{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:03:10Z","timestamp":1775797390227,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202101060054"],"award-info":[{"award-number":["202101060054"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.slast.2024.100209","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T13:40:57Z","timestamp":1728654057000},"page":"100209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bio inspired microfluidic-based analysis of Klebsiella pneumoniae virulence factors and antimicrobial resistance"],"prefix":"10.1016","volume":"29","author":[{"given":"Xiaoping","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Bin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.slast.2024.100209_bib0001","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/pathogens11090976","article-title":"Demographics, radiological findings, and clinical outcomes of Klebsiella pneumonia vs. Non-Klebsiella pneumoniae pyogenic liver abscess: a systematic review and meta-analysis with trial sequential analysis","volume":"11","author":"Chan","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.slast.2024.100209_bib0002","first-page":"89","article-title":"Research progress of highly virulent Klebsiella pneumoniae","author":"Chen","year":"2019","journal-title":"Chin J Exp Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.slast.2024.100209_bib0003","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/joim.13007","article-title":"Hypervirulent Klebsiella pneumoniae \u2013 clinical and molecular perspectives","volume":"287","author":"Choby","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.slast.2024.100209_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.105152","article-title":"The molecular characteristics, clinical manifestations, and risk factors of hypervirulent Klebsiella pneumoniae infections in a large teaching hospital in southwest China","volume":"162","author":"Ding","year":"2022","journal-title":"Microb Pathog"},{"issue":"6","key":"10.1016\/j.slast.2024.100209_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01863-18","article-title":"The capsule regulatory network of klebsiella pneumoniae defined by density-traDISort","volume":"9","author":"Dorman","year":"2018","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106025","article-title":"Hypervirulent and hypermucoviscous strains of Klebsiella pneumoniae challenged by antimicrobial strategies using visible light","volume":"56","author":"dos Anjos","year":"2020","journal-title":"Int J Antimicrob Agents"},{"issue":"9","key":"10.1016\/j.slast.2024.100209_bib0007","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00959-18","article-title":"Hypervirulent Klebsiella pneumoniae: a call for consensus definition and international collaboration","volume":"56","author":"Harada","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.slast.2024.100209_bib0008","first-page":"619","article-title":"Clinical characteristics and virulence gene detection of patients with liver abscess caused by Klebsiella pneumoniae","author":"He","year":"2021","journal-title":"Chin J Infect Control"},{"key":"10.1016\/j.slast.2024.100209_bib0009","first-page":"641","article-title":"Research advances in diagnosis and treatment of bacterial liver abscess","author":"Huang","year":"2018","journal-title":"J Clin Hepatol"},{"issue":"5","key":"10.1016\/j.slast.2024.100209_bib0010","first-page":"1072","article-title":"Virulence gene detection and homology analysis of Klebsiella pneumoniae inducing liver abscess","volume":"36","author":"JianFeng","year":"2020","journal-title":"J Clin Hepatol"},{"key":"10.1016\/j.slast.2024.100209_bib0011","first-page":"429","article-title":"Research progress on invasive infection of highly virulent Klebsiella pneumoniae","author":"Jiang","year":"2021","journal-title":"Chin Med Guide"},{"key":"10.1016\/j.slast.2024.100209_bib0012","first-page":"473","article-title":"Research progress on virulence and drug resistance mechanism of highly virulent Klebsiella pneumoniae","author":"Jiang","year":"2020","journal-title":"Chin J Infect Control"},{"key":"10.1016\/j.slast.2024.100209_bib0013","first-page":"210","article-title":"Klebsiella pneumoniae liver abscess","volume":"50","author":"Jun","year":"2018"},{"issue":"2","key":"10.1016\/j.slast.2024.100209_bib0014","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/antibiotics12020234","article-title":"Carbapenem-resistant Klebsiella pneumoniae: virulence factors, molecular epidemiology and latest updates in treatment options","volume":"12","author":"Karampatakis","year":"2023","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-018-0875-y","article-title":"A comparison of pyogenic liver abscess in patients with or without diabetes: a retrospective study of 246 cases","volume":"18","author":"Li","year":"2018","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.slast.2024.100209_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.783523","article-title":"Multicenter surveillance of capsular serotypes, virulence genes, and antimicrobial susceptibilities of Klebsiella pneumoniae causing bacteremia in Taiwan, 2017\u20132019","volume":"13","author":"Liao","year":"2022","journal-title":"Front Microbiol"},{"issue":"OCT","key":"10.1016\/j.slast.2024.100209_bib0017","article-title":"Fnr-dependent rmpa and rmpa2 regulation of capsule polysaccharide biosynthesis in klebsiella pneumoniae","volume":"10","author":"Lin","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.slast.2024.100209_bib0018","first-page":"696","article-title":"Distribution characteristics and drug resistance analysis of carbapenem-resistant pathogens","author":"Liu","year":"2020","journal-title":"Chin J Antibiot"},{"key":"10.1016\/j.slast.2024.100209_bib0019","first-page":"55","article-title":"Analysis of clinical and etiological characteristics of 71 cases of liver abscess","author":"Mao","year":"2021","journal-title":"Guangzhou Med"},{"issue":"3","key":"10.1016\/j.slast.2024.100209_bib0020","article-title":"Klebsiella liver abscess: an emerging infection worldwide","volume":"7","author":"nagra","year":"2020","journal-title":"Int J Clin Stud Med Case Rep"},{"key":"10.1016\/j.slast.2024.100209_bib0021","first-page":"748","article-title":"Clinical analysis and drug resistance analysis of hypermucinous Klebsiella pneumoniae infection","author":"Yan","year":"2021","journal-title":"China Trop Med"},{"issue":"2","key":"10.1016\/j.slast.2024.100209_bib0022","doi-asserted-by":"crossref","DOI":"10.1128\/aac.02011-21","article-title":"New Delhi Metallo-beta-lactamase facilitates the emergence of Cefiderocol Resistance in Enterobacter cloacae","volume":"66","author":"Nurjadi","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.slast.2024.100209_bib0023","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cmi.2020.05.012","article-title":"Detection of multiple hypervirulent Klebsiella pneumoniae strains in a New York City hospital through screening of virulence genes","volume":"27","author":"Parrott","year":"2021","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0024","article-title":"Virulence factors, capsular serotypes and antimicrobial resistance of Hypervirulent Klebsiella pneumoniae and classical Klebsiella pneumoniae in Southeast Iran","volume":"51","author":"Rastegar","year":"2019","journal-title":"Infect Chemother"},{"issue":"03","key":"10.1016\/j.slast.2024.100209_bib0025","first-page":"283","article-title":"Occurrence and characterization of hyperviscous K1 and K2 serotype in Klebsiella pneumoniael","volume":"10","author":"Remya","year":"2018","journal-title":"J Lab Phys"},{"issue":"5","key":"10.1016\/j.slast.2024.100209_bib0026","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s15010-022-01793-z","article-title":"Large retrospective study analysing predictive factors of primary treatment failure, recurrence and death in pyogenic liver abscesses","volume":"50","author":"Rossi","year":"2022","journal-title":"Infection"},{"key":"10.1016\/j.slast.2024.100209_bib0027","doi-asserted-by":"crossref","first-page":"e00547","DOI":"10.1016\/j.idcr.2019.e00547","article-title":"Hypermucoviscous Klebsiella pneumoniae: a challenge in community acquired infection","volume":"17","author":"S\u00e1nchez-L\u00f3pez","year":"2019","journal-title":"IDCases"},{"issue":"7","key":"10.1016\/j.slast.2024.100209_bib0028","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/life11070676","article-title":"Hypervirulent Klebsiella pneumoniae endogenous endophthalmitis\u2014a global emerging disease","volume":"11","author":"Serban","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.slast.2024.100209_bib0029","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.2147\/IDR.S371477","article-title":"Clinical and Microbiological Characteristics of Klebsiella pneumoniae Bloodstream Infection in a Chinese Hospital: Hypervirulent and Multiclonal","volume":"15","author":"Sheng","year":"2022","journal-title":"Infect Drug Resist"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-78442-8","article-title":"The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients","volume":"10","author":"Tai","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0031","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jmii.2017.07.003","article-title":"Hypermucoviscosity, rmpA, and aerobactin are associated with community-acquired Klebsiella pneumoniae bacteremic isolates causing liver abscess in Singapore","volume":"52","author":"Tan","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.slast.2024.100209_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.581543","article-title":"Epidemiological characteristics and formation mechanisms of multidrug-resistant Hypervirulent Klebsiella pneumoniae","volume":"11","author":"Tang","year":"2020","journal-title":"Front Microbiol"},{"issue":"9","key":"10.1016\/j.slast.2024.100209_bib0033","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1007\/s00330-022-08740-4","article-title":"Development and validation of a prediction model based on clinical and CT features for invasiveness of K. pneumoniae liver abscess","volume":"32","author":"Wang","year":"2022","journal-title":"Eur Radiol"},{"key":"10.1016\/j.slast.2024.100209_bib0034","first-page":"55","article-title":"Analysis of clinical characteristics and prognostic factors of bacterial liver abscess with and without diabetes","author":"Wu","year":"2019","journal-title":"J Int Epidemiol Infect Dis"},{"key":"10.1016\/j.slast.2024.100209_bib0035","first-page":"221","article-title":"Clinical features and mechanism of high virulence of Klebsiella pneumoniae","author":"Ye","year":"2017","journal-title":"Int Respir J"},{"key":"10.1016\/j.slast.2024.100209_bib0036","first-page":"1477","article-title":"Research progress on virulence and drug resistance mechanism of highly virulent Klebsiella pneumoniae","author":"Zhou","year":"2022","journal-title":"Dis Surveill"},{"issue":"6","key":"10.1016\/j.slast.2024.100209_bib0037","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1086\/516369","article-title":"Primary liver abscess due to Klebsiella pneumoniae in Taiwan","volume":"26","author":"Wang","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"11","key":"10.1016\/j.slast.2024.100209_bib0038","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1473-3099(12)70205-0","article-title":"Klebsiella pneumoniae liver abscess: a new invasive syndrome","volume":"12","author":"Siu","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.slast.2024.100209_bib0039","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1086\/519262","article-title":"Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess","volume":"45","author":"Fang","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.slast.2024.100209_bib0040","first-page":"230","article-title":"Clinical significance of Klebsiella pneumoniae bacteremia in diabetic patients with liver abscess","volume":"48","author":"Lai","year":"2004","journal-title":"J Infect"},{"issue":"11","key":"10.1016\/j.slast.2024.100209_bib0041","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1086\/425616","article-title":"Pyogenic liver abscess: recent trends in etiology and mortality","volume":"39","author":"Rahimian","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.slast.2024.100209_bib0042","first-page":"707","article-title":"Pyogenic liver abscess caused by Klebsiella pneumoniae: analysis of 42 cases","volume":"39","author":"Yang","year":"2010","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.slast.2024.100209_bib0043","series-title":"Antibiotic Resistance Threats in the United States, 2019","year":"2019"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0044","first-page":"1","article-title":"Emergence of carbapenem-resistant Klebsiella pneumoniae in liver abscess: a warning signal","volume":"9","author":"Liu","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"issue":"suppl_1","key":"10.1016\/j.slast.2024.100209_bib0045","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/infdis\/jiw282","article-title":"The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace","volume":"215","author":"Logan","year":"2017","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.slast.2024.100209_bib0046","first-page":"806","article-title":"Hypervirulent Klebsiella pneumoniae liver abscess: a comprehensive review of the literature","volume":"52","author":"Wu","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"issue":"5","key":"10.1016\/j.slast.2024.100209_bib0047","first-page":"621","article-title":"Klebsiella pneumoniae liver abscess: a new and emerging infectious disease in Taiwan","volume":"45","author":"Fang","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.slast.2024.100209_bib0048","first-page":"1230","article-title":"The global spread of hypervirulent Klebsiella pneumoniae and the emergence of multidrug-resistant strains","volume":"25","author":"Hsu","year":"2019","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0049","first-page":"15","article-title":"Carbapenem-resistant Klebsiella pneumoniae infections in the United States: an overview of the epidemiology and clinical impact","volume":"9","author":"Shankar","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"issue":"5","key":"10.1016\/j.slast.2024.100209_bib0050","first-page":"717","article-title":"Carbapenem-resistant Klebsiella pneumoniae: mechanisms and treatment options","volume":"51","author":"Giddins","year":"2018","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"10.1016\/j.slast.2024.100209_bib0051","first-page":"1","article-title":"Antibiotic resistance in Klebsiella pneumoniae: a review of recent developments and clinical implications","volume":"9","author":"Liu","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"issue":"2","key":"10.1016\/j.slast.2024.100209_bib0052","first-page":"117","article-title":"Carbapenem-resistant Klebsiella pneumoniae infections: clinical impact and treatment options","volume":"68","author":"Doi","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.slast.2024.100209_bib0053","first-page":"1595","article-title":"Efficacy of antibiotic treatment for Klebsiella pneumoniae liver abscesses: a meta-analysis","volume":"76","author":"Fang","year":"2021","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"10.1016\/j.slast.2024.100209_bib0054","first-page":"e00022","article-title":"Clinical outcomes of Klebsiella pneumoniae liver abscesses and the role of antibiotic resistance","volume":"33","author":"Chen","year":"2020","journal-title":"Clin Microbiol Rev"}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630324000918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630324000918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:04:58Z","timestamp":1755619498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630324000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2472630324000918"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2024.100209","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bio inspired microfluidic-based analysis of Klebsiella pneumoniae virulence factors and antimicrobial resistance","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2024.100209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100209"}}