{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:12:12Z","timestamp":1790284332375,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20204Y0131"],"award-info":[{"award-number":["20204Y0131"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1451000"],"award-info":[{"award-number":["21ZR1451000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.slast.2024.100190","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T18:36:35Z","timestamp":1726598195000},"page":"100190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Connexin 43 controls metastatic behavior in triple negative breast cancer through TGF\u03b21-Smad3-intergin \u03b1V signaling axis Based on optical image diagnosis"],"prefix":"10.1016","volume":"29","author":[{"given":"Yun","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.slast.2024.100190_bib0001","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"10.1016\/j.slast.2024.100190_bib0002","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/annonc\/mdt303","article-title":"Panel m: personalizing the treatment of women with early breast cancer: highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2013","volume":"24","author":"Goldhirsch","year":"2013","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0003","article-title":"Triple negative breast cancer: a review of present and future diagnostic modalities","volume":"57","author":"Dass","year":"2021","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0004","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3816\/CBC.2009.n.005","article-title":"Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design","volume":"9","author":"Kassam","year":"2009","journal-title":"Clin Breast Cancer"},{"issue":"2","key":"10.1016\/j.slast.2024.100190_bib0005","first-page":"175","article-title":"Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites","volume":"948","author":"Nicolson","year":"1988","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1016\/j.slast.2024.100190_bib0006","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1014787014851","article-title":"The role of connexin-mediated cell-cell communication in breast cancer metastasis","volume":"6","author":"Carystinos","year":"2001","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0007","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrc.2016.142","article-title":"Gap junctions and cancer: communicating for 50 years","volume":"17","author":"Aasen","year":"2017","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"10.1016\/j.slast.2024.100190_bib0008","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.tcb.2016.06.003","article-title":"Next-generation connexin and pannexin cell biology","volume":"26","author":"Esseltine","year":"2016","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0009","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1038\/s41598-021-82057-y","article-title":"A risk progression breast epithelial 3D culture model reveals Cx43\/hsa_circ_0077755\/miR-182 as a biomarker axis for heightened risk of breast cancer initiation","volume":"11","author":"Naser Al Deen","year":"2021","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.slast.2024.100190_bib0010","first-page":"2091","article-title":"Hsa-miR-206 represses the proliferation and invasion of breast cancer cells by targeting Cx43","volume":"19","author":"Fu","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.slast.2024.100190_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11040460","article-title":"Cx43 expression correlates with breast cancer metastasis in MDA-MB-231 Cells In Vitro, in a mouse xenograft model and in human breast cancer tissues","volume":"11","author":"Kazan","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.slast.2024.100190_bib0012","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1158\/0008-5472.CAN-04-2367","article-title":"Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype","volume":"65","author":"Shao","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.slast.2024.100190_bib0013","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.2147\/OTT.S229076","article-title":"Connexin 43 Modulates the cellular resistance to paclitaxel via targeting beta-tubulin in triple-negative breast cancer","volume":"13","author":"Fu","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"10286","key":"10.1016\/j.slast.2024.100190_bib0014","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.slast.2024.100190_bib0015","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.slast.2024.100190_bib0016","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.taap.2017.11.020","article-title":"Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers","volume":"338","author":"Tsai","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0017","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10549-018-5063-9","article-title":"Connexin 43 is an independent predictor of patient outcome in breast cancer patients","volume":"174","author":"Chasampalioti","year":"2019","journal-title":"Breast Cancer Res Tr"},{"issue":"11","key":"10.1016\/j.slast.2024.100190_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112541","article-title":"Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis","volume":"9","author":"Teleki","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0019","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.slast.2024.100190_bib0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tcb.2014.12.006","article-title":"Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance","volume":"25","author":"Seguin","year":"2015","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.slast.2024.100190_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11010106","article-title":"Connexins and integrins in exosomes","volume":"11","author":"Shimaoka","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.slast.2024.100190_bib0022","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/bjc.2016.312","article-title":"The complexity of integrins in cancer and new scopes for therapeutic targeting","volume":"115","author":"Hamidi","year":"2016","journal-title":"Br J Cancer"},{"issue":"21","key":"10.1016\/j.slast.2024.100190_bib0023","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.4161\/cc.8.21.9963","article-title":"Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac)","volume":"8","author":"Glinskii","year":"2009","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.slast.2024.100190_bib0024","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00441-016-2474-y","article-title":"The role of integrins in TGFbeta activation in the tumour stroma","volume":"365","author":"Khan","year":"2016","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.slast.2024.100190_bib0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/embor.2009.276","article-title":"Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing","volume":"11","author":"Margadant","year":"2010","journal-title":"EMBO Rep"},{"issue":"5","key":"10.1016\/j.slast.2024.100190_bib0026","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3727\/096504017X15051723858706","article-title":"Ursolic acid attenuates TGF-beta1-induced epithelial-mesenchymal transition in NSCLC by targeting integrin alphaVbeta5\/MMPs signaling","volume":"27","author":"Ruan","year":"2019","journal-title":"Oncol Res"},{"issue":"2","key":"10.1016\/j.slast.2024.100190_bib0027","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yexcr.2017.03.051","article-title":"Integrin signaling potentiates transforming growth factor-beta 1 (TGF-beta 1) dependent down-regulation of E-Cadherin expression - Important implications for epithelial to mesenchymal transition (EMT) in renal cell carcinoma","volume":"355","author":"Feldkoren","year":"2017","journal-title":"Exp Cell Res."},{"key":"10.1016\/j.slast.2024.100190_bib0028","article-title":"A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin alpha v expression","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"10.1016\/j.slast.2024.100190_bib0029","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.canlet.2007.05.001","article-title":"Tissue microarray analysis of connexin expression and its prognostic significance in human breast cancer","volume":"255","author":"Conklin","year":"2007","journal-title":"Cancer Lett."}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630324000724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630324000724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:13:26Z","timestamp":1762629206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630324000724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2472630324000724"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2024.100190","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connexin 43 controls metastatic behavior in triple negative breast cancer through TGF\u03b21-Smad3-intergin \u03b1V signaling axis Based on optical image diagnosis","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2024.100190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100190"}}