{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:36:17Z","timestamp":1787790977409,"version":"build-2784847793"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.sjbs.2020.08.030","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T04:49:01Z","timestamp":1598417341000},"page":"50-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Reticulocyte Hemoglobin Content for the Diagnosis of Functional Iron Deficiency in Hemodialyzed patients"],"prefix":"10.1016","volume":"28","author":[{"given":"Ali A.","family":"Alageeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatmah S.","family":"Alqahtany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farjah H.","family":"Algahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.sjbs.2020.08.030_b0005","doi-asserted-by":"crossref","first-page":"12735","DOI":"10.1074\/jbc.R117.786632","article-title":"Iron transport proteins: Gateways of cellular and systemic iron homeostasis","volume":"292","author":"Knutson","year":"2017","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.sjbs.2020.08.030_b0010","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s40265-016-0569-0","article-title":"Iatrogenic Iron Overload in Dialysis Patients at the Beginning of the 21st Century","volume":"76","author":"Rostoker","year":"2016","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/j.sjbs.2020.08.030_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/ndt\/gft443","article-title":"The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients","volume":"29","author":"Zumbrennen-Bullough","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"15","key":"10.1016\/j.sjbs.2020.08.030_b0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009206","article-title":"Association of Anemia and Iron Parameters With Mortality Among Patients Undergoing Prevalent Hemodialysis in Taiwan: The AIM - HD Study","volume":"7","author":"Kuo","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.sjbs.2020.08.030_b0025","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1523-1755.2004.00357.x","article-title":"Prevalence of anemia in erythropoietin-treated pediatric as compared to adult chronic dialysis patients","volume":"65","author":"Chavers","year":"2004","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.sjbs.2020.08.030_b0030","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bjhh.2015.02.001","article-title":"Resistance of dialyzed patients to erythropoietin","volume":"37","author":"Alves","year":"2015","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"5","key":"10.1016\/j.sjbs.2020.08.030_b0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000320733","article-title":"Importance of ferritin for optimizing anemia therapy in chronic kidney disease","volume":"32","author":"Nakanishi","year":"2010","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.sjbs.2020.08.030_b0040","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/C3MT00347G","article-title":"Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells","author":"Kell","year":"2014","journal-title":"Metallomics"},{"issue":"8","key":"10.1016\/j.sjbs.2020.08.030_b0045","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","article-title":"Serum ferritin: Past, present and future","volume":"1800","author":"Wang","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"10.1016\/j.sjbs.2020.08.030_b0050","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1515\/cclm-2016-0041","article-title":"Evaluation of the hypochromic erythrocyte and reticulocyte hemoglobin content provided by the Sysmex XE-5000 analyzer in diagnosis of iron deficiency erythropoiesis","volume":"54","author":"Buttarello","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.sjbs.2020.08.030_b0055","first-page":"9","article-title":"Evaluation of the Efficiency of the Reticulocyte Hemoglobin Content on Diagnosis for Iron Deficiency Anemia in Chinese Adults","volume":"2017","author":"Cai","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.sjbs.2020.08.030_b0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12882-019-1263-8","article-title":"Evaluation of iron stores in hemodialysis patients on maintenance ferric Carboxymaltose dosing","volume":"20","author":"Diebold","year":"2019","journal-title":"BMC Nephrol"},{"issue":"1","key":"10.1016\/j.sjbs.2020.08.030_b0065","first-page":"73","article-title":"Mohammed Abdelrahman, Monitoring Iron status in End-Stage Renal Disease Patients on Hemodialysis","volume":"18","author":"Ali Rafi","year":"2007","journal-title":"Saudi J Kidney Dis Transplant"},{"issue":"2","key":"10.1016\/j.sjbs.2020.08.030_b0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000486968","article-title":"Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?","volume":"47","author":"Wish","year":"2018","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.sjbs.2020.08.030_b0075","unstructured":"G, T., Renal anemia: a nephrologist\u2019s view. HIPPOKRATIA 2011: p. 39-43."},{"key":"10.1016\/j.sjbs.2020.08.030_b0080","first-page":"195","article-title":"Erythropoietin stimulating agents in the management of anemia of chronic kidney disease","volume":"2","author":"Hayat","year":"2008","journal-title":"Patient Preference and Adherence"},{"key":"10.1016\/j.sjbs.2020.08.030_b0085","first-page":"3","article-title":"IRON INDICES IN PATIENTS WITH FUNCTIONAL ANEMIA IN CHRONIC KIDNEY DISEASE","volume":"24","author":"Reddy","year":"2013","journal-title":"The Journal of the International Federation of Clinical Chemistry and Laboratory Medicine"},{"issue":"1","key":"10.1016\/j.sjbs.2020.08.030_b0090","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ki.1997.323","article-title":"Reticulocyte hemoglobin content in the evaluation of iron status of hemodialysis patients","volume":"52","author":"Fishbane","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.sjbs.2020.08.030_b0095","unstructured":"Corp., I., IBM SPSS Statistics for Windows, Version 19.0, 2010, IBM Corp.: Armonk, NY:."},{"key":"10.1016\/j.sjbs.2020.08.030_b0100","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4274\/Tjh.2012.0107","article-title":"Clinical Signifi cance of Reticulocyte Hemoglobin Content in the Diagnosis of Iron Defi ciency Anemia","volume":"30","author":"Karag\u00fclle","year":"2013","journal-title":"Turk J Hematol"},{"key":"10.1016\/j.sjbs.2020.08.030_b0105","doi-asserted-by":"crossref","unstructured":"Fukui, Y., et al., Reticulocyte hemoglobin content as a marker of iron status in patients receiving maintenance hemodialysis. Clin Exp Nephrol (2002) 6:147\u2013153, 2002. 6: p. 147-153.","DOI":"10.1007\/s101570200025"},{"issue":"1","key":"10.1016\/j.sjbs.2020.08.030_b0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1751-553X.2007.00901.x","article-title":"Evaluation of reticulocyte haemoglobin content as marker of iron deficiency and predictor of response to intravenous iron in haemodialysis patients","volume":"30","author":"Kim","year":"2008","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.sjbs.2020.08.030_b0115","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s101570300007","article-title":"Assessment of iron deficiency in chronic hemodialysis patients: investigation of cutoff values for reticulocyte hemoglobin content","volume":"7","author":"Miyata","year":"2003","journal-title":"Clin Exp Nephrol"},{"issue":"6","key":"10.1016\/j.sjbs.2020.08.030_b0120","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1309\/AJCPQAX0JFHFS0OA","article-title":"Diagnosis of iron deficiency in patients undergoing hemodialysis","volume":"133","author":"Buttarello","year":"2010","journal-title":"Am J Clin Pathol"},{"issue":"11","key":"10.1016\/j.sjbs.2020.08.030_b0125","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1515\/CCLM.2009.301","article-title":"Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolism","volume":"47","author":"Urrechaga","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.sjbs.2020.08.030_b0130","doi-asserted-by":"crossref","unstructured":"Neal Mittman, M., Rajanna Sreedhara, MD, Robert Mushnick, MD, Jyoti Chattopadhyay, PhD, and P. David Zelmanovic, Mehdi Vaseghi, MD, and Morrell M. Avram, MD, FACP, Reticulocyte Hemoglobin Content Predicts Functional Iron Deficiency in Hemodialysis Patients Receiving rHuEP0. American Journal of Kidney Diseases,, 1997. 30(6): p. 912-922.","DOI":"10.1016\/S0272-6386(97)90104-9"},{"key":"10.1016\/j.sjbs.2020.08.030_b0135","doi-asserted-by":"crossref","unstructured":"GABAY, C. and I. KUSHNER, Acute Phase proteins and other systemic responses to inflammation. The New England Journal of Medicine, 1999. Volume 340 Number 6 \u00b7 453: p. 449-454.","DOI":"10.1056\/NEJM199902113400607"},{"key":"10.1016\/j.sjbs.2020.08.030_b0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000337673","article-title":"Influence of inflammatory disorders and infection on iron absorption and efficacy of iron-fortified foods","volume":"70","author":"Hurrell","year":"2012","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"10.1016\/j.sjbs.2020.08.030_b0145","unstructured":"Saito, H., METABOLISM OF IRON STORES. Nagoya J. Med. Sci, 2014. 76: p. p. 235 ~ 254."},{"key":"10.1016\/j.sjbs.2020.08.030_b0150","doi-asserted-by":"crossref","unstructured":"Menno P. Kooistra':\u201c, E.C.N., Ad van Es3 and N.M.M.-B. , Albert Struyvenberg\/ and Joannes J. M. Marxv\u201d, Iron absorption in erythropoietin-treated haemodialysis patients:effects of iron availability, inflammation and aluminium. Nephrol Dial Transplant 1998. 13: p. 82-88.","DOI":"10.1093\/ndt\/13.1.82"},{"issue":"13\u201314","key":"10.1016\/j.sjbs.2020.08.030_b0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10354-016-0505-7","article-title":"Iron deficiency or anemia of inflammation? : Differential diagnosis and mechanisms of anemia of inflammation","volume":"166","author":"Nairz","year":"2016","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.sjbs.2020.08.030_b0160","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","article-title":"Iron homeostasis and the inflammatory response","volume":"30","author":"Wessling-Resnick","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.sjbs.2020.08.030_b0165","unstructured":"MJ Kotze1, D.v.V., SJ van Rensburg2, R Erasmus, PATHOGENIC MECHANISMS UNDERLYING IRON DEFICIENCY AND IRON OVERLOAD:NEW INSIGHTS FOR CLINICAL APPLICATION. The Journal of the International Federation of Clinical Chemistry and Laboratory Medicine, 2009. 20(2): p. 108-123."},{"issue":"2","key":"10.1016\/j.sjbs.2020.08.030_b0170","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ki.1989.43","article-title":"Iron status in patients receiving erythropoietin for dialysis-associated anemia","volume":"35","author":"Van Wyck","year":"1989","journal-title":"Kidney Int"},{"key":"10.1016\/j.sjbs.2020.08.030_b0175","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1038\/sj.ki.4490858","article-title":"Erythropoietin hyporesponsiveness: From iron deficiency to iron overload","volume":"55","author":"Tarng","year":"1999","journal-title":"Kidney International"},{"issue":"3","key":"10.1016\/j.sjbs.2020.08.030_b0180","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1423-0410.2007.01014.x","article-title":"Efficacy and safety of intravenous iron therapy as an alternative\/adjunct to allogeneic blood transfusion","volume":"94","author":"Mu\u00f1oz","year":"2008","journal-title":"Vox Sang"}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X20303776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X20303776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:05:17Z","timestamp":1761152717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X20303776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1319562X20303776"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2020.08.030","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Reticulocyte Hemoglobin Content for the Diagnosis of Functional Iron Deficiency in Hemodialyzed patients","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2020.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}