{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:18:48Z","timestamp":1792761528382,"version":"4.5.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.siny.2023.101501","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T13:27:33Z","timestamp":1700746053000},"page":"101501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neonatal surfactant therapy beyond respiratory distress syndrome"],"prefix":"10.1016","volume":"28","author":[{"given":"Peter A.","family":"Dargaville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egbert","family":"Herting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger F.","family":"Soll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.siny.2023.101501_bib1","first-page":"751","article-title":"Surfactant pool sizes and severity of respiratory distress syndrome in prematurely delivered lambs","volume":"127","author":"Jobe","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.siny.2023.101501_bib2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm\/144.6.1376","article-title":"Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid. Correlation with surface activity, severity of respiratory distress syndrome, and outcome in small premature infants","volume":"144","author":"Hallman","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.siny.2023.101501_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.200304-479OC","article-title":"Surfactant protein profile of pulmonary surfactant in premature infants","volume":"168","author":"Ballard","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM199303253281208","article-title":"Pulmonary surfactant therapy","volume":"328","author":"Jobe","year":"1993","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"10.1016\/j.siny.2023.101501_bib5","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1038\/sj.jp.7211320","article-title":"Overview of surfactant replacement trials","volume":"25","author":"Suresh","year":"2005","journal-title":"J Perinatol"},{"key":"10.1016\/j.siny.2023.101501_bib6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0925-4439(98)00080-5","article-title":"Principles of surfactant replacement","volume":"1408","author":"Robertson","year":"1998","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 2","key":"10.1016\/j.siny.2023.101501_bib7","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/jp.2009.32","article-title":"Pulmonary surfactant kinetics of the newborn infant: novel insights from studies with stable isotopes","volume":"29","author":"Carnielli","year":"2009","journal-title":"J Perinatol"},{"key":"10.1016\/j.siny.2023.101501_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1067\/mpd.2003.94","article-title":"Surfactant phosphatidylcholine pool size in human neonates with congenital diaphragmatic hernia requiring ECMO","volume":"142","author":"Janssen","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1067\/mpd.2001.109602","article-title":"Surfactant and surfactant inhibitors in meconium aspiration syndrome","volume":"138","author":"Dargaville","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1165\/rcmb.2019-0413OC","article-title":"Surfactant injury in the early phase of severe meconium aspiration syndrome","volume":"63","author":"Autilio","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.siny.2023.101501_bib11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0140-6736(77)91281-8","article-title":"Group-B streptococci in the newborn","volume":"1","author":"Saunders","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2023.101501_bib12","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/bmj.288.6431.1635","article-title":"Non-specificity of surfactant deficiency in neonatal respiratory disorders","volume":"288","author":"James","year":"1984","journal-title":"Br Med J"},{"key":"10.1016\/j.siny.2023.101501_bib13","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pmed.0040237","article-title":"Surfactant maturation is not delayed in human fetuses with diaphragmatic hernia","volume":"4","author":"Boucherat","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.siny.2023.101501_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0002-9378(95)90624-X","article-title":"Fetal lung maturation in congenital diaphragmatic hernia","volume":"173","author":"Moya","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2023.101501_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00003246-199803000-00035","article-title":"Prospective evaluation of surfactant composition in bronchoalveolar lavage fluid of infants with congenital diaphragmatic hernia and of age-matched controls","volume":"26","author":"Ijsselstijn","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1203\/01.PDR.0000084344.42409.C6","article-title":"Pulmonary surfactant disaturated-phosphatidylcholine (DSPC) turnover and pool size in newborn infants with congenital diaphragmatic hernia (CDH)","volume":"54","author":"Cogo","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-3476(05)82839-2","article-title":"Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation","volume":"116","author":"Lotze","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib18","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/00003246-199606000-00029","article-title":"Surfactant content in children with inflammatory lung disease","volume":"24","author":"LeVine","year":"1996","journal-title":"Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0022-3468(92)90865-5","article-title":"Pathophysiology of congenital diaphragmatic hernia II: the fetal lamb CDH model is surfactant deficient","volume":"27","author":"Glick","year":"1992","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1164\/ajrccm.160.3.9811048","article-title":"Comparison of two methods of diagnostic lung lavage in ventilated infants with lung disease","volume":"160","author":"Dargaville","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1152\/jappl.1987.62.2.429","article-title":"Artificial pulmonary surfactant inhibited by proteins","volume":"62","author":"Fuchimukai","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.siny.2023.101501_bib22","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1183\/09031936.93.06070971","article-title":"Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations","volume":"6","author":"Seeger","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1016\/j.siny.2023.101501_bib23","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1152\/jappl.1987.63.4.1434","article-title":"Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity","volume":"63","author":"Holm","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.siny.2023.101501_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9378(11)80003-7","article-title":"Inhibition of pulmonary surfactant function by meconium","volume":"164","author":"Moses","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.siny.2023.101501_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1203\/00006450-199808000-00008","article-title":"Morphology and function of pulmonary surfactant inhibited by meconium","volume":"44","author":"Bae","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1203\/00006450-200107000-00010","article-title":"Resistance of different surfactant preparations to inactivation by meconium","volume":"50","author":"Herting","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00003246-198504000-00005","article-title":"Effect of intra-alveolar meconium on pulmonary surface tension properties","volume":"13","author":"Chen","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1164\/ajrccm.162.2.9909099","article-title":"Polymer-surfactant treatment of meconium-induced acute lung injury","volume":"162","author":"Lu","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1574-6968.2000.tb09183.x","article-title":"Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids","volume":"188","author":"Flieger","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.siny.2023.101501_bib30","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.2165\/00003495-200565180-00003","article-title":"Surfactant therapy for meconium aspiration syndrome: current status","volume":"65","author":"Dargaville","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.siny.2023.101501_bib31","doi-asserted-by":"crossref","first-page":"217A","DOI":"10.1203\/00006450-199604001-01307","article-title":"Surfactant distribution in the piglet model of meconium aspiration","volume":"39","author":"Hudson","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1203\/00006450-199310000-00021","article-title":"Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique","volume":"34","author":"Segerer","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1542\/peds.87.1.101","article-title":"Surfactant treatment of full-term newborns with respiratory failure","volume":"87","author":"Auten","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1542\/peds.92.1.135","article-title":"Surfactant therapy in full-term neonates with severe respiratory failure","volume":"92","author":"Khammash","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ppul.1950130209","article-title":"High-frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure","volume":"13","author":"Davis","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.siny.2023.101501_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3476(06)80131-9","article-title":"Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation","volume":"122","author":"Lotze","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-2008-1034531","article-title":"[Surfactant therapy in severe neonatal respiratory failure--multicenter study--II. Surfactant therapy in 10 newborn infants with meconium aspiration syndrome]. [German]","volume":"205","author":"Blanke","year":"1993","journal-title":"Klin P\u00e4diatr"},{"key":"10.1016\/j.siny.2023.101501_bib38","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/BF02532529","article-title":"Treatment of severe meconium aspiration syndrome with porcine surfactant. Collaborative Surfactant Study Group","volume":"155","author":"Halliday","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1542\/peds.97.1.48","article-title":"Surfactant replacement therapy for meconium aspiration syndrome","volume":"97","author":"Findlay","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-3476(98)70482-2","article-title":"Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group","volume":"132","author":"Lotze","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib41","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1651-2227.2005.tb02008.x","article-title":"Treatment of severe meconium aspiration syndrome with porcine surfactant: a multicentre, randomized, controlled trial","volume":"94","year":"2005","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.siny.2023.101501_bib42","first-page":"1545","article-title":"A randomized trial of natural surfactant for moderate to severe meconium aspiration syndrome","volume":"57","author":"Maturana","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib43","first-page":"CD002054","article-title":"Surfactant for meconium aspiration syndrome in term and late preterm infants","volume":"12","author":"El Shahed","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.siny.2023.101501_bib44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/tropej\/fmy081","article-title":"Lung lavage with dilute surfactant vs. bolus surfactant for meconium aspiration syndrome","volume":"65","author":"Arayici","year":"2019","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib45","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1542\/peds.2005-2215","article-title":"The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome","volume":"117","author":"Dargaville","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib46","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/jp.2008.241","article-title":"Meconium aspiration syndrome remains a significant problem in the NICU: outcomes and treatment patterns in term neonates admitted for intensive care during a ten-year period","volume":"29","author":"Singh","year":"2009","journal-title":"J Perinatol"},{"key":"10.1016\/j.siny.2023.101501_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/pch\/pxaa116","article-title":"Guidelines for surfactant replacement therapy in neonates","volume":"26","author":"Ng","year":"2021","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.siny.2023.101501_bib48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000528914","article-title":"European Consensus guidelines on the management of respiratory distress syndrome: 2022 update","volume":"120","author":"Sweet","year":"2023","journal-title":"Neonatology"},{"key":"10.1016\/j.siny.2023.101501_bib49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1542\/peds.2013-3443","article-title":"Surfactant replacement therapy for preterm and term neonates with respiratory distress","volume":"133","author":"Polin","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib50","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1159\/000337346","article-title":"Innovation in surfactant therapy I: surfactant lavage and surfactant administration by fluid bolus using minimally invasive techniques","volume":"101","author":"Dargaville","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.siny.2023.101501_bib51","first-page":"1031","article-title":"Meconium aspiration in the newborn","volume":"56","author":"Burke-Strickland","year":"1973","journal-title":"Minn Med"},{"key":"10.1016\/j.siny.2023.101501_bib52","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1203\/00006450-199811000-00013","article-title":"Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome","volume":"44","author":"Cochrane","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib53","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1164\/rccm.200301-121OC","article-title":"Therapeutic lung lavage in the piglet model of meconium aspiration syndrome","volume":"168","author":"Dargaville","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib54","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1542\/peds.109.6.1081","article-title":"A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndrome","volume":"109","author":"Wiswell","year":"2002","journal-title":"Pediatrics"},{"issue":"Suppl 3","key":"10.1016\/j.siny.2023.101501_bib55","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/jp.2008.163","article-title":"Treatment of MAS with PPHN using combined therapy: SLL, bolus surfactant and iNO","volume":"28","author":"Gadzinowski","year":"2008","journal-title":"J Perinatol"},{"key":"10.1016\/j.siny.2023.101501_bib56","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpeds.2010.08.044","article-title":"Randomized controlled trial of lung lavage with dilute surfactant for meconium aspiration syndrome","volume":"158","author":"Dargaville","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib57","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/tropej\/fmy024","article-title":"Surfactant lung lavage vs. standard care in the treatment of meconium aspiration syndrome - a randomized trial","volume":"65","author":"Bandiya","year":"2019","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib58","series-title":"Hot Topics in Neonatology '97 Conference Proceedings","first-page":"259","article-title":"Bronchial lavage with surfactant solution for the treatment of meconium aspiration syndrome","author":"Ogawa","year":"1997"},{"key":"10.1016\/j.siny.2023.101501_bib59","first-page":"CD003486","article-title":"Lung lavage for meconium aspiration syndrome in newborn infants","volume":"4","author":"Hahn","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.siny.2023.101501_bib60","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1111\/apa.12070","article-title":"Fluid recovery during lung lavage in meconium aspiration syndrome","volume":"102","author":"Dargaville","year":"2013","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.siny.2023.101501_bib61","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bj.2021.07.011","article-title":"Strategies to protect surfactant and enhance its activity","volume":"44","author":"De","year":"2021","journal-title":"Biomed J"},{"key":"10.1016\/j.siny.2023.101501_bib62","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S2213-2600(17)30214-X","article-title":"The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity","volume":"5","author":"De","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.siny.2023.101501_bib63","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1148\/124.3.771","article-title":"The radiographic features of early onset Group B streptococcal neonatal sepsis","volume":"124","author":"Ablow","year":"1977","journal-title":"Radiology"},{"key":"10.1016\/j.siny.2023.101501_bib64","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1542\/peds.106.5.957","article-title":"Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group","volume":"106","author":"Herting","year":"2000","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"10.1016\/j.siny.2023.101501_bib65","first-page":"33","article-title":"Effectiveness of treatment with surfactant in premature infants with respiratory failure and pulmonary infection","volume":"83","author":"Vento","year":"2012","journal-title":"Acta Biomed"},{"key":"10.1016\/j.siny.2023.101501_bib66","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1128\/CDLI.7.5.817-822.2000","article-title":"Influence of modified natural or synthetic surfactant preparations on growth of bacteria causing infections in the neonatal period","volume":"7","author":"Rauprich","year":"2000","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.siny.2023.101501_bib67","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1203\/00006450-199412000-00017","article-title":"Experimental neonatal group B streptococcal pneumonia: effect of a modified porcine surfactant on bacterial proliferation in ventilated near-term rabbits","volume":"36","author":"Herting","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib68","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41390-022-02152-2","article-title":"Efficacy of synthetic surfactant (CHF5633) bolus and\/or lavage in meconium-induced lung injury in ventilated newborn rabbits","volume":"93","author":"Xu","year":"2023","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2023.101501_bib69","article-title":"SP-A and SP-D: dual functioning immune molecules with antiviral and immunomodulatory properties","volume":"11","author":"Watson","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.siny.2023.101501_bib70","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1164\/rccm.200312-1779OC","article-title":"Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia","volume":"169","author":"van Kaam","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib71","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1542\/peds.93.3.538","article-title":"Bovine surfactant in full-term neonates with adult respiratory distress syndrome-like disorders","volume":"93","author":"Gortner","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib72","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000196367","article-title":"Successful surfactant replacement therapy in two infants with ARDS due to chlamydial pneumonia","volume":"61","author":"Harms","year":"1994","journal-title":"Respiration"},{"key":"10.1016\/j.siny.2023.101501_bib73","first-page":"SC09","article-title":"Surfactant therapy for early onset pneumonia in late preterm and term neonates needing mechanical ventilation","volume":"11","author":"Deshpande","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.siny.2023.101501_bib74","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.55730\/1300-0144.5523","article-title":"Can surfactants affect mortality and morbidity in term infants with respiratory failure?","volume":"52","author":"Ozdemir","year":"2022","journal-title":"Turk J Med Sci"},{"key":"10.1016\/j.siny.2023.101501_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101739","article-title":"Clinical characteristics and outcomes in neonates with perinatal acute respiratory distress syndrome in China: a national, multicentre, cross-sectional study","volume":"55","author":"Chen","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.siny.2023.101501_bib76","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00431-020-03821-2","article-title":"Bovine surfactant in the treatment of pneumonia-induced-neonatal acute respiratory distress syndrome (NARDS) in neonates beyond 34 weeks of gestation: a multicentre, randomized, assessor-blinded, placebo-controlled trial","volume":"180","author":"Rong","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib77","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/ajrccm.162.4.9909004","article-title":"Exogenous surfactant supplementation in infants with respiratory syncytial virus bronchiolitis","volume":"162","author":"Tibby","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib78","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00130478-200207000-00011","article-title":"Multicenter, randomized, controlled study of porcine surfactant in severe respiratory syncytial virus-induced respiratory failure","volume":"3","author":"Luchetti","year":"2002","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib79","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.chest.2021.01.028","article-title":"Surfactant for the treatment of ARDS in a patient with COVID-19","volume":"160","author":"Heching","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.siny.2023.101501_bib80","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1542\/peds.106.5.1135","article-title":"Commentary on surfactant treatment of neonates with respiratory failure and group B streptococcal infection","volume":"106","author":"Jobe","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib81","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1164\/ajrccm.157.2.9612072","article-title":"Surfactant protein A is decreased in a rat model of congenital diaphragmatic hernia","volume":"157","author":"Mysore","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib82","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0022-3468(93)90250-O","article-title":"Biochemical immaturity of lungs in congenital diaphragmatic hernia","volume":"28","author":"Suen","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib83","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000244326","article-title":"Pulmonary surfactant dysfunction in congenital diaphragmatic hernia: experimental and clinical findings","volume":"69","author":"Valls-i-Soler","year":"1996","journal-title":"Biol Neonate"},{"key":"10.1016\/j.siny.2023.101501_bib84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-3476(94)70322-1","article-title":"Pathophysiology of congenital diaphragmatic hernia. V. Effect of exogenous surfactant therapy on gas exchange and lung mechanics in the lamb congenital diaphragmatic hernia model","volume":"124","author":"Wilcox","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib85","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0022-3468(96)90484-4","article-title":"Surfactant decreases pulmonary vascular resistance and increases pulmonary blood flow in the fetal lamb model of congenital diaphragmatic hernia","volume":"31","author":"O'Toole","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib86","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0022-3468(96)90097-4","article-title":"Surfactant rescue in the fetal lamb model of congenital diaphragmatic hernia","volume":"31","author":"O'Toole","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib87","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0140-6736(91)92151-Q","article-title":"Surfactant replacement therapy in high-risk congenital diaphragmatic hernia","volume":"338","author":"Bos","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.siny.2023.101501_bib88","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0022-3468(92)90386-L","article-title":"Pathophysiology of congenital diaphragmatic hernia. III: exogenous surfactant therapy for the high-risk neonate with CDH","volume":"27","author":"Glick","year":"1992","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib89","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0022-3468(94)90580-0","article-title":"Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency","volume":"29","author":"Lotze","year":"1994","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib90","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.jpedsurg.2004.07.005","article-title":"Surfactant replacement therapy on ECMO does not improve outcome in neonates with congenital diaphragmatic hernia","volume":"39","author":"Colby","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib91","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jpedsurg.2004.02.011","article-title":"Surfactant does not improve survival rate in preterm infants with congenital diaphragmatic hernia","volume":"39","author":"Lally","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.siny.2023.101501_bib92","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jpeds.2004.04.056","article-title":"Is surfactant therapy beneficial in the treatment of the term newborn infant with congenital diaphragmatic hernia?","volume":"145","author":"Van","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib93","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1542\/peds.51.2.175","article-title":"Pathogenesis of hemorrhagic pulmonary edema and massive pulmonary hemorrhage in the newborn","volume":"51","author":"Cole","year":"1973","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib94","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0022-3476(05)80963-1","article-title":"Pulmonary hemorrhage and exogenous surfactant therapy: a metaanalysis","volume":"123","author":"Raju","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib95","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/01.PCC.0000244405.96885.96","article-title":"Successful use of surfactant to treat severe intrapulmonary hemorrhage after iatrogenic lung injury--A case report","volume":"7","author":"Haas","year":"2006","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.siny.2023.101501_bib96","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1542\/peds.95.1.32","article-title":"Surfactant therapy in neonates with respiratory deterioration due to pulmonary hemorrhage","volume":"95","author":"Pandit","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.siny.2023.101501_bib97","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00431-003-1276-x","article-title":"Surfactant therapy in neonates with respiratory failure due to haemorrhagic pulmonary oedema","volume":"162","author":"Amizuka","year":"2003","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.siny.2023.101501_bib98","first-page":"CD005254","article-title":"Surfactant for pulmonary haemorrhage in neonates","volume":"2","author":"Aziz","year":"2020","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X2300077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X2300077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:48:41Z","timestamp":1761677321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X2300077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":98,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1744165X2300077X"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2023.101501","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal surfactant therapy beyond respiratory distress syndrome","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2023.101501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101501"}}