{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:06:50Z","timestamp":1761181610462,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["IFKSURG-1435-012"],"award-info":[{"award-number":["IFKSURG-1435-012"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.sjbs.2021.01.006","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:33:26Z","timestamp":1611254006000},"page":"2029-2039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["In-silico network-based analysis of drugs used against COVID-19: Human well-being study"],"prefix":"10.1016","volume":"28","author":[{"given":"Zarlish","family":"Attique","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashaq","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid A.","family":"al-Ghanim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah","family":"Al-Mulhm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Rizwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anum","family":"Munir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Al-Suliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al-Misned","family":"F.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Mahboob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-019-3326-z","article-title":"ZDOG: Zooming in on dominating genes with mutations in cancer pathways","volume":"20","author":"Alberts","year":"2019","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.sjbs.2021.01.006_b0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4155\/tde-2020-0035","article-title":"COVID-19 pandemic: An overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics","volume":"11","author":"Amawi","year":"2020","journal-title":"Therapeutic Delivery"},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-017-2427-0","article-title":"Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-\u03b21b (MIRACLE trial): Study protocol for a randomized controlled trial","volume":"19","author":"Arabi","year":"2018","journal-title":"Trials"},{"key":"10.1016\/j.sjbs.2021.01.006_b0020","series-title":"Hydroxychloroquine and Chloroquine Retinopathy","article-title":"Hydroxychloroquine and chloroquine retinopathy","author":"Browning","year":"2014"},{"issue":"19","key":"10.1016\/j.sjbs.2021.01.006_b0025","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2001282","article-title":"A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19","volume":"382","author":"Cao","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10223","key":"10.1016\/j.sjbs.2021.01.006_b0030","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster","volume":"395","author":"Chan","year":"2020","journal-title":"The Lancet"},{"issue":"10","key":"10.1016\/j.sjbs.2021.01.006_b0035","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s40264-018-0689-4","article-title":"Cardiac complications attributed to chloroquine and hydroxychloroquine: A systematic review of the literature","volume":"41","author":"Chatre","year":"2018","journal-title":"Drug Saf."},{"issue":"10223","key":"10.1016\/j.sjbs.2021.01.006_b0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.sjbs.2021.01.006_b0045","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/thorax.2003.012658","article-title":"Role of lopinavir\/ritonavir in the treatment of SARS: Initial virological and clinical findings","volume":"59","author":"Chu","year":"2004","journal-title":"Thorax"},{"issue":"D1","key":"10.1016\/j.sjbs.2021.01.006_b0050","doi-asserted-by":"crossref","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: A redesign and expansion of the drug-gene interaction database","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5582\/ddt.2020.01012","article-title":"Discovering drugs to treat coronavirus disease 2019 (COVID-19)","volume":"14","author":"Dong","year":"2020","journal-title":"Drug Discov. Therapeut."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-017-1559-2","article-title":"Reactome pathway analysis: A high-performance in-memory approach","volume":"18","author":"Fabregat","year":"2017","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.sjbs.2021.01.006_b0065","unstructured":"FDA, 2020. Frequently asked questions on the revocation of the emergency use authorization for hydroxychloroquine sulfate and chloroquine phosphate. https:\/\/www.fda.gov\/media\/138946\/download."},{"issue":"April","key":"10.1016\/j.sjbs.2021.01.006_b0070","first-page":"9","article-title":"Chloroquine and hydroxychloroquine in covid-19","volume":"369","author":"Ferner","year":"2020","journal-title":"The BMJ"},{"issue":"4","key":"10.1016\/j.sjbs.2021.01.006_b0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/FPC.0000000000000270","article-title":"PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics\/pharmacodynamics","volume":"27","author":"Fohner","year":"2017","journal-title":"Pharmacogenet. Genom."},{"issue":"W1","key":"10.1016\/j.sjbs.2021.01.006_b0080","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.sjbs.2021.01.006_b0085","first-page":"1","article-title":"Mild or moderate Covid-19","author":"Gandhi","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"March","key":"10.1016\/j.sjbs.2021.01.006_b0090","doi-asserted-by":"crossref","first-page":"102017","DOI":"10.1016\/j.ctrv.2020.102017","article-title":"Bevacizumab (Avastin\u00ae) in cancer treatment: A review of 15 years of clinical experience and future outlook","volume":"86","author":"Garcia","year":"2020","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0095","doi-asserted-by":"crossref","first-page":"105949","DOI":"10.1016\/j.ijantimicag.2020.105949","article-title":"Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial","volume":"56","author":"Gautret","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"18","key":"10.1016\/j.sjbs.2021.01.006_b0100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/bioinformatics\/bts389","article-title":"EnrichNet: Network-based gene set enrichment analysis","volume":"28","author":"Glaab","year":"2012","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.sjbs.2021.01.006_b0105","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nmeth.2689","article-title":"DGIdb: Mining the druggable genome","volume":"10","author":"Griffith","year":"2013","journal-title":"Nat. Methods"},{"issue":"3 SUPPL. 1","key":"10.1016\/j.sjbs.2021.01.006_b0110","article-title":"Clinical toleration and safety of azithromycin","volume":"91","author":"Hopkins","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1016\/j.sjbs.2021.01.006_b0115","article-title":"Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection","author":"Infante","year":"2020","journal-title":"Expert Rev. Anti-Infect. Therapy"},{"issue":"3","key":"10.1016\/j.sjbs.2021.01.006_b0120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jmii.2020.03.034","article-title":"Treatment options for COVID-19: The reality and challenges","volume":"53","author":"Jean","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"12","key":"10.1016\/j.sjbs.2021.01.006_b0125","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41584-018-0111-8","article-title":"Hydroxychloroquine retinopathy\u2014implications of research advances for rheumatology care","volume":"14","author":"Jorge","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.sjbs.2021.01.006_b0130","first-page":"1","article-title":"Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach","author":"Khan","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"5","key":"10.1016\/j.sjbs.2021.01.006_b0135","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0003489419826139","article-title":"Bevacizumab as treatment for epistaxis in hereditary hemorrhagic telangiectasia: A literature review","volume":"128","author":"Kini","year":"2019","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.sjbs.2021.01.006_b0140","doi-asserted-by":"crossref","unstructured":"Kumar, S., 2020. Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach Evaluation of the effectiveness of pGM-CSF as an adjuvant in the delivery of recombinant plasmid pCDNA3.1\/His B-MIC3 in mice against toxoplasmosis. Researchgate.Net, February. https:\/\/doi.org\/10.20944\/preprints202002.0071.v1.","DOI":"10.20944\/preprints202002.0071.v1"},{"issue":"D1","key":"10.1016\/j.sjbs.2021.01.006_b0145","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/nar\/gkt1068","article-title":"DrugBank 4.0: Shedding new light on drug metabolism","volume":"42","author":"Law","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.sjbs.2021.01.006_b0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pharmthera.2017.08.012","article-title":"Bevacizumab-induced hypertension: Clinical presentation and molecular understanding","volume":"182","author":"Li","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"10224","key":"10.1016\/j.sjbs.2021.01.006_b0155","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.sjbs.2021.01.006_b0160","doi-asserted-by":"crossref","first-page":"87","DOI":"10.18773\/austprescr.2015.030","article-title":"Prescribing azithromycin","volume":"38","author":"McMullan","year":"2015","journal-title":"Austr. Prescriber"},{"issue":"22","key":"10.1016\/j.sjbs.2021.01.006_b0165","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1093\/bioinformatics\/btq562","article-title":"GeneMANIA cytoscape plugin: Fast gene function predictions on the desktop","volume":"26","author":"Montojo","year":"2010","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.sjbs.2021.01.006_b0170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s40264-020-00933-4","article-title":"Chloroquine for COVID-19 Infection","volume":"43","author":"Moore","year":"2020","journal-title":"Drug Saf."},{"issue":"SUPPL. 1","key":"10.1016\/j.sjbs.2021.01.006_b0175","first-page":"1","article-title":"GeneMANIA: A real-time multiple association network integration algorithm for predicting gene function","volume":"9","author":"Mostafavi","year":"2008","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape automation: Empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.sjbs.2021.01.006_b0185","first-page":"1","article-title":"Peptide-like and small-molecule inhibitors against Covid-19","author":"Pant","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"3","key":"10.1016\/j.sjbs.2021.01.006_b0195","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/14740338.2017.1269168","article-title":"Hydroxychloroquine in systemic lupus erythematosus (SLE)","volume":"16","author":"Ponticelli","year":"2017","journal-title":"Expert Opin. Drug Saf."},{"issue":"7","key":"10.1016\/j.sjbs.2021.01.006_b0200","doi-asserted-by":"crossref","first-page":"12389","DOI":"10.18632\/oncotarget.13310","article-title":"Bevacizumab in ovarian cancer: A critical review of phase III studies","volume":"8","author":"Rossi","year":"2017","journal-title":"Oncotarget"},{"issue":"22","key":"10.1016\/j.sjbs.2021.01.006_b0190","first-page":"426","article-title":"Cytoscape: A software environment for integrated models","volume":"13","author":"Shannon","year":"1971","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.sjbs.2021.01.006_b0205","first-page":"465","article-title":"Lopinavir\u2013ritonavir in severe COVID-19","volume":"26","author":"Stower","year":"2020","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-2116-8","article-title":"Epitope-based peptide vaccine design and target site depiction against Middle East respiratory syndrome coronavirus: an immune-informatics study","volume":"17","author":"Tahir Ul Qamar","year":"2019","journal-title":"J. Translat. Med."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41525-020-00143-y","article-title":"Pharmacogenomics of COVID-19 therapies","volume":"5","author":"Takahashi","year":"2020","journal-title":"npj Genomic Med."},{"issue":"3","key":"10.1016\/j.sjbs.2021.01.006_b0220","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/bioinformatics\/btu671","article-title":"Novel function discovery with GeneMANIA: A new integrated resource for gene function prediction in Escherichia coli","volume":"31","author":"Vlasblom","year":"2015","journal-title":"Bioinformatics"},{"issue":"SUPPL. 2","key":"10.1016\/j.sjbs.2021.01.006_b0225","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.sjbs.2021.01.006_b0230","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"SUPPL. 1","key":"10.1016\/j.sjbs.2021.01.006_b0235","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: A knowledgebase for drugs, drug actions and drug targets","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"10225","key":"10.1016\/j.sjbs.2021.01.006_b0240","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(20)30260-9","article-title":"Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study","volume":"395","author":"Wu","year":"2020","journal-title":"The Lancet"},{"issue":"10","key":"10.1016\/j.sjbs.2021.01.006_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0109180","article-title":"Chloroquine is a zinc ionophore","volume":"9","author":"Xue","year":"2014","journal-title":"PLoS ONE"},{"issue":"18","key":"10.1016\/j.sjbs.2021.01.006_b0250","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1158\/1078-0432.CCR-07-4762","article-title":"Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer","volume":"14","author":"Yang","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.sjbs.2021.01.006_b0255","first-page":"1706","article-title":"Hydroxychloroquine-induced cardiomyopathy: case report, pathophysiology, diagnosis, and treatment","volume":"30","author":"Yogasundaram","year":"2014","journal-title":"Can. J. Cardiol."},{"issue":"1","key":"10.1016\/j.sjbs.2021.01.006_b0260","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jinf.2020.03.060","article-title":"Arbidol monotherapy is superior to lopinavir\/ritonavir in treating COVID-19","volume":"81","author":"Zhu","year":"2020","journal-title":"J. Infect."},{"issue":"Web Server issue","key":"10.1016\/j.sjbs.2021.01.006_b0265","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/nar\/gkt533","article-title":"GeneMANIA prediction server 2013 update","volume":"41","author":"Zuberi","year":"2013","journal-title":"Nucleic Acids Res."}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21000061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21000061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:04:24Z","timestamp":1761152664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X21000061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1319562X21000061"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.01.006","relation":{},"ISSN":["1319-562X"],"issn-type":[{"type":"print","value":"1319-562X"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In-silico network-based analysis of drugs used against COVID-19: Human well-being study","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}