{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:30:23Z","timestamp":1789504223762,"version":"build-2803163510"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_j.sjpain.2017.09.002_s_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Numerous publications describe chronic pain following surgery in both adults and children. However, data in the paediatric population are still sparse and both prevalence of chronic pain after surgery and risk factors of this complication still undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2017.09.002_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively evaluated the prevalence of chronic pain and its neuropathic pain component at 1 year following correction of idiopathic scoliosis in children less than 18 years of age. Pain was defined as the presence of pain (numerical rating scale \u2013 NRS \u22654), the presence of signs of neurologic damage within the area of surgery and the presence of the neuropathic symptoms as a DN4 (Douleur Neuropathique 4) questionnaire \u22654. Factors investigated as potentially associated with the presence of a persistent neuropathic pain were: age, weight, the presence of continuous preoperative pain over the 3 months before surgery, surgical characteristics, pain scores during the first five postoperative days, and DN4 at day 3. Statistical analysis employed univariate analysis and a multivariate logistic regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2017.09.002_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty six patients were included in the study. Nineteen (52.8%) had pain at one year after surgery. Among them 17 (48.2%) had neuropathic pain. Logistic regression found continuous pain over the 3 months preceding surgery and day 1 morphine consumption \u22650.5 mg kg\n                      <jats:sup>-1<\/jats:sup>\n                      as independent predictors of persistent chronic pain with a neuropathic component. The overall model accuracy was 80.6 and the area under the curve of the model was 0.89 (95% confidence interval 0.78\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2017.09.002_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present study found a high proportion of paediatric patients developing chronic persistent pain after surgical correction of scoliosis diformity. It allows identifying two factors associated with the occurrence of persistent chronic pain with a neuropathic component: the presence of persistent preoperative pain during the 3 months preceeding surgery and postoperative opioid consumption at day 1 \u2013;0.5 mg kg\n                      <jats:sup>-1<\/jats:sup>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_j.sjpain.2017.09.002_s_005\">\n                    <jats:title>Implication<\/jats:title>\n                    <jats:p>Patients scheduled for spine surgery and presenting with preoperative pain should be considered at risk of chronic pain after surgery and managed accordingly by the chronic and\/or acute pain team. Postoperative opioid consumption should be lowered as possible by using multimodal analgesia and regional analgesia such as postoperative epidural analgesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.sjpain.2017.09.002","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T15:46:44Z","timestamp":1506095204000},"page":"339-344","source":"Crossref","is-referenced-by-count":46,"title":["Predictors of chronic neuropathic pain after scoliosis surgery in children"],"prefix":"10.1515","volume":"17","author":[{"given":"Florence","family":"Julien-Marsollier","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care , Robert Debr\u00e9 University Hospital, Paris Diderot University , Paris Sorbonne Cit\u00e9, Paris , France"},{"name":"Denis Diderot University , Paris VII, 10 avenue de Verdun , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaelle","family":"David","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care , Robert Debr\u00e9 University Hospital, Paris Diderot University , Paris Sorbonne Cit\u00e9, Paris , France"},{"name":"Denis Diderot University , Paris VII, 10 avenue de Verdun , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hilly","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care , Robert Debr\u00e9 University Hospital, Paris Diderot University , Paris Sorbonne Cit\u00e9, Paris , France"},{"name":"Denis Diderot University , Paris VII, 10 avenue de Verdun , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Brasher","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia & Pain Management , Royal Children\u2019s Hospital , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphn\u00e9","family":"Michelet","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care , Robert Debr\u00e9 University Hospital, Paris Diderot University , Paris Sorbonne Cit\u00e9, Paris , France"},{"name":"Denis Diderot University , Paris VII, 10 avenue de Verdun , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souhayl","family":"Dahmani","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care , Robert Debr\u00e9 University Hospital, Paris Diderot University , Paris Sorbonne Cit\u00e9, Paris , France"},{"name":"Denis Diderot University , Paris VII, 10 avenue de Verdun , Paris , France"},{"name":"DHU PROTECT INSERM U 1141, Robert Debr\u00e9 University Hospital , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_001","doi-asserted-by":"crossref","unstructured":"Brasher C, Gafsous B, Dugue S, Thiollier A, Kinderf J, Nivoche Y, Grace R, Dahmani S. Postoperative pain management in children and infants: an update. Paediatr Drugs 2014;16:129\u201340.","DOI":"10.1007\/s40272-013-0062-0"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_002","doi-asserted-by":"crossref","unstructured":"Walker SM, Meredith-Middleton J, Cooke-Yarborough C, Fitzgerald M. Neonatal inflammation and primary afferent terminal plasticity in the rat dorsal horn. Pain 2003;105:185\u201395.","DOI":"10.1016\/S0304-3959(03)00201-X"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_003","doi-asserted-by":"crossref","unstructured":"Hohmeister J, Demirak\u00e7a S, Zohsel K, Flor H, Hermann C. Responses to pain in school-aged children with experience in a neonatal intensive care unit: cognitive aspects and maternal influences. Eur J Pain (London, England) 2009;13:94\u2013101.","DOI":"10.1016\/j.ejpain.2008.03.004"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_004","doi-asserted-by":"crossref","unstructured":"Kristensen AD, Ahlburg P, Lauridsen MC, Jensen TS, Nikolajsen L. Chronic pain after inguinal hernia repair in children. Br J Anaesth 2012;109: 603-8.","DOI":"10.1093\/bja\/aes250"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_005","unstructured":"Duale C, Ouchchane L, Schoeffler P, Group EI, Dubray C. Neuropathic aspects of persistent postsurgical pain: a French multicenter survey with 6-month prospective follow-up. J Pain 2014;15:24.e1-20."},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_006","doi-asserted-by":"crossref","unstructured":"Kurmann A, Fischer H, Dell-Kuster S, Rosenthal R, Audige L, Schupfer G, Metzger J, Honigmann P. Effect of intraoperative infiltration with local anesthesia on the development of chronic pain after inguinal hernia repair: a randomized, triple-blinded, placebo-controlled trial. Surgery 2015;157:144\u201354.","DOI":"10.1016\/j.surg.2014.07.008"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_007","doi-asserted-by":"crossref","unstructured":"Lauridsen MH, Kristensen AD, Hjortdal VE, Jensen TS, Nikolajsen L. Chronic pain in children after cardiac surgery via sternotomy. Cardiol Young 2014;24: 893-9.","DOI":"10.1017\/S104795111300139X"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_008","doi-asserted-by":"crossref","unstructured":"Lavand\u2019homme P. The progression from acute to chronic pain. Curr Opin Anaesthesiol 2011;24:545\u201350.","DOI":"10.1097\/ACO.0b013e32834a4f74"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_009","doi-asserted-by":"crossref","unstructured":"Neil MJ, Macrae WA. Post surgical pain - the transition from acute to chronic pain. Rev Pain 2009;3:6\u20139.","DOI":"10.1177\/204946370900300203"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_010","doi-asserted-by":"crossref","unstructured":"Nikolajsen L, Brix LD. Chronic pain after surgery in children. Curr Opin Anaesthesiol 2014;27:507\u201312.","DOI":"10.1097\/ACO.0000000000000110"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_011","doi-asserted-by":"crossref","unstructured":"Reuben SS. Chronic pain after surgery: what can we do to prevent it. Curr Pain Headache Rep 2007;11:5\u201313.","DOI":"10.1007\/s11916-007-0015-9"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_012","doi-asserted-by":"crossref","unstructured":"Szabova A, Goldschneider K, Rose J. Special considerations and recommendations for interventions for pediatric chronic pain. Int Anesthesiol Clin 2012;50:120\u20139.","DOI":"10.1097\/AIA.0b013e3182719235"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_013","doi-asserted-by":"crossref","unstructured":"Walco GA, Dworkin RH, Krane EJ, LeBel AA, Treede R-D. Neuropathic pain in children: special considerations.Mayo Clin Proc 2010;85:S33\u201341.","DOI":"10.4065\/mcp.2009.0647"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_014","doi-asserted-by":"crossref","unstructured":"Mathew E, Kim E, Goldschneider KR. Pharmacological treatment of chronic non-cancer pain in pediatric patients. Paediatr Drugs 2014;16:457\u201371.","DOI":"10.1007\/s40272-014-0092-2"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_015","doi-asserted-by":"crossref","unstructured":"Molton IR, Graham C, Stoelb BL, Jensen MP. Current psychological approaches to the management of chronic pain. Curr Opin Anaesthesiol 2007;20:485\u20139.","DOI":"10.1097\/ACO.0b013e3282ef6b40"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_016","doi-asserted-by":"crossref","unstructured":"McGreevy K, Bottros MM, Raja SN. Preventing chronic pain following acute pain: risk factors, preventive strategies, and their efficacy. Eur J Pain Suppl 2011;5:365\u201372.","DOI":"10.1016\/j.eujps.2011.08.013"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_017","doi-asserted-by":"crossref","unstructured":"Page MG, Stinson J, Campbell F, Isaac L, Katz J. Identification of pain-related psychological risk factors for the development and maintenance of pediatric chronic postsurgical pain. J Pain Res 2013;6:167\u201380.","DOI":"10.2147\/JPR.S40846"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_018","doi-asserted-by":"crossref","unstructured":"Shipton EA. The transition from acute to chronic post surgical pain. Anaesth Intens Care 2011;39:824\u201336.","DOI":"10.1177\/0310057X1103900506"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_019","doi-asserted-by":"crossref","unstructured":"Dupuis C, Michelet D, Hilly J, Diallo T, Vidal C, Delivet H, Nivoche Y, Mazda K, Dahmani S. Predictive factors for homologous transfusion during paediatric scoliosis surgery. Anaesth Crit Care Pain Med 2015;34: 327-32.","DOI":"10.1016\/j.accpm.2015.04.003"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_020","doi-asserted-by":"crossref","unstructured":"Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lant\u00e9ri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 2005;114:29\u201336.","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_021","doi-asserted-by":"crossref","unstructured":"Fortier MA, Chou J, Maurer EL, Kain ZN. Acute to chronic postoperative pain in children: preliminary findings. J PediatrSurg 2011;46:1700\u20135.","DOI":"10.1016\/j.jpedsurg.2011.03.074"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_022","doi-asserted-by":"crossref","unstructured":"Kahanovitz N, Weiser S. The psychological impact of idiopathic scoliosis on the adolescent female. A preliminary multi-centerstudy.Spine 1989;14:483\u20135.","DOI":"10.1097\/00007632-198905000-00001"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_023","doi-asserted-by":"crossref","unstructured":"Landman Z, Oswald T, Sanders J, Diab M, Spinal Deformity Study Group. Prevalence and predictors of pain in surgical treatment of adolescent idiopathic scoliosis. Spine 2011;36:825\u20139.","DOI":"10.1097\/BRS.0b013e3181de8c2b"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_024","doi-asserted-by":"crossref","unstructured":"Bastrom TP, Marks MC, Yaszay B, Newton PO, Harms Study G. Prevalence of postoperative pain in adolescent idiopathic scoliosis and the association with preoperative pain. Spine 2013;38:1848\u201352.","DOI":"10.1097\/BRS.0b013e3182a4aa97"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_025","doi-asserted-by":"crossref","unstructured":"Lindeman M, Behm K. Cognitive strategies and self-esteem as predictors of brace-wear noncompliance in patients with idiopathic scoliosis and kyphosis. J PediatrOrthoped 1999;19:493\u20139.","DOI":"10.1097\/00004694-199907000-00013"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_026","doi-asserted-by":"crossref","unstructured":"MacLean WE, Green NE, Pierre CB, Ray DC. Stress and coping with scoliosis: psychological effects on adolescents and their families. J Pediatr Orthoped 1989;9:257\u201361.","DOI":"10.1097\/01241398-198905000-00001"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_027","doi-asserted-by":"crossref","unstructured":"Noonan KJ, Dolan LA, Jacobson WC, Weinstein SL. Long-term psychosocial characteristics of patients treated for idiopathic scoliosis. J Pediatr Orthoped 1997;17:712\u20137.","DOI":"10.1097\/01241398-199711000-00004"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_028","doi-asserted-by":"crossref","unstructured":"Sinclair CM, Meredith P, Strong J, Feeney R. Personal and contextual factors affecting the functional ability of children and adolescents with chronic pain: a systematic review. J Dev Behav Pediatr 2016;37:327\u201342.","DOI":"10.1097\/DBP.0000000000000300"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_029","doi-asserted-by":"crossref","unstructured":"Chidambaran V, Ding L, Moore DL, Spruance K, Cudilo EM, Pilipenko V, Hossain M, Sturm P, Kashikar-Zuck S, Martin LJ, Sadhasivam S. Predicting the pain continuum after adolescent idiopathic scoliosis surgery: a prospective cohort study. EurJ Pain (London, England) 2017;21:1252\u201365.","DOI":"10.1002\/ejp.1025"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_030","doi-asserted-by":"crossref","unstructured":"Sieberg CB, Simons LE, Edelstein MR, DeAngelis MR, Pielech M, Sethna N, Hresko MT. Pain prevalence and trajectories following pediatric spinal fusion surgery. J Pain 2013;14:1694\u2013702.","DOI":"10.1016\/j.jpain.2013.09.005"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_031","doi-asserted-by":"crossref","unstructured":"Monticone M, Nava C, Leggero V, Rocca B, Salvaderi S, Ferrante S, Ambrosini E. Measurement properties of translated versions of the Scoliosis Research Society-22 Patient Questionnaire, SRS-22: a systematic review. Qual Life Res: Int J Qual Life Asp Treatment Care Rehabil 2015;24:1981\u201398.","DOI":"10.1007\/s11136-015-0935-5"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_032","doi-asserted-by":"crossref","unstructured":"Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. BrJ Anaesth 2014;112:991\u20131004.","DOI":"10.1093\/bja\/aeu137"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_033","doi-asserted-by":"crossref","unstructured":"Roeckel L-A, Le Coz G-M, Gav\u00e9riaux-Ruff C, Simonin F. Opioid-induced hyperalgesia: cellular and molecular mechanisms. Neuroscience 2016;338:160\u201382.","DOI":"10.1016\/j.neuroscience.2016.06.029"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_034","doi-asserted-by":"crossref","unstructured":"Wilder-Smith OH, Schreyer T, Scheffer GJ, Arendt-Nielsen L. Patients with chronic pain after abdominal surgeryshow less preoperative endogenous pain inhibition and more postoperative hyperalgesia: a pilot study. J Pain Palliat Care Pharmacother 2010;24:119\u201328.","DOI":"10.3109\/15360281003706069"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_035","doi-asserted-by":"crossref","unstructured":"Wilder-Smith OHG. Chronic pain and surgery: a review of new insights from sensory testing. J Pain Palliat Care Pharmacother 2011;25:146\u201359.","DOI":"10.3109\/15360288.2010.505256"},{"key":"2025120909543888885_j_j.sjpain.2017.09.002_ref_036","doi-asserted-by":"crossref","unstructured":"Taenzer AH, Clark C. Efficacy of postoperative epidural analgesia in adolescent scoliosis surgery: a meta-analysis. Paediatr Anaesth 2010;20:135\u201343.","DOI":"10.1111\/j.1460-9592.2009.03226.x"}],"container-title":["Scandinavian Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/sjpain\/17\/1\/article-p339.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1877886017301933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1877886017301933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1016\/j.sjpain.2017.09.002\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1016\/j.sjpain.2017.09.002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:48:05Z","timestamp":1765280885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1016\/j.sjpain.2017.09.002\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,10,1]]},"published-print":{"date-parts":[[2017,10,1]]}},"alternative-id":["10.1016\/j.sjpain.2017.09.002"],"URL":"https:\/\/doi.org\/10.1016\/j.sjpain.2017.09.002","relation":{},"ISSN":["1877-8860","1877-8879"],"issn-type":[{"value":"1877-8860","type":"print"},{"value":"1877-8879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,1]]}}}