{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:26:46Z","timestamp":1769426806055,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023674","name":"King Khalid University Deanship of Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/131\/44"],"award-info":[{"award-number":["RGP2\/131\/44"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Journal of Biological Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.sjbs.2024.104048","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T05:44:35Z","timestamp":1717998275000},"page":"104048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Isolation of 6-gingerol and semi-synthesis of 1,4-benzodiazepines derivatives: An in-situ pharmacokinetics properties, molecular docking and molecular dynamics simulation assessments"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-8278","authenticated-orcid":false,"given":"Mariyappan","family":"Vaithiyalingam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-5264","authenticated-orcid":false,"given":"Ramasamy","family":"Mohan Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-5970","authenticated-orcid":false,"given":"Prerna","family":"Khagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-392X","authenticated-orcid":false,"given":"Sarvesh","family":"Sabarathinam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-2134","authenticated-orcid":false,"given":"Yahia","family":"Alghazwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-4562","authenticated-orcid":false,"given":"Kumarappan","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sjbs.2024.104048_b0005","article-title":"Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases:\u201cReverse pharmacology\u201d and \u201cbedside to bench\u201d approach","author":"Aggarwal","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.sjbs.2024.104048_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030744","article-title":"Preparation and evaluation of 6-gingerol derivatives as novel antioxidants and antiplatelet agents","author":"Ahmed","year":"2023","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.sjbs.2024.104048_b0015","doi-asserted-by":"crossref","DOI":"10.1021\/jm2001597","article-title":"New insight into the central benzodiazepine receptor\u2013ligand interactions: Design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4h-imidazo[1,5-a][1,4]benzodiazepines and related compounds","author":"Anzini","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.sjbs.2024.104048_b0025","doi-asserted-by":"crossref","DOI":"10.1039\/C9GC02605C","article-title":"Oxidation of secondary alcohols using solid-supported hypervalent iodine catalysts","author":"Ballaschk","year":"2019","journal-title":"Green Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0030","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky318","article-title":"Protox-ii: A webserver for the prediction of toxicity of chemicals","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sjbs.2024.104048_b0035","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btu104","article-title":"Improved protein\u2013ligand binding affinity prediction by using a curvature-dependent surface-area model","author":"Cao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.sjbs.2024.104048_b0040","doi-asserted-by":"crossref","unstructured":"Daina, A., Zoete, V., 2016. A boiled-egg to predict gastrointestinal absorption and brain penetration of small molecules. DOI: 10.1002\/cmdc.201600182.","DOI":"10.1002\/cmdc.201600182"},{"key":"10.1016\/j.sjbs.2024.104048_b0045","doi-asserted-by":"crossref","DOI":"10.1021\/ci500467k","article-title":"Ilogp: A simple, robust, and efficient description of n-octanol\/water partition coefficient for drug design using the gb\/sa approach","author":"Daina","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.sjbs.2024.104048_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"Swissadme: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.sjbs.2024.104048_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111043","article-title":"Impact of drying and extractions processes on the recovery of gingerols and shogaols, the main bioactive compounds of ginger","author":"Dalsasso","year":"2022","journal-title":"Food Res Int"},{"key":"10.1016\/j.sjbs.2024.104048_b0060","doi-asserted-by":"crossref","DOI":"10.1039\/D1FO03610F","article-title":"10-gingerol, a natural ampk agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation","author":"Deng","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.sjbs.2024.104048_b0065","doi-asserted-by":"crossref","DOI":"10.4155\/fmc-2022-0052","article-title":"Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting inha","author":"Dhivya","year":"2022","journal-title":"Future Med Chem"},{"key":"10.1016\/j.sjbs.2024.104048_b0070","article-title":"Inhibition of mycobacterium tuberculosis inha (enoyl-acyl carrier protein reductase) by synthetic chalcones: A molecular modelling analysis and in-vitro evidence","author":"Dhivya","year":"2022","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.sjbs.2024.104048_b0075","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku401","article-title":"Protox: A web server for the in silico prediction of rodent oral toxicity","author":"Drwal","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sjbs.2024.104048_b0080","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2023-0202","article-title":"Gc-ms analysis of an ethanolic extract of ocimum species: A network pharmacology analysis insight towards obesity","author":"Gnanamurthy","year":"2024","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.sjbs.2024.104048_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.431","article-title":"Bempedoic acid: A nonstatin drug for the management of hypercholesterolemia","author":"Govindaraju","year":"2021","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.sjbs.2024.104048_b0090","doi-asserted-by":"crossref","DOI":"10.2174\/1573406415666190826160251","article-title":"New insights towards 1,4-benzodiazepines from curcumin. Design, synthesis and antimicrobial activities","author":"Hamed","year":"2020","journal-title":"Med Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0095","doi-asserted-by":"crossref","DOI":"10.4103\/0974-8520.100295","article-title":"Drug discovery from plant sources: An integrated approach","author":"Katiyar","year":"2012","journal-title":"Ayu"},{"key":"10.1016\/j.sjbs.2024.104048_b0100","doi-asserted-by":"crossref","DOI":"10.4155\/fmc-2023-0007","article-title":"Synthesis of quercetin-iron (fe) complex and its in silico and in vitro confirmation towards antibacterial activity","author":"Khagar","year":"2023","journal-title":"Future Med Chem"},{"key":"10.1016\/j.sjbs.2024.104048_b0105","article-title":"The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein b, apolipoprotein a-i and malondialdehyde in type 2 diabetic patients","author":"Khandouzi","year":"2015","journal-title":"IranJ Pharm Res."},{"key":"10.1016\/j.sjbs.2024.104048_b0110","doi-asserted-by":"crossref","DOI":"10.1039\/C9OB00343F","article-title":"Versatility of glycals in synthetic organic chemistry: Coupling reactions, diversity oriented synthesis and natural product synthesis","author":"Kinfe","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0115","doi-asserted-by":"crossref","unstructured":"Elias Nortaa Kunedeb, S., Frederick, K., 2019. Harnessing the therapeutic properties of ginger (<em>zingiber officinale<\/em> roscoe) for the management of plant diseases. Ginger cultivation and its antimicrobial and pharmacological potentials. W. Haiping. Rijeka, IntechOpen: Ch. 6.","DOI":"10.5772\/intechopen.90464"},{"key":"10.1016\/j.sjbs.2024.104048_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.chempr.2018.01.012","article-title":"Bioactive compound collections: From design to target identification","author":"Laraia","year":"2018","journal-title":"Chem"},{"key":"10.1016\/j.sjbs.2024.104048_b0125","article-title":"Stereoselective total synthesis of etnangien and etnangien methyl ester","author":"Li","year":"2010","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0130","article-title":"Cb-dock: A web server for cavity detection-guided protein\u2013ligand blind docking","author":"Liu","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.sjbs.2024.104048_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2020.109193","article-title":"Improvement of 6-gingerol production in ginger rhizomes (zingiber officinale roscoe) plants by mutation breeding using gamma irradiation","author":"Magdy","year":"2020","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.sjbs.2024.104048_b0140","doi-asserted-by":"crossref","unstructured":"Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., Li, H.-B., 2019. Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe).","DOI":"10.3390\/foods8060185"},{"key":"10.1016\/j.sjbs.2024.104048_b0145","article-title":"Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence","author":"Mashhadi","year":"2013","journal-title":"Int J Prev Med."},{"key":"10.1016\/j.sjbs.2024.104048_b0150","doi-asserted-by":"crossref","DOI":"10.1007\/s12892-022-00159-z","article-title":"Antioxidant potential of medicinal plants","author":"Pammi","year":"2023","journal-title":"J. Crop Sci. Biotechnol."},{"key":"10.1016\/j.sjbs.2024.104048_b0155","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"Pkcsm: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0160","doi-asserted-by":"crossref","DOI":"10.1039\/D1NJ02887A","article-title":"Silica\u2013sulfuric acid and alumina\u2013sulfuric acid: Versatile supported br\u00f8nsted acid catalysts","author":"Pramanik","year":"2021","journal-title":"New J. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.obmed.2021.100346","article-title":"Therapeutic use of guggulsterone in covid-19 induced obesity (covibesity) and significant role in immunomodulatory effect","author":"Preethi","year":"2021","journal-title":"Obes Med"},{"key":"10.1016\/j.sjbs.2024.104048_b0170","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2022-0020","article-title":"The role of guggulsterone on the nf-\u03bab pathway in inflammatory bowel disease: Preclinical evidence","author":"Priya","year":"2022","journal-title":"Future Sci OA"},{"key":"10.1016\/j.sjbs.2024.104048_b0175","doi-asserted-by":"crossref","DOI":"10.1080\/14786419.2023.2255920","article-title":"Isolation and in-silico approach of modified embelin derivative from embelia ribes fruits as anti-alzheimer agent","author":"Rupesh","year":"2023","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.sjbs.2024.104048_b0180","doi-asserted-by":"crossref","DOI":"10.1080\/07391102.2023.2252085","article-title":"Chalcones reloaded: An integration of network pharmacology and molecular docking for type 2 diabetes therapy","author":"Sabarathinam","year":"2023","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.sjbs.2024.104048_b0185","doi-asserted-by":"crossref","DOI":"10.2174\/1872312814666201112122110","article-title":"Assessment of herb-drug interactions based on the pharmacokinetic changes of probe drug, midazolam","author":"Sabarathinam","year":"2021","journal-title":"Drug Metab Lett"},{"key":"10.1016\/j.sjbs.2024.104048_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.obmed.2021.100326","article-title":"Isomers of guggulsterone in hyperlipidemia","author":"Sabarathinam","year":"2021","journal-title":"Obes Med"},{"key":"10.1016\/j.sjbs.2024.104048_b0195","doi-asserted-by":"crossref","DOI":"10.4155\/fmc-2023-0161","article-title":"Pharmacokinetic correlation of structurally modified chalcone derivatives as promising leads to treat tuberculosis","author":"Sabarathinam","year":"2023","journal-title":"Future Med Chem"},{"key":"10.1016\/j.sjbs.2024.104048_b0200","article-title":"A short exploration of selected sensitive cyp3a4 substrates (probe drug)","author":"Sabarathinam","year":"2021","journal-title":"Drug Metab Lett"},{"key":"10.1016\/j.sjbs.2024.104048_b0205","article-title":"Drug designing and toxicity screening of halogen and nitrogen-augmented catechin in sarcopenic obesity","author":"Sabarathinam","year":"2023","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.sjbs.2024.104048_b0210","doi-asserted-by":"crossref","DOI":"10.1039\/C4OB00835A","article-title":"Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification","author":"Sahn","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.sjbs.2024.104048_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2021.101211","article-title":"Therapeutic efficacy of 6-gingerol and 6-shogaol in promoting browning of white adipocytes vis-\u00e0-vis enhanced thermogenesis portrayed in high fat milieu","author":"Sampath","year":"2021","journal-title":"Food Biosci."},{"key":"10.1016\/j.sjbs.2024.104048_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2017.12.016","article-title":"Prevalence and pattern of usage of complementary and alternative medicine among south indian asthma patients in a tertiary care hospital","author":"Sarvesh","year":"2018","journal-title":"Complement Ther Clin Pract"},{"key":"10.1016\/j.sjbs.2024.104048_b0225","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.473","article-title":"Network pharmacology and in silico pharmacokinetic prediction of ozanimod in the management of ulcerative colitis: A computational study","author":"Sivasakthi","year":"2022","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.sjbs.2024.104048_b0230","doi-asserted-by":"crossref","DOI":"10.1021\/om50005a041","article-title":"Silafunctional compounds in organic synthesis. Part 20. Hydrogen peroxide oxidation of the silicon-carbon bond in organoalkoxysilanes","author":"Tamao","year":"1983","journal-title":"Organometallics"},{"key":"10.1016\/j.sjbs.2024.104048_b0235","doi-asserted-by":"crossref","DOI":"10.1021\/ol900210h","article-title":"Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines","author":"Tardibono","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.sjbs.2024.104048_b0240","doi-asserted-by":"crossref","DOI":"10.1039\/D2RA06045K","article-title":"Synthetic aspects of 1,4- and 1,5-benzodiazepines using o-phenylenediamine: A study of past quinquennial","author":"Teli","year":"2023","journal-title":"RSC Adv"},{"key":"10.1016\/j.sjbs.2024.104048_b0245","doi-asserted-by":"crossref","DOI":"10.1039\/b823399c","article-title":"Hypervalent iodine-mediated oxidation of alcohols","author":"Uyanik","year":"2009","journal-title":"Chem. Commun."},{"key":"10.1016\/j.sjbs.2024.104048_b0250","doi-asserted-by":"crossref","DOI":"10.1007\/s12010-022-04173-3","article-title":"Isolation and in silico study of curcumin from curcuma longa and its anti-diabetic activity","author":"Vaithiyalingam","year":"2023","journal-title":"Appl Biochem Biotechnol"}],"container-title":["Saudi Journal of Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X24001268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319562X24001268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T13:11:24Z","timestamp":1728133884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319562X24001268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1319562X24001268"],"URL":"https:\/\/doi.org\/10.1016\/j.sjbs.2024.104048","relation":{},"ISSN":["1319-562X"],"issn-type":[{"value":"1319-562X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation of 6-gingerol and semi-synthesis of 1,4-benzodiazepines derivatives: An in-situ pharmacokinetics properties, molecular docking and molecular dynamics simulation assessments","name":"articletitle","label":"Article Title"},{"value":"Saudi Journal of Biological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sjbs.2024.104048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"104048"}}