{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:51:41Z","timestamp":1771671101831,"version":"3.50.1"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_j.sjpain.2013.06.001_s_001\">\n                    <jats:title>Background and methods<\/jats:title>\n                    <jats:p>Minimally invasive parathyroidectomy requires limited analgesia and short recovery times. The preferred post-operative analgesic regimen for this patient population has not been established but non-narcotic components would be quite appropriate. The aim of the study was to determine whether intravenous (IV) acetaminophen (1 g) or ketorolac (30 mg) provide better pain control after parathyroidectomy. A parallel, randomized, double blind, comparative study was completed on 180 patients scheduled for outpatient parathyroidectomy utilizing general anesthesia. Patients were randomized to a blinded administration of either intravenous acetaminophen 1 g or ketorolac 30 mg intra-operatively. Upon arrival but before premedication, baseline pain scores were assessed in all patients. A consecutive series of postoperative pain scores were collected every 15 min using a 10 cm visual analog pain scale (VAS) upon arrival to the post anesthesia care unit (PACU) until discharge by blinded study personnel. Other data collected included: anesthesia time, surgical time, time to discharge, supplemental morphine and postoperative side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2013.06.001_s_002\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall mean postoperative VAS scores were not significantly different between the two treatment groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07). However, ketorolac produced significantly lower pain scores compared with acetaminophen in the later postoperative periods (3.9 \u00b1 1.9 vs. 4.8 \u00b1 2.4 at 45 min,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009; 3.4 \u00b1 1.7 vs. 4.5 \u00b1 2.1 at 60min,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04; and 3.2 \u00b1 2.1 vs. 4.4 \u00b1 2.1 at 75 min,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Supplemental morphine was administered to 3 patients in the ketorolac group and 9 patients in the acetaminophen group but total consumption was not significantly different between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.13). The occurrence of nausea was significantly lower in the ketorolac group compared with the IV acetaminophen group (3.4% vs. 14.6%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). The overall incidence of morphine supplementation, vomiting, headache, muscular pain, dizziness, and drowsiness were not significantly different when compared between the treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2013.06.001_s_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both postoperative regimens provided adequate analgesia but patients receiving ketorolac intraoperatively had significantly lower pain scores at later recovery time points and significantly lower occurrences of nausea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2013.06.001_s_004\">\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>The large volume of patients undergoing parathyroidectomies at our facility warranted a study to develop a standardized postoperative analgesic regimen. We conclude both medications can be utilized safely in this patient population, but there is a slight advantage in pain control with the usage of ketorolac for minimally invasive parathyroidectomies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.sjpain.2013.06.001","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T17:01:27Z","timestamp":1372957287000},"page":"249-253","source":"Crossref","is-referenced-by-count":10,"title":["Intravenous acetaminophen vs. ketorolac for postoperative analgesia after ambulatory parathyroidectomy"],"prefix":"10.1515","volume":"4","author":[{"given":"Amrat","family":"Anand","sequence":"first","affiliation":[{"name":"Florida Gulf to Bay Anesthesiology Associates LLC , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collin J.","family":"Sprenker","sequence":"additional","affiliation":[{"name":"Florida Gulf to Bay Anesthesiology Associates LLC , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Karlnoski","sequence":"additional","affiliation":[{"name":"Florida Gulf to Bay Anesthesiology Associates LLC , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Norman","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center , Tampa General Hospital , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branko","family":"Miladinovic","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Medicine and Health Outcomes Research , University of South Florida , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Wilburn","sequence":"additional","affiliation":[{"name":"University of North Florida , Nurse Anesthesia Program , Jacksonville , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Southall","sequence":"additional","affiliation":[{"name":"University of North Florida , Nurse Anesthesia Program , Jacksonville , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devanand","family":"Mangar","sequence":"additional","affiliation":[{"name":"Florida Gulf to Bay Anesthesiology Associates LLC , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Camporesi","sequence":"additional","affiliation":[{"name":"Florida Gulf to Bay Anesthesiology Associates LLC , Tampa , FL , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2025120909595506723_j_j.sjpain.2013.06.001_ref_001","doi-asserted-by":"crossref","unstructured":"Suliburk JW, Perrier ND. 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