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Neonatal Screen."},{"issue":"2","key":"10.1016\/j.sjbs.2023.103685_b0440","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3126\/jnps.v38i2.19196","article-title":"Cystic fibrosis with Severe Anaemia and Hypoproteinaemia","volume":"38","author":"Siddique","year":"2018","journal-title":"J. Nepal Paediatr. Soc."},{"issue":"8","key":"10.1016\/j.sjbs.2023.103685_b0445","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/resp.12656","article-title":"Epidemiology and genetics of cystic fibrosis in Asia: In preparation for the next-generation treatments","volume":"20","author":"Singh","year":"2015","journal-title":"Respirology (Carlton, Vic)"},{"issue":"7","key":"10.1016\/j.sjbs.2023.103685_b0450","doi-asserted-by":"crossref","first-page":"e0133890","DOI":"10.1371\/journal.pone.0133890","article-title":"Distribution of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutations in a Cohort of Patients Residing in Palestine","volume":"10","author":"Siryani","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.sjbs.2023.103685_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2019.103681","article-title":"Deletion of exons 16\u201317b of CFTR is frequently identified in Korean patients with cystic fibrosis","volume":"62","author":"Sohn","year":"2019","journal-title":"Eur. J. Med. Genet."},{"issue":"4","key":"10.1016\/j.sjbs.2023.103685_b0460","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jcf.2015.08.007","article-title":"The impact of a national population carrier screening program on cystic fibrosis birth rate and age at diagnosis: Implications for newborn screening","volume":"15","author":"Stafler","year":"2016","journal-title":"J. Cystic Fibrosis: Off. J. Eur. Cystic Fibrosis Soc."},{"key":"10.1016\/j.sjbs.2023.103685_b0465","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/gim.2015.157","article-title":"Cystic fibrosis on the African continent","volume":"18","author":"Stewart","year":"2016","journal-title":"Genet Med"},{"issue":"20","key":"10.1016\/j.sjbs.2023.103685_b0470","first-page":"818","article-title":"Cystic fibrosis in the South West African Afrikaner. An example of population drift, possibly with heterozygote advantage","volume":"49","author":"Super","year":"1975","journal-title":"S. Afr. Med. J. = Suid-Afrikaanse tydskrif vir geneeskunde"},{"issue":"5","key":"10.1016\/j.sjbs.2023.103685_b0475","first-page":"361","article-title":"Case report of a Thai male cystic fibrosis patinet with the 1898+ 1G -->T splicing mutation in the CFTR gene: a review of East Asian cases. Mutations in brief no. 196. Online","volume":"12","author":"Suwanjutha","year":"1998","journal-title":"Hum. Mutation"},{"issue":"10","key":"10.1016\/j.sjbs.2023.103685_b0480","first-page":"1756","article-title":"Cystic fibrosis in three northeast Thai infants is CF really a rare disease in the Thai population?","volume":"89","author":"Teeratakulpisarn","year":"2006","journal-title":"J. Med. Assoc. Thailand = Chotmaihet thangphaet"},{"key":"10.1016\/j.sjbs.2023.103685_b0485","doi-asserted-by":"crossref","first-page":"15063","DOI":"10.1038\/hgv.2015.63","article-title":"p. G970D is the most frequent CFTR mutation in Chinese patients with cystic fibrosis","volume":"3","author":"Tian","year":"2016","journal-title":"Hum. Genome Variat."},{"issue":"2","key":"10.1016\/j.sjbs.2023.103685_b0490","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jgf2.151","article-title":"Diagnosis of cystic fibrosis in an adult Japanese male","volume":"19","author":"Tomoda","year":"2018","journal-title":"J. Gen. Fam. Med."},{"issue":"9","key":"10.1016\/j.sjbs.2023.103685_b0495","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1086\/651598","article-title":"Distribution of CFTR variations in an Indonesian enteric fever cohort","volume":"50","author":"Van de Vosse","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.sjbs.2023.103685_b0500","first-page":"624","article-title":"Cystic fibrosis in South Africa: A changing diagnostic paradigm","volume":"108","author":"Van Rensburg","year":"2018","journal-title":"S. Afr. Med. 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Radiol."},{"issue":"1","key":"10.1016\/j.sjbs.2023.103685_b0530","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s13023-021-02049-z","article-title":"Demographic characteristics, clinical and laboratory features, and the distribution of pathogenic variants in the CFTR gene in the Cypriot cystic fibrosis (CF) population demonstrate the utility of a national CF patient registry","volume":"16","author":"Yiallouros","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"issue":"2","key":"10.1016\/j.sjbs.2023.103685_b0535","first-page":"6177","article-title":"The spectrum of mutations analysis of exons 10 and 17a of CFTR gene in Iraqi patients with cystic fibrosis disease","volume":"20","author":"Zaidan","year":"2020","journal-title":"Biochem Cell Arch"},{"issue":"3","key":"10.1016\/j.sjbs.2023.103685_b0540","doi-asserted-by":"crossref","first-page":"00856","DOI":"10.1183\/23120541.00856-2020","article-title":"Cystic fibrosis in South Africa: spectrum of disease and determinants of outcome","volume":"7","author":"Zampoli","year":"2021","journal-title":"ERJ Open Res."},{"issue":"3","key":"10.1016\/j.sjbs.2023.103685_b0545","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.1002\/ppul.23539","article-title":"Differences in gene mutations between Chinese and Caucasian cystic fibrosis patients","volume":"52","author":"Zheng","year":"2017","journal-title":"Pediatr. 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