{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:18:51Z","timestamp":1792034331578,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Fetal and Neonatal Medicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.siny.2024.101565","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T12:12:45Z","timestamp":1731413565000},"page":"101565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Management of patent ductus arteriosus \u2013 Evidence to practice"],"prefix":"10.1016","volume":"29","author":[{"given":"Samir","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Donn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.siny.2024.101565_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-0028-1090594","article-title":"The ductus arteriosus rarely requires treatment in infants > 1000 grams","volume":"25","author":"Nemerofsky","year":"2008","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.siny.2024.101565_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2431-9-50","article-title":"Prioritising neonatal medicines research: UK Medicines for Children Research Network scoping survey","volume":"9","author":"Turner","year":"2009","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.siny.2024.101565_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1542\/peds.2008-2418","article-title":"Failure of ductus arteriosus closure is associated with increased mortality in preterm infants","volume":"123","author":"Noori","year":"2009","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib4","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1542\/peds.104.6.1345","article-title":"Risk factors for chronic lung disease in the surfactant era: a North Carolina population-based study of very low birth weight infants. North Carolina Neonatologists Association","volume":"104","author":"Marshall","year":"1999","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2024.101565_bib5","first-page":"184","article-title":"Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study","volume":"40","author":"Dollberg","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.siny.2024.101565_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1203\/PDR.0b013e3181827c2c","article-title":"Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus","volume":"64","author":"Liu","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.siny.2024.101565_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0952-8180(90)90097-M","article-title":"The transitional circulation: physiology and anaesthetic implications","volume":"2","author":"Clarke","year":"1990","journal-title":"J Clin Anesth"},{"issue":"7","key":"10.1016\/j.siny.2024.101565_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/ped.12915","article-title":"Early predictive echocardiographic features of hemodynamically significant patent ductus arteriosus in preterm VLBW infants","volume":"58","author":"Polat","year":"2016","journal-title":"Pediatr Int : official journal of the Japan Pediatric Society"},{"issue":"Suppl 1","key":"10.1016\/j.siny.2024.101565_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41390-018-0077-x","article-title":"Application of NPE in the assessment of a patent ductus arteriosus","volume":"84","author":"van Laere","year":"2018","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.siny.2024.101565_bib10","doi-asserted-by":"crossref","first-page":"F64","DOI":"10.1136\/archdischild-2013-304197","article-title":"Tissue Doppler imaging in very preterm infants during the first 24 h of life: an observational study","volume":"99","author":"Lee","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/echo.12463","article-title":"Tissue Doppler-derived strain and strain rate during the first 28 days of life in very low birth weight infants","volume":"31","author":"Helfer","year":"2014","journal-title":"Echocardiography (Mount Kisco, NY)"},{"issue":"26","key":"10.1016\/j.siny.2024.101565_bib12","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","article-title":"Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants","volume":"344","author":"Schmidt","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2024.101565_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.earlhumdev.2016.12.007","article-title":"Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants","volume":"105","author":"Weisz","year":"2017","journal-title":"Early Hum Dev"},{"issue":"4","key":"10.1016\/j.siny.2024.101565_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.siny.2015.03.004","article-title":"Preterm patent ductus arteriosus: a continuing conundrum for the neonatologist?","volume":"20","author":"Evans","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.siny.2024.101565_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.siny.2018.06.001","article-title":"Contemporary approach to the patent ductus arteriosus and future considerations","volume":"23","author":"Gupta","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.siny.2024.101565_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.siny.2018.03.007","article-title":"Role of neonatologist-performed echocardiography in the assessment and management of patent ductus arteriosus physiology in the newborn","volume":"23","author":"de Boode","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib17","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jpeds.2015.09.028","article-title":"A patent ductus arteriosus severity score predicts chronic lung disease or death before discharge","volume":"167","author":"El-Khuffash","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2024.101565_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.earlhumdev.2016.12.007","article-title":"Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants","volume":"105","author":"Weisz","year":"2017","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.siny.2024.101565_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.earlhumdev.2016.12.008","article-title":"A conservative treatment of patent ductus arteriosus in very low birth weight infants","volume":"104","author":"Letshwiti","year":"2017","journal-title":"Early Hum Dev"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib20","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jpeds.2004.07.035","article-title":"Prevention of intraventricular hemorrhage by indomethacin in male preterm infants","volume":"145","author":"Ment","year":"2004","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.siny.2024.101565_bib21","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","author":"Ohlsson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib22","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jpeds.2011.12.031","article-title":"Timing of patent ductus arteriosus treatment and respiratory outcome in premature infants: a double-blind randomized controlled trial","volume":"160","author":"Sosenko","year":"2012","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.siny.2024.101565_bib23","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jama.2018.1896","article-title":"Association of placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis","volume":"319","author":"Mitra","year":"2018","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.siny.2024.101565_bib24","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.siny.2024.101565_bib25","doi-asserted-by":"crossref","first-page":"F99","DOI":"10.1136\/archdischild-2013-304695","article-title":"A randomised placebo-controlled trial of early treatment of the patent ductus arteriosus","volume":"99","author":"Kluckow","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.siny.2024.101565_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpeds.2020.12.008","article-title":"Effect of early targeted treatment of ductus arteriosus with ibuprofen on survival without cerebral palsy at 2 Years in infants with extreme prematurity: a randomized clinical trial","volume":"233","author":"Roz\u00e9","year":"2021","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2024.101565_bib27","article-title":"BeNeDuctus trial investigators. Expectant management or early ibuprofen for patent ductus arteriosus","author":"Hundscheid","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2024.101565_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jpeds.2020.10.024","article-title":"A pilot randomized controlled trial of early targeted patent ductus arteriosus treatment using a risk based severity score (the PDA RCT)","volume":"229","author":"El-Khuffash","year":"2021","journal-title":"J Pediatr"},{"key":"10.1016\/j.siny.2024.101565_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJMoa2305582","article-title":"Trial of selective early treatment of patent ductus arteriosus with ibuprofen","volume":"390","author":"Gupta","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.siny.2024.101565_bib30","first-page":"A132","article-title":"Long-term neurodevelopmental and respiratory outcomes after selective early treatment of patent ductus arteriosus","volume":"109","author":"Gupta","year":"2024","journal-title":"Arch Dis Child"}],"container-title":["Seminars in Fetal and Neonatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X24000477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744165X24000477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T03:16:05Z","timestamp":1736306165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744165X24000477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1744165X24000477"],"URL":"https:\/\/doi.org\/10.1016\/j.siny.2024.101565","relation":{},"ISSN":["1744-165X"],"issn-type":[{"value":"1744-165X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of patent ductus arteriosus \u2013 Evidence to practice","name":"articletitle","label":"Article Title"},{"value":"Seminars in Fetal and Neonatal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.siny.2024.101565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101565"}}