{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:35Z","timestamp":1791846395183,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.slast.2026.100402","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:19:41Z","timestamp":1771489181000},"page":"100402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Single cell transcriptomic atlas reveals macrophage polarization dynamics and intercellular communication networks in gingival tissue of periodontitis patients undergoing orthodontic treatment"],"prefix":"10.1016","volume":"38","author":[{"given":"Cong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.slast.2026.100402_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"10.1016\/j.slast.2026.100402_bib0002","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.slast.2026.100402_bib0003","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tim.2016.02.010","article-title":"Dancing with the stars: how choreographed bacterial interactions dictate nososymbiocity and give rise to keystone pathogens, accessory pathogens, and pathobionts","volume":"24","author":"Hajishengallis","year":"2016","journal-title":"Trends Microbiol"},{"issue":"5","key":"10.1016\/j.slast.2026.100402_bib0004","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ajodo.2003.12.026","article-title":"Factors of importance for the development of dehiscences during labial movement of mandibular incisors: a retrospective study of adult orthodontic patients","volume":"127","author":"Melsen","year":"2005","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"3","key":"10.1016\/j.slast.2026.100402_bib0005","first-page":"355","article-title":"Root resorption and orthodontic treatment in periodontal compromised vs periodontally healthy patients: a comparative study","volume":"152","author":"Jiang","year":"2017","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"10","key":"10.1016\/j.slast.2026.100402_bib0006","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jdent.2014.07.013","article-title":"Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis","volume":"42","author":"Gkantidis","year":"2014","journal-title":"J Dent"},{"issue":"9","key":"10.1016\/j.slast.2026.100402_bib0007","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1902\/jop.2016.160081","article-title":"Enhanced activity of the macrophage M1\/M2 phenotypes and phenotypic switch to M1 in periodontal infection","volume":"87","author":"Yu","year":"2016","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0008","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"issue":"7446","key":"10.1016\/j.slast.2026.100402_bib0009","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/prd.12032","article-title":"Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone","volume":"63","author":"Sima","year":"2013","journal-title":"Periodontol 2000"},{"issue":"9","key":"10.1016\/j.slast.2026.100402_bib0011","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1177\/0022034515589714","article-title":"M1-like macrophage polarization promotes orthodontic tooth movement","volume":"94","author":"He","year":"2015","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2017.06.014","article-title":"Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity","volume":"22","author":"Xiao","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"7637","key":"10.1016\/j.slast.2026.100402_bib0013","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature21350","article-title":"Scaling single-cell genomics from phenomenology to mechanism","volume":"541","author":"Tanay","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0014","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2017.76","article-title":"Single-cell RNA sequencing to explore immune cell heterogeneity","volume":"18","author":"Papalexi","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.slast.2026.100402_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"7719","key":"10.1016\/j.slast.2026.100402_bib0016","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.slast.2026.100402_bib0017","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0018","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ni.3324","article-title":"New insights into the multidimensional concept of macrophage ontogeny, activation and function","volume":"17","author":"Ginhoux","year":"2016","journal-title":"Nat Immunol"},{"issue":"10","key":"10.1016\/j.slast.2026.100402_bib0019","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1177\/0022034518785857","article-title":"Macrophages: bridge between resolution of inflammation and tissue repair","volume":"97","author":"Garlet","year":"2018","journal-title":"J Dent Res"},{"issue":"12","key":"10.1016\/j.slast.2026.100402_bib0020","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"issue":"9","key":"10.1016\/j.slast.2026.100402_bib0021","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"11","key":"10.1016\/j.slast.2026.100402_bib0022","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"7148","key":"10.1016\/j.slast.2026.100402_bib0023","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPAR\u03b3 controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.slast.2026.100402_bib0024","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"Guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.slast.2026.100402_bib0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage immunometabolism: where are we (going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.slast.2026.100402_bib0026","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.slast.2026.100402_bib0027","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20030286","article-title":"MIF signal transduction initiated by binding to CD74","volume":"197","author":"Leng","year":"2003","journal-title":"J Exp Med"},{"issue":"43","key":"10.1016\/j.slast.2026.100402_bib0028","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","author":"McWhorter","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.slast.2026.100402_bib0029","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.slast.2026.100402_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"7350","key":"10.1016\/j.slast.2026.100402_bib0031","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.slast.2026.100402_bib0032","article-title":"Functions and mechanisms of mechanotransduction in orthodontic tooth movement","volume":"2017","author":"Chen","year":"2017","journal-title":"Biomed Res Int"},{"issue":"4","key":"10.1016\/j.slast.2026.100402_bib0033","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"issue":"12","key":"10.1016\/j.slast.2026.100402_bib0034","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10.1016\/j.slast.2026.100402_bib0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"Glass","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"6359","key":"10.1016\/j.slast.2026.100402_bib0036","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.aan6828","article-title":"Single-cell transcriptomics to explore the immune system in health and disease","volume":"358","author":"Stubbington","year":"2017","journal-title":"Science"}],"updated-by":[{"DOI":"10.1016\/j.slast.2026.100439","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000}},{"DOI":"10.1016\/j.slast.2026.100439","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000}}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:26:38Z","timestamp":1777735598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630326000154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S2472630326000154"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2026.100402","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single cell transcriptomic atlas reveals macrophage polarization dynamics and intercellular communication networks in gingival tissue of periodontitis patients undergoing orthodontic treatment","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2026.100402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100402"}}