{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:00:10Z","timestamp":1772121610404,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.slasd.2021.10.012","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:27:15Z","timestamp":1643070435000},"page":"8-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Identification of potent small molecule inhibitors of SARS-CoV-2 entry"],"prefix":"10.1016","volume":"27","author":[{"given":"Sonia","family":"Mediouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Anthony","family":"Jablonski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Scott","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalit","family":"Batra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Rood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian Mitchelle S.","family":"de Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Rahaim Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuerong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia A.","family":"Getmanenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu-Trinh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Hull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Bannister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Baillargeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Scampavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Farzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana T.","family":"Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Spicer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.slasd.2021.10.012_bib0001","doi-asserted-by":"crossref","first-page":"e13637","DOI":"10.1111\/ijcp.13637","article-title":"Review on the coronavirus disease (COVID-19) pandemic: its outbreak and current status","volume":"74","author":"Almaghaslah","year":"2020","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.slasd.2021.10.012_bib0002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0003","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.prrv.2004.07.009","article-title":"The chronology of the 2002,2003 SARS mini pandemic","volume":"5","author":"Cherry","year":"2004","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.slasd.2021.10.012_bib0004","article-title":"Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2","author":"Mou","year":"2020","journal-title":"BioRxiv"},{"key":"10.1016\/j.slasd.2021.10.012_bib0005","doi-asserted-by":"crossref","first-page":"10628","DOI":"10.1128\/JVI.78.19.10628-10635.2004","article-title":"Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2","volume":"78","author":"Moore","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5501\/wjv.v5.i2.85","article-title":"Determination of 50% endpoint titer using a simple formula","volume":"5","author":"Ramakrishnan","year":"2016","journal-title":"World J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0007","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1073\/pnas.1810137115","article-title":"The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis","volume":"115","author":"Janes","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.slasd.2021.10.012_bib0008","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/2472555218820809","article-title":"The scripps molecular screening center and translational research institute","volume":"24","author":"Baillargeon","year":"2019","journal-title":"SLAS Discov"},{"key":"10.1016\/j.slasd.2021.10.012_bib0009","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"Simple statistical parameter for use in evaluation and validation of high throughput screening assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.slasd.2021.10.012_bib0010","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057103258285","article-title":"Improved statistical methods for hit selection in high-throughput screening","volume":"8","author":"Brideau","year":"2003","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.slasd.2021.10.012_bib0011","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1177\/2472555220963667","article-title":"High-throughput screening for drugs that inhibit papain-like protease in SARS-CoV-2","author":"Smith","year":"2020","journal-title":"SLAS Discov"},{"key":"10.1016\/j.slasd.2021.10.012_bib0012","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.chempr.2020.04.023","article-title":"Chemistry and biology of SARS-CoV-2","volume":"6","author":"Domling","year":"2020","journal-title":"Chem"},{"key":"10.1016\/j.slasd.2021.10.012_bib0013","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2577-1","article-title":"Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing","volume":"586","author":"Riva","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.slasd.2021.10.012_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100470","article-title":"Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and Influenza virus","volume":"296","author":"Vitner","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.slasd.2021.10.012_bib0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.slasd.2021.10.012_bib0016","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41401-020-0485-4","article-title":"Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19","volume":"41","author":"Huang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.slasd.2021.10.012_bib0017","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1073\/pnas.0505577102","article-title":"Inhibitors of Cathepsin L prevent severe acute respiratory syndrome coronavirus entry","volume":"102","author":"Simmons","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.slasd.2021.10.012_bib0018","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.antiviral.2015.01.011","article-title":"Protease inhibitors targeting coronavirus and filovirus entry","volume":"116","author":"Zhou","year":"2015","journal-title":"Antiviral Res"},{"key":"10.1016\/j.slasd.2021.10.012_bib0019","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1128\/JVI.00415-08","article-title":"Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide","volume":"82","author":"Bosch","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228735","article-title":"Glucosylceramide synthase maintains influenza virus entry and infection","volume":"15","author":"Drews","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.slasd.2021.10.012_bib0021","first-page":"161","article-title":"Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?","volume":"91","author":"Baglivo","year":"2020","journal-title":"Acta Biomed"},{"key":"10.1016\/j.slasd.2021.10.012_bib0022","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.virol.2017.12.015","article-title":"Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells","volume":"517","author":"Millet","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.slasd.2021.10.012_bib0023","unstructured":"Straus, M.R.; Bidon, M.; Tang, T.; et\u00a0al. FDA approved calcium channel blockers inhibit SARS-CoV-2 infectivity in epithelial lung cells. bioRxiv [Online] DOI: 10.1101\/2020.07.21.214577. https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2020\/10\/21\/2020.07.21.214577.full.pdf."},{"key":"10.1016\/j.slasd.2021.10.012_bib0024","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1096\/fj.06-6589com","article-title":"Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways","volume":"21","author":"Liu","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.slasd.2021.10.012_bib0025","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3389\/fimmu.2020.02167","volume":"11","author":"Verrall","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0026","author":"Thomas"},{"key":"10.1016\/j.slasd.2021.10.012_bib0027","doi-asserted-by":"crossref","first-page":"e00014","DOI":"10.1128\/JVI.00014-21","article-title":"Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection","volume":"95","author":"Chen","year":"2021","journal-title":"J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0028","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1158\/2159-8290.CD-18-0706","article-title":"PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer","volume":"9","author":"Rebecca","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.slasd.2021.10.012_bib0029","doi-asserted-by":"crossref","first-page":"e00120","DOI":"10.1128\/CMR.00162-20","article-title":"Remdesivir against COVID-19 and Other viral diseases","volume":"34","author":"Malin","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.slasd.2021.10.012_bib0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.slasd.2021.10.012_bib0031","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1099\/jgv.0.001453","article-title":"SARS-coronavirus-2 replication in vero E6 cells: replication kinetics, rapid adaptation and cytopathology","volume":"101","author":"Ogando","year":"2020","journal-title":"J Gen Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0032","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.slasd.2021.10.012_bib0033","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.slasd.2021.10.012_bib0034","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2577-1","article-title":"Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing","volume":"586","author":"Riva","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.slasd.2021.10.012_bib0035","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41422-020-0356-z","article-title":"Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease","volume":"30","author":"Ma","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.slasd.2021.10.012_bib0036","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1177\/1087057113483559","article-title":"High-throughput screen for pharmacoperones of the vasopressin type 2 receptor","volume":"18","author":"Conn","year":"2013","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.slasd.2021.10.012_bib0037","doi-asserted-by":"crossref","first-page":"e00120","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of sars coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0038","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/vaccines9030243","article-title":"Emerging SARS-CoV-2 variants and impact in global vaccination programs against SARS-CoV-2\/COVID-19","volume":"9","author":"G\u00f3mez","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.slasd.2021.10.012_bib0039","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.slasd.2021.10.012_bib0040","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1038\/s41467-020-19808-4","article-title":"SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.slasd.2021.10.012_bib0041","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.3390\/ijms22147425","article-title":"Structural evaluation of the spike glycoprotein variants on SARS-CoV-2 transmission and immune evasion","volume":"22","author":"Salleh","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.slasd.2021.10.012_bib0042","article-title":"Evaluation of the effect of D614G, N501Y and S477N mutation in SARS-CoV-2 through computational approach","author":"Kumar","year":"2020","journal-title":"Preprints"},{"key":"10.1016\/j.slasd.2021.10.012_bib0043","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.apsb.2015.08.001","article-title":"Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and Cathepsin inhibitors","volume":"5","author":"Siklos","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.slasd.2021.10.012_bib0044","unstructured":"P. Loftus Hopkins, J. S. Covid-19 vaccine makers take aim at dangerous new strains. https:\/\/www.wsj.com\/articles\/covid-19-vaccine-makers-take-aim-at-dangerous-new-strains-11612357201"},{"key":"10.1016\/j.slasd.2021.10.012_bib0045","unstructured":"Board, A. Will vaccines stop the new coronavirus strains? Here's what scientists say. https:\/\/www.advisory.com\/daily-briefing\/2021\/01\/08\/virus-mutations."},{"key":"10.1016\/j.slasd.2021.10.012_bib0046","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0006-291X(88)81355-X","article-title":"Synthesis of a new cell penetrating calpain inhibitor (calpeptin)","volume":"153","author":"Tsujinaka","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.slasd.2021.10.012_bib0047","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bmcl.2003.11.029","article-title":"Design of small molecule ketoamide-based inhibitors of Cathepsin K","volume":"14","author":"Catalano","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.slasd.2021.10.012_bib0048","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting extracellular vesicles formation and release: a review of EV inhibitors","volume":"9","author":"Catalano","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.slasd.2021.10.012_bib0049","doi-asserted-by":"crossref","first-page":"10112","DOI":"10.1128\/JVI.01001-12","article-title":"Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain","volume":"86","author":"Schneider","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0050","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.abf7945","article-title":"X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease","volume":"372","author":"Gunther","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.slasd.2021.10.012_bib0051","first-page":"549","article-title":"The effect of calpeptin on injury and atrophy of diaphragm under mechanical ventilation in rats","volume":"26","author":"Shi","year":"2014","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.slasd.2021.10.012_bib0052","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.prp.2018.06.019","article-title":"Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain\/IkappaBalpha signaling in mice and BEAS-2B cells","volume":"214","author":"Zuo","year":"2018","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.slasd.2021.10.012_bib0053","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1365-2249.2010.04257.x","article-title":"The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice","volume":"162","author":"Tabata","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0054","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/cea.12805","article-title":"Calpain-activated mTORC2\/Akt pathway mediates airway smooth muscle remodelling in asthma","volume":"47","author":"Rao","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.slasd.2021.10.012_bib0055","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00210-018-1499-z","article-title":"Calpain inhibition attenuates bleomycin-induced pulmonary fibrosis via switching the development of epithelial-mesenchymal transition","volume":"391","author":"Liu","year":"2018","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"10.1016\/j.slasd.2021.10.012_bib0056","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3390\/ijms19041158","article-title":"Antitumor effect of calcium-mediated destabilization of epithelial growth factor receptor on non-small cell lung carcinoma","volume":"19","author":"Kim","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.slasd.2021.10.012_bib0057","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1038\/s41598-017-04017-9","article-title":"Inhibition of Calpains protects Mn-induced neurotransmitter release disorders in synaptosomes from mice: involvement of SNARE complex and synaptic vesicle fusion","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.slasd.2021.10.012_bib0058","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1007\/s12035-018-1379-z","article-title":"Calpain inhibition increases smn protein in spinal cord motoneurons and ameliorates the spinal muscular atrophy phenotype in mice","volume":"56","author":"de la Fuente","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0059","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s11064-015-1722-y","article-title":"Neuroprotective effect of calpeptin on acrylamide-induced neuropathy in rats","volume":"40","author":"Wei","year":"2015","journal-title":"Neurochem Res"},{"key":"10.1016\/j.slasd.2021.10.012_bib0060","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s11033-010-0183-2","article-title":"The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats","volume":"38","author":"Peng","year":"2011","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.slasd.2021.10.012_bib0061","doi-asserted-by":"crossref","first-page":"H1744","DOI":"10.1152\/ajpheart.00338.2009","article-title":"Calpain inhibition preserves myocardial structure and function following myocardial infarction","volume":"297","author":"Mani","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.slasd.2021.10.012_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-140402","article-title":"Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014","volume":"42","author":"Froestl","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.slasd.2021.10.012_bib0063","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clinthera.2013.11.006","article-title":"Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials","volume":"36","author":"Zanetta","year":"2014","journal-title":"Clin Ther"},{"key":"10.1016\/j.slasd.2021.10.012_bib0064","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.107.123000","article-title":"Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis","volume":"322","author":"Bordet","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.slasd.2021.10.012_bib0065","doi-asserted-by":"crossref","first-page":"04","DOI":"10.12703\/P7-04","article-title":"Spinal muscular atrophy: from tissue specificity to therapeutic strategies","volume":"7","author":"Iascone","year":"2015","journal-title":"F1000Prime Rep"}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555221000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555221000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:55:01Z","timestamp":1762862101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555221000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2472555221000125"],"URL":"https:\/\/doi.org\/10.1016\/j.slasd.2021.10.012","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.05.455262","asserted-by":"object"}]},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of potent small molecule inhibitors of SARS-CoV-2 entry","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slasd.2021.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}]}}