{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:03:57Z","timestamp":1791896637540,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.slast.2025.100254","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T08:07:54Z","timestamp":1738656474000},"page":"100254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Systemic trafficking of macrophages in implant wear debris-induced periprosthetic osteolysis"],"prefix":"10.1016","volume":"31","author":[{"given":"Mengyun","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.slast.2025.100254_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1310262","article-title":"Roles of inflammatory cell infiltrate in periprosthetic osteolysis","volume":"14","author":"Panez-Toro","year":"2023","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.slast.2025.100254_bib0002","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1302\/0301-620X.103B11.BJJ-2020-2334.R1","article-title":"What factors drive polyethylene wear in total knee arthroplasty?: results of a large retrieval series","volume":"103-B","author":"Currier","year":"2021","journal-title":"Bone Joint J"},{"issue":"20","key":"10.1016\/j.slast.2025.100254_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12206615","article-title":"Wear, osteolysis, and aseptic loosening following total hip arthroplasty in young patients with highly cross-linked polyethylene: a review of studies with a follow-up of over 15 years","volume":"12","author":"Deans","year":"2023","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.slast.2025.100254_bib0004","article-title":"The role of the Innate Immune system in wear debris-induced inflammatory peri-implant osteolysis in total joint arthroplasty","volume":"9","author":"Connors","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.slast.2025.100254_bib0005","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.actbio.2017.11.001","article-title":"Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants uncovers a common gene expression signature of rheumatoid arthritis","volume":"65","author":"Terkawi","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.slast.2025.100254_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104482","article-title":"A review on osteoclast diseases and osteoclastogenesis inhibitors recently developed from natural resources","volume":"142","author":"Wang","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.slast.2025.100254_bib0007","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3389\/fimmu.2018.01145","article-title":"Disease-associated particulates and joint inflammation; mechanistic insights and potential therapeutic targets","volume":"9","author":"Mahon","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0008","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1186\/s12879-022-07824-2","article-title":"Acremonium (Sarocladium) periprosthetic joint infection: case report, literature review, and proposed antifungal regimen","volume":"22","author":"Tabliago","year":"2022","journal-title":"BMC Infect Dis"},{"issue":"12","key":"10.1016\/j.slast.2025.100254_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122091","article-title":"Periprosthetic osteolysis: mechanisms, prevention and treatment","volume":"8","author":"Goodman","year":"2019","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0010","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1038\/s41467-022-31646-0","article-title":"Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis","volume":"13","author":"Alhasan","year":"2022","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0011","doi-asserted-by":"crossref","first-page":"25","DOI":"10.13107\/jocr.2023.v13.i02.3542","article-title":"Massive periprosthetic osteolysis spreads to the soft tissue and pelvic region after primary total hip replacement: a case report","volume":"13","author":"Ponomarjova","year":"2023","journal-title":"J Orthop Case Rep"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0012","doi-asserted-by":"crossref","first-page":"okab013","DOI":"10.1093\/neuopn\/okab013","article-title":"Periprosthetic osteolysis in cervical total disc arthroplasty: a single institutional experience","volume":"2","author":"Ebinu","year":"2021","journal-title":"Neurosurgery Practice"},{"issue":"10","key":"10.1016\/j.slast.2025.100254_bib0013","doi-asserted-by":"crossref","first-page":"768","DOI":"10.5312\/wjo.v12.i10.768","article-title":"Osteolysis in total hip arthroplasty in relation to metal ion release: comparison between monolithic prostheses and different modularities","volume":"12","author":"Manfreda","year":"2021","journal-title":"World J Orthop"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0014","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1243\/0954411971534304","article-title":"Biological reaction to debris in relation to joint prostheses","volume":"211","author":"Revell","year":"1997","journal-title":"Proc Inst Mech Eng H"},{"key":"10.1016\/j.slast.2025.100254_bib0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jmbbm.2014.01.005","article-title":"Periprosthetic wear particle migration and distribution modelling and the implication for osteolysis in cementless total hip replacement","volume":"32","author":"Alidousti","year":"2014","journal-title":"J Mech Behav Biomed Mater"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0016","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0883-5403(00)91259-2","article-title":"Migration of polyethylene wear debris in one type of uncemented femoral component with circumferential porous coating: an autopsy study of 5 femurs","volume":"15","author":"von Knoch","year":"2000","journal-title":"J Arthroplasty"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0017","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10753-019-01149-0","article-title":"Impaired autophagy in the fibroblasts by titanium particles increased the release of CX3CL1 and promoted the chemotactic migration of monocytes","volume":"43","author":"Wu","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.slast.2025.100254_bib0018","article-title":"Lonafarnib inhibits farnesyltransferase via suppressing ERK signaling pathway to prevent osteoclastogenesis in titanium particle-induced osteolysis","volume":"13","author":"Huang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.slast.2025.100254_bib0019","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jbm.a.32744","article-title":"Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by noninvasive imaging","volume":"94A","author":"Ren","year":"2010","journal-title":"J Biomed Mater Res Part A"},{"issue":"36","key":"10.1016\/j.slast.2025.100254_bib0020","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1016\/j.biomaterials.2008.09.004","article-title":"Systemic trafficking of macrophages induced by bone cement particles in nude mice","volume":"29","author":"Ren","year":"2008","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.slast.2025.100254_bib0021","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jor.21287","article-title":"Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis","volume":"29","author":"Yang","year":"2011","journal-title":"J Orthop Res"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0022","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11914-022-00720-3","article-title":"Macrophage polarization and the osteoimmunology of periprosthetic osteolysis","volume":"20","author":"Goodman","year":"2022","journal-title":"Curr Osteoporos Rep"},{"issue":"9","key":"10.1016\/j.slast.2025.100254_bib0023","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1002\/jbm.a.34981","article-title":"Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles","volume":"102","author":"Yao","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.slast.2025.100254_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1123753","article-title":"The dual role of autophagy in periprosthetic osteolysis","volume":"11","author":"Yin","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.slast.2025.100254_bib0025","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1177\/0022034518777973","article-title":"Resolving macrophages counter osteolysis by anabolic actions on bone cells","volume":"97","author":"Viniegra","year":"2018","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.slast.2025.100254_bib0026","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/cmi.12536","article-title":"Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish","volume":"18","author":"Vincent","year":"2016","journal-title":"Cell Microbiol"},{"issue":"6","key":"10.1016\/j.slast.2025.100254_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061995","article-title":"Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets","volume":"9","author":"Scioli","year":"2020","journal-title":"J Clin Med"},{"issue":"9","key":"10.1016\/j.slast.2025.100254_bib0028","doi-asserted-by":"crossref","first-page":"12996","DOI":"10.18632\/aging.202973","article-title":"Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2","volume":"13","author":"Li","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"8","key":"10.1016\/j.slast.2025.100254_bib0029","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/j.actbio.2014.04.034","article-title":"Suppression of wear-particle-induced pro-inflammatory cytokine and chemokine production in macrophages via NF-\u03baB decoy oligodeoxynucleotide: a preliminary report","volume":"10","author":"Lin","year":"2014","journal-title":"Acta Biomater"},{"issue":"5","key":"10.1016\/j.slast.2025.100254_bib0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.shk.0000228801.56223.92","article-title":"Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1\/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production","volume":"26","author":"Gomes","year":"2006","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.slast.2025.100254_bib0031","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/jor.21548","article-title":"Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles","volume":"30","author":"Gibon","year":"2012","journal-title":"J Orthop Res"},{"key":"10.1016\/j.slast.2025.100254_bib0032","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fendo.2018.00313","article-title":"Role of tumor-derived chemokines in osteolytic bone metastasis","volume":"9","author":"Coniglio","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113343","article-title":"Single-cell RNA analysis of chemokine expression in heterogeneous CD14(+) monocytes with lipopolysaccharide-induced bone resorption","volume":"420","author":"Luo","year":"2022","journal-title":"Exp Cell Res"},{"issue":"3","key":"10.1016\/j.slast.2025.100254_bib0034","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/os.13608","article-title":"HUCMSC-derived exosomes suppress the titanium particles-induced osteolysis in mice through inhibiting CCL2 and CCL3","volume":"15","author":"Li","year":"2023","journal-title":"Orthop Surg"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12906-020-03014-2","article-title":"Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production","volume":"20","author":"Liang","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0036","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/leu.2015.259","article-title":"Osteolytic lesions, cytogenetic features and bone marrow levels of cytokines and chemokines in multiple myeloma patients: role of chemokine (C-C motif) ligand 20","volume":"30","author":"Palma","year":"2016","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0037","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5414\/CNP61030","article-title":"Differential expression of beta-chemokines MCP-1 and RANTES and their receptors CCR1, CCR2, CCR5 in acute rejection and chronic allograft nephropathy of human renal allografts","volume":"61","author":"R\u00fcster","year":"2004","journal-title":"Clin Nephrol"},{"issue":"4","key":"10.1016\/j.slast.2025.100254_bib0038","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006808","article-title":"Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression","volume":"11","author":"Xu","year":"2023","journal-title":"J Immunother Cancer"},{"issue":"4","key":"10.1016\/j.slast.2025.100254_bib0039","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s13167-019-00182-1","article-title":"Immunohistological staining of unknown chemokine RANTES\/CCL5 expression in jawbone marrow defects-osteoimmunology and disruption of bone remodeling in clinical case studies targeting on predictive preventive personalized medicine","volume":"10","author":"Lechner","year":"2019","journal-title":"Epma j"},{"key":"10.1016\/j.slast.2025.100254_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103209","article-title":"Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression","volume":"74","author":"Gu","year":"2024","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.slast.2025.100254_bib0041","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","article-title":"The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell Mol Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.slast.2025.100254_bib0042","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.slast.2025.100254_bib0043","first-page":"1055","article-title":"The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles","volume":"28","author":"Lochner","year":"2011","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0044","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S8756-3282(03)00086-3","article-title":"Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease","volume":"33","author":"Bendre","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.slast.2025.100254_bib0045","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.3389\/fimmu.2020.01720","article-title":"Blockade of XCL1\/lymphotactin ameliorates severity of periprosthetic osteolysis triggered by polyethylene-particles","volume":"11","author":"Tian","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.slast.2025.100254_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111503","article-title":"Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis","volume":"138","author":"Yamada","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.slast.2025.100254_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-9936-1_1","article-title":"Studying the pro-migratory effects of MIF","volume":"2080","author":"Hoffmann","year":"2020","journal-title":"Methods Mol Biol"},{"issue":"8","key":"10.1016\/j.slast.2025.100254_bib0048","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1039\/D3MA00733B","article-title":"Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis","volume":"5","author":"Chen","year":"2024","journal-title":"Mater Adv"},{"issue":"12","key":"10.1016\/j.slast.2025.100254_bib0049","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.slast.2025.100254_bib0050","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000360988","article-title":"Calcitonin gene-related peptide modulates the production of pro-inflammatory cytokines associated with periprosthetic osteolysis by THP-1 macrophage-like cells","volume":"22","author":"Jablonski","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.slast.2025.100254_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.746391","article-title":"Icariin alleviates wear particle-induced periprosthetic osteolysis via down-regulation of the estrogen receptor \u03b1-mediated NF-\u03bab signaling pathway in macrophages","volume":"12","author":"Guangtao","year":"2021","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.slast.2025.100254_bib0052","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/jbm.b.35019","article-title":"Determination of optimal concentration of vitamin E in polyethylene liners for producing minimal biological response to prosthetic wear debris","volume":"110","author":"Matsumae","year":"2022","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"3","key":"10.1016\/j.slast.2025.100254_bib0053","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1074\/jbc.M112.419788","article-title":"Interleukin-6\/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration","volume":"288","author":"Zhang","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.slast.2025.100254_bib0054","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4049\/jimmunol.178.1.463","article-title":"Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages","volume":"178","author":"Thorley","year":"2007","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.slast.2025.100254_bib0055","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41571-021-00588-9","article-title":"Harnessing cytokines and chemokines for cancer therapy","volume":"19","author":"Propper","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.slast.2025.100254_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213762","article-title":"Co-release of nitric oxide and l-arginine from poly (\u03b2-amino ester)-based adhesive reprogram macrophages for accelerated wound healing and angiogenesis in vitro and in vivo","volume":"158","author":"Heydari","year":"2024","journal-title":"Biomater Adv"},{"issue":"10","key":"10.1016\/j.slast.2025.100254_bib0057","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1007\/s13346-021-01110-5","article-title":"Recent progress of macrophage vesicle-based drug delivery systems","volume":"12","author":"Xu","year":"2022","journal-title":"Drug Deliv Transl Res"},{"issue":"2","key":"10.1016\/j.slast.2025.100254_bib0058","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.apsb.2022.09.016","article-title":"Salmonella-mediated blood\u2012brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo\/bacterial glioma therapy","volume":"13","author":"Mi","year":"2023","journal-title":"Acta Pharm Sin B"},{"issue":"43","key":"10.1016\/j.slast.2025.100254_bib0059","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1021\/acsnano.4c10053","article-title":"Bone destruction-chemotactic osteoprogenitor cells deliver liposome nanomedicines for the treatment of osteosarcoma and osteoporosis","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630325000123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630325000123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:07:41Z","timestamp":1747285661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630325000123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":59,"alternative-id":["S2472630325000123"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2025.100254","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic trafficking of macrophages in implant wear debris-induced periprosthetic osteolysis","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2025.100254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100254"}}