{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:43:03Z","timestamp":1787496183041,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["1\/0392\/17"],"award-info":[{"award-number":["1\/0392\/17"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["1\/0204\/20"],"award-info":[{"award-number":["1\/0204\/20"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.sjbs.2021.03.055","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T03:56:12Z","timestamp":1616817372000},"page":"3789-3798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dietary flaxseed's protective effects on body tissues of mice after oral exposure to xylene"],"prefix":"10.1016","volume":"28","author":[{"given":"Zuzana","family":"Andrej\u010d\u00e1kov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslava","family":"Vl\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drahom\u00edra","family":"Sopkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kozio\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Koziorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"Fabi\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"\u0160ef\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katar\u00edna","family":"Holovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viera","family":"Alm\u00e1\u0161iov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Sirotkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2021.03.055_b0005","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry, 2007). A Toxicological Profile for Xylene, U.S. Department of health and human services, https:\/\/www.atsdr.cdc.gov\/ToxProfiles\/tp71.pdf. Accessed 10 September 2007."},{"key":"10.1016\/j.sjbs.2021.03.055_b0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.5650\/jos.62.709","article-title":"Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive wistar rats","volume":"62","author":"Al-Bishri","year":"2013","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0015","doi-asserted-by":"crossref","unstructured":"Al \u2013Ghamdi, S.S., Raftery, M.J., Yaqoob, M.M., 2004. Toluene and p-xylene induced LLC-PK1 apoptosis. Drug Chem Toxicol 27, 425\u2013432.","DOI":"10.1081\/DCT-200039782"},{"key":"10.1016\/j.sjbs.2021.03.055_b0020","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/asj.12558","article-title":"Synbiotics suppress the release of lactate dehydrogenase, promote non-specific immunity and integrity of jejunum mucosa in piglets","volume":"87","author":"Andrej\u010d\u00e1kov\u00e1","year":"2016","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.sjbs.2021.03.055_b0025","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12602-019-09578-x","article-title":"The application of Lactobacillus reuteri CCM 8617 and flaxseed positively improved the health of mice challenged with enterotoxigenic E. coli O149:F4","volume":"12","author":"Andrej\u010d\u00e1kov\u00e1","year":"2020","journal-title":"Probiotics Antimicro. Prot."},{"key":"10.1016\/j.sjbs.2021.03.055_b0030","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3382\/japr\/pfz019","article-title":"Impact of choline supplementation on hepatic histopathology, phospholipid content, and tocopherol status in layer hens fed flaxseed","volume":"28","author":"Aziza","year":"2019","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0035","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ptr.2169","article-title":"Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice","volume":"21","author":"Bhatia","year":"2007","journal-title":"Phytother Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0040","first-page":"184","article-title":"Effects of components present in flaxseed on human colon adenocarcinoma Caco-2 cells: possible mechanisms of flaxseed on colon cancer development in animals","volume":"4","author":"Bommareddy","year":"2010","journal-title":"Drug Discoveries & Therapeutics"},{"key":"10.1016\/j.sjbs.2021.03.055_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/s11756-011-0155-6","article-title":"The role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer","volume":"67","author":"Bomba","year":"2012","journal-title":"Biologia"},{"key":"10.1016\/j.sjbs.2021.03.055_b0050","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnut.2018.00004","article-title":"The effect of flaxseed in breast cancer: a literature review","volume":"5","author":"Calado","year":"2018","journal-title":"Front Nutr"},{"key":"10.1016\/j.sjbs.2021.03.055_b0055","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1128\/AEM.71.10.6077-6085.2005","article-title":"Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans","volume":"71","author":"Clavel","year":"2005","journal-title":"Appl. Environ. Microb."},{"key":"10.1016\/j.sjbs.2021.03.055_b0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/01480548809018107","article-title":"Oral toxicology studies with xylene isomers and mixed xylenes","volume":"11","author":"Condie","year":"1988","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0065","doi-asserted-by":"crossref","first-page":"ftv065","DOI":"10.1093\/femspd\/ftv065","article-title":"Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells","volume":"73","author":"Cr\u00e9met","year":"2015","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.sjbs.2021.03.055_b0070","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D\u2019Amelio","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.sjbs.2021.03.055_b0075","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0080","unstructured":"Envigo, 2015. Hematology and Clinical Chemistry \u2014 Female ICR (CD-1\u00ae) Outbred Mice. https:\/\/insights.envigo.com\/hubfs\/resources\/data-sheets\/icr-cd-1-7-8-wk-females-cbc.pdf. Accessed 16 September 2015."},{"key":"10.1016\/j.sjbs.2021.03.055_b0085","first-page":"262","article-title":"\u00bfC\u00f3mo evaluar la elevaci\u00f3n de las enzimas hep\u00e1ticas en personas aparentemente sanas? Su importancia para el m\u00e9dico general","volume":"33","author":"Garc\u00eda Ferrera","year":"2013","journal-title":"Revista de Gastroenterolog\u00eda del Per\u00fa"},{"key":"10.1016\/j.sjbs.2021.03.055_b0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/rvsc.1999.0317","article-title":"Lactate dehydrogenase isoenzyme distribution and patterns in chicken organs","volume":"67","author":"Heinov\u00e1","year":"1999","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.sjbs.2021.03.055_b0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11130-013-0372-y","article-title":"Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats","volume":"68","author":"Hern\u00e1ndez-Salazar","year":"2013","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.sjbs.2021.03.055_b0100","first-page":"1480","article-title":"Evaluation of the protective role of flaxseed oil on inflammatory mediators, antioxidant defense system and oxidative stress of liver tissue in hypercholesterolemic rats","volume":"6","author":"Hussein","year":"2016","journal-title":"Int. J. Pharm. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0105","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.meatsci.2009.10.015","article-title":"Feeding co-extruded flaxseed to pigs: Effects of duration and feeding level on growth performance and backfat fatty acid composition of grower\u2013finisher pigs","volume":"84","author":"Ju\u00e1rez","year":"2010","journal-title":"Meat. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-029X.64299","article-title":"Xylene: An overview of its health hazards and preventive measures","volume":"14","author":"Kandyala","year":"2010","journal-title":"J. Oral. Maxillofac Pathol."},{"issue":"specialissue 2","key":"10.1016\/j.sjbs.2021.03.055_b0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.15414\/jmbfs.2015.4.special2.45-48","article-title":"Effect of natural plant extracts on porcine functions","volume":"4","author":"K\u00e1dasi","year":"2015","journal-title":"J. Microbiol. Biotech. Food Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tiv.2006.08.004","article-title":"Inactivation of lactate dehydrogenase by several chemicals: Implications for in vitro toxicology studies","volume":"21","author":"Kending","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.sjbs.2021.03.055_b0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2478\/fv-2020-0015","article-title":"Protective effect of flaxseed on the health of experimental animals exposed to xylene","volume":"64","author":"Kur\u00e1\u0148ov\u00e1","year":"2020","journal-title":"Folia Veterinaria"},{"key":"10.1016\/j.sjbs.2021.03.055_b0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/00313029400169711","article-title":"Xylene: its toxicity, measurement of exposure levels, absorption, metabolism and clearance","volume":"26","author":"Langman","year":"1994","journal-title":"Pathology"},{"key":"10.1016\/j.sjbs.2021.03.055_b0135","first-page":"9","article-title":"Gastrointestinal activity of dietary flaxseed lignans, omega-3 fatty acids and fbres","volume":"16","author":"Laurino","year":"2017","journal-title":"Nutrafoods"},{"key":"10.1016\/j.sjbs.2021.03.055_b0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4162\/nrp.2018.12.2.93","article-title":"Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide","volume":"12","author":"Lee","year":"2018","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.sjbs.2021.03.055_b0145","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0168-1656(92)90158-6","article-title":"Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker","volume":"25","author":"Legrand","year":"1992","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0150","doi-asserted-by":"crossref","first-page":"1628592","DOI":"10.1080\/20013078.2019.1628592","article-title":"Acetylcholinesterase is not a generic marker of extracellular vesicles","volume":"8","author":"Liao","year":"2019","journal-title":"J. Extracell Vesicles"},{"key":"10.1016\/j.sjbs.2021.03.055_b0155","series-title":"Transaminases: Valoraci\u00f3n y significaci\u00f3n cl\u00ednica","first-page":"267","author":"Mart\u00edn","year":"2020"},{"key":"10.1016\/j.sjbs.2021.03.055_b0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/nutrit\/nux052","article-title":"Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials","volume":"76","author":"Mohammadi-Sartang","year":"2018","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.sjbs.2021.03.055_b0165","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1038\/s41598-018-24043-5","article-title":"Dietary supplementation with flaxseed meal and oat hulls modulates intestinal histomorphometric characteristics, digesta- and mucosa-associated microbiota in pigs","volume":"8","author":"Ndou","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.sjbs.2021.03.055_b0170","first-page":"1167","article-title":"A review of environmental and occupational exposure to xylene and its health concerns","volume":"14","author":"Niaz","year":"2015","journal-title":"EXCLI J"},{"key":"10.1016\/j.sjbs.2021.03.055_b0175","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.trsl.2009.06.011","article-title":"Cerebrospinal fluid lactate dehydrogenase isoenzymes in children with bacterial and aseptic meningitis","volume":"154","author":"Nussinovitch","year":"2009","journal-title":"Transl. Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0180","doi-asserted-by":"crossref","unstructured":"Ostapchenko, V.G., Snir, J., Suchy, M., Fan, J., Cobb, M.R., Chronik, B.A., Kovacs, M., Prado, V.F., Hudson, R.H.E., Pasternak, S.H., Prado, M.A.M., Bartha. R., 2019. Detection of active caspase-3 in mouse models of stroke and Alzheimer\u2019s disease with a novel dual positron emission tomography\/fluorescent tracer [68Ga]Ga-TC3-OGDOTA. Contrast Media Mol Imaging 6403274.","DOI":"10.1155\/2019\/6403274"},{"key":"10.1016\/j.sjbs.2021.03.055_b0185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.17306\/J.AFS.2014.2.8","article-title":"Health efects of dietary fibre","volume":"13","author":"Otles","year":"2014","journal-title":"Acta Sci. Pol. Technol. Aliment"},{"key":"10.1016\/j.sjbs.2021.03.055_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02540","article-title":"Protective effects of hydro-alcoholic extract of foeniculum vulgare and linum usitatissimum on ovarian follicle reserve in the first-generation mouse pups","volume":"5","author":"Pourjafari","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.sjbs.2021.03.055_b0195","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/1381612822666151112151130","article-title":"Prevention and treatment of atherosclerosis with flaxseed-derived compound secoisolariciresinol diglucoside","volume":"22","author":"Prasad","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.sjbs.2021.03.055_b0200","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/mnfr.201200439","article-title":"Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks","volume":"57","author":"Rietjens","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5271\/sjweh.2658","article-title":"Percutaneous absorption of m-xylene from a mixture of m-xylene and isobutyl alcohol in man","volume":"5","author":"Riihimaki","year":"1979","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.sjbs.2021.03.055_b0210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/HYPERTENSIONAHA.113.02094","article-title":"Potent antihypertensive action of dietary flaxseed in hypertensive patients","volume":"62","author":"Rodriguez-Leyva","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.sjbs.2021.03.055_b0215","first-page":"2385","article-title":"Cancer chemopreventive potential of the egyptian flaxseed oil in a rat colon carcinogenesis bioassay \u2013 implications for its mechanism of action","volume":"12","author":"Salim","year":"2011","journal-title":"Asian Pacifc J. Can. Prev."},{"key":"10.1016\/j.sjbs.2021.03.055_b0220","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5487\/TR.2017.33.3.233","article-title":"Xylene induces oxidative stress and mitochondria damage in isolated human lymphocytes","volume":"33","author":"Salimi","year":"2017","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01270909","article-title":"Dose-dependent neurochemical changes during short-term inhalation exposure to m-xylene","volume":"45","author":"Savoleinen","year":"1980","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0230","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/02772248.2015.1047671","article-title":"Involvement of mitochondrial-mediated caspase-3 activation and lysosomal labilization in acrylamide-induced liver toxicity","volume":"97","author":"Seydi","year":"2015","journal-title":"Toxicol. Environ. Chem."},{"key":"10.1016\/j.sjbs.2021.03.055_b0235","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/jasmr.jasmr_9_19","article-title":"Role of citicoline as a protective agent on toluene-induced toxicity in rats","volume":"14","author":"Shaffie","year":"2019","journal-title":"J. Arab. Soc. Med. Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0240","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.sjbs.2016.09.021","article-title":"The potential protective influence of flaxseed oil against renal toxicity induced by thioacetamide in rats","volume":"25","author":"Shaikh Omar","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0245","series-title":"Methods in Neurosciences","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/B978-0-12-185255-9.50016-X","article-title":"Image analytic techniques for quantification of immunocytochemical staining in the nervous system","author":"Smolen","year":"1990"},{"key":"10.1016\/j.sjbs.2021.03.055_b0250","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/09712119.2015.1124333","article-title":"The application of probiotics and flaxseed promotes metabolism of n-3 polyunsaturated fatty acids in pigs","volume":"45","author":"Sopkov\u00e1","year":"2017","journal-title":"J. Appl. Anim. Res."},{"key":"10.1016\/j.sjbs.2021.03.055_b0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2210-10-13","article-title":"Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver","volume":"12","author":"Srilaxmi","year":"2010","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0260","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1079\/BJN19850061","article-title":"The digestion of fibre by pigs. 2. Volatile fatty acid concentrations in large intestine digesta","volume":"53","author":"Stanogias","year":"1985","journal-title":"Br J. Nutr."},{"key":"10.1016\/j.sjbs.2021.03.055_b0265","doi-asserted-by":"crossref","first-page":"268","DOI":"10.17221\/7497-CJAS","article-title":"Effect of Lactobacillus plantarum LS\/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon","volume":"59","author":"Strojn\u00fd","year":"2014","journal-title":"Czech J. Anim. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0270","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s43141-020-00024-y","article-title":"Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning","volume":"18","author":"Tallat","year":"2020","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.sjbs.2021.03.055_b0275","first-page":"245","article-title":"The effect of xylene exposure on the liver","volume":"38","author":"Ungv\u00e1ry","year":"1990","journal-title":"Acta Morphol Hung"},{"key":"10.1016\/j.sjbs.2021.03.055_b0280","unstructured":"US EPA (United States Environmental Protection Agency), 2003. Toxicological Review of Xylenes (CAS No. 1330-20-7), Support of Summary Information on the Integrated Risk Information System (IRIS) 2003, p.26. https:\/\/cfpub.epa.gov\/ncea\/iris\/iris_documents\/documents\/toxreviews\/0270tr.pdf Accessed January 2003."},{"key":"10.1016\/j.sjbs.2021.03.055_b0285","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.anireprosci.2018.04.066","article-title":"Supplemental flaxseed modulates ovarian functions of weanling gilts via the action of selected fatty acids","volume":"193","author":"Vl\u010dkov\u00e1","year":"2018","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0290","doi-asserted-by":"crossref","unstructured":"Wallig, M.A., Rousseaux, C.G., Haschek, W.M., Bolon, B., 2018. Fundamentals of toxicologic pathology (3rd Edition), Chapter \u2013 15, 395\u2013442.","DOI":"10.1016\/B978-0-12-809841-7.00015-0"},{"key":"10.1016\/j.sjbs.2021.03.055_b0295","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.foodchem.2016.03.001","article-title":"Effect of germination on lignan biosynthesis, and antioxidant and antiproliferative activities in flaxseed (Linum Usitatissimum L.)","volume":"205","author":"Wang","year":"2016","journal-title":"Food Chem"},{"key":"10.1016\/j.sjbs.2021.03.055_b0300","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1254\/jphs.13R17CP","article-title":"New insights into the pharmacological potential of plant flavonoids in the catecholamine system","volume":"124","author":"Yanagihara","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.sjbs.2021.03.055_b0305","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12944-017-0431-8","article-title":"Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice","volume":"16","author":"Zhang","year":"2017","journal-title":"Lipids Health Dis"}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21002266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21002266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:53:41Z","timestamp":1778594021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X21002266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1319562X21002266"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.03.055","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary flaxseed's protective effects on body tissues of mice after oral exposure to xylene","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.03.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}