{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:14:23Z","timestamp":1791476063595,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004919","name":"King Abdulaziz City for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.sjbs.2019.11.042","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T21:21:41Z","timestamp":1575580901000},"page":"611-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Investigating the antiangiogenic potential of Rumex vesicarius (humeidh), anticancer activity in cancer cell lines and assessment of developmental toxicity in zebrafish embryos"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-2443","authenticated-orcid":false,"given":"Muhammad","family":"Farooq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nael","family":"Abutaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-5387","authenticated-orcid":false,"given":"Shahid","family":"Mahboob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almohannad","family":"Baabbad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf D.","family":"Almoutiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ahmed A.M.","family":"Wadaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2019.11.042_b0005","first-page":"53120","article-title":"Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: a systematic review and meta-analysis","author":"Abdel-Qadir","year":"2017","journal-title":"Cancer Treat Rev."},{"issue":"6","key":"10.1016\/j.sjbs.2019.11.042_b0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jare.2017.06.006","article-title":"Anti-angiogenic agents for the treatment of solid tumors: potential pathways, therapy and current strategies \u2013 a review","volume":"8","author":"Al-Abd","year":"2017","journal-title":"J. Adv. Res."},{"issue":"6","key":"10.1016\/j.sjbs.2019.11.042_b0015","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF03401744","article-title":"Curcumin is an in vivo inhibitor of angiogenesis","volume":"4","author":"Arbiser","year":"1998","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.sjbs.2019.11.042_b0020","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1582-4934.2008.00274.x","article-title":"Gamma-secretase: a multifaceted regulator of angiogenesis","volume":"12","author":"Boulton","year":"2008","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.sjbs.2019.11.042_b0025","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1074\/jbc.M116.747766","article-title":"A quininib analogue and cysteinyl leukotriene receptor antagonist inhibits vascular endothelial growth factor (VEGF)-independent angiogenesis and exerts an additive antiangiogenic response with bevacizumab","volume":"292","author":"Butler","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.sjbs.2019.11.042_b0030","article-title":"Future options of anti-angiogenic cancer therapy.","volume":"3521","author":"Cao","year":"2016","journal-title":"Chin. J. Cancer"},{"issue":"3","key":"10.1016\/j.sjbs.2019.11.042_b0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/10286020410001690190","article-title":"Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants","volume":"7","author":"Cao","year":"2005","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.sjbs.2019.11.042_b0040","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41401-018-0191-7","article-title":"C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis","volume":"40","author":"Chen","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.sjbs.2019.11.042_b0045","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/CIRCRESAHA.107.150110","article-title":"A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes","volume":"101","author":"Clark","year":"2007","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.sjbs.2019.11.042_b0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tcm.2008.11.007","article-title":"Endothelial nicotinic acetylcholine receptors and angiogenesis","volume":"18","author":"Cooke","year":"2008","journal-title":"Trends Cardiovasc. Med."},{"issue":"14","key":"10.1016\/j.sjbs.2019.11.042_b0055","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1158\/1078-0432.CCR-08-0024","article-title":"Phase II trial of curcumin in patients with advanced pancreatic cancer","volume":"14","author":"Dhillon","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.sjbs.2019.11.042_b0060","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/ptr.6170","article-title":"Current natural therapies in the treatment against glioblastoma","volume":"32","author":"Erices","year":"2018","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.sjbs.2019.11.042_b0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1248\/bpb.b17-00674","article-title":"Synthesis of novel class of N-alkyl-isatin-3-iminobenzoic acid derivatives and their biological activity in zebrafish embryos and human cancer cell lines","volume":"41","author":"Farooq","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.sjbs.2019.11.042_b0070","first-page":"87457","article-title":"Design and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos","author":"Farooq","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.sjbs.2019.11.042_b0075","first-page":"99","article-title":"SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1\/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types","volume":"59","author":"Fong","year":"1999","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.sjbs.2019.11.042_b0080","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3109\/13880209.2014.967782","article-title":"Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats","volume":"53","author":"Ganaie","year":"2015","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.sjbs.2019.11.042_b0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1871520619666181224121004","article-title":"Current perspectives in the application of medicinal plants against cancer: novel therapeutic agents","volume":"19","author":"Gezici","year":"2019","journal-title":"Anticancer Agents Med. Chem."},{"issue":"23","key":"10.1016\/j.sjbs.2019.11.042_b0090","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1093\/bioinformatics\/btt540","article-title":"Shaping the interaction landscape of bioactive molecules","volume":"29","author":"Gfeller","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.sjbs.2019.11.042_b0095","article-title":"Flora of Eastern Saudi-Arabia \u2013 Mandaville, Jp","author":"Harley","year":"1991","journal-title":"Tls-Times Lit"},{"issue":"6","key":"10.1016\/j.sjbs.2019.11.042_b0100","first-page":"1521","article-title":"Differential effects of Viscum album extract IscadorQu on cell cycle progression and apoptosis in cancer cells","volume":"25","author":"Harmsma","year":"2004","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.sjbs.2019.11.042_b0105","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1006\/mvre.2001.2383","article-title":"Inhibition of vascular endothelial growth factor-associated tyrosine kinase activity with SU5416 blocks sprouting in the microvascular endothelial cell spheroid model of angiogenesis","volume":"63","author":"Haspel","year":"2002","journal-title":"Microvasc. Res."},{"issue":"3 Suppl","key":"10.1016\/j.sjbs.2019.11.042_b0110","doi-asserted-by":"crossref","first-page":"816S","DOI":"10.1093\/jn\/136.3.816S","article-title":"Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer","volume":"136","author":"Ishikawa","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.sjbs.2019.11.042_b0115","first-page":"(4)|S742","article-title":"Evaluation of anticancer activity of leaves of Rumex vesicarius Linn and Symplocos racemosa Roxb. by brine shrimp lethality and (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) methods","volume":"11","author":"Manure","year":"2017","journal-title":"Int. J. Green Pharm."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0120","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.chembiol.2009.02.010","article-title":"Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets","volume":"16","author":"Kalen","year":"2009","journal-title":"Chem. Biol."},{"issue":"11","key":"10.1016\/j.sjbs.2019.11.042_b0125","doi-asserted-by":"crossref","first-page":"14513","DOI":"10.1007\/s13277-016-5364-8","article-title":"Natural products against cancer angiogenesis","volume":"37","author":"Khalid","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.sjbs.2019.11.042_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-13-354","article-title":"Cytotoxicity, mode of action and antibacterial activities of selected Saudi Arabian medicinal plants.","author":"Kuete","year":"2013","journal-title":"BMC Complement Altern. Med."},{"issue":"2","key":"10.1016\/j.sjbs.2019.11.042_b0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","article-title":"In vivo imaging of embryonic vascular development using transgenic zebrafish","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ijc.11267","article-title":"Baicalein and baicalin are potent inhibitors of angiogenesis: inhibition of endothelial cell proliferation, migration and differentiation","volume":"106","author":"Liu","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.sjbs.2019.11.042_b0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11060-019-03234-8","article-title":"Efficacy and safety of bevacizumab for vestibular schwannoma in neurofibromatosis type 2: a systematic review and meta-analysis of treatment outcomes","volume":"144","author":"Lu","year":"2019","journal-title":"J. Neurooncol."},{"issue":"3","key":"10.1016\/j.sjbs.2019.11.042_b0150","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1582-4934.2007.00056.x","article-title":"Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope","volume":"11","author":"Medina","year":"2007","journal-title":"J. Cell Mol. Med."},{"issue":"12","key":"10.1016\/j.sjbs.2019.11.042_b0155","first-page":"4848","article-title":"The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function","volume":"6","author":"Mendel","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0160","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/PAS.0b013e318243555b","article-title":"Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors","volume":"36","author":"Miettinen","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0165","doi-asserted-by":"crossref","first-page":"46","DOI":"10.21010\/ajtcam.v15i4.7","article-title":"Anticancer potential of plant extracts from riyadh (Saudi Arabia) on Mda-Mb-231 breast cancer cells","volume":"15","author":"Nasr","year":"2018","journal-title":"Afr. J. Traditional, Complem. Alternat. Med."},{"issue":"1","key":"10.1016\/j.sjbs.2019.11.042_b0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13045-019-0718-5","article-title":"Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy","volume":"12","author":"Qin","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.sjbs.2019.11.042_b0180","doi-asserted-by":"crossref","unstructured":"R.H.D, undefined 1952. Probit Analysis. By D. J. Finney, M.A., Sc.D., [2nd ed. Pp. xiv + 318. Cambridge University Press, 1952. 35s.]. J. Inst. Actuaries 78(3), pp. 388\u2013390.","DOI":"10.1017\/S0020268100052938"},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0185","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbrc.2008.11.127","article-title":"Pharmacologically induced angiogenesis in transgenic zebrafish","volume":"378","author":"Raghunath","year":"2009","journal-title":"Biochem. Biophys. Res. Co"},{"issue":"2","key":"10.1016\/j.sjbs.2019.11.042_b0190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fitote.2003.12.012","article-title":"Medicinal plant diversity in the flora of Saudi Arabia 1: a report on seven plant families","volume":"75","author":"Rahman","year":"2004","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.sjbs.2019.11.042_b0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12918-018-0668-5","article-title":"Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors","volume":"12","author":"Song","year":"2018","journal-title":"BMC Syst. Biol."},{"issue":"10","key":"10.1016\/j.sjbs.2019.11.042_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/biom9100591","article-title":"Investigating the multi-target pharmacological mechanism of hedyotis diffusa willd acting on prostate cancer: a network pharmacology approach","volume":"9","author":"Song","year":"2019","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.sjbs.2019.11.042_b0205","first-page":"509","article-title":"Potential action of Rumex vesicarius (L.) against potassium dichromate and gentamicin induced nephrotoxicity in experimental rats","volume":"31","author":"Subramaniyan","year":"2018","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.sjbs.2019.11.042_b0210","first-page":"175198","article-title":"The genus rumex: review of traditional uses, phytochemistry and pharmacology","author":"Vasas","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0215","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","article-title":"Tumor angiogenesis and vascular normalization: alternative therapeutic targets","volume":"20","author":"Viallard","year":"2017","journal-title":"Angiogenesis"},{"key":"10.1016\/j.sjbs.2019.11.042_b0220","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/j.semcancer.2015.01.001","article-title":"Broad targeting of angiogenesis for cancer prevention and therapy","volume":"35","author":"Wang","year":"2015","journal-title":"Seminars Cancer Biol."},{"issue":"19","key":"10.1016\/j.sjbs.2019.11.042_b0225","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1158\/0008-5472.CAN-04-1443","article-title":"BAY 43\u20139006 exhibits broad spectrum oral antitumor activity and targets the RAF\/MEK\/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis","volume":"64","author":"Wilhelm","year":"2004","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.sjbs.2019.11.042_b0230","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/ATVBAHA.114.304539","article-title":"FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis","volume":"35","author":"Yakkundi","year":"2015","journal-title":"Arterioscler Thromb Vasc. Biol."},{"issue":"2","key":"10.1016\/j.sjbs.2019.11.042_b0235","doi-asserted-by":"crossref","first-page":"L220","DOI":"10.1152\/ajplung.90474.2008","article-title":"Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype","volume":"296","author":"Zhu","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X19302761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X19302761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T16:58:17Z","timestamp":1761152297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X19302761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1319562X19302761"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2019.11.042","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the antiangiogenic potential of Rumex vesicarius (humeidh), anticancer activity in cancer cell lines and assessment of developmental toxicity in zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2019.11.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}