{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:11:01Z","timestamp":1783383061458,"version":"3.54.6"},"reference-count":19,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP-2020\/269"],"award-info":[{"award-number":["TURSP-2020\/269"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.sjbs.2021.11.068","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T01:52:59Z","timestamp":1638755579000},"page":"2323-2328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Protective effect of Bosutinib with caspase inhibitors on human K562 cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Roua S.","family":"Baty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2021.11.068_b0005","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.18632\/oncotarget.13643","article-title":"Novel Src\/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src\/Abl signaling","volume":"8","author":"Bieerkehazhi","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.sjbs.2021.11.068_b0010","article-title":"Downregulation of miR-142a contributes to the enhanced anti-apoptotic ability of murine chronic myelogenous leukemia cells","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.sjbs.2021.11.068_b0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1200\/JCO.2017.74.7162","article-title":"Bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia: results from the randomized BFORE trial","volume":"36","author":"Cortes","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.sjbs.2021.11.068_b0020","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3390\/ijms21061960","article-title":"The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer","volume":"21","author":"Ding","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.sjbs.2021.11.068_b0025","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.2217\/fon-2019-0555","article-title":"The role of bosutinib in the treatment of chronic myeloid leukemia","volume":"16","author":"Gambacorti-Passerini","year":"2020","journal-title":"Future Oncol."},{"key":"10.1016\/j.sjbs.2021.11.068_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03732-6","article-title":"Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis","volume":"12","author":"Jiang","year":"2021","journal-title":"Cell Death Disease."},{"issue":"3","key":"10.1016\/j.sjbs.2021.11.068_b0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cyto.a.20357","article-title":"Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete \u201csub-G1\u201d peaks on DNA content histograms","volume":"71A","author":"Kajstura","year":"2007","journal-title":"Cytometry Part A: J. Int. Soc. Anal. Cytol."},{"key":"10.1016\/j.sjbs.2021.11.068_b0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-642-01222-8_9","article-title":"Bosutinib","author":"Keller","year":"2010","journal-title":"Small Mol. Oncol."},{"key":"10.1016\/j.sjbs.2021.11.068_b0045","first-page":"115","article-title":"Bosutinib in the management of chronic myelogenous leukemia","volume":"7","author":"Keller-von Amsberg","year":"2013","journal-title":"Biologics: Targets Therapy."},{"key":"10.1016\/j.sjbs.2021.11.068_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20259-0","article-title":"Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem\/progenitor cells in chronic myelogenous leukemia","volume":"12","author":"Lei","year":"2021","journal-title":"Nature Commun."},{"issue":"3","key":"10.1016\/j.sjbs.2021.11.068_b0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/leu.2008.334","article-title":"Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells","volume":"23","author":"Remsing Rix","year":"2009","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.sjbs.2021.11.068_b0060","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1529-8817.2009.00733.x","article-title":"Inhibition of caspase-like activities prevents the appearance of reactive oxygen species and dark-induced apoptosis in the unicellular chlorophyte Dunaliella Tertiolecta 1","volume":"45","author":"Segovia","year":"2009","journal-title":"J. Phycol."},{"key":"10.1016\/j.sjbs.2021.11.068_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-021-01025-x","article-title":"Chronic Myelogenous Leukemia in Childhood","volume":"23","author":"Smith","year":"2021","journal-title":"Current Oncol. Rep."},{"key":"10.1016\/j.sjbs.2021.11.068_b0070","first-page":"1629","article-title":"Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines","volume":"34","author":"Tarpley","year":"2014","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.sjbs.2021.11.068_b0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000224644","article-title":"Lactate dehydrogenase leakage as a marker for apoptotic cell degradation induced by influenza virus infection in human fetal membrane cells","volume":"52","author":"Uchide","year":"2009","journal-title":"Intervirology"},{"key":"10.1016\/j.sjbs.2021.11.068_b0080","doi-asserted-by":"crossref","first-page":"106273","DOI":"10.1016\/j.leukres.2019.106273","article-title":"Role of cancer immunology in chronic myelogenous leukemia","volume":"88","author":"Ureshino","year":"2020","journal-title":"Leuk. Res."},{"key":"10.1016\/j.sjbs.2021.11.068_b0085","first-page":"100261","article-title":"Chronic myelogenous leukemia occurring in two brothers: The opposite sides of the same coin? Leukemia","volume":"16","author":"Verrou","year":"2021","journal-title":"Res. Reports."},{"issue":"3","key":"10.1016\/j.sjbs.2021.11.068_b0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.blre.2011.02.001","article-title":"Interpretation of cytogenetic and molecular results in patients treated for CML","volume":"25","author":"Vigil","year":"2011","journal-title":"Blood Rev."},{"issue":"1","key":"10.1016\/j.sjbs.2021.11.068_b0095","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/cdd.2010.72","article-title":"zVAD-induced necroptosis in L929 cells depends on autocrine production of TNF \u03b1 mediated by the PKC\u2013MAPKs\u2013AP-1 pathway","volume":"18","author":"Wu","year":"2011","journal-title":"Cell Death Differ."}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21010330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X21010330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:25:15Z","timestamp":1761153915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X21010330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1319562X21010330"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.11.068","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Bosutinib with caspase inhibitors on human K562 cells","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2021.11.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}