/pr.2013.20","article-title":"Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn","volume":"73","author":"Konduri","year":"2013","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.siny.2022.101347_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1086\/674903","article-title":"Hydrocortisone normalizes phosphodiesterase-5 activity in pulmonary artery smooth muscle cells from lambs with persistent pulmonary hypertension of the newborn","volume":"4","author":"Perez","year":"2014","journal-title":"Pulm Circ"},{"issue":"10","key":"10.1016\/j.siny.2022.101347_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/children7100180","article-title":"How do we monitor oxygenation during the management of PPHN? Alveolar, arterial, mixed venous oxygen tension or peripheral saturation?","volume":"7","author":"Chandrasekharan","year":"2020","journal-title":"Children"},{"issue":"2","key":"10.1016\/j.siny.2022.101347_bib76","doi-asserted-by":"crossref","first-page":"101070","DOI":"10.1016\/j.siny.2019.101070","article-title":"Oxygen therapy in preterm infants with pulmonary hypertension","volume":"25","author":"Chandrasekharan","year":"2020","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib77","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jpeds.2013.04.043","article-title":"Perinatal asphyxia with hyperoxemia within the first hour of life is associated with moderate to severe hypoxic-ischemic encephalopathy","volume":"163","author":"Kapadia","year":"2013","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.siny.2022.101347_bib78","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1067\/mpd.2003.91","article-title":"Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen","volume":"142","author":"Vento","year":"2003","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib79","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/pr.2015.259","article-title":"Neonatal resuscitation adhering to oxygen saturation guidelines in asphyxiated lambs with meconium aspiration","volume":"79","author":"Rawat","year":"2016","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.siny.2022.101347_bib80","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1165\/rcmb.2019-0449OC","article-title":"Optimal oxygen targets in term lambs with meconium aspiration syndrome and pulmonary hypertension","volume":"63","author":"Rawat","year":"2020","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X22000269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X22000269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:46:16Z","timestamp":1761677176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X22000269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1744165X22000269"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2022.101347","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary hypertension and oxidative stress: Where is the link?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2022.101347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101347"}}