{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:01:15Z","timestamp":1786996875271,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP\u20132020\/197"],"award-info":[{"award-number":["TURSP\u20132020\/197"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.sjbs.2021.08.020","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T23:52:14Z","timestamp":1628725934000},"page":"5500-5517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities"],"prefix":"10.1016","volume":"28","author":[{"given":"Saima","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rashid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riffat","family":"Batool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Afzal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banzeer Ahsan","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabassum","family":"Yaseen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Aldhahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez","family":"Althobaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2021.08.020_b0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/14786419.2014.950960","article-title":"A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl4-induced injury on human hepatoma cell line (Huh7)","volume":"29","author":"Abdel-Monem","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.sjbs.2021.08.020_b0010","first-page":"872","article-title":"Marine natural products and their potential applications as anti-infective agents","volume":"7","author":"Abou-Elela","year":"2009","journal-title":"World Appl. Sci. J."},{"key":"10.1016\/j.sjbs.2021.08.020_b0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4103\/1995-7645.242314","article-title":"Role of dietary phytochemicals in modulation of miRNA expression: Natural swords combating breast cancer","volume":"11","author":"Abbasi","year":"2018","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.sjbs.2021.08.020_b0020","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.pharep.2019.03.001","article-title":"Potential phytochemicals in the prevention and treatment of esophagus cancer: A green therapeutic approach","volume":"71","author":"Abbasi","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.sjbs.2021.08.020_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.128490","article-title":"Green formulation and chemical characterizations of Rhamnella gilgitica aqueous leaves extract conjugated NiONPs and their multiple therapeutic properties","volume":"1218","author":"Abbasi","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.sjbs.2021.08.020_b0030","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/jemt.23522","article-title":"Environmentally friendly green approach for the fabrication of silver oxide nanoparticles: Characterization and diverse biomedical applications","volume":"83","author":"Abbasi","year":"2020","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.sjbs.2021.08.020_b0035","doi-asserted-by":"crossref","first-page":"1250e7","DOI":"10.1088\/2053-1591\/ab664d","article-title":"Bioinspired synthesis and activity characterization of iron oxide nanoparticles made using Rhamnus Triquetra leaf extract","volume":"6","author":"Abbasi","year":"2020","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.sjbs.2021.08.020_b0040","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jemt.23577","article-title":"Phytofabrication of cobalt oxide nanoparticles from Rhamnus virgata leaves extract and investigation of different bioactivities","volume":"84","author":"Abbasi","year":"2021","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.sjbs.2021.08.020_b0045","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0050","first-page":"1117","article-title":"Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats","volume":"105","author":"Ali","year":"2018","journal-title":"Biomed."},{"key":"10.1016\/j.sjbs.2021.08.020_b0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5897\/JPP2015.0367","article-title":"Determination of metabolites products by Cassia angustifolia and evaluate antimicobial activity","volume":"8","author":"Al-Marzoqi","year":"2016","journal-title":"J. Pharmacogn. Phytotherapy"},{"key":"10.1016\/j.sjbs.2021.08.020_b0060","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3389\/fphar.2017.00731","article-title":"Rumex dentatus inhibits cell proliferation, arrests cell cycle, and induces apoptosis in MDA-MB-231 cells through suppression of the NF-\u03baB pathway","volume":"8","author":"Batool","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0065","first-page":"772","article-title":"Rumex dentatus could be a potent alternative to treatment of micro-bial infections and of breast cancer","volume":"39","author":"Batool","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.sjbs.2021.08.020_b0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4103\/2221-1691.290133","article-title":"In vitro antioxidant and anti-cancer activities and phytochemical analysis of Commelina benghalensis L. root extracts. Asian Pac","volume":"10","author":"Batool","year":"2020","journal-title":"J Trop. Biomed."},{"key":"10.1016\/j.sjbs.2021.08.020_b0075","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-2005-837790","article-title":"Chemical composition and antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris","volume":"71","author":"Cha","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.sjbs.2021.08.020_b0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ajme.2015.07.001","article-title":"In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells","volume":"52","author":"Dahham","year":"2016","journal-title":"Alexandria J. Med."},{"key":"10.1016\/j.sjbs.2021.08.020_b0085","first-page":"747","article-title":"Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion","volume":"23","author":"Ding","year":"2018","journal-title":"J. Buon"},{"key":"10.1016\/j.sjbs.2021.08.020_b0090","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.7314\/APJCP.2015.16.6.2129","article-title":"Molecular mechanisms of apoptosis and roles in cancer development and treatment","volume":"16","author":"Goldar","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.sjbs.2021.08.020_b0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fshw.2017.06.001","article-title":"Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells","volume":"6","author":"Gouthamchandra","year":"2017","journal-title":"Food Sci. Hum. Well."},{"key":"10.1016\/j.sjbs.2021.08.020_b0100","doi-asserted-by":"crossref","first-page":"32305","DOI":"10.18632\/oncotarget.25955","article-title":"Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions","volume":"9","author":"Guesmi","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.sjbs.2021.08.020_b0105","first-page":"117","article-title":"Protective Effect of Curcumin on Hepatocarcinoma induced by N-Nitrosodiethylamine in Male Rats","volume":"13","author":"Hashemi","year":"2015","journal-title":"Nat. Sci."},{"key":"10.1016\/j.sjbs.2021.08.020_b0110","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijfoodmicro.2011.04.028","article-title":"Chemical composition, cytotoxicity effect and antimicrobial activity of Ceratonia siliqua essential oil with preservative effects against Listeria inoculated in minced beef meat","volume":"148","author":"Hsouna","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0115","article-title":"Antioxidant, antimicrobial, and free radical scavenging potential of aerial parts of Periploca aphylla and Ricinus communis","author":"Iqbal","year":"2012","journal-title":"ISRN"},{"key":"10.1016\/j.sjbs.2021.08.020_b0120","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.apjtb.2017.10.016","article-title":"Plant-derived anticancer agents: A green anticancer approach","volume":"7","author":"Iqbal","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.sjbs.2021.08.020_b0125","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.biopha.2018.09.096","article-title":"Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications","volume":"108","author":"Iqbal","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.sjbs.2021.08.020_b0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2018.03.007","article-title":"Potential phytocompounds for developing breast cancer therapeutics: nature\u2019s healing touch","volume":"827","author":"Iqbal","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/1995-7645.228432","article-title":"Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives","volume":"11","author":"Iqbal","year":"2018","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.sjbs.2021.08.020_b0140","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.biopha.2018.10.107","article-title":"Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives","volume":"109","author":"Iqbal","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.sjbs.2021.08.020_b0145","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.30848\/PJB2019-3(34)","article-title":"Phylogenetic relationships within the cosmopolitan family rhamnaceae using atpB gene promoter","volume":"51","author":"Iqbal","year":"2019","journal-title":"Pak. J. Bot."},{"key":"10.1016\/j.sjbs.2021.08.020_b0150","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1462-5822.2008.01137.x","article-title":"Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-\u03baB and MAPK signalling","volume":"10","author":"Iyer","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0155","first-page":"341","article-title":"Screening of antioxidant activity, total phenolics and gas chromatograph and mass spectrometer (GC-MS) study of Delonix regia","volume":"2","author":"Jancy Rani","year":"2011","journal-title":"Afr. J. Biochem. Res."},{"key":"10.1016\/j.sjbs.2021.08.020_b0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF03032599","article-title":"The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis","volume":"7","author":"John","year":"2001","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.sjbs.2021.08.020_b0165","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/s10495-011-0629-6","article-title":"Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K\/Akt signaling pathways","volume":"16","author":"Kannaiyan","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.sjbs.2021.08.020_b0170","doi-asserted-by":"crossref","unstructured":"Komonrit, P., and Banjerdpongchai, R., 2018. Effect of Pseuderanthemum palatiferum (Nees) Radlk fresh leaf ethanolic extract on human breast cancer MDA-MB-231 regulated cell death. Tumor Biol. 40, 1010428318800182.","DOI":"10.1177\/1010428318800182"},{"key":"10.1016\/j.sjbs.2021.08.020_b0175","first-page":"191","article-title":"Screening of antioxidant activity, total phenolics and GC-MS study of Vitex negundo","volume":"4","author":"Kumar","year":"2010","journal-title":"Afr. J. Biochem. Res."},{"key":"10.1016\/j.sjbs.2021.08.020_b0180","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1002\/jcb.27738","article-title":"Oleuropein induces apoptosis via abrogating NF-\u03baB activation cascade in estrogen receptor\u2013negative breast cancer cells","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.sjbs.2021.08.020_b0185","first-page":"1","article-title":"Ricinus communis L. fruit extract inhibits migration\/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo","volume":"9","author":"Majumder","year":"2019","journal-title":"Sci. Rep-UK"},{"key":"10.1016\/j.sjbs.2021.08.020_b0190","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.saa.2014.10.043","article-title":"Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities","volume":"138","author":"Manikandan","year":"2015","journal-title":"Spectrochimica Acta A."},{"key":"10.1016\/j.sjbs.2021.08.020_b0195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12906-016-1290-y","article-title":"Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line","volume":"16","author":"Najmuddin","year":"2016","journal-title":"BMC Complem. Altern. M."},{"key":"10.1016\/j.sjbs.2021.08.020_b0200","first-page":"287","article-title":"Biological activity and mass spectrometric analysis of Vernonia amygdalina fractions","volume":"2","author":"Oyugi","year":"2011","journal-title":"J. Biosci. Tech."},{"key":"10.1016\/j.sjbs.2021.08.020_b0205","first-page":"346","article-title":"Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest","volume":"23","author":"Qi","year":"2018","journal-title":"J. Buon"},{"issue":"7","key":"10.1016\/j.sjbs.2021.08.020_b0210","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji : an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.sjbs.2021.08.020_b0215","first-page":"2135","article-title":"Neem seed oil induces apoptosis in MCF-7 and MDA MB-231 human breast cancer cells","volume":"18","author":"Sharma","year":"2017","journal-title":"Asian Pac. J. Cancer P: APJCP."},{"key":"10.1016\/j.sjbs.2021.08.020_b0220","first-page":"1085","article-title":"Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells","volume":"32","author":"Sigstedt","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0225","series-title":"Word cancer report 2014","author":"Stewart","year":"2014"},{"key":"10.1016\/j.sjbs.2021.08.020_b0230","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer","volume":"71","author":"Sung","year":"2021","journal-title":"J. Clin."},{"key":"10.1016\/j.sjbs.2021.08.020_b0235","first-page":"645","article-title":"Antimicrobial and anti-oxidant potential of Periploca hydaspidis","volume":"10","author":"Ullah","year":"2015","journal-title":"Bangl. J. Pharmacol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0240","first-page":"1263","article-title":"In vitro evaluation of hemolytic activity and cell viability assay of hexanoic extracts of Bridelia ferruginea benth","volume":"4","author":"Vinjamuri","year":"2015","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.sjbs.2021.08.020_b0245","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.sjbs.2021.08.020_b0250","first-page":"922","article-title":"Polydatin promotes apoptosis through upregulation the ratio of Bax\/Bcl-2 and inhibits proliferation by attenuating the \u03b2-catenin signaling in human osteosarcoma cells","volume":"8","author":"Xu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.sjbs.2021.08.020_b0255","first-page":"6415","article-title":"MicroRNA-519 suppresses cell growth and invasion by reducing HuR levels in hepatocellular carcinoma","volume":"10","author":"Zhang","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.sjbs.2021.08.020_b0260","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/jemt.23687","article-title":"Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss","volume":"84","author":"Zahra","year":"2021","journal-title":"Seeds. Microsc Res Tech"},{"key":"10.1016\/j.sjbs.2021.08.020_b0265","article-title":"Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials","author":"Zahra","year":"2021","journal-title":"Microsc. Res. Tech."}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21006872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21006872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:16:35Z","timestamp":1761153395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X21006872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1319562X21006872"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.08.020","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}