{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:20:19Z","timestamp":1788268819249,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery in Practice and Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.sipas.2026.100353","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:14:00Z","timestamp":1783469640000},"page":"100353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tranexamic acid in radical cystectomy: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"26","author":[{"given":"Fatemeh","family":"Fereidooni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Dehbozorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davoud","family":"Khalilzadeh Bonab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-4399","authenticated-orcid":false,"given":"Arman","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mirhosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.sipas.2026.100353_bib0001","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.euo.2019.11.005","volume":"3","author":"Bruins","year":"2020","journal-title":"Eur Urol Oncol"},{"issue":"5","key":"10.1016\/j.sipas.2026.100353_bib0002","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.eururo.2013.01.004","article-title":"The impact of perioperative blood transfusion on cancer recurrence and survival following radical cystectomy","volume":"63","author":"Linder","year":"2013","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.sipas.2026.100353_bib0003","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/SLA.0b013e31817f2c1a","article-title":"Evidence-based surgical care and the evolution of fast-track surgery","volume":"248","author":"Kehlet","year":"2008","journal-title":"Ann Surg"},{"issue":"17","key":"10.1016\/j.sipas.2026.100353_bib0004","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood-2018-10-860809","article-title":"Transfusion-associated circulatory overload and transfusion-related acute lung injury","volume":"133","author":"Semple","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.sipas.2026.100353_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.suronc.2021.101592","article-title":"Impact of perioperative blood transfusions on oncologic outcomes after radical cystectomy: a systematic review and meta-analysis of comparative studies","volume":"38","author":"Uysal","year":"2021","journal-title":"Surg Oncol"},{"issue":"2","key":"10.1016\/j.sipas.2026.100353_bib0006","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/21681805.2017.1295399","article-title":"Dramatic impact of blood transfusion on cancer-specific survival after radical cystectomy irrespective of tumor stage","volume":"51","author":"Buchner","year":"2017","journal-title":"Scand J Urol"},{"issue":"2","key":"10.1016\/j.sipas.2026.100353_bib0007","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ejh.13348","article-title":"The many roles of tranexamic acid: an overview of the clinical indications for TXA in medical and surgical patients","volume":"104","author":"Cai","year":"2020","journal-title":"Eur J Haematol"},{"issue":"25","key":"10.1016\/j.sipas.2026.100353_bib0008","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034146","article-title":"Efficacy and safety of intravenous tranexamic acid in urologic surgery: a systematic review and meta-analysis of randomized controlled trials","volume":"102","author":"Lin","year":"2023","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.sipas.2026.100353_bib0009","doi-asserted-by":"crossref","first-page":"443","DOI":"10.5811\/westjem.2019.4.41698","article-title":"Mortality and thrombosis in injured adults receiving tranexamic acid in the post-CRASH-2 era","volume":"20","author":"Benipal","year":"2019","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.sipas.2026.100353_bib0010","first-page":"372","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0011","first-page":"1","article-title":"The newcastle-ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","volume":"2","author":"Peterson","year":"2011","journal-title":"Ottawa Hosp Res Inst"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0028","doi-asserted-by":"crossref","DOI":"10.1007\/s00345-024-05168-x","article-title":"Tranexamic acid reduces perioperative blood transfusions following open radical cystectomy \u2013 a propensity-score matched analysis","volume":"42","author":"Egen","year":"2024","journal-title":"World J Urol"},{"issue":"12","key":"10.1016\/j.sipas.2026.100353_bib0029","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1001\/jamasurg.2024.4183","article-title":"Tranexamic acid during radical cystectomy: a randomized clinical trial","volume":"159","author":"Breau","year":"2024","journal-title":"JAMA Surg"},{"key":"10.1016\/j.sipas.2026.100353_bib0030","doi-asserted-by":"crossref","DOI":"10.1097\/01.JU.0001008768.36634.79.03","article-title":"Intraoperative tranexamic acid in radical cystectomy: impact on bleeding, thromboembolism, and survival outcomes","volume":"211","author":"Ahmed","year":"2024","journal-title":"J Urol"},{"key":"10.1016\/j.sipas.2026.100353_bib0031","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.urology.2016.02.044","article-title":"Efficacy and safety of intraoperative tranexamic acid infusion for reducing blood transfusion during open radical cystectomy","volume":"92","author":"Zaid","year":"2016","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0012","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.urolonc.2013.06.006","article-title":"Blood loss associated with radical cystectomy: a prospective, randomized study comparing impact LigaSure vs. stapling device","volume":"32","author":"Thompson","year":"2014","journal-title":"Urol Oncol"},{"issue":"6","key":"10.1016\/j.sipas.2026.100353_bib0013","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0022-5347(05)65524-3","article-title":"Estimated blood loss and transfusion requirements of radical cystectomy","volume":"166","author":"Chang","year":"2001","journal-title":"J Urol"},{"issue":"12","key":"10.1016\/j.sipas.2026.100353_bib0014","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1007\/s11695-023-06902-x","article-title":"Effect of tranexamic acid on postoperative bleeding in sleeve gastrectomy: a randomized trial","volume":"33","author":"Sermet","year":"2023","journal-title":"Obes Surg"},{"issue":"8","key":"10.1016\/j.sipas.2026.100353_bib0015","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.3390\/jcm15083017","article-title":"Perioperative patient blood management: evidence-based strategies for surgeons and anesthesiologists: a narrative review","volume":"15","author":"Nikolouzakis","year":"2026","journal-title":"J Clin Med"},{"key":"10.1016\/j.sipas.2026.100353_bib0016","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-4165(81)90312-3","article-title":"Studies on the mechanism of the antifibrinolytic action of tranexamic acid","volume":"673","author":"Hoylaerts","year":"1981","journal-title":"Biochim Biophys Acta - Gen Subj"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4055\/cios24184","article-title":"Efficacy and safety of topical tranexamic acid in elderly hip fractures undergoing surgical treatment: meta-analysis of randomized controlled trials","volume":"17","author":"Artykbay","year":"2025","journal-title":"Clin Orthop Surg"},{"key":"10.1016\/j.sipas.2026.100353_bib0018","doi-asserted-by":"crossref","first-page":"e496","DOI":"10.1016\/j.clbc.2025.01.011","article-title":"Tranexamic Acid in breast surgery - A systematic review and meta-analysis","volume":"25","author":"Buheiri","year":"2025","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.sipas.2026.100353_bib0019","first-page":"47","article-title":"Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials","author":"Lottermann","year":"2025","journal-title":"Rev Bras Ginecol Obstet"},{"key":"10.1016\/j.sipas.2026.100353_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2025.1550854","article-title":"Effect of tranexamic acid in spine surgeries: a systematic review and network meta-analysis","volume":"12","author":"Shim","year":"2025","journal-title":"Front Surg"},{"issue":"8","key":"10.1016\/j.sipas.2026.100353_bib0021","article-title":"Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials","volume":"5","author":"Cheema","year":"2023","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0022","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ohn.973","article-title":"The utility and safety of prophylactic tranexamic acid in tonsillectomy: a systematic review and meta-analysis","volume":"172","author":"Smaily","year":"2025","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10463","key":"10.1016\/j.sipas.2026.100353_bib0023","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(24)02102-0","article-title":"Tranexamic acid for postpartum bleeding: a systematic review and individual patient data meta-analysis of randomised controlled trials","volume":"404","author":"Ker","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.sipas.2026.100353_bib0024","doi-asserted-by":"crossref","DOI":"10.1186\/s12894-026-02162-w","article-title":"The effect of tranexamic acid in perioperative bleeding transfusion in radical cystectomy: a systematic review and meta-analysis","volume":"26","author":"Makabe","year":"2026","journal-title":"BMC Urol"},{"issue":"6","key":"10.1016\/j.sipas.2026.100353_bib0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.5489\/cuaj.8254","article-title":"The impact of tranexamic acid on perioperative outcomes in urological surgeries A systematic review and meta-analysis","volume":"17","author":"Kim","year":"2023","journal-title":"Can Urol Assoc J"},{"issue":"1","key":"10.1016\/j.sipas.2026.100353_bib0026","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s40001-025-02385-x","article-title":"Tranexamic acid in spontaneous intracerebral hemorrhage: a meta-analysis","volume":"30","author":"Chang","year":"2025","journal-title":"Eur J Med Res"},{"issue":"Suppl 1","key":"10.1016\/j.sipas.2026.100353_bib0027","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13224-024-01983-9","article-title":"Effect of prophylactic tranexamic acid in per-operative and post-operative blood loss in hysterectomy for benign condition: a randomized controlled study","volume":"75","author":"Arvind","year":"2025","journal-title":"J Obstet Gynaecol India"}],"container-title":["Surgery in Practice and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666262026000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666262026000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:44:48Z","timestamp":1788266688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666262026000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S2666262026000288"],"URL":"https:\/\/doi.org\/10.1016\/j.sipas.2026.100353","relation":{},"ISSN":["2666-2620"],"issn-type":[{"value":"2666-2620","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tranexamic acid in radical cystectomy: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Surgery in Practice and Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sipas.2026.100353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100353"}}