{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:19:48Z","timestamp":1792009188267,"version":"4.4.0"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research (CIHR)","doi-asserted-by":"publisher","award":["GHL-63209"],"award-info":[{"award-number":["GHL-63209"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","scandinavianjournalpain.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_j.sjpain.2016.05.039_s_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of neuropathic pain in children is challenging, and requires a multimodal approach of pharmacologic, physical, and psychological therapies; however there is little evidence to guide practice. Amitriptyline and gabapentin are first-line drugs for treating neuropathic pain in adults, yet no studies have examined their efficacy, or compared them directly, to determine which might be better for pain relief and sleep disturbance in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2016.05.039_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After informed consent was obtained, 34 patients aged 7\u201318 years diagnosed with complex regional pain syndrome type I (CRPS I) or a neuropathic pain condition were randomly allocated to receive either amitriptyline or gabapentin. Patients were followed for 6 weeks and assessed for pain intensity, sleep quality and adverse events. We blinded study personnel, including health-care providers, participants, parents, the research coordinator and the data analyst. Patients then completed quantitative sensory testing (QST) and a psychosocial pain assessment with the team psychologist, within 1\u20133 days of the start of the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2016.05.039_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of the 6-week trial, patients on both drugs had important reductions in pain, having surpassed the minimally important difference (MID) of 1. The difference between the groups however was not statistically significant. For the secondary outcomes, we found no statistically significant difference between the two drugs in sleep score or adverse events suggesting that both drugs improve sleep score to a similar degree and are equally safe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2016.05.039_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Amitriptyline and gabapentin significantly decreased pain intensity scores and improved sleep. There were no significant differences between the two drugs in their effects on pain reduction or sleep disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2016.05.039_s_005\">\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Although larger, multi-centred trials are needed to confirm our findings, including longterm follow-up, both drugs appear to be safe and effective in treating paediatric patients in the first-line treatment of CRPS I and neuropathic pain over 6-weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.sjpain.2016.05.039","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T17:02:21Z","timestamp":1466269341000},"page":"156-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children"],"prefix":"10.1515","volume":"13","author":[{"given":"Stephen","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Pain Medicine , Hospital for Sick Children, Toronto Ontario , Canada"},{"name":"University of Toronto, Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine , Hospital for Sick Children, Toronto Ontario , Canada"},{"name":"University of Toronto, Toronto , Ontario , Canada"},{"name":"Child Health Evaluative Services, The Research Institute, The Hospital for Sick Children, Toronto , Ontario , Canada"},{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health , University of Toronto, Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khush","family":"Amaria","sequence":"additional","affiliation":[{"name":"Department of Psychology , The Hospital for Sick Children, Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine , Hospital for Sick Children, Toronto Ontario , Canada"},{"name":"University of Toronto, Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine , Hospital for Sick Children, Toronto Ontario , Canada"},{"name":"University of Toronto, Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyne","family":"Pehora","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine , Hospital for Sick Children, Toronto Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"McGrath","sequence":"additional","affiliation":[{"name":"Pain Innovations Inc., London , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"2025120909563234372_j_j.sjpain.2016.05.039_ref_001","doi-asserted-by":"crossref","unstructured":"Perquin CW, Hazebroek-Kampschreur AA, Hunfeld JA, Bohnen AM, van Suijlekom-Smit LW, Passchier J, van der Wouden JC. 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