{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:04:28Z","timestamp":1783652668474,"version":"3.55.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["140178"],"award-info":[{"award-number":["140178"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.slasd.2023.11.002","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T23:54:05Z","timestamp":1700178845000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic approaches for Type 1 Diabetes: Promising cell-based approaches to achieve ultimate success"],"prefix":"10.1016","volume":"29","author":[{"given":"Sahar","family":"Sepyani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Momenzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Safabakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-7181","authenticated-orcid":false,"given":"Reza","family":"Nedaeinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.slasd.2023.11.002_bib0001","first-page":"1","article-title":"Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025","volume":"10","author":"Lin","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0002","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S2213-8587(19)30412-7","article-title":"Type 1 Diabetes\u2014early life origins and changing epidemiology","volume":"8","author":"Norris","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/diabetology2020004","article-title":"Diabetes mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management","volume":"2","author":"Alam","year":"2021","journal-title":"Diabetology"},{"key":"10.1016\/j.slasd.2023.11.002_bib0004","first-page":"359","article-title":"Human embryonic stem cells (hESC) as a source of insulin-producing cells","volume":"2","author":"Sackett","year":"2019"},{"key":"10.1016\/j.slasd.2023.11.002_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.mod.2020.103634","article-title":"Mechanisms of development \u03b2 - cell specific transcription factors in the context of diabetes mellitus and \u03b2 - cell regeneration","volume":"163","author":"Balakrishnan","year":"2020","journal-title":"Mech Dev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0006","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.slasd.2023.11.002_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.108820","article-title":"The future of insulin therapy","volume":"175","author":"Heise","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.slasd.2023.11.002_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9020283","article-title":"Stem cell therapy for diabetes: beta cells versus pancreatic progenitors","volume":"9","author":"Memon","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.slasd.2023.11.002_bib0009","article-title":"Generation of stem cell-derived \u03b2-cells from patients with Type 1 Diabetes","volume":"7","author":"Millman","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.slasd.2023.11.002_bib0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm.4030","article-title":"Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice","volume":"22","author":"Vegas","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.slasd.2023.11.002_bib0011","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1210\/js.2019-00040","article-title":"Reprogramming cells to make insulin","volume":"3","author":"McKimpson","year":"2019","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.slasd.2023.11.002_bib0012","doi-asserted-by":"crossref","unstructured":"Aigha I.I., Abdelalim E.M. NKX6. 1 transcription factor\u00a0: a crucial regulator of pancreatic \u03b2 cell development, identity, and proliferation. 2020;0:1\u201314.","DOI":"10.1186\/s13287-020-01977-0"},{"key":"10.1016\/j.slasd.2023.11.002_bib0013","article-title":"Roles of epigenetic modifications in the differentiation and function of pancreatic \u03b2 -cells","volume":"8","author":"Xu","year":"2020","journal-title":"Front cell Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0014","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tig.2015.02.008","article-title":"Epigenetic modifications and long noncoding RNAs influence pancreas development and function","volume":"31","author":"Arnes","year":"2015","journal-title":"Trends Genet"},{"key":"10.1016\/j.slasd.2023.11.002_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0164457","article-title":"An abbreviated protocol for in vitro generation of functional human embryonic stem cell-derived beta-like cells","volume":"11","author":"Massumi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.slasd.2023.11.002_bib0016","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.slasd.2023.11.002_bib0017","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19382014.2015.1075687","article-title":"Transcription factor regulation of pancreatic organogenesis, differentiation and maturation","volume":"8","author":"Dassaye","year":"2022","journal-title":"Islets"},{"key":"10.1016\/j.slasd.2023.11.002_bib0018","unstructured":"O'rahilly R.. Developmental stages in human embryos: including a revision of Streeter's Horizons and a survey of the Carnegie collection. 1987."},{"key":"10.1016\/j.slasd.2023.11.002_bib0019","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.2337\/db12-1479","article-title":"Development of the human pancreas from foregut to endocrine commitment","volume":"62","author":"Jennings","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.slasd.2023.11.002_bib0020","doi-asserted-by":"crossref","unstructured":"Jennings R.E. Transcription factors that shape the mammalian pancreas. 2020:1974\u201380.","DOI":"10.1007\/s00125-020-05161-0"},{"key":"10.1016\/j.slasd.2023.11.002_bib0021","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.cellbio.042308.113344","article-title":"Vertebrate endoderm development and organ formation","volume":"25","author":"Zorn","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0022","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2005.05.035","article-title":"Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice","volume":"284","author":"Mart\u00edn","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0023","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1369\/jhc.2009.953307","article-title":"Endocrine cell clustering during human pancreas development","volume":"57","author":"Jeon","year":"2009","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.slasd.2023.11.002_bib0024","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00125-011-2344-9","article-title":"Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas","volume":"55","author":"Riedel","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.slasd.2023.11.002_bib0025","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/biomedicines10030571","article-title":"Approaches to inducing \u03b2 -cell regeneration","volume":"10","author":"Levine","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.slasd.2023.11.002_bib0026","doi-asserted-by":"crossref","DOI":"10.1186\/2045-824X-6-22","article-title":"Lymphangiogenesis and angiogenesis during human fetal pancreas development","volume":"6","author":"Roost","year":"2014","journal-title":"Vasc Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0027","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.devcel.2013.03.016","article-title":"Gene regulatory networks governing pancreas development","volume":"25","author":"Arda","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0028","doi-asserted-by":"crossref","first-page":"10500","DOI":"10.1073\/pnas.0704054104","article-title":"Sox9 coordinates a transcriptional network in pancreatic progenitor cells","volume":"104","author":"LF","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.slasd.2023.11.002_bib0029","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db10-1068","article-title":"Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development","volume":"60","author":"Seymour","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.slasd.2023.11.002_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-cellbio-101512-122405","article-title":"Pancreas organogenesis: from lineage determination to morphogenesis","volume":"29","author":"Shih","year":"2013","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0031","unstructured":"Plumb C. Cellular models to study the emergence, expansion and differentiation of pancreatic progenitor cells in vitro. 2019."},{"key":"10.1016\/j.slasd.2023.11.002_bib0032","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1242\/dev.078634","article-title":"A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation","volume":"139","author":"Shih","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.slasd.2023.11.002_bib0033","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1242\/dev.039214","article-title":"Pancreatic neurogenin 3-expressing cells are unipotent islet precursors","volume":"136","author":"Desgraz","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.slasd.2023.11.002_bib0034","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/jcp.25459","article-title":"Pancreatic endoderm-derived from diabetic patient-specific induced pluripotent stem cell generates glucose-responsive insulin-secreting cells","volume":"232","author":"Rajaei","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0035","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmet.2017.08.007","article-title":"Pancreatic \u03b2 cell regeneration as a possible therapy for diabetes","volume":"27","author":"Aguayo-Mazzucato","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.slasd.2023.11.002_bib0036","doi-asserted-by":"crossref","first-page":"266","DOI":"10.11613\/BM.2013.033","article-title":"Diabetes and beta cell function: from mechanisms to evaluation and clinical implications","volume":"23","author":"Cernea","year":"2013","journal-title":"Biochem medica"},{"key":"10.1016\/j.slasd.2023.11.002_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.623889","article-title":"In vitro characterization of insulin\u2212producing \u03b2-cell spheroids","volume":"8","author":"Ntamo","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0038","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5483\/BMBRep.2019.52.5.089","article-title":"Recent advances in organoid culture for insulin production and diabetes therapy: methods and challenges","volume":"52","author":"Dayem","year":"2019","journal-title":"BMB Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0039","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0040","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.slasd.2023.11.002_bib0041","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone\u2013expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D'Amour","year":"2006","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0042","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/cr.2007.28","article-title":"In vitro derivation of functional insulin-producing cells from human embryonic stem cells","volume":"17","author":"Jiang","year":"2007","journal-title":"Cell Res"},{"key":"10.1016\/j.slasd.2023.11.002_bib0043","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db11-1711","article-title":"Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice","volume":"61","author":"Rezania","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.slasd.2023.11.002_bib0044","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/stem.1489","article-title":"Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo","volume":"31","author":"Rezania","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.slasd.2023.11.002_bib0045","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1038\/s41596-021-00560-y","article-title":"Generation of insulin-producing pancreatic \u03b2 cells from multiple human stem cell lines","volume":"16","author":"Hogrebe","year":"2021","journal-title":"Nat Protoc"},{"key":"10.1016\/j.slasd.2023.11.002_bib0046","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jcp.21615","article-title":"Insulin producing cells derived from embryonic stem cells: are we there yet?","volume":"218","author":"Raikwar","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0047","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.0237371100","article-title":"Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells","volume":"100","author":"Blyszczuk","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.slasd.2023.11.002_bib0048","doi-asserted-by":"crossref","first-page":"e24058","DOI":"10.1371\/journal.pone.0024058","article-title":"Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population","volume":"6","author":"Kubo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.slasd.2023.11.002_bib0049","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13287-018-1038-3","article-title":"Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors","volume":"9","author":"Ida","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.slasd.2023.11.002_bib0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.diabres.2014.03.017","article-title":"Differentiation of iPSCs into insulin-producing cells via adenoviral transfection of PDX-1, NeuroD1 and MafA","volume":"104","author":"Wang","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.slasd.2023.11.002_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/dmrr.3400","article-title":"PDX1\u2212\/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin-secreting cells","volume":"37","author":"Memon","year":"2021","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0052","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3727\/096368912X653057","article-title":"The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improves the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells","volume":"22","author":"Xu","year":"2013","journal-title":"Cell Transpl"},{"key":"10.1016\/j.slasd.2023.11.002_bib0053","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic \u03b2 cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0054","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41556-018-0271-4","article-title":"Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived \u03b2 cells","volume":"21","author":"Nair","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0055","doi-asserted-by":"crossref","first-page":"e27564","DOI":"10.7554\/eLife.27564","article-title":"Reconstructing human pancreatic differentiation by mapping specific cell populations during development","volume":"6","author":"Ramond","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.slasd.2023.11.002_bib0056","doi-asserted-by":"crossref","unstructured":"Karimova M.V., Gvazava I.G. Overcoming the limitations of stem cell-derived beta cells. 2022;12:810.","DOI":"10.3390\/biom12060810"},{"key":"10.1016\/j.slasd.2023.11.002_bib0057","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jdi.12475","article-title":"\u03b2-Cell regeneration through the transdifferentiation of pancreatic cells: pancreatic progenitor cells in the pancreas","volume":"7","author":"Kim","year":"2016","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.slasd.2023.11.002_bib0058","doi-asserted-by":"crossref","first-page":"e01846","DOI":"10.7554\/eLife.01846","article-title":"In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes","volume":"3","author":"Li","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.slasd.2023.11.002_bib0059","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.slasd.2023.11.002_bib0060","doi-asserted-by":"crossref","first-page":"e00940","DOI":"10.7554\/eLife.00940","article-title":"Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells","volume":"2","author":"Lee","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.slasd.2023.11.002_bib0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-33838-5","article-title":"Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells","volume":"8","author":"Azzarelli","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0062","first-page":"1","article-title":"Regeneration of \u03b2 cells from cell phenotype conversion among the pancreatic endocrine cells","volume":"8","author":"Wei","year":"2022","journal-title":"Chronic Dis Transl Med"},{"key":"10.1016\/j.slasd.2023.11.002_bib0063","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/mt.2015.181","article-title":"PAX4 gene transfer induces \u03b1-to-\u03b2 cell phenotypic conversion and confers therapeutic benefits for diabetes treatment","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol Ther"},{"key":"10.1016\/j.slasd.2023.11.002_bib0064","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.stem.2017.11.020","article-title":"Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes","volume":"22","author":"Xiao","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0065","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1507\/endocrj.K06-116","article-title":"In vitro transdifferentiation of mature hepatocytes into insulin-producing cells","volume":"53","author":"Yamada","year":"2006","journal-title":"Endocr J"},{"key":"10.1016\/j.slasd.2023.11.002_bib0066","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00125-006-0509-8","article-title":"Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach","volume":"50","author":"Fodor","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.slasd.2023.11.002_bib0067","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.stem.2016.01.003","article-title":"Reprogrammed stomach tissue as a renewable source of functional \u03b2 cells for blood glucose regulation","volume":"18","author":"Ariyachet","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0068","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.celrep.2014.02.013","article-title":"De novo formation of insulin-producing \u201cNeo-\u03b2 cell islets\u201d from intestinal crypts","volume":"6","author":"Chen","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0069","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s12015-020-10036-3","article-title":"From mesenchymal stromal\/stem cells to insulin-producing cells: progress and challenges","volume":"16","author":"Ghoneim","year":"2020","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5242","article-title":"FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures","volume":"5","author":"Bouchi","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.slasd.2023.11.002_bib0071","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2005.08.004","article-title":"FoxO1 protects against pancreatic \u03b2 cell failure through NeuroD and MafA induction","volume":"2","author":"Kitamura","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.slasd.2023.11.002_bib0072","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.2337\/db14-1696","article-title":"Legacy effect of Foxo1 in pancreatic endocrine progenitors on adult \u03b2-cell mass and function","volume":"64","author":"Talchai","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.slasd.2023.11.002_bib0073","doi-asserted-by":"crossref","unstructured":"Du W., Wang J., Kuo T., Wang L., McKimpson W., Son J., et\u00a0al. Triple Notch\/Tgf\u03b2\/FoxO1 blockade converts multiple intestinal sub-lineages into \u03b2-like cells and lowers glycemia in diabetic animals. Biorxiv 2022:2003\u201322.","DOI":"10.1101\/2022.03.21.484748"},{"key":"10.1016\/j.slasd.2023.11.002_bib0074","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1634\/stemcells.2007-0164","article-title":"Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation","volume":"25","author":"Karnieli","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.slasd.2023.11.002_bib0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.diff.2009.07.004","article-title":"Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage","volume":"78","author":"Parekh","year":"2009","journal-title":"Differentiation"},{"key":"10.1016\/j.slasd.2023.11.002_bib0076","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3727\/096368911X612530","article-title":"Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells","volume":"21","author":"Prabakar","year":"2012","journal-title":"Cell Transpl"},{"key":"10.1016\/j.slasd.2023.11.002_bib0077","doi-asserted-by":"crossref","DOI":"10.1177\/2041731416638198","article-title":"Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment","volume":"7","author":"Sabek","year":"2016","journal-title":"J Tissue Eng"},{"key":"10.1016\/j.slasd.2023.11.002_bib0078","article-title":"Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells","volume":"2012","author":"Guo","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.slasd.2023.11.002_bib0079","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1387\/ijdb.092953hk","article-title":"Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice","volume":"54","author":"Kajiyama","year":"2010","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0080","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/cdd.2014.193","article-title":"Reprogramming of human pancreatic exocrine cells to \u03b2-like cells","volume":"22","author":"Lemper","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.slasd.2023.11.002_bib0081","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/labinvest.2010.124","article-title":"Quantitative analysis of cell composition and purity of human pancreatic islet preparations","volume":"90","author":"Pisania","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.slasd.2023.11.002_bib0082","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.beem.2014.05.002","article-title":"Neural control of the endocrine pancreas","volume":"28","author":"Rodriguez-Diaz","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.slasd.2023.11.002_bib0083","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/tri.13721","article-title":"Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas","volume":"33","author":"Wassmer","year":"2020","journal-title":"Transpl Int"},{"key":"10.1016\/j.slasd.2023.11.002_bib0084","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3390\/cells11152330","article-title":"Pseudoislet aggregation of pancreatic \u03b2-cells improves glucose stimulated insulin secretion by altering glucose metabolism and increasing ATP production","volume":"11","author":"Cornell","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.slasd.2023.11.002_bib0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.gene.2018.11.058","article-title":"Bioengineering-inspired three-dimensional culture systems: organoids to create tumor microenvironment","volume":"686","author":"Saglam-Metiner","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.slasd.2023.11.002_bib0086","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122551","article-title":"Spheroid fabrication using concave microwells enhances the differentiation efficacy and function of insulin-producing cells via cytoskeletal changes","volume":"9","author":"Lee","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.slasd.2023.11.002_bib0087","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ten.tea.2008.0181","article-title":"Three-dimensional differentiation of embryonic stem cells into islet-like insulin-producing clusters","volume":"15","author":"Wang","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.slasd.2023.11.002_bib0088","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1089\/scd.2016.0115","article-title":"Development of islet organoids from H9 human embryonic stem cells in biomimetic 3D scaffolds","volume":"26","author":"Wang","year":"2017","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0089","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1101\/gad.220244.113","article-title":"Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence","volume":"27","author":"Rodr\u00edguez-Seguel","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0090","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14127","article-title":"Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2","volume":"8","author":"Cerd\u00e1-Esteban","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.slasd.2023.11.002_bib0091","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2009.12.009","article-title":"Gut endocrine cell development","volume":"323","author":"May","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0092","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1039\/C8LC01298A","article-title":"Engineering human islet organoids from iPSCs using an organ-on-chip platform","volume":"19","author":"Tao","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.slasd.2023.11.002_bib0093","first-page":"1","article-title":"Methods for generating vascularized islet-like organoids via self-condensation","volume":"45","author":"Takahashi","year":"2018","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0094","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.biomaterials.2018.05.031","article-title":"3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform","volume":"177","author":"Candiello","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.slasd.2023.11.002_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21176225","article-title":"Spheroids as a type of three-dimensional cell cultures\u2014examples of methods of preparation and the most important application","volume":"21","author":"Bia\u0142kowska","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.slasd.2023.11.002_bib0096","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8841865","article-title":"Generation of insulin-producing cells from canine adipose tissue-derived mesenchymal stem cells","author":"Teshima","year":"2020","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.slasd.2023.11.002_bib0097","first-page":"67","article-title":"Therapeutic cell encapsulation techniques and applications in diabetes","author":"Steele","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0098","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1056\/NEJMc070201","article-title":"Visualization of early engraftment in clinical islet transplantation by positron-emission tomography","volume":"356","author":"Eich","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.slasd.2023.11.002_bib0099","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2018.04.018","article-title":"Cell encapsulation: overcoming barriers in cell transplantation in diabetes and beyond","volume":"139","author":"Farina","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0100","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.stem.2018.05.016","article-title":"Stem cell therapies for treating diabetes: progress and remaining challenges","volume":"22","author":"Sneddon","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.slasd.2023.11.002_bib0101","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cmet.2021.03.021","article-title":"Perspective Human pluripotent stem cell-derived insulin-producing cells\u00a0: a regenerative medicine perspective","volume":"33","author":"Migliorini","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.slasd.2023.11.002_bib0102","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1021\/acsnano.7b01239","article-title":"Nanoporous immunoprotective device for stem-cell-derived \u03b2-cell replacement therapy","volume":"11","author":"Chang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.slasd.2023.11.002_bib0103","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.631463","article-title":"Stem cell-based clinical trials for diabetes mellitus","volume":"12","author":"de Klerk","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0104","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-018-1028-y","article-title":"Transplantation of macroencapsulated insulin-producing cells","volume":"18","author":"Hwa","year":"2018","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.slasd.2023.11.002_bib0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jdi.12788","article-title":"Microencapsulation for cell therapy of Type 1 Diabetes mellitus: the interplay between common beliefs, prejudices and real progress","volume":"9","author":"Calafiore","year":"2018","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.slasd.2023.11.002_bib0106","first-page":"413","article-title":"CXCL12 as innovative immune isolating chemokine for microencapsulated Allo and Xeno-transplantation in NHPs","author":"Sremac","year":"2016","journal-title":"Am J Transpl"},{"key":"10.1016\/j.slasd.2023.11.002_bib0107","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41551-018-0275-1","article-title":"Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques","volume":"2","author":"Bochenek","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.slasd.2023.11.002_bib0108","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700169","article-title":"3D printed vascularized device for subcutaneous transplantation of human islets","volume":"12","author":"Farina","year":"2017","journal-title":"Biotechnol J"},{"key":"10.1016\/j.slasd.2023.11.002_bib0109","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.addr.2013.07.018","article-title":"Encapsulated islets for diabetes therapy: history, current progress, and critical issues requiring solution","volume":"67","author":"Scharp","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.slasd.2023.11.002_bib0110","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tips.2015.05.003","article-title":"Cell encapsulation: technical and clinical advances","volume":"36","author":"Orive","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.slasd.2023.11.002_bib0111","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbm.820291208","article-title":"Neovascularization of synthetic membranes directed by membrane microarchitecture","volume":"29","author":"Brauker","year":"1995","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.slasd.2023.11.002_bib0112","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1749-6632.1957.tb52492.x","article-title":"Studies on tissue homotransplantation in mice, using diffusion-chamber methods","volume":"64","author":"GH","year":"1957","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.slasd.2023.11.002_bib0113","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/978-1-4419-5786-3_10","article-title":"Inorganic nanoporous membranes for immunoisolated cell-based drug delivery","volume":"670","author":"Mendelsohn","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.slasd.2023.11.002_bib0114","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5500\/wjt.v6.i1.69","article-title":"Survival of encapsulated islets: more than a membrane story","volume":"6","author":"Barkai","year":"2016","journal-title":"World J Transpl"},{"key":"10.1016\/j.slasd.2023.11.002_bib0115","article-title":"Insulin expression and glucose-responsive circulating C-peptide in Type 1 Diabetes patients implanted subcutaneously with pluripotent stem cell-derived pancreatic endoderm cells in a macro-device","author":"Shapiro","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.slasd.2023.11.002_bib0116","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1007\/s00125-016-3947-y","article-title":"Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells","volume":"59","author":"Bensellam","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.slasd.2023.11.002_bib0117","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3727\/096368912X657341","article-title":"Enhanced oxygen supply improves islet viability in a new bioartificial pancreas","volume":"22","author":"Barkai","year":"2013","journal-title":"Cell Transpl"},{"key":"10.1016\/j.slasd.2023.11.002_bib0118","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1097\/TP.0000000000000864","article-title":"Diabetes is reversed in a murine model by marginal mass syngeneic islet transplantation using a subcutaneous cell pouch device","volume":"99","author":"Pepper","year":"2015","journal-title":"Transplantation"}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555223000801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555223000801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:56:21Z","timestamp":1762862181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555223000801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2472555223000801"],"URL":"https:\/\/doi.org\/10.1016\/j.slasd.2023.11.002","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic approaches for Type 1 Diabetes: Promising cell-based approaches to achieve ultimate success","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slasd.2023.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}]}}