{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:24:30Z","timestamp":1782962670432,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014587","name":"Patuakhali Science and Technology University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.sjbs.2023.103624","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T11:42:39Z","timestamp":1678362159000},"page":"103624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrating in vivo and in silico approaches to investigate the potential of Zingiber roseum rhizome extract against pyrexia, inflammation and pain"],"prefix":"10.1016","volume":"30","author":[{"given":"Md.","family":"Naiemur Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khondoker","family":"Shahin Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakhawat","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemayet","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AFM","family":"Shahid Ud Daula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2023.103624_b0005","doi-asserted-by":"crossref","unstructured":"Al-Amin, M., Siddiqui, M.A., Ruma, S.A., Mustafa, N., Hossain, C.F.J.J.o.R.i.P., 2019. Antimicrobial activity of the crude extract, fractions and isolation of zerumbone from the rhizomes of zingiber roseum.","DOI":"10.12991\/jrp.2019.163"},{"key":"10.1016\/j.sjbs.2023.103624_b0010","series-title":"Zingiber roseum rosc","author":"Amanat","year":"2021"},{"key":"10.1016\/j.sjbs.2023.103624_b0015","unstructured":"Babu, C.R., 1977. Herbaceous flora of dehra dun."},{"key":"10.1016\/j.sjbs.2023.103624_b0020","doi-asserted-by":"crossref","unstructured":"Chen, O., Donnelly, C.R., Ji, R.-R.J.C.o.i.n., 2020. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.","DOI":"10.1016\/j.conb.2019.11.006"},{"key":"10.1016\/j.sjbs.2023.103624_b0025","doi-asserted-by":"crossref","unstructured":"Dinarello, C.A., Cannon, J.G., Wolff, S.M.J.R.o.i.d., 1988. New concepts on the pathogenesis of fever.","DOI":"10.1093\/clinids\/10.1.168"},{"key":"10.1016\/j.sjbs.2023.103624_b0030","doi-asserted-by":"crossref","unstructured":"Dinarello, C.A.J.T.J.o.i.d., 1999. Cytokines as endogenous pyrogens.","DOI":"10.1086\/513856"},{"key":"10.1016\/j.sjbs.2023.103624_b0035","unstructured":"Duarte, I., Nakamura, M., Ferreira, S.J.B.j.o.m., Biologicas, b.r.R.b.d.p.M.e., 1988. Participation of the sympathetic system in acetic acid-induced writhing in mice."},{"key":"10.1016\/j.sjbs.2023.103624_b0040","doi-asserted-by":"crossref","unstructured":"Engstad, C.S., Engstad, R.E., Olsen, J.-O., \u00d8sterud, B.J.I.i., 2002. The effect of soluble \u03b2-1, 3-glucan and lipopolysaccharide on cytokine production and coagulation activation in whole blood.","DOI":"10.1016\/S1567-5769(02)00134-0"},{"key":"10.1016\/j.sjbs.2023.103624_b0045","unstructured":"Ganesan, S., Pandi, N.R., Banumathy, N.J.E.o.I.M., 2007. Ethnomedicinal survey of alagarkoil hills (reserved forest), tamil nadu, india."},{"key":"10.1016\/j.sjbs.2023.103624_b0050","doi-asserted-by":"crossref","unstructured":"Ghosh, T., Mondal, B., Ghosh, T., Sutradhar, M., Mukherjee, G., Drew, M.G.J.I.c.a., 2007. Synthesis, structure, solution chemistry and the electronic effect of para substituents on the vanadium center in a family of mixed-ligand [vvo (ono)(on)] complexes.","DOI":"10.1016\/j.ica.2006.10.003"},{"key":"10.1016\/j.sjbs.2023.103624_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(98)12154-2","article-title":"Cox-2 inhibitors","author":"Hawkey","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.sjbs.2023.103624_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/S0968-0896(01)00386-8","article-title":"Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity","author":"Hosoda","year":"2002","journal-title":"Bioorganic and Medicinal Chemistry"},{"key":"10.1016\/j.sjbs.2023.103624_b0065","doi-asserted-by":"crossref","unstructured":"Huerta-Madronal, M., Caro-Leon, J., Espinosa-Cano, E., Aguilar, M.R., V\u00e1zquez-Lasa, B.J.C.P., 2021. Chitosan\u2013rosmarinic acid conjugates with antioxidant, anti-inflammatory and photoprotective properties.","DOI":"10.1016\/j.carbpol.2021.118619"},{"key":"10.1016\/j.sjbs.2023.103624_b0070","doi-asserted-by":"crossref","unstructured":"Hunskaar, S., Hole, K.J.P., 1987. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain.","DOI":"10.1016\/0304-3959(87)90088-1"},{"key":"10.1016\/j.sjbs.2023.103624_b0075","doi-asserted-by":"crossref","unstructured":"Javed, F., Jabeen, Q., Aslam, N., Awan, A.M.J.J.o.E., 2020. Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of indigofera argentea burm. F.","DOI":"10.1016\/j.jep.2020.112966"},{"key":"10.1016\/j.sjbs.2023.103624_b0080","doi-asserted-by":"crossref","unstructured":"Jou, D., Casas-Vazquez, J., Lebon, G., 1996. Recent bibliography on extended irreversible thermodynamics and related topics (1992-1995).","DOI":"10.1515\/jnet.1996.21.2.103"},{"key":"10.1016\/j.sjbs.2023.103624_b0085","doi-asserted-by":"crossref","unstructured":"Khan, I., Nisar, M., Ebad, F., Nadeem, S., Saeed, M., Khan, H., Khuda, F., Karim, N., Ahmad, Z.J.J.o.e., 2009. Anti-inflammatory activities of sieboldogenin from smilax china linn.: Experimental and computational studies.","DOI":"10.1016\/j.jep.2008.10.009"},{"key":"10.1016\/j.sjbs.2023.103624_b0090","doi-asserted-by":"crossref","unstructured":"Lakshman, K., Shivaprasad, H., Jaiprakash, B., Mohan, S., 2006. Anti-inflammatory and antipyretic activities of hemidesmus indicus root extract.","DOI":"10.4314\/ajtcam.v3i1.31143"},{"key":"10.1016\/j.sjbs.2023.103624_b0095","unstructured":"Leelaprakash, G., Dass, S.M.J.I.J.o.D.D., Research, 2011. Invitro anti-inflammatory activity of methanol extract of enicostemma axillare."},{"key":"10.1016\/j.sjbs.2023.103624_b0100","unstructured":"Maheshwari, J., Kalakoti, B., Lal, B.J.A.S.o.l., 1986. Ethnomedicine of bhil tribe of jhabua district, mp."},{"key":"10.1016\/j.sjbs.2023.103624_b0105","doi-asserted-by":"crossref","unstructured":"Marwaha, A., Goel, R., Mahajan, M.P.J.B., letters, m.c., 2007. Pass-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.","DOI":"10.1016\/j.bmcl.2007.06.071"},{"key":"10.1016\/j.sjbs.2023.103624_b0110","doi-asserted-by":"crossref","unstructured":"Medzhitov, R.J.C., 2010. Inflammation 2010: New adventures of an old flame.","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"10.1016\/j.sjbs.2023.103624_b0115","doi-asserted-by":"crossref","unstructured":"O'Boyle, N.M., Banck, M., James, C.A., Morley, C., Vandermeersch, T., Hutchison, G.R.J.J.o.c., 2011. Open babel: An open chemical toolbox.","DOI":"10.1186\/1758-2946-3-33"},{"key":"10.1016\/j.sjbs.2023.103624_b0120","unstructured":"Padal, S., Ramakrishna, H., Devender, R.J.I.J.M.A.P., 2012. Ethnomedicinal studies for endemic diseases by the tribes of munchingiputtu mandal, visakhapatnam district, andhra pradesh, india."},{"key":"10.1016\/j.sjbs.2023.103624_b0125","doi-asserted-by":"crossref","unstructured":"Parida, M., Posadas, G., Inoue, S., Hasebe, F., Morita, K.J.J.o.c.m., 2004. Real-time reverse transcription loop-mediated isothermal amplification for rapid detection of west nile virus.","DOI":"10.1128\/JCM.42.1.257-263.2004"},{"key":"10.1016\/j.sjbs.2023.103624_b0130","doi-asserted-by":"crossref","unstructured":"Pawlik, T.M., Paulino, A.F., Mcginn, C.J., Baker, L.H., Cohen, D.S., Morris, J.S., Rees, R., Sondak, V.K.J.C.I.I.J.o.t.A.C.S., 2003. Cutaneous angiosarcoma of the scalp: A multidisciplinary approach.","DOI":"10.1002\/cncr.11667"},{"key":"10.1016\/j.sjbs.2023.103624_b0135","doi-asserted-by":"crossref","unstructured":"Ranneh, Y., Ali, F., Akim, A.M., Hamid, H.A., Khazaai, H., Fadel, A.J.A.B.C., 2017. Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: A review.","DOI":"10.1007\/s13765-017-0285-9"},{"key":"10.1016\/j.sjbs.2023.103624_b0140","doi-asserted-by":"crossref","unstructured":"Rauf, A., Khan, R., Khan, H., Ullah, B., Pervez, S.J.B.C., Medicine, A., 2014. Antipyretic and antinociceptive potential of extract\/fractions of potentilla evestita and its isolated compound, acacetin.","DOI":"10.1186\/1472-6882-14-448"},{"key":"10.1016\/j.sjbs.2023.103624_b0145","doi-asserted-by":"crossref","unstructured":"Reza, M.S., Jashimuddin, M., Ahmed, J., Abeer, M., Naznin, N.E., Jafrin, S., Haque, M.E., Barek, M.A., Daula, A.S.U.J.J.o.E., 2021. Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of aeginetia indica.","DOI":"10.1016\/j.jep.2021.113915"},{"key":"10.1016\/j.sjbs.2023.103624_b0150","doi-asserted-by":"crossref","unstructured":"Roy, R., Daula, A.S.U., Akter, A., Sultana, S., Barek, M.A., Liya, I.J., Basher, M.A.J.J.o.e., 2019. Antipyretic and anti-nociceptive effects of methanol extract of leaves of fimbristylis miliacea in mice model.","DOI":"10.1016\/j.jep.2019.112080"},{"key":"10.1016\/j.sjbs.2023.103624_b0155","doi-asserted-by":"crossref","unstructured":"Ruwizhi, N., Aderibigbe, B.A.J.I.j.o.m.s., 2020. Cinnamic acid derivatives and their biological efficacy.","DOI":"10.3390\/ijms21165712"},{"key":"10.1016\/j.sjbs.2023.103624_b0160","doi-asserted-by":"crossref","unstructured":"Shibata, M., Ohkubo, T., Takahashi, H., Inoki, R.J.p., 1989. Modified formalin test: Characteristic biphasic pain response.","DOI":"10.1016\/0304-3959(89)90222-4"},{"key":"10.1016\/j.sjbs.2023.103624_b0165","doi-asserted-by":"crossref","unstructured":"Shukla, R., Pandey, V., Vadnere, G.P., Lodhi, S., 2019. Role of flavonoids in management of inflammatory disorders. Bioactive food as dietary interventions for arthritis and related inflammatory diseases, Elsevier: 293-322.","DOI":"10.1016\/B978-0-12-813820-5.00018-0"},{"key":"10.1016\/j.sjbs.2023.103624_b0170","doi-asserted-by":"crossref","unstructured":"Siegmund, E., Cadmus, R., Lu, G.J.P.o.t.S.f.E.B., Medicine, 1957. A method for evaluating both non-narcotic and narcotic analgesics.","DOI":"10.3181\/00379727-95-23345"},{"key":"10.1016\/j.sjbs.2023.103624_b0175","doi-asserted-by":"crossref","unstructured":"Sultana, S., Asif, H.M., Akhtar, N., Ahmad, K.J.A.P.J.o.T.D., 2015. Medicinal plants with potential antipyretic activity: A review.","DOI":"10.1016\/S2222-1808(15)60890-8"},{"key":"10.1016\/j.sjbs.2023.103624_b0180","unstructured":"Tate, G., Mandell, B.F., Laposata, M., Ohliger, D., Baker, D.G., Schumacher, H.R., Zurier, R.B.J.J.R., 1989. Suppression of acute and chronic inflammation by dietary gamma linolenic acid."},{"key":"10.1016\/j.sjbs.2023.103624_b0185","doi-asserted-by":"crossref","unstructured":"Tomazetti, J., \u00c1vila, D.S., Ferreira, A.P.O., Martins, J.S., Souza, F.R., Royer, C., Rubin, M.A., Oliveira, M.R., Bonacorso, H.G., Martins, M.A.P.J.J.o.N.M., 2005. Baker yeast-induced fever in young rats: Characterization and validation of an animal model for antipyretics screening.","DOI":"10.1016\/j.jneumeth.2005.03.002"},{"key":"10.1016\/j.sjbs.2023.103624_b0190","doi-asserted-by":"crossref","unstructured":"Truong, V.-L., Jeong, W.-S.J.I.J.o.M.S., 2021. Cellular defensive mechanisms of tea polyphenols: Structure-activity relationship.","DOI":"10.3390\/ijms22179109"},{"key":"10.1016\/j.sjbs.2023.103624_b0195","doi-asserted-by":"crossref","unstructured":"Vane, J., Bakhle, Y., Botting, R.J.A.r.o.p., toxicology, 1998. Cyclooxygenases 1 and 2.","DOI":"10.1146\/annurev.pharmtox.38.1.97"},{"key":"10.1016\/j.sjbs.2023.103624_b0200","article-title":"Pathway to carrageenan-induced inflammation in the hind limb of the rat","author":"Vinegar","year":"1987","journal-title":"Federation proceedings"},{"key":"10.1016\/j.sjbs.2023.103624_b0205","doi-asserted-by":"crossref","unstructured":"Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L., DeCarvalho, A.C., Lyu, S., Li, P., Li, Y.J.C.c., 2017. Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment.","DOI":"10.1016\/j.ccell.2017.06.003"},{"key":"10.1016\/j.sjbs.2023.103624_b0210","doi-asserted-by":"crossref","unstructured":"Wang, X., Cao, Y., Chen, S., Lin, J., Bian, J., Huang, D.J.J.o.A., Chemistry, F., 2021. Anti-inflammation activity of flavones and their structure\u2013activity relationship.","DOI":"10.1021\/acs.jafc.1c02015"},{"key":"10.1016\/j.sjbs.2023.103624_b0215","doi-asserted-by":"crossref","unstructured":"Yi, X., Liang, Y., Huerta-Sanchez, E., Jin, X., Cuo, Z.X.P., Pool, J.E., Xu, X., Jiang, H., Vinckenbosch, N., Korneliussen, T.S.J.s., 2010. Sequencing of 50 human exomes reveals adaptation to high altitude.","DOI":"10.1126\/science.1190371"},{"key":"10.1016\/j.sjbs.2023.103624_b0220","series-title":"Comprehensive pediatric hospital medicine","author":"Zaoutis","year":"2007"}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X23000694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X23000694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:28:22Z","timestamp":1761154102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X23000694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1319562X23000694"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2023.103624","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating in vivo and in silico approaches to investigate the potential of Zingiber roseum rhizome extract against pyrexia, inflammation and pain","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2023.103624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"103624"}}