{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:55:52Z","timestamp":1782413752569,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017293","name":"Chinese Academy of Sciences Suzhou Institute of Nano-tech and Nano-Bionics Vacuum Interconnected Nanotech Workstation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016105","name":"Quzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025K013"],"award-info":[{"award-number":["2025K013"]}],"id":[{"id":"10.13039\/501100016105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.slast.2026.100412","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:54:28Z","timestamp":1773474868000},"page":"100412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Integrative transcriptomic profiling reveals molecular signatures of disease progression from gastroesophageal reflux disease to Barrett's esophagus: A foundation for single-cell resolution studies"],"prefix":"10.1016","volume":"38","author":[{"given":"Shanshan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.slast.2026.100412_bib0001","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.gtc.2015.02.001","article-title":"Epidemiology of Barrett's esophagus and esophageal adenocarcinoma","volume":"44","author":"Runge","year":"2015","journal-title":"Gastroenterol Clin North Am"},{"issue":"3","key":"10.1016\/j.slast.2026.100412_bib0002","first-page":"165","article-title":"Systematic review and meta-analysis of prevalence and risk factors for Barrett's esophagus","volume":"12","author":"Thapa","year":"2019","journal-title":"Gastroenterol Res"},{"issue":"9","key":"10.1016\/j.slast.2026.100412_bib0003","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMra1314704","article-title":"Barrett's esophagus","volume":"371","author":"Spechler","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.slast.2026.100412_bib0004","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1053\/j.gastro.2005.08.053","article-title":"Prevalence of Barrett's esophagus in the general population: an endoscopic study","volume":"129","author":"Ronkainen","year":"2005","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.slast.2026.100412_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/jnci\/dji024","article-title":"The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence","volume":"97","author":"Pohl","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"10.1016\/j.slast.2026.100412_bib0006","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4251\/wjgo.v6.i5.112","article-title":"Esophageal cancer: a review of epidemiology, pathogenesis, staging workup and treatment modalities","volume":"6","author":"Napier","year":"2014","journal-title":"World J Gastrointest Oncol"},{"issue":"6","key":"10.1016\/j.slast.2026.100412_bib0007","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/jgh.13289","article-title":"Trends in esophageal cancer survival in United States adults from 1973 to 2009: a SEER database analysis","volume":"31","author":"Njei","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.slast.2026.100412_bib0008","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1136\/gutjnl-2020-321600","article-title":"Global burden of oesophageal and gastric cancer by histology and subsite in 2018","volume":"69","author":"Arnold","year":"2020","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.slast.2026.100412_bib0009","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1056\/NEJM199903183401101","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma","volume":"340","author":"Lagergren","year":"1999","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.slast.2026.100412_bib0010","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1056\/NEJMoa1103042","article-title":"Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus","volume":"365","author":"Hvid-Jensen","year":"2011","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.slast.2026.100412_bib0011","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"14","key":"10.1016\/j.slast.2026.100412_bib0012","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1093\/nar\/gku555","article-title":"Single-cell RNA-seq: advances and future challenges","volume":"42","author":"Saliba","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"7680","key":"10.1016\/j.slast.2026.100412_bib0013","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"issue":"7746","key":"10.1016\/j.slast.2026.100412_bib0014","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","article-title":"Colonic epithelial cell diversity in health and inflammatory bowel disease","volume":"567","author":"Parikh","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.slast.2026.100412_bib0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gutjnl-2019-320368","article-title":"Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.slast.2026.100412_bib0016","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1158\/1541-7786.MCR-17-0332","article-title":"Novel aberrations uncovered in Barrett's esophagus and esophageal adenocarcinoma using whole transcriptome sequencing","volume":"15","author":"Maag","year":"2017","journal-title":"Mol Cancer Res"},{"issue":"8","key":"10.1016\/j.slast.2026.100412_bib0017","first-page":"1430","article-title":"Structural alterations of the mucosa stroma in the Barrett's esophagus metaplasia-dysplasia-adenocarcinoma sequence","volume":"27","author":"Bobryshev","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.slast.2026.100412_bib0018","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1038\/s41467-018-06796-9","article-title":"Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands","volume":"9","author":"Owen","year":"2018","journal-title":"Nat Commun"},{"issue":"15","key":"10.1016\/j.slast.2026.100412_bib0019","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1056\/NEJMoa1103042","article-title":"Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus","volume":"365","author":"Hvid-Jensen","year":"2011","journal-title":"N Engl J Med"},{"issue":"6556","key":"10.1016\/j.slast.2026.100412_bib0020","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.abd1449","article-title":"Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition","volume":"373","author":"Nowicki-Osuch","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.slast.2026.100412_bib0021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2407-7-97","article-title":"Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study","volume":"7","author":"Beales","year":"2007","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.slast.2026.100412_bib0022","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/01.sla.0000118751.95179.c6","article-title":"NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy","volume":"239","author":"Abdel-Latif","year":"2004","journal-title":"Ann Surg"},{"issue":"11","key":"10.1016\/j.slast.2026.100412_bib0023","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1517\/13543784.2010.520701","article-title":"Akt inhibitors in clinical development for the treatment of cancer","volume":"19","author":"Pal","year":"2010","journal-title":"Expert Opin Investig Drugs"},{"issue":"7636","key":"10.1016\/j.slast.2026.100412_bib0024","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.slast.2026.100412_bib0025","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.slast.2026.100412_bib0026","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1053\/j.gastro.2020.01.044","article-title":"Identification of subtypes of Barrett's esophagus and esophageal adenocarcinoma based on DNA methylation profiles and integration of transcriptome and genome data","volume":"158","author":"Jammula","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.slast.2026.100412_bib0027","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.canlet.2015.10.019","article-title":"Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma","volume":"370","author":"Kavanagh","year":"2016","journal-title":"Cancer Lett"},{"issue":"6","key":"10.1016\/j.slast.2026.100412_bib0028","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.1820459116","article-title":"Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma","volume":"116","author":"Ebbing","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.slast.2026.100412_bib0029","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/gut.51.3.316","article-title":"Inflammatory gradient in Barrett's oesophagus: implications for disease complications","volume":"51","author":"Fitzgerald","year":"2002","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.slast.2026.100412_bib0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2011.12.004","article-title":"Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia","volume":"21","author":"Quante","year":"2012","journal-title":"Cancer Cell"}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:27:56Z","timestamp":1777735676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630326000257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"alternative-id":["S2472630326000257"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2026.100412","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative transcriptomic profiling reveals molecular signatures of disease progression from gastroesophageal reflux disease to Barrett's esophagus: A foundation for single-cell resolution studies","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2026.100412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100412"}}